| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LOC112694756 | uncharaterized LOC112694756 | 0.0666927 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0563804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.054914 |
| HMGA2 | high mobility group AT-hook 2 | 0.0545079 |
| POTEF | POTE ankyrin domain family, member F | 0.0544788 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0432197 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.043196 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0420726 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0415917 |
| ANGPTL4 | angiopoietin-like 4 | 0.0401889 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0372099 |
| PRR16 | proline rich 16 | 0.0368449 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0363551 |
| RPL4 | ribosomal protein L4 | 0.0358433 |
| RAI14 | retinoic acid induced 14 | 0.0327469 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0321773 |
| EGFR | epidermal growth factor receptor | 0.032118 |
| PTMA | prothymosin, alpha | 0.0320702 |
| COL5A1 | collagen, type V, alpha 1 | 0.0314989 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0302747 |
| AHNAK | AHNAK nucleoprotein | 0.0293146 |
| PKM | pyruvate kinase, muscle | 0.0274479 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0272749 |
| FMN1 | formin 1 | 0.0268192 |
| CAPRIN2 | caprin family member 2 | 0.026757 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0265744 |
| PODXL | podocalyxin-like | 0.0262377 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0262045 |
| PRSS23 | protease, serine, 23 | 0.0259982 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.0258739 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.025858 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0256635 |
| IGF2 | insulin-like growth factor 2 | 0.0254822 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0254111 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.0252499 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0251916 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.025082 |
| SVIL | supervillin | 0.0248808 |
| PRKCA | protein kinase C, alpha | 0.0248522 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0247638 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0247281 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0245538 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0243377 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0237022 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0234307 |
| DST | dystonin | 0.0232957 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0232021 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0223761 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0219459 |
| PCED1B | PC-esterase domain containing 1B | 0.0215576 |
| CCNK | cyclin K | 0.0215369 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0207606 |
| HLA-A | major histocompatibility complex, class I, A | 0.0206019 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0205737 |
| NRG1 | neuregulin 1 | 0.0203565 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0201364 |
| MMP12 | matrix metallopeptidase 12 | 0.0200526 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0200392 |
| GGT7 | gamma-glutamyltransferase 7 | 0.0198977 |
| IPO11 | importin 11 | 0.0198205 |
| RAI1 | retinoic acid induced 1 | 0.0196344 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0195236 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0194549 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0194271 |
| ETV6 | ets variant 6 | 0.0193189 |
| FNDC3A | fibronectin type III domain containing 3A | 0.019283 |
| RNF213 | ring finger protein 213 | 0.0190376 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0188528 |
| THBS1 | thrombospondin 1 | 0.0188056 |
| ECE1 | endothelin converting enzyme 1 | 0.0187465 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0186273 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.018585 |
| PYGL | phosphorylase, glycogen, liver | 0.0184222 |
| LRRC49 | leucine rich repeat containing 49 | 0.0183972 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0182842 |
| PLPP6 | phospholipid phosphatase 6 | 0.0181714 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0181633 |
| SESN2 | sestrin 2 | 0.0180569 |
| VIM | vimentin | 0.0179349 |
| CYTH1 | cytohesin 1 | 0.0178929 |
| TRAM2 | translocation associated membrane protein 2 | 0.0178235 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0177928 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0177522 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.01774 |
| ANXA2 | annexin A2 | 0.0176493 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0176345 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0174568 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0173915 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.017386 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0173397 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0172831 |
| CTSC | cathepsin C | 0.0172325 |
| MSH3 | mutS homolog 3 | 0.0171292 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0171146 |
| IMMT | inner membrane protein, mitochondrial | 0.0170778 |
| KLHL29 | kelch-like family member 29 | 0.0169734 |
| TCF12 | transcription factor 12 | 0.0167868 |
| WFDC10B | WAP four-disulfide core domain 10B | 0.0167022 |
| AEBP2 | AE binding protein 2 | 0.0166981 |
| UTP6 | UTP6, small subunit (SSU) processome component, homolog (yeast) | 0.0166295 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.267444 |
