Vortioxetine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.207742
FN1 fibronectin 1 0.159863
SOD2 superoxide dismutase 2, mitochondrial 0.115551
MSN moesin 0.08022
EEF2 eukaryotic translation elongation factor 2 0.0574365
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.055253
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0549675
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0523219
COL6A3 collagen, type VI, alpha 3 0.0522185
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0478902
VEGFA vascular endothelial growth factor A 0.0473083
FNDC3B fibronectin type III domain containing 3B 0.0443972
UGCG UDP-glucose ceramide glucosyltransferase 0.0425373
APLP2 amyloid beta (A4) precursor-like protein 2 0.0423115
NAMPT nicotinamide phosphoribosyltransferase 0.0393698
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0392416
VCL vinculin 0.0391422
ELL2 elongation factor, RNA polymerase II, 2 0.0384495
AKAP12 A kinase (PRKA) anchor protein 12 0.0351399
PCBP2 poly(rC) binding protein 2 0.0350712
SRRM2 serine/arginine repetitive matrix 2 0.0347052
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0323594
C3 complement component 3 0.0321509
EGR1 early growth response 1 0.0314193
ARRDC3 arrestin domain containing 3 0.0313246
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0284994
UBA6 ubiquitin-like modifier activating enzyme 6 0.0283856
APP amyloid beta (A4) precursor protein 0.0277018
CCNL1 cyclin L1 0.0269417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262114
FLNB filamin B, beta 0.0258462
VCAN versican 0.0255433
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0250737
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0247833
TIMP2 TIMP metallopeptidase inhibitor 2 0.0242952
RTN4 reticulon 4 0.0242868
NONO non-POU domain containing, octamer-binding 0.0237789
MYOF myoferlin 0.0227624
TNIP1 TNFAIP3 interacting protein 1 0.0213913
ANLN anillin, actin binding protein 0.021366
TNS3 tensin 3 0.0210309
ATP13A3 ATPase type 13A3 0.0204857
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0204637
ZNF292 zinc finger protein 292 0.0204597
MKI67 marker of proliferation Ki-67 0.0202061
DST dystonin 0.0201353
CDCP1 CUB domain containing protein 1 0.0199932
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0197843
RPL3 ribosomal protein L3 0.0196354
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0196166
PLS3 plastin 3 0.01961
PLPP6 phospholipid phosphatase 6 0.0190262
BRD2 bromodomain containing 2 0.018872
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0188455
CENPF centromere protein F, 350/400kDa 0.0188184
FAM219A family with sequence similarity 219, member A 0.0182808
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.017748
PPARD peroxisome proliferator-activated receptor delta 0.0175062
PKM pyruvate kinase, muscle 0.0171305
KIF4A kinesin family member 4A 0.016897
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0168591
ANKRD36B ankyrin repeat domain 36B 0.0166884
AXL AXL receptor tyrosine kinase 0.0164705
NGLY1 N-glycanase 1 0.0163362
ADAM17 ADAM metallopeptidase domain 17 0.0163187
CKAP5 cytoskeleton associated protein 5 0.0163144
HILPDA hypoxia inducible lipid droplet-associated 0.016206
ECPAS Ecm29 proteasome adaptor and scaffold 0.0161697
SNX3 sorting nexin 3 0.015982
VMP1 vacuole membrane protein 1 0.0156542
CTNND1 catenin (cadherin-associated protein), delta 1 0.0155931
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0155638
USP47 ubiquitin specific peptidase 47 0.0153228
TPX2 TPX2, microtubule-associated 0.0152231
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0151336
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0151173
ESYT2 extended synaptotagmin-like protein 2 0.0150922
SPAG9 sperm associated antigen 9 0.0150568
RB1CC1 RB1-inducible coiled-coil 1 0.0149882
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0148563
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0146945
MACF1 microtubule-actin crosslinking factor 1 0.0146672
SYAP1 synapse associated protein 1 0.0145644
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0145426
NAV1 neuron navigator 1 0.0143805
LDHA lactate dehydrogenase A 0.0143298
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0142951
AFDN afadin, adherens junction formation factor 0.0141467
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0141214
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0140733
SRSF11 serine/arginine-rich splicing factor 11 0.0140551
TPM1 tropomyosin 1 (alpha) 0.0140418
WDFY1 WD repeat and FYVE domain containing 1 0.0138568
PRKCSH protein kinase C substrate 80K-H 0.013723
DOCK7 dedicator of cytokinesis 7 0.0136322
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.013611
