| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16035876 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in XEN 103 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.88 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.8 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.74 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.66 |
| POLR3B | polymerase (RNA) III (DNA directed) polypeptide B | 0.65 |
| DBNL | drebrin-like | 0.6 |
| LTA4H | leukotriene A4 hydrolase | 0.58 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.58 |
| ATF3 | activating transcription factor 3 | 0.57 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.56 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 0.53 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.51 |
| BBS2 | Bardet-Biedl syndrome 2 | 0.5 |
| CEP44 | centrosomal protein 44kDa | 0.48 |
| ADIPOR1 | adiponectin receptor 1 | 0.48 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | 0.45 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.45 |
| MLXIPL | MLX interacting protein-like | 0.44 |
| DENND4B | DENN/MADD domain containing 4B | 0.43 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.42 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.42 |
| GAS8 | growth arrest-specific 8 | 0.42 |
| AKNA | AT-hook transcription factor | 0.42 |
| RBMX | RNA binding motif protein, X-linked | 0.4 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.39 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.38 |
| GLDC | glycine dehydrogenase (decarboxylating) | 0.37 |
| CLK4 | CDC-like kinase 4 | 0.37 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | 0.37 |
| RHOB | ras homolog family member B | 0.37 |
| CERCAM | cerebral endothelial cell adhesion molecule | 0.36 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.36 |
| TXNDC9 | thioredoxin domain containing 9 | 0.36 |
| CDK11A | cyclin-dependent kinase 11A | 0.36 |
| ZSCAN20 | zinc finger and SCAN domain containing 20 | 0.35 |
| RGS12 | regulator of G-protein signaling 12 | 0.35 |
| ATXN3 | ataxin 3 | 0.35 |
| LAMA2 | laminin, alpha 2 | 0.34 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.34 |
| CDC5L | cell division cycle 5-like | 0.34 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.33 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.33 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.33 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.33 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.32 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.32 |
| XDH | xanthine dehydrogenase | 0.32 |
| SLC12A8 | solute carrier family 12, member 8 | 0.32 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | 0.32 |
| INTS7 | integrator complex subunit 7 | 0.32 |
| JAG1 | jagged 1 | 0.31 |
| PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 | 0.31 |
| CASZ1 | castor zinc finger 1 | 0.31 |
| WDR5B | WD repeat domain 5B | 0.31 |
| VWA3B | von Willebrand factor A domain containing 3B | 0.31 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.3 |
| LDLR | low density lipoprotein receptor | 0.3 |
| SPIDR | scaffolding protein involved in DNA repair | 0.3 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.3 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | 0.29 |
| CKB | creatine kinase, brain | 0.29 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.29 |
| CCM2 | cerebral cavernous malformation 2 | 0.29 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.29 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.29 |
| OSBPL7 | oxysterol binding protein-like 7 | 0.29 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.29 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 0.29 |
| FOXP1 | forkhead box P1 | 0.29 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.28 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.28 |
| ZNF165 | zinc finger protein 165 | 0.28 |
| PUS10 | pseudouridylate synthase 10 | 0.28 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.28 |
| ZFHX3 | zinc finger homeobox 3 | 0.28 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.27 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.27 |
| ZBTB17 | zinc finger and BTB domain containing 17 | 0.27 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.27 |
| FAM234B | family with sequence similarity 234 member B | 0.27 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | 0.27 |
| GORAB | golgin, RAB6-interacting | 0.27 |
| CENPP | centromere protein P | 0.27 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.27 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.27 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 0.27 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.27 |
| TMEM230 | transmembrane protein 230 | 0.26 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.26 |
| DUSP5 | dual specificity phosphatase 5 | 0.26 |
| LARP6 | La ribonucleoprotein domain family, member 6 | 0.26 |
| CNTNAP3 | contactin associated protein-like 3 | 0.26 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.26 |
| MRC2 | mannose receptor, C type 2 | 0.26 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.26 |
| ULBP1 | UL16 binding protein 1 | 0.26 |
| CTPS1 | CTP synthase 1 | 0.26 |
| BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 | 0.25 |
