| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.275447 |
| FN1 | fibronectin 1 | 0.224726 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.176055 |
| ITGA1 | integrin, alpha 1 | 0.121686 |
| NRG1 | neuregulin 1 | 0.111391 |
| HMGA2 | high mobility group AT-hook 2 | 0.100118 |
| TMEM156 | transmembrane protein 156 | 0.0811659 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0801978 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0744507 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0689169 |
| GLIS3 | GLIS family zinc finger 3 | 0.0658073 |
| TMSB4X | thymosin beta 4, X-linked | 0.0657562 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0557536 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0511446 |
| OSMR | oncostatin M receptor | 0.047077 |
| ASPH | aspartate beta-hydroxylase | 0.0438089 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0404797 |
| APP | amyloid beta (A4) precursor protein | 0.0404147 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0398726 |
| ETV6 | ets variant 6 | 0.0392547 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0392272 |
| ETV1 | ets variant 1 | 0.0384924 |
| SFTPA2 | surfactant protein A2 | 0.0383747 |
| SMOX | spermine oxidase | 0.0382475 |
| HMGB3 | high mobility group box 3 | 0.0364876 |
| SYT1 | synaptotagmin I | 0.0361829 |
| MKI67 | marker of proliferation Ki-67 | 0.0351863 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0349746 |
| NTN4 | netrin 4 | 0.0349722 |
| CENPF | centromere protein F, 350/400kDa | 0.0345447 |
| RAI14 | retinoic acid induced 14 | 0.0320974 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0301212 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0299352 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0299098 |
| AHR | aryl hydrocarbon receptor | 0.0297817 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0295227 |
| SQSTM1 | sequestosome 1 | 0.029029 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0278979 |
| HLA-B | major histocompatibility complex, class I, B | 0.0272006 |
| CD44 | CD44 molecule (Indian blood group) | 0.0269226 |
| TPR | translocated promoter region, nuclear basket protein | 0.0268421 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0263686 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0261977 |
| SSH1 | slingshot protein phosphatase 1 | 0.0258043 |
| PELO | pelota homolog (Drosophila) | 0.0245689 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0245572 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0244722 |
| AOPEP | aminopeptidase O (putative) | 0.0242 |
| KLHL5 | kelch-like family member 5 | 0.0239512 |
| FRY | furry homolog (Drosophila) | 0.0234732 |
| NRP1 | neuropilin 1 | 0.0234642 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0233683 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0233575 |
| CAB39 | calcium binding protein 39 | 0.0231187 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0227705 |
| SMAD3 | SMAD family member 3 | 0.0224054 |
| VCL | vinculin | 0.0221458 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0213867 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0213822 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0213652 |
| EREG | epiregulin | 0.0212211 |
| FBN1 | fibrillin 1 | 0.0207892 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0206654 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0206193 |
| THBS1 | thrombospondin 1 | 0.0205114 |
| LAMA4 | laminin, alpha 4 | 0.0202376 |
| PLEC | plectin | 0.020184 |
| ADD3 | adducin 3 (gamma) | 0.0200762 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0197639 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0197615 |
| GLUL | glutamate-ammonia ligase | 0.0196085 |
| SEPTIN9 | septin 9 | 0.0194825 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0192249 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0191758 |
| GOLGA3 | golgin A3 | 0.0191697 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.018855 |
| FOXP1 | forkhead box P1 | 0.0188443 |
| EFNA5 | ephrin-A5 | 0.0186898 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.018674 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0185954 |
| BPTF | bromodomain PHD finger transcription factor | 0.0183983 |
| KLF10 | Kruppel-like factor 10 | 0.0182997 |
| TNS3 | tensin 3 | 0.0182978 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.017995 |
| CTSB | cathepsin B | 0.0179178 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0177792 |
| CLTC | clathrin, heavy chain (Hc) | 0.0177759 |
| FAM20C | family with sequence similarity 20, member C | 0.0175842 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0173164 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0172681 |
| BICC1 | BicC family RNA binding protein 1 | 0.0171117 |
| HLA-A | major histocompatibility complex, class I, A | 0.0171031 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0170559 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0169563 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0169254 |
| RUNX2 | runt-related transcription factor 2 | 0.0168988 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0167934 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0167622 |
| DST | dystonin | 0.0166524 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0166179 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.226198 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.112378 |
