Werner Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [LS]. (Human Disease Ontology, DOID_5688)
External Link https://www.disgenet.org/browser/0/1/0/C0043119
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Genes

127 genes associated with the disease Werner Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACTB actin, beta
ADIPOQ adiponectin, C1Q and collagen domain containing
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ANK1 ankyrin 1, erythrocytic
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
APOA1 apolipoprotein A-I
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CALCA calcitonin-related polypeptide alpha
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAT catalase
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CES2 carboxylesterase 2
CHD9 chromodomain helicase DNA binding protein 9
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
COL3A1 collagen, type III, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DCN decorin
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DESI1 desumoylating isopeptidase 1
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENOSF1 enolase superfamily member 1
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
EWSR1 EWS RNA-binding protein 1
EXD3 exonuclease 3'-5' domain containing 3
EXO1 exonuclease 1
FANCD2 Fanconi anemia, complementation group D2
FEN1 flap structure-specific endonuclease 1
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
GCK glucokinase (hexokinase 4)
GOLGA3 golgin A3
GRAP2 GRB2-related adaptor protein 2
GTF2IRD2 GTF2I repeat domain containing 2
GYPA glycophorin A (MNS blood group)
H2AX H2A.X variant histone
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HOXA1 homeobox A1
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXA13 homeobox A13
HOXA3 homeobox A3
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXA6 homeobox A6
HOXA7 homeobox A7
HOXA9 homeobox A9
ICAM1 intercellular adhesion molecule 1
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INSR insulin receptor
KDR kinase insert domain receptor
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MBNL1 muscleblind-like splicing regulator 1
MECP2 methyl CpG binding protein 2
MLH1 mutL homolog 1
MMRN1 multimerin 1
MON2 MON2 homolog (S. cerevisiae)
MRE11 MRE11 homolog, double strand break repair nuclease
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEIL1 nei endonuclease VIII-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL4 piwi-like RNA-mediated gene silencing 4
PLG plasminogen
PLIN1 perilipin 1
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLL polymerase (DNA directed), lambda
POU1F1 POU class 1 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF19 pre-mRNA processing factor 19
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RAD54L RAD54-like (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RECQL RecQ helicase-like
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS3 ribosomal protein S3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SAMHD1 SAM domain and HD domain 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT6 sirtuin 6
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35G1 solute carrier family 35, member G1
SSRP1 structure specific recognition protein 1
SUMO1 small ubiquitin-like modifier 1
TAGLN transgelin
TERT telomerase reverse transcriptase
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
WRN Werner syndrome, RecQ helicase-like
WRNIP1 Werner helicase interacting protein 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6