| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4299 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in W-13 HCl relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VAV1 | vav 1 guanine nucleotide exchange factor | 1.37 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 1.31 |
| YPEL5 | yippee-like 5 (Drosophila) | 1.16 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 1.05 |
| B2M | beta-2-microglobulin | 1.03 |
| ZNF169 | zinc finger protein 169 | 0.96 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.94 |
| RETREG1 | reticulophagy regulator 1 | 0.88 |
| ANKRD36C | ankyrin repeat domain 36C | 0.84 |
| TSPAN3 | tetraspanin 3 | 0.84 |
| RANBP10 | RAN binding protein 10 | 0.83 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.7 |
| KSR2 | kinase suppressor of ras 2 | 0.65 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.64 |
| ANGPTL4 | angiopoietin-like 4 | 0.63 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.62 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.6 |
| FGB | fibrinogen beta chain | 0.55 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 0.53 |
| ZNF564 | zinc finger protein 564 | 0.52 |
| TTN | titin | 0.51 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.5 |
| WASF2 | WAS protein family, member 2 | 0.49 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.48 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.46 |
| GCAT | glycine C-acetyltransferase | 0.44 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.43 |
| WDR59 | WD repeat domain 59 | 0.43 |
| CD63 | CD63 molecule | 0.42 |
| LRRC8B | leucine rich repeat containing 8 family, member B | 0.41 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.4 |
| SMO | smoothened, frizzled class receptor | 0.39 |
| FN1 | fibronectin 1 | 0.39 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.39 |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | 0.38 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.38 |
| SASH1 | SAM and SH3 domain containing 1 | 0.38 |
| PROS1 | protein S (alpha) | 0.38 |
| NDRG1 | N-myc downstream regulated 1 | 0.37 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.37 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.36 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.36 |
| AASS | aminoadipate-semialdehyde synthase | 0.36 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.36 |
| ADI1 | acireductone dioxygenase 1 | 0.36 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | 0.36 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 0.36 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.36 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.36 |
| ZNF200 | zinc finger protein 200 | 0.36 |
| RARA | retinoic acid receptor, alpha | 0.35 |
| TMEM94 | transmembrane protein 94 | 0.35 |
| C19ORF54 | chromosome 19 open reading frame 54 | 0.35 |
| ZNF226 | zinc finger protein 226 | 0.35 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.35 |
| LMNA | lamin A/C | 0.34 |
| PRKCH | protein kinase C, eta | 0.34 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.33 |
| GON7 | GON7 subunit of KEOPS complex | 0.33 |
| TMEM248 | transmembrane protein 248 | 0.33 |
| ZNF888 | zinc finger protein 888 | 0.33 |
| LRRC7 | leucine rich repeat containing 7 | 0.33 |
| S100A14 | S100 calcium binding protein A14 | 0.33 |
| BPTF | bromodomain PHD finger transcription factor | 0.33 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.33 |
| XTBD1 | XRN2 binding domain containing 1 | 0.33 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | 0.32 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.32 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.32 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.32 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.32 |
| DSCAM | Down syndrome cell adhesion molecule | 0.31 |
| MPZL2 | myelin protein zero-like 2 | 0.31 |
| RPL31 | ribosomal protein L31 | 0.31 |
| HIST2H2BF | histone cluster 2, H2bf | 0.31 |
| LIX1L | Lix1 homolog (chicken) like | 0.3 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.3 |
| RTN4 | reticulon 4 | 0.3 |
| OSCP1 | organic solute carrier partner 1 | 0.29 |
| H2AZ1 | H2A.Z variant histone 1 | 0.29 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 0.29 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.29 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.29 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.29 |
| PTMS | parathymosin | 0.29 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 0.29 |
| RUNX1 | runt-related transcription factor 1 | 0.29 |
| ABRACL | ABRA C-terminal like | 0.29 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.29 |
| SPAG17 | sperm associated antigen 17 | 0.29 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 0.28 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.28 |
| ATXN7 | ataxin 7 | 0.28 |
| DNPEP | aspartyl aminopeptidase | 0.28 |
| ATG4C | autophagy related 4C, cysteine peptidase | 0.28 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.28 |
| PDCD6 | programmed cell death 6 | 0.28 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.28 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.27 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TUBAL3 | tubulin, alpha-like 3 | -0.99 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | -0.66 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | -0.64 |
