WNT_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/WNT_UP.V1_UP
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Genes

348 genes differentially expressed following the WNT_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM28 ADAM metallopeptidase domain 28
ADGRB1 adhesion G protein-coupled receptor B1
ADGRG3 adhesion G protein-coupled receptor G3
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
AURKB aurora kinase B
BCL7C B-cell CLL/lymphoma 7C
BTG4 B-cell translocation gene 4
C8G complement component 8, gamma polypeptide
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCR3 chemokine (C-C motif) receptor 3
CCR8 chemokine (C-C motif) receptor 8
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD96 CD96 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CFC1 cripto, FRL-1, cryptic family 1
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CKAP4 cytoskeleton-associated protein 4
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLDN6 claudin 6
CLDN8 claudin 8
CLEC16A C-type lectin domain family 16, member A
CLEC4E C-type lectin domain family 4, member E
CNGA2 cyclic nucleotide gated channel alpha 2
COL4A4 collagen, type IV, alpha 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRMP1 collapsin response mediator protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DBP D site of albumin promoter (albumin D-box) binding protein
DCC DCC netrin 1 receptor
DHCR24 24-dehydrocholesterol reductase
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13
DPYSL4 dihydropyrimidinase-like 4
DTNB dystrobrevin, beta
EDA ectodysplasin A
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
EYA2 EYA transcriptional coactivator and phosphatase 2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF18 fibroblast growth factor 18
FICD FIC domain containing
FNTB farnesyltransferase, CAAX box, beta
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXK1 forkhead box K1
FPR2 formyl peptide receptor 2
FXYD3 FXYD domain containing ion transport regulator 3
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GHRH growth hormone releasing hormone
GJD2 gap junction protein, delta 2, 36kDa
GLI1 GLI family zinc finger 1
GNMT glycine N-methyltransferase
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HES5 hes family bHLH transcription factor 5
HOXD10 homeobox D10
HOXD3 homeobox D3
HPS4 Hermansky-Pudlak syndrome 4
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HTRA3 HtrA serine peptidase 3
HYOU1 hypoxia up-regulated 1
IGF2 insulin-like growth factor 2
IL12B interleukin 12B
IL6 interleukin 6
INHBB inhibin, beta B
INSM1 insulinoma-associated 1
INSRR insulin receptor-related receptor
IRX3 iroquois homeobox 3
ISLR immunoglobulin superfamily containing leucine-rich repeat
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNK4 potassium channel, two pore domain subfamily K, member 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIFC1 kinesin family member C1
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT27 keratin 27, type I
KRT85 keratin 85, type II
KRT86 keratin 86, type II
KRTAP8-1 keratin associated protein 8-1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCAT lecithin-cholesterol acyltransferase
LCN2 lipocalin 2
LRG1 leucine-rich alpha-2-glycoprotein 1
LTA lymphotoxin alpha
LTB4R leukotriene B4 receptor
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAST2 microtubule associated serine/threonine kinase 2
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFAP2 microfibrillar-associated protein 2
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MST1R macrophage stimulating 1 receptor
MTF1 metal-regulatory transcription factor 1
MYO5B myosin VB
MYOM1 myomesin 1
MYRF myelin regulatory factor
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEUROD2 neuronal differentiation 2
NF1 neurofibromin 1
NLRX1 NLR family member X1
NPY4R neuropeptide Y receptor Y4
NTSR1 neurotensin receptor 1 (high affinity)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OXT oxytocin/neurophysin I prepropeptide
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PDC phosducin
PDYN prodynorphin
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta
PKLR pyruvate kinase, liver and RBC
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAC9 placenta-specific 9
PMF1 polyamine-modulated factor 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POMC proopiomelanocortin
POSTN periostin, osteoblast specific factor
POU1F1 POU class 1 homeobox 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT1 palmitoyl-protein thioesterase 1
PRL prolactin
PRSS29P protease, serine, 29, pseudogene
PTPRO protein tyrosine phosphatase, receptor type, O
RAD9A RAD9 homolog A (S. pombe)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBPMS RNA binding protein with multiple splicing
REG1B regenerating islet-derived 1 beta
RETNLB resistin like beta
RNF112 ring finger protein 112
RPAP3 RNA polymerase II associated protein 3
RSPO1 R-spondin 1
SAA3P serum amyloid A3 pseudogene
SDC4 syndecan 4
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETD6 SET domain containing 6
SFN stratifin
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLN sarcolipin
SNN stannin
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STK36 serine/threonine kinase 36
STRN4 striatin, calmodulin binding protein 4
STS steroid sulfatase (microsomal), isozyme S
SYT3 synaptotagmin III
SYT9 synaptotagmin IX
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEF thyrotrophic embryonic factor
TEN1 TEN1 CST complex subunit
TFF3 trefoil factor 3 (intestinal)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THRB thyroid hormone receptor, beta
THYN1 thymocyte nuclear protein 1
TPK1 thiamin pyrophosphokinase 1
TSPO2 translocator protein 2
