WHSC1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Wolf-Hirschhorn syndrome candidate 1|This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7468)
External Link http://www.ncbi.nlm.nih.gov/gene/7468
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135 interacting proteins for WHSC1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ACTB actin, beta
ADAR adenosine deaminase, RNA-specific
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGAP4 Rho GTPase activating protein 4
ATM ATM serine/threonine kinase
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BAZ1B bromodomain adjacent to zinc finger domain, 1B
CD3EAP CD3e molecule, epsilon associated protein
CDC5L cell division cycle 5-like
CDKN2AIP CDKN2A interacting protein
CHERP calcium homeostasis endoplasmic reticulum protein
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
EWSR1 EWS RNA-binding protein 1
EZR ezrin
FUS FUS RNA binding protein
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPATCH4 G patch domain containing 4
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDLBP high density lipoprotein binding protein
HIST2H3A histone cluster 2, H3a
HIST3H3 histone cluster 3, H3
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI16 interferon, gamma-inducible protein 16
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP1 IQ motif containing GTPase activating protein 1
KDM1A lysine (K)-specific demethylase 1A
KHSRP KH-type splicing regulatory protein
LMNA lamin A/C
LMNB1 lamin B1
LSM1 LSM1, U6 small nuclear RNA associated
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MYBBP1A MYB binding protein (P160) 1a
NOL10 nucleolar protein 10
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
NUP93 nucleoporin 93kDa
PARP1 poly (ADP-ribose) polymerase 1
PBRM1 polybromo 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDCD11 programmed cell death 11
PDS5A PDS5 cohesin associated factor A
PES1 pescadillo ribosomal biogenesis factor 1
PKP2 plakophilin 2
PLRG1 pleiotropic regulator 1
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PRPF6 pre-mRNA processing factor 6
PSIP1 PC4 and SFRS1 interacting protein 1
PSPC1 paraspeckle component 1
PTBP1 polypyrimidine tract binding protein 1
RAD50 RAD50 homolog (S. cerevisiae)
RANGAP1 Ran GTPase activating protein 1
RAVER1 ribonucleoprotein, PTB-binding 1
RBBP4 retinoblastoma binding protein 4
RBM10 RNA binding motif protein 10
RBM14 RNA binding motif protein 14
RBM25 RNA binding motif protein 25
RBMX RNA binding motif protein, X-linked
RPN1 ribophorin I
RRP1 ribosomal RNA processing 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUVBL2 RuvB-like AAA ATPase 2
SART3 squamous cell carcinoma antigen recognized by T cells 3
SDAD1 SDA1 domain containing 1
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFPQ splicing factor proline/glutamine-rich
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SIRT7 sirtuin 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMC1A structural maintenance of chromosomes 1A
STRBP spermatid perinuclear RNA binding protein
SUN2 Sad1 and UNC84 domain containing 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARDBP TAR DNA binding protein
TBL3 transducin (beta)-like 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2B topoisomerase (DNA) II beta 180kDa
TOR1AIP1 torsin A interacting protein 1
TRIM28 tripartite motif containing 28
UBC ubiquitin C
USP39 ubiquitin specific peptidase 39
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VIM vimentin
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFR zinc finger RNA binding protein