XBP1 Gene Set

Dataset TRANSFAC Curated Transcription Factor Targets
Category genomics
Type transcription factor
Description X-box binding protein 1|This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7494)
External Link http://www.ncbi.nlm.nih.gov/gene/7494
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132 target genes of the XBP1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
APLN apelin
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARL1 ADP-ribosylation factor-like 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ASXL2 additional sex combs like transcriptional regulator 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C9ORF84 chromosome 9 open reading frame 84
CADPS Ca++-dependent secretion activator
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCND1 cyclin D1
CDC42 cell division cycle 42
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLSTN3 calsyntenin 3
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DENND5A DENN/MADD domain containing 5A
DHDDS dehydrodolichyl diphosphate synthase
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNM3 dynamin 3
DUSP7 dual specificity phosphatase 7
E2F3 E2F transcription factor 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELF1 E74-like factor 1 (ets domain transcription factor)
EML1 echinoderm microtubule associated protein like 1
EPB41 erythrocyte membrane protein band 4.1
EPC1 enhancer of polycomb homolog 1 (Drosophila)
FKBP14 FK506 binding protein 14, 22 kDa
FOXRED1 FAD-dependent oxidoreductase domain containing 1
GALE UDP-galactose-4-epimerase
GARS glycyl-tRNA synthetase
GLA galactosidase, alpha
GLRA2 glycine receptor, alpha 2
GOSR2 golgi SNAP receptor complex member 2
GPR3 G protein-coupled receptor 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GYS1 glycogen synthase 1 (muscle)
HBP1 HMG-box transcription factor 1
HCRTR2 hypocretin (orexin) receptor 2
HID1 HID1 domain containing
HMBOX1 homeobox containing 1
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HOXA11 homeobox A11
HOXA3 homeobox A3
HOXB5 homeobox B5
HOXB7 homeobox B7
IL10 interleukin 10
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
INTS9 integrator complex subunit 9
IRS4 insulin receptor substrate 4
ITCH itchy E3 ubiquitin protein ligase
JADE1 jade family PHD finger 1
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIF12 kinesin family member 12
KISS1 KiSS-1 metastasis-suppressor
KRTCAP2 keratinocyte associated protein 2
LHX5 LIM homeobox 5
LMBRD1 LMBR1 domain containing 1
LRRC59 leucine rich repeat containing 59
MAGEL2 melanoma antigen family L2
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOGS mannosyl-oligosaccharide glucosidase
MORF4L2 mortality factor 4 like 2
MRPS18B mitochondrial ribosomal protein S18B
NEUROD2 neuronal differentiation 2
NKX2-2 NK2 homeobox 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPAS2 neuronal PAS domain protein 2
OSBP oxysterol binding protein
PAX1 paired box 1
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDIA4 protein disulfide isomerase family A, member 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRDX4 peroxiredoxin 4
PRELID1 PRELI domain containing 1
PRRX1 paired related homeobox 1
PTCHD1 patched domain containing 1
PURA purine-rich element binding protein A
QRICH1 glutamine-rich 1
RAB1A RAB1A, member RAS oncogene family
RAB24 RAB24, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RBM26 RNA binding motif protein 26
RBM39 RNA binding motif protein 39
RBP5 retinol binding protein 5, cellular
REEP3 receptor accessory protein 3
RFTN2 raftlin family member 2
RGS1 regulator of G-protein signaling 1
RHEBL1 Ras homolog enriched in brain like 1
RPL36AL ribosomal protein L36a-like
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SEC24D SEC24 family member D
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SIK2 salt-inducible kinase 2
SKIDA1 SKI/DACH domain containing 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SND1 staphylococcal nuclease and tudor domain containing 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX21 SRY (sex determining region Y)-box 21
SRP68 signal recognition particle 68kDa
SRPR signal recognition particle receptor (docking protein)
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULF1 sulfatase 1
SYT3 synaptotagmin III
TCF4 transcription factor 4
TM9SF1 transmembrane 9 superfamily member 1
TMEM125 transmembrane protein 125
TP53INP2 tumor protein p53 inducible nuclear protein 2
TRIB2 tribbles pseudokinase 2
TRIM46 tripartite motif containing 46
TRIM55 tripartite motif containing 55
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN7 tetraspanin 7
TYRO3 TYRO3 protein tyrosine kinase
UBE2B ubiquitin-conjugating enzyme E2B
USO1 USO1 vesicle transport factor
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YIPF5 Yip1 domain family, member 5
ZBTB47 zinc finger and BTB domain containing 47