Vortioxetine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle 0.085138
LOC112694756 uncharaterized LOC112694756 0.0783508
EEF2 eukaryotic translation elongation factor 2 0.0774369
TMSB4X thymosin beta 4, X-linked 0.0714901
PDE4B phosphodiesterase 4B, cAMP-specific 0.067438
RPL3 ribosomal protein L3 0.0665333
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0644699
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0545647
EZR ezrin 0.0540789
EGFR epidermal growth factor receptor 0.0533349
VCL vinculin 0.0502747
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0484426
CALR calreticulin 0.0483038
APP amyloid beta (A4) precursor protein 0.0461932
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0452465
PGK1 phosphoglycerate kinase 1 0.044443
SRRM2 serine/arginine repetitive matrix 2 0.0443969
BMP10 bone morphogenetic protein 10 0.0441203
FBLN2 fibulin 2 0.0429162
CD47 CD47 molecule 0.0421059
HSPA8 heat shock 70kDa protein 8 0.0411782
NPAS2 neuronal PAS domain protein 2 0.0402555
LPP LIM domain containing preferred translocation partner in lipoma 0.0381263
POTEF POTE ankyrin domain family, member F 0.0375499
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0374427
LOXL3 lysyl oxidase-like 3 0.0358732
CLTC clathrin, heavy chain (Hc) 0.0357471
ANXA1 annexin A1 0.0351144
SEPTIN9 septin 9 0.0343124
PICALM phosphatidylinositol binding clathrin assembly protein 0.0341347
AMOTL2 angiomotin like 2 0.0330533
CPED1 cadherin-like and PC-esterase domain containing 1 0.0320485
RPL4 ribosomal protein L4 0.0313739
TGFBR3 transforming growth factor, beta receptor III 0.031086
ENO2 enolase 2 (gamma, neuronal) 0.0310129
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0307327
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0307115
TTC28 tetratricopeptide repeat domain 28 0.0304134
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0298094
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0293552
HDGF hepatoma-derived growth factor 0.0284488
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0283709
MED13L mediator complex subunit 13-like 0.0283618
ECPAS Ecm29 proteasome adaptor and scaffold 0.0278592
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0276048
GLI3 GLI family zinc finger 3 0.0269211
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0258223
TOP2B topoisomerase (DNA) II beta 180kDa 0.0250678
MYO5A myosin VA (heavy chain 12, myoxin) 0.0248305
IRS1 insulin receptor substrate 1 0.0243293
CCN2 cellular communication network factor 2 0.0240952
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0240054
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0232775
PRELID2 PRELI domain containing 2 0.0226892
ZDHHC21 zinc finger, DHHC-type containing 21 0.0226358
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0226054
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0223565
NBEA neurobeachin 0.022352
BLTP2 bridge-like lipid transfer protein family member 2 0.0220761
GYS1 glycogen synthase 1 (muscle) 0.0215793
ANKRD36 ankyrin repeat domain 36 0.0213342
DOCK5 dedicator of cytokinesis 5 0.0213111
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0211944
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0210024
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0209721
COPA coatomer protein complex, subunit alpha 0.0208725
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0205538
ANKRD36B ankyrin repeat domain 36B 0.0203573
BCLAF1 BCL2-associated transcription factor 1 0.019942
PTPRF protein tyrosine phosphatase, receptor type, F 0.0198144
SOX6 SRY (sex determining region Y)-box 6 0.0196372
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0195779
H1-4 H1.4 linker histone, cluster member 0.0193306
FUBP1 far upstream element (FUSE) binding protein 1 0.0191842
MYH9 myosin, heavy chain 9, non-muscle 0.0191838
ZNF608 zinc finger protein 608 0.0188285
PYGB phosphorylase, glycogen; brain 0.0186053
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0185908
ZFYVE9 zinc finger, FYVE domain containing 9 0.0184816
ADAM10 ADAM metallopeptidase domain 10 0.0183076
NUMA1 nuclear mitotic apparatus protein 1 0.0179913
KDM5C lysine (K)-specific demethylase 5C 0.0178705
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0178174
PHC3 polyhomeotic homolog 3 (Drosophila) 0.017746
ECT2 epithelial cell transforming 2 0.0175712
MED13 mediator complex subunit 13 0.0174451
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0172199
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0171547
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0169274
ZNF638 zinc finger protein 638 0.0167238
SAMD4A sterile alpha motif domain containing 4A 0.0166967
FAM114A1 family with sequence similarity 114, member A1 0.0166164
GOLGA3 golgin A3 0.0165804
MYO5C myosin VC 0.016566
XPO1 exportin 1 0.0164547
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0163925
CKAP5 cytoskeleton associated protein 5 0.0163522