| SMYD3 | SET and MYND domain containing 3 | -0.0874115 |
| GOLGA4 | golgin A4 | -0.0739007 |
| RBM39 | RNA binding motif protein 39 | -0.0660853 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0591443 |
| ANKRD28 | ankyrin repeat domain 28 | -0.059053 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0573774 |
| TXNRD1 | thioredoxin reductase 1 | -0.0561957 |
| ZNF292 | zinc finger protein 292 | -0.055098 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0530715 |
| DSCAM | Down syndrome cell adhesion molecule | -0.053049 |
| SNX14 | sorting nexin 14 | -0.0524028 |
| NUP58 | nucleoporin 58 | -0.0522285 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0517414 |
| FMNL2 | formin-like 2 | -0.0513479 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0499131 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0493694 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0490436 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0481826 |
| YAP1 | Yes-associated protein 1 | -0.047943 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0468695 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0445036 |
| SMAD3 | SMAD family member 3 | -0.0433137 |
| ERBIN | erbb2 interacting protein | -0.0429608 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0423227 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0412127 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0409045 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0406114 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0404654 |
| SETX | senataxin | -0.0397927 |
| GNAS | GNAS complex locus | -0.0392706 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0386188 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0382286 |
| RPLP1 | ribosomal protein, large, P1 | -0.0375084 |
| RRBP1 | ribosome binding protein 1 | -0.0366698 |
| GOLGB1 | golgin B1 | -0.03477 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0345319 |
| CENPF | centromere protein F, 350/400kDa | -0.0343139 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.03431 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0340576 |
| NOP58 | NOP58 ribonucleoprotein | -0.0340404 |
| CEP170 | centrosomal protein 170kDa | -0.0333202 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0330105 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.032126 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0318684 |
| UBAC2 | UBA domain containing 2 | -0.0317528 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0316769 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0308266 |
| RPL23 | ribosomal protein L23 | -0.030799 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0306085 |
| BBX | bobby sox homolog (Drosophila) | -0.0304874 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0304104 |
| MATR3 | matrin 3 | -0.0302968 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0298789 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0296568 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0295136 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.029246 |
| DEK | DEK proto-oncogene | -0.0291689 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0290105 |
| MT2A | metallothionein 2A | -0.0290055 |
| TMEM123 | transmembrane protein 123 | -0.0289783 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0288289 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0288261 |
| AK1 | adenylate kinase 1 | -0.0286357 |
| RPL30 | ribosomal protein L30 | -0.0276205 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.027511 |
| MRE11 | MRE11 homolog, double strand break repair nuclease | -0.0274807 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0274599 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0274249 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0272692 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0272512 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0272369 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.027165 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0271313 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0271208 |
| NUP98 | nucleoporin 98kDa | -0.0270322 |
| TJP2 | tight junction protein 2 | -0.0267308 |
| RPS2 | ribosomal protein S2 | -0.0267065 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0266307 |
| SP3 | Sp3 transcription factor | -0.026562 |
| TCERG1 | transcription elongation regulator 1 | -0.0265251 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0265142 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.026457 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0262235 |
| DIDO1 | death inducer-obliterator 1 | -0.0259968 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0258115 |
| ATM | ATM serine/threonine kinase | -0.0256627 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.025596 |
| ANLN | anillin, actin binding protein | -0.0255849 |
| SON | SON DNA binding protein | -0.0254929 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0253844 |
| CLINT1 | clathrin interactor 1 | -0.0250993 |
| YBX3 | Y box binding protein 3 | -0.0250059 |
| NGLY1 | N-glycanase 1 | -0.0249878 |
| MORF4L2 | mortality factor 4 like 2 | -0.0246347 |
| RPL9 | ribosomal protein L9 | -0.0244948 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0243262 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.024261 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0242305 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0239633 |