UBXN11 UBX domain protein 11
UGT8 UDP glycosyltransferase 8
UTF1 undifferentiated embryonic cell transcription factor 1
UTS2R urotensin 2 receptor
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAX2 ventral anterior homeobox 2
XCR1 chemokine (C motif) receptor 1
ZFP92 ZFP92 zinc finger protein
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
AARD alanine and arginine rich domain containing protein
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ADAM19 ADAM metallopeptidase domain 19
ADAM2 ADAM metallopeptidase domain 2
ADAR adenosine deaminase, RNA-specific
ADCY4 adenylate cyclase 4
ADRB1 adrenoceptor beta 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIRE autoimmune regulator
AKR1E2 aldo-keto reductase family 1, member E2
APC2 adenomatosis polyposis coli 2
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BPGM 2,3-bisphosphoglycerate mutase
C16ORF89 chromosome 16 open reading frame 89
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC130 coiled-coil domain containing 130
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD93 CD93 molecule
CDO1 cysteine dioxygenase type 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CECR5 cat eye syndrome chromosome region, candidate 5
CELF1 CUGBP, Elav-like family member 1
CFHR1 complement factor H-related 1
CLEC4D C-type lectin domain family 4, member D
CLN3 ceroid-lipofuscinosis, neuronal 3
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
CNTN1 contactin 1
COL9A1 collagen, type IX, alpha 1
CORT cortistatin
CPN1 carboxypeptidase N, polypeptide 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYBA cytochrome b-245, alpha polypeptide
CYTH1 cytohesin 1
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DIO2 deiodinase, iodothyronine, type II
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNASE1L3 deoxyribonuclease I-like 3
DPF3 D4, zinc and double PHD fingers, family 3
EFNB2 ephrin-B2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ETV4 ets variant 4
F10 coagulation factor X
FAAH fatty acid amide hydrolase
FAM60A family with sequence similarity 60, member A
FBXO8 F-box protein 8
FOXN3 forkhead box N3
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GBP4 guanylate binding protein 4
GFAP glial fibrillary acidic protein
GGNBP1 gametogenetin binding protein 1 (pseudogene)
GPATCH2 G patch domain containing 2
GPX3 glutathione peroxidase 3
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRM8 glutamate receptor, metabotropic 8
GSTA4 glutathione S-transferase alpha 4
HAND1 heart and neural crest derivatives expressed 1
HDGFL1 hepatoma derived growth factor-like 1
HES3 hes family bHLH transcription factor 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXB5 homeobox B5
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IFIH1 interferon induced with helicase C domain 1
IGFBP6 insulin-like growth factor binding protein 6
IL12RB1 interleukin 12 receptor, beta 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KDM5A lysine (K)-specific demethylase 5A
KITLG KIT ligand
KRT6B keratin 6B, type II
KRTAP3-1 keratin associated protein 3-1
LAMA1 laminin, alpha 1
LBP lipopolysaccharide binding protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHB luteinizing hormone beta polypeptide
LHX1 LIM homeobox 1
LSR lipolysis stimulated lipoprotein receptor
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK7 mitogen-activated protein kinase 7
MEP1A meprin A, alpha (PABA peptide hydrolase)
MET MET proto-oncogene, receptor tyrosine kinase
MMP3 matrix metallopeptidase 3
MRAP melanocortin 2 receptor accessory protein
MYOG myogenin (myogenic factor 4)
NAGK N-acetylglucosamine kinase
NCOA2 nuclear receptor coactivator 2
NEO1 neogenin 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NGEF neuronal guanine nucleotide exchange factor
NGF nerve growth factor (beta polypeptide)
NMT2 N-myristoyltransferase 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5DC2 5'-nucleotidase domain containing 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCLN occludin
OLFM1 olfactomedin 1
PCDH7 protocadherin 7
PCDHA10 protocadherin alpha 10
PCP2 Purkinje cell protein 2
PHOSPHO2 phosphatase, orphan 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G10 phospholipase A2, group X
PLA2G1B phospholipase A2, group IB (pancreas)
PLXNA1 plexin A1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRH1 proline-rich protein HaeIII subfamily 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAI2 retinoic acid induced 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RASD1 RAS, dexamethasone-induced 1
RSPH1 radial spoke head 1 homolog (Chlamydomonas)
SDSL serine dehydratase-like
SEPT6 septin 6
SERGEF secretion regulating guanine nucleotide exchange factor
SH2D2A SH2 domain containing 2A
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC22A18 solute carrier family 22, member 18
SPRR2B small proline-rich protein 2B
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
STC1 stanniocalcin 1
STK11IP serine/threonine kinase 11 interacting protein
SYNGR4 synaptogyrin 4
SYT11 synaptotagmin XI
SYT8 synaptotagmin VIII
TAL2 T-cell acute lymphocytic leukemia 2
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TBXA2R thromboxane A2 receptor
TFR2 transferrin receptor 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
TLR6 toll-like receptor 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNI3 troponin I type 3 (cardiac)
TRAPPC5 trafficking protein particle complex 5
TSHB thyroid stimulating hormone, beta
TSPAN5 tetraspanin 5
TUSC2 tumor suppressor candidate 2
UBR1 ubiquitin protein ligase E3 component n-recognin 1
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
VIM vimentin
VPREB1 pre-B lymphocyte 1
VWA7 von Willebrand factor A domain containing 7