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0163244
MYOF myoferlin 0.016264
MAP2K1 mitogen-activated protein kinase kinase 1 0.0162411

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.229116
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208413
RPS6 ribosomal protein S6 -0.144166
RPS8 ribosomal protein S8 -0.0996722
TPT1 tumor protein, translationally-controlled 1 -0.0953763
RPL35A ribosomal protein L35a -0.0853399
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0846968
RPLP1 ribosomal protein, large, P1 -0.0806889
RPS19 ribosomal protein S19 -0.0777771
S100A6 S100 calcium binding protein A6 -0.0706558
GOLGA4 golgin A4 -0.0645147
RPL34 ribosomal protein L34 -0.0632043
TXNRD1 thioredoxin reductase 1 -0.058142
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0572549
RPL12 ribosomal protein L12 -0.0568791
ACTG1 actin gamma 1 -0.0558027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0548253
RPL31 ribosomal protein L31 -0.0495793
RPS27A ribosomal protein S27a -0.0492664
GARS1 glycyl-tRNA synthetase 1 -0.0479445
RPL13A ribosomal protein L13a -0.0472618
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0470405
RPLP2 ribosomal protein, large, P2 -0.0469792
PFN1 profilin 1 -0.0458778
MON2 MON2 homolog (S. cerevisiae) -0.0453276
RBM39 RNA binding motif protein 39 -0.0445838
RTN4 reticulon 4 -0.0443266
RPL9 ribosomal protein L9 -0.0442838
EIF1 eukaryotic translation initiation factor 1 -0.0438663
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0432442
EXT1 exostosin glycosyltransferase 1 -0.0426308
RPS25 ribosomal protein S25 -0.0422406
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0421747
RPL26 ribosomal protein L26 -0.0420824
RPL23 ribosomal protein L23 -0.0414328
COG5 component of oligomeric golgi complex 5 -0.0412374
RPLP0 ribosomal protein, large, P0 -0.0400604
NAP1L1 nucleosome assembly protein 1-like 1 -0.0394555
RPS23 ribosomal protein S23 -0.0394399
RPL32 ribosomal protein L32 -0.0381892
ZNF292 zinc finger protein 292 -0.0378464
RPL36 ribosomal protein L36 -0.0377962
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0375744
PDE4D phosphodiesterase 4D, cAMP-specific -0.0375732
ANKRD11 ankyrin repeat domain 11 -0.0370126
DOCK3 dedicator of cytokinesis 3 -0.0367068
B2M beta-2-microglobulin -0.0364434
HSPB1 heat shock 27kDa protein 1 -0.036388
PNISR PNN-interacting serine/arginine-rich protein -0.0363325
GNAS GNAS complex locus -0.0361884
NFIA nuclear factor I/A -0.0354878
RSL1D1 ribosomal L1 domain containing 1 -0.0353399
RAB7A RAB7A, member RAS oncogene family -0.0335033
GCLM glutamate-cysteine ligase, modifier subunit -0.0332813
FTL ferritin, light polypeptide -0.0332318
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0331797
TMSB10 thymosin beta 10 -0.0330366
RPS14 ribosomal protein S14 -0.0325238
PTBP2 polypyrimidine tract binding protein 2 -0.0317169
PHIP pleckstrin homology domain interacting protein -0.0309994
RRBP1 ribosome binding protein 1 -0.030921
RPL19 ribosomal protein L19 -0.0308717
CAMKMT calmodulin-lysine N-methyltransferase -0.0308028
SPAG9 sperm associated antigen 9 -0.0308001
S100A10 S100 calcium binding protein A10 -0.0307929
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0307863
RACK1 receptor for activated C kinase 1 -0.0307427
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0306477
ADNP activity-dependent neuroprotector homeobox -0.0302753
RPS21 ribosomal protein S21 -0.0301957
PDGFC platelet derived growth factor C -0.0298133
ARB2A ARB2 cotranscriptional regulator A -0.0295259
NOP58 NOP58 ribonucleoprotein -0.0292076
TMOD3 tropomodulin 3 (ubiquitous) -0.0290194
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0288004
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0286448
SQSTM1 sequestosome 1 -0.0286019
RPS12 ribosomal protein S12 -0.0285014
JMJD1C jumonji domain containing 1C -0.0284053
MIS18BP1 MIS18 binding protein 1 -0.0282334
RHOA ras homolog family member A -0.0281659
FER fer (fps/fes related) tyrosine kinase -0.0280181
RPS13 ribosomal protein S13 -0.0278176
RB1CC1 RB1-inducible coiled-coil 1 -0.027761
BRWD1 bromodomain and WD repeat domain containing 1 -0.0276809
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0275795
PIAS1 protein inhibitor of activated STAT, 1 -0.0274992
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0273336
RPS17 ribosomal protein S17 -0.0269943
MEF2A myocyte enhancer factor 2A -0.0269853
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0269446
RPS20 ribosomal protein S20 -0.0269373
KLF6 Kruppel-like factor 6 -0.0268991
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0267214
TAS2R14 taste receptor, type 2, member 14 -0.0265034
HMGA1 high mobility group AT-hook 1 -0.0263944
RPS5 ribosomal protein S5 -0.0263943
ABI1 abl-interactor 1 -0.0263768
SDCBP syndecan binding protein (syntenin) -0.0263474
TMEM41B transmembrane protein 41B -0.026294