| NDRG1 | N-myc downstream regulated 1 | -0.109792 |
| PTMA | prothymosin, alpha | -0.0971571 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0780838 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0764245 |
| RPS6 | ribosomal protein S6 | -0.0745645 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0660561 |
| FTL | ferritin, light polypeptide | -0.0649934 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0641175 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0635436 |
| MT2A | metallothionein 2A | -0.0610957 |
| VIM | vimentin | -0.0608602 |
| TMSB10 | thymosin beta 10 | -0.0575153 |
| CD109 | CD109 molecule | -0.0558611 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0519852 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0497707 |
| RPL37A | ribosomal protein L37a | -0.0491045 |
| RPLP1 | ribosomal protein, large, P1 | -0.0480489 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0469719 |
| RPS12 | ribosomal protein S12 | -0.0465423 |
| RPS19 | ribosomal protein S19 | -0.0461275 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0457979 |
| FAM13A | family with sequence similarity 13, member A | -0.0440059 |
| RPL12 | ribosomal protein L12 | -0.0438202 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0423898 |
| RPL23 | ribosomal protein L23 | -0.0410895 |
| GOLGA4 | golgin A4 | -0.0398169 |
| RPL26 | ribosomal protein L26 | -0.0395258 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0388152 |
| OGA | O-GlcNAcase | -0.0383593 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.037952 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0361297 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0352576 |
| HELZ | helicase with zinc finger | -0.0336551 |
| RPS3 | ribosomal protein S3 | -0.0331457 |
| RPL9 | ribosomal protein L9 | -0.0331142 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0328258 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0326028 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0323524 |
| COPA | coatomer protein complex, subunit alpha | -0.0321553 |
| RPL31 | ribosomal protein L31 | -0.0307763 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0300456 |
| RPL35A | ribosomal protein L35a | -0.0298033 |
| RTN4 | reticulon 4 | -0.0293294 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0292922 |
| RPS8 | ribosomal protein S8 | -0.02917 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0289273 |
| RPS27 | ribosomal protein S27 | -0.0288662 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0280483 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0278986 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.027831 |
| RPL28 | ribosomal protein L28 | -0.0278153 |
| RPS20 | ribosomal protein S20 | -0.027702 |
| GNAS | GNAS complex locus | -0.0274965 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0272531 |
| RPL19 | ribosomal protein L19 | -0.0269058 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0267842 |
| RACK1 | receptor for activated C kinase 1 | -0.0263573 |
| RPL34 | ribosomal protein L34 | -0.0262483 |
| RBM39 | RNA binding motif protein 39 | -0.0261921 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0259514 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0259011 |
| CADM1 | cell adhesion molecule 1 | -0.0255707 |
| SPAG9 | sperm associated antigen 9 | -0.0254673 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0254414 |
| XPO1 | exportin 1 | -0.0252713 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0247777 |
| CTBP2 | C-terminal binding protein 2 | -0.0243249 |
| SETD5 | SET domain containing 5 | -0.0242515 |
| RPS16 | ribosomal protein S16 | -0.024205 |
| ZNF292 | zinc finger protein 292 | -0.0241541 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0241231 |
| RPS25 | ribosomal protein S25 | -0.0241205 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0237364 |
| GPC6 | glypican 6 | -0.0232859 |
| RPL8 | ribosomal protein L8 | -0.0232473 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.023162 |
| HMGA1 | high mobility group AT-hook 1 | -0.0230116 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0230018 |
| TPD52 | tumor protein D52 | -0.0229614 |
| SRP54 | signal recognition particle 54kDa | -0.0229127 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0225989 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0225319 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0225279 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0224291 |
| FBXO11 | F-box protein 11 | -0.0221478 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0221007 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0218521 |
| RPS24 | ribosomal protein S24 | -0.0218239 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0218151 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0217993 |
| YME1L1 | YME1-like 1 ATPase | -0.0217185 |
| DSTN | destrin (actin depolymerizing factor) | -0.021675 |
| NUP58 | nucleoporin 58 | -0.0213886 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0212702 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0210926 |
| SEPTIN2 | septin 2 | -0.0210485 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0208188 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0207325 |
