| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.120863 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0922741 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0912065 |
| FN1 | fibronectin 1 | 0.078304 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0733891 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0585228 |
| FTL | ferritin, light polypeptide | 0.0582027 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0567797 |
| RPS3 | ribosomal protein S3 | 0.0492193 |
| COL5A1 | collagen, type V, alpha 1 | 0.046329 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.044194 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0422669 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0400897 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0375983 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0358853 |
| VIM | vimentin | 0.0322866 |
| CANX | calnexin | 0.0314843 |
| PGK1 | phosphoglycerate kinase 1 | 0.0312841 |
| CALR | calreticulin | 0.0309995 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309444 |
| POTEF | POTE ankyrin domain family, member F | 0.0308857 |
| PGM3 | phosphoglucomutase 3 | 0.02981 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.028738 |
| BPTF | bromodomain PHD finger transcription factor | 0.0284859 |
| GLG1 | golgi glycoprotein 1 | 0.0274485 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0265514 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0257178 |
| CTSB | cathepsin B | 0.0256401 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0250125 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0237807 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.023699 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0234129 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0233917 |
| EFNA5 | ephrin-A5 | 0.0232608 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0228637 |
| TPM2 | tropomyosin 2 (beta) | 0.0228242 |
| HDLBP | high density lipoprotein binding protein | 0.0227185 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0224972 |
| CALU | calumenin | 0.022462 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0223645 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0223012 |
| HMGA2 | high mobility group AT-hook 2 | 0.0221952 |
| SFTPA2 | surfactant protein A2 | 0.0220717 |
| NKTR | natural killer cell triggering receptor | 0.0216021 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0215328 |
| RRBP1 | ribosome binding protein 1 | 0.0214808 |
| RPL4 | ribosomal protein L4 | 0.0214627 |
| GOLGA4 | golgin A4 | 0.0214024 |
| RPS8 | ribosomal protein S8 | 0.0210729 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0209206 |
| C1D | C1D nuclear receptor corepressor | 0.0206755 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0205026 |
| RAD51B | RAD51 paralog B | 0.0204481 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0203357 |
| COPA | coatomer protein complex, subunit alpha | 0.020322 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0201961 |
| PRSS23 | protease, serine, 23 | 0.0200213 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.019998 |
| TMSB4X | thymosin beta 4, X-linked | 0.0198271 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0196198 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0195122 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.019369 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0193376 |
| FLNA | filamin A, alpha | 0.0192866 |
| LAMB1 | laminin, beta 1 | 0.0191439 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0191438 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0190501 |
| PTGES2 | prostaglandin E synthase 2 | 0.0190049 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0188211 |
| SEC24D | SEC24 family member D | 0.0187047 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0186189 |
| RPL34 | ribosomal protein L34 | 0.0185281 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0183829 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0182324 |
| RNF145 | ring finger protein 145 | 0.0178862 |
| ACTN4 | actinin, alpha 4 | 0.0178803 |
| YEATS2 | YEATS domain containing 2 | 0.0178714 |
| RBM33 | RNA binding motif protein 33 | 0.0178641 |
| SERINC1 | serine incorporator 1 | 0.0178046 |
| RPL9 | ribosomal protein L9 | 0.0177186 |
| MORF4L2 | mortality factor 4 like 2 | 0.0177026 |
| FAM168A | family with sequence similarity 168, member A | 0.0176573 |
| CCDC88A | coiled-coil domain containing 88A | 0.0175925 |
| TMEM184B | transmembrane protein 184B | 0.0175106 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0174985 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0173161 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0172303 |
| RASA3 | RAS p21 protein activator 3 | 0.0171163 |
| RB1 | retinoblastoma 1 | 0.0170522 |
| KAZN | kazrin, periplakin interacting protein | 0.0169398 |
| CUL4A | cullin 4A | 0.0168027 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0165656 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0165652 |
| MSN | moesin | 0.0165492 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0165407 |
| RPL5 | ribosomal protein L5 | 0.016536 |
| VDAC1 | voltage-dependent anion channel 1 | 0.016429 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0162832 |
| ITGAV | integrin, alpha V | 0.0161791 |
| RPL35A | ribosomal protein L35a | 0.0161628 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112711 |