| TMEM199 | transmembrane protein 199 | -0.62 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.61 |
| TRIB3 | tribbles pseudokinase 3 | -0.56 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.52 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.51 |
| TMEM64 | transmembrane protein 64 | -0.5 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.5 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.5 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -0.49 |
| CNST | consortin, connexin sorting protein | -0.48 |
| KLHL15 | kelch-like family member 15 | -0.47 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.47 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.45 |
| DOCK11 | dedicator of cytokinesis 11 | -0.45 |
| GPN3 | GPN-loop GTPase 3 | -0.44 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.44 |
| ZNF566 | zinc finger protein 566 | -0.44 |
| ZNF362 | zinc finger protein 362 | -0.44 |
| MYO18B | myosin XVIIIB | -0.44 |
| USP43 | ubiquitin specific peptidase 43 | -0.44 |
| CALU | calumenin | -0.43 |
| NAAA | N-acylethanolamine acid amidase | -0.43 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.42 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | -0.41 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.41 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.41 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.41 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.4 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | -0.4 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.4 |
| E4F1 | E4F transcription factor 1 | -0.39 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.39 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | -0.39 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.39 |
| MTMR3 | myotubularin related protein 3 | -0.39 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.38 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.38 |
| PCNX1 | pecanex 1 | -0.38 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.37 |
| ETAA1 | Ewing tumor-associated antigen 1 | -0.37 |
| ENO1 | enolase 1, (alpha) | -0.37 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -0.37 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | -0.37 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.37 |
| COL7A1 | collagen, type VII, alpha 1 | -0.37 |
| TGDS | TDP-glucose 4,6-dehydratase | -0.37 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.36 |
| TXNDC11 | thioredoxin domain containing 11 | -0.36 |
| ZNF236 | zinc finger protein 236 | -0.35 |
| MFAP3 | microfibrillar-associated protein 3 | -0.35 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -0.35 |
| HIST3H2BB | histone cluster 3, H2bb | -0.35 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.35 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.34 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.34 |
| FLNA | filamin A, alpha | -0.33 |
| METTL25 | methyltransferase like 25 | -0.32 |
| PYGO2 | pygopus family PHD finger 2 | -0.32 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | -0.32 |
| MYADM | myeloid-associated differentiation marker | -0.32 |
| PLK4 | polo-like kinase 4 | -0.32 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.32 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.32 |
| RAD51D | RAD51 paralog D | -0.31 |
| DNAH9 | dynein, axonemal, heavy chain 9 | -0.31 |
| FBRSL1 | fibrosin-like 1 | -0.3 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -0.3 |
| ATP13A2 | ATPase type 13A2 | -0.3 |
| MIPOL1 | mirror-image polydactyly 1 | -0.3 |
| NCKAP5L | NCK-associated protein 5-like | -0.3 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | -0.3 |
| DAPK2 | death-associated protein kinase 2 | -0.29 |
| CCDC14 | coiled-coil domain containing 14 | -0.29 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.29 |
| FAT2 | FAT atypical cadherin 2 | -0.29 |
| H3C1 | H3 clustered histone 1 | -0.29 |
| CEP295 | centrosomal protein 295kDa | -0.29 |
| SP110 | SP110 nuclear body protein | -0.28 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.28 |
| HSPE1 | heat shock 10kDa protein 1 | -0.28 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -0.28 |
| ZNF561 | zinc finger protein 561 | -0.28 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.28 |
| ABHD2 | abhydrolase domain containing 2 | -0.27 |
| ZFPM1 | zinc finger protein, FOG family member 1 | -0.27 |
| LYST | lysosomal trafficking regulator | -0.27 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.27 |
| RRAGC | Ras-related GTP binding C | -0.27 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.27 |
| SGMS1 | sphingomyelin synthase 1 | -0.26 |
| LMO4 | LIM domain only 4 | -0.26 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.26 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | -0.26 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.26 |
| E2F1 | E2F transcription factor 1 | -0.26 |
| MON1B | MON1 secretory trafficking family member B | -0.26 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | -0.26 |