ICAM1 intercellular adhesion molecule 1 0.0134732
SMC1A structural maintenance of chromosomes 1A 0.0133757
DARS1 aspartyl-tRNA synthetase 1 0.0133458
COL8A1 collagen, type VIII, alpha 1 0.0132295

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.195895
TPT1 tumor protein, translationally-controlled 1 -0.15991
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0982579
IER3 immediate early response 3 -0.0981256
TMSB10 thymosin beta 10 -0.0848627
FTL ferritin, light polypeptide -0.0845435
RPS6 ribosomal protein S6 -0.0826697
RPL23 ribosomal protein L23 -0.0817189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.076543
RPS24 ribosomal protein S24 -0.0755956
RPS8 ribosomal protein S8 -0.0643375
RPLP1 ribosomal protein, large, P1 -0.0629974
RPL37A ribosomal protein L37a -0.0616864
RPS3 ribosomal protein S3 -0.0594948
GLIS3 GLIS family zinc finger 3 -0.0573871
HLA-B major histocompatibility complex, class I, B -0.0568001
RPL35A ribosomal protein L35a -0.0522345
RPL26 ribosomal protein L26 -0.0521788
RPS12 ribosomal protein S12 -0.049885
MT2A metallothionein 2A -0.0497657
RPL12 ribosomal protein L12 -0.0495244
NAP1L1 nucleosome assembly protein 1-like 1 -0.0488475
PTMA prothymosin, alpha -0.0474771
RPLP2 ribosomal protein, large, P2 -0.0467382
HMGA2 high mobility group AT-hook 2 -0.0464264
RPL36A ribosomal protein L36a -0.0457675
CDH13 cadherin 13 -0.0445433
RPS4X ribosomal protein S4, X-linked -0.0440982
RPS27A ribosomal protein S27a -0.0428543
RPLP0 ribosomal protein, large, P0 -0.0408662
RPL19 ribosomal protein L19 -0.0400685
ACTG1 actin gamma 1 -0.0397469
RPL32 ribosomal protein L32 -0.0392629
RPS21 ribosomal protein S21 -0.0374524
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0367275
RPL9 ribosomal protein L9 -0.0365522
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.036064
RPS25 ribosomal protein S25 -0.0359978
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0351408
RPL11 ribosomal protein L11 -0.0350924
ZMYND8 zinc finger, MYND-type containing 8 -0.0350574
RPS19 ribosomal protein S19 -0.0345754
RACK1 receptor for activated C kinase 1 -0.0339093
EIF1 eukaryotic translation initiation factor 1 -0.0335318
RPL38 ribosomal protein L38 -0.0312353
RPL37 ribosomal protein L37 -0.0306208
KDM3A lysine (K)-specific demethylase 3A -0.0305271
RPL28 ribosomal protein L28 -0.0304463
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.030384
SLC38A1 solute carrier family 38, member 1 -0.0301283
WSB1 WD repeat and SOCS box containing 1 -0.0299432
BTG1 B-cell translocation gene 1, anti-proliferative -0.0299378
RPL36 ribosomal protein L36 -0.0296874
IGFBP3 insulin-like growth factor binding protein 3 -0.0293273
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0293248
RAB7A RAB7A, member RAS oncogene family -0.0292172
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0290639
GNAS GNAS complex locus -0.0288896
RPL5 ribosomal protein L5 -0.0287543
BICC1 BicC family RNA binding protein 1 -0.0287362
RPL7A ribosomal protein L7a -0.0283796
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0278231
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0275908
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0274194
COL1A1 collagen, type I, alpha 1 -0.0272062
RPL34 ribosomal protein L34 -0.027111
RPS14 ribosomal protein S14 -0.0270288
RPL14 ribosomal protein L14 -0.0269869
RPS29 ribosomal protein S29 -0.0269207
RPL13A ribosomal protein L13a -0.0269111
RPS17 ribosomal protein S17 -0.0259071
SQSTM1 sequestosome 1 -0.0256157
EFNA5 ephrin-A5 -0.0250492
RPL35 ribosomal protein L35 -0.0246312
RPS13 ribosomal protein S13 -0.0244163
NACA nascent polypeptide-associated complex alpha subunit -0.0242947
TKT transketolase -0.0240293
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0239328
GPC6 glypican 6 -0.0239278
AHNAK AHNAK nucleoprotein -0.0236513
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0235962
RPS23 ribosomal protein S23 -0.0233957
RPS10 ribosomal protein S10 -0.0232777
RPL31 ribosomal protein L31 -0.023048
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0225576
RPS20 ribosomal protein S20 -0.0225219
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0225128
PTPRK protein tyrosine phosphatase, receptor type, K -0.0224252
ASPH aspartate beta-hydroxylase -0.0219667
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0218105
RPL30 ribosomal protein L30 -0.0213234
FUS FUS RNA binding protein -0.0212413
PARD3 par-3 family cell polarity regulator -0.0211354
CAVIN1 caveolae associated protein 1 -0.0209697
RPL27A ribosomal protein L27a -0.0209056
CDK13 cyclin-dependent kinase 13 -0.0207866
NRN1 neuritin 1 -0.0204022
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0199087
SRGN serglycin -0.0197215
UBB ubiquitin B -0.0197027