| CCNYL1 | cyclin Y-like 1 | 0.25 |
| FAM160A1 | family with sequence similarity 160, member A1 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD2 | abhydrolase domain containing 2 | -0.84 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.77 |
| TNNC2 | troponin C type 2 (fast) | -0.67 |
| GPR180 | G protein-coupled receptor 180 | -0.66 |
| POMP | proteasome maturation protein | -0.64 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.63 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.62 |
| YAP1 | Yes-associated protein 1 | -0.61 |
| TMEM200A | transmembrane protein 200A | -0.6 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.6 |
| RPLP1 | ribosomal protein, large, P1 | -0.58 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.58 |
| RPLP2 | ribosomal protein, large, P2 | -0.57 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.56 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.56 |
| IL18 | interleukin 18 | -0.54 |
| TMEM222 | transmembrane protein 222 | -0.53 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.52 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.52 |
| BAG4 | BCL2-associated athanogene 4 | -0.52 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | -0.51 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.51 |
| FEM1C | fem-1 homolog c (C. elegans) | -0.49 |
| APOE | apolipoprotein E | -0.49 |
| CLTA | clathrin, light chain A | -0.49 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | -0.49 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.48 |
| ANAPC16 | anaphase promoting complex subunit 16 | -0.48 |
| PXN | paxillin | -0.48 |
| ADIRF | adipogenesis regulatory factor | -0.48 |
| TMEM173 | transmembrane protein 173 | -0.48 |
| TPM4 | tropomyosin 4 | -0.48 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | -0.47 |
| LYPLA2 | lysophospholipase II | -0.47 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.46 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.46 |
| ARL8A | ADP-ribosylation factor-like 8A | -0.45 |
| TMX2 | thioredoxin-related transmembrane protein 2 | -0.45 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.45 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | -0.44 |
| ISCA2 | iron-sulfur cluster assembly 2 | -0.44 |
| CCND3 | cyclin D3 | -0.44 |
| MTPN | myotrophin | -0.44 |
| PYGO2 | pygopus family PHD finger 2 | -0.43 |
| PTMA | prothymosin, alpha | -0.43 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.43 |
| BCAS2 | breast carcinoma amplified sequence 2 | -0.42 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.41 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.41 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.41 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.41 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.41 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -0.41 |
| NUCB1 | nucleobindin 1 | -0.41 |
| TXN2 | thioredoxin 2 | -0.41 |
| TMSB10 | thymosin beta 10 | -0.41 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.4 |
| SKP1 | S-phase kinase-associated protein 1 | -0.4 |
| GRAMD1A | GRAM domain containing 1A | -0.39 |
| UBQLN1 | ubiquilin 1 | -0.39 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -0.39 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.39 |
| GPS2 | G protein pathway suppressor 2 | -0.39 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.38 |
| KLHL15 | kelch-like family member 15 | -0.38 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.38 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.38 |
| TXNL1 | thioredoxin-like 1 | -0.38 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -0.38 |
| TPM3 | tropomyosin 3 | -0.38 |
| EMC10 | ER membrane protein complex subunit 10 | -0.38 |
| FBXO46 | F-box protein 46 | -0.37 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.37 |
| RPL10 | ribosomal protein L10 | -0.37 |
| GID8 | GID complex subunit 8 | -0.37 |
| RCOR2 | REST corepressor 2 | -0.37 |
| HYPK | huntingtin interacting protein K | -0.37 |
| UBQLN2 | ubiquilin 2 | -0.37 |
| TPI1 | triosephosphate isomerase 1 | -0.36 |
| PGRMC1 | progesterone receptor membrane component 1 | -0.36 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.36 |
| ZNRD2 | zinc ribbon domain containing 2 | -0.36 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.36 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.36 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | -0.36 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.36 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.36 |
| TLE2 | transducin-like enhancer of split 2 | -0.36 |
| PFDN6 | prefoldin subunit 6 | -0.35 |
| TPM2 | tropomyosin 2 (beta) | -0.35 |
| NENF | neudesin neurotrophic factor | -0.34 |
| PYCR3 | pyrroline-5-carboxylate reductase 3 | -0.34 |
| API5 | apoptosis inhibitor 5 | -0.34 |
| BORCS7 | BLOC-1 related complex subunit 7 | -0.34 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.34 |
| FEN1 | flap structure-specific endonuclease 1 | -0.34 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.34 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.34 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -0.34 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.33 |