| MT2A | metallothionein 2A | -0.0760158 |
| B2M | beta-2-microglobulin | -0.0741341 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0707554 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0557182 |
| COL1A2 | collagen, type I, alpha 2 | -0.0547799 |
| ZNF292 | zinc finger protein 292 | -0.0544042 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0540962 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.052721 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.046582 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0461308 |
| MAP1B | microtubule-associated protein 1B | -0.0449403 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0445975 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0408426 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.040505 |
| ADM | adrenomedullin | -0.0389262 |
| RTN4 | reticulon 4 | -0.0387872 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0380512 |
| STC1 | stanniocalcin 1 | -0.0376731 |
| SPAG9 | sperm associated antigen 9 | -0.03738 |
| LOX | lysyl oxidase | -0.0363831 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0357909 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0356016 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0344634 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0339299 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0338609 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0335011 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0333105 |
| PRRC2C | proline-rich coiled-coil 2C | -0.033145 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0330245 |
| IL6ST | interleukin 6 signal transducer | -0.0327742 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0325886 |
| RBM39 | RNA binding motif protein 39 | -0.0320448 |
| INHBA | inhibin, beta A | -0.0320208 |
| SDC4 | syndecan 4 | -0.0309369 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0307364 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0302785 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0302496 |
| SMAD3 | SMAD family member 3 | -0.0300423 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0298457 |
| ARF4 | ADP-ribosylation factor 4 | -0.0297998 |
| PDE10A | phosphodiesterase 10A | -0.0295956 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0293955 |
| HLA-C | major histocompatibility complex, class I, C | -0.02934 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0287102 |
| HIP1 | huntingtin interacting protein 1 | -0.028257 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0277591 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0276903 |
| H3-3B | H3.3 histone B | -0.0276254 |
| PRRC1 | proline-rich coiled-coil 1 | -0.02724 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0272203 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.027181 |
| NUP153 | nucleoporin 153kDa | -0.0270233 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0270182 |
| HLA-B | major histocompatibility complex, class I, B | -0.0269073 |
| ARRDC3 | arrestin domain containing 3 | -0.0266864 |
| RNF213 | ring finger protein 213 | -0.0262635 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0258893 |
| FOSL1 | FOS-like antigen 1 | -0.0258233 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0257073 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0252333 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.025198 |
| TPR | translocated promoter region, nuclear basket protein | -0.0249978 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0248157 |
| RAI14 | retinoic acid induced 14 | -0.0245437 |
| QKI | QKI, KH domain containing, RNA binding | -0.0241543 |
| NUCB2 | nucleobindin 2 | -0.0239809 |
| IL6 | interleukin 6 | -0.0238777 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0237365 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0236463 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0233926 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.023386 |
| TFG | TRK-fused gene | -0.0231837 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0231545 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0226861 |
| SUCO | SUN domain containing ossification factor | -0.0224982 |
| UBC | ubiquitin C | -0.0223674 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0223531 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0223 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0219 |
| IL7R | interleukin 7 receptor | -0.0217777 |
| CCNI | cyclin I | -0.021534 |
| NUP58 | nucleoporin 58 | -0.0214894 |
| EMP1 | epithelial membrane protein 1 | -0.0214664 |
| EHD2 | EH-domain containing 2 | -0.0213261 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0213038 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.021024 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0208659 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0208327 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0205796 |
| EGR1 | early growth response 1 | -0.0202255 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0200199 |
| ANXA1 | annexin A1 | -0.0199059 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0198252 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0197807 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0196726 |
| PRKD3 | protein kinase D3 | -0.0196512 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.019611 |
| CCNL1 | cyclin L1 | -0.019466 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0193882 |
