XIAP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase|This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 331)
External Link http://www.ncbi.nlm.nih.gov/gene/331
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Genes

188 interacting proteins for XIAP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACVR1B activin A receptor, type IB
ACVRL1 activin A receptor type II-like 1
AFP alpha-fetoprotein
AHCY adenosylhomocysteinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMOT angiomotin
ANKRD13A ankyrin repeat domain 13A
APAF1 apoptotic peptidase activating factor 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATAD3B ATPase family, AAA domain containing 3B
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA1 breast cancer 1, early onset
BUB3 BUB3 mitotic checkpoint protein
C19ORF33 chromosome 19 open reading frame 33
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCS copper chaperone for superoxide dismutase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC27 cell division cycle 27
CHEK1 checkpoint kinase 1
COMMD1 copper metabolism (Murr1) domain containing 1
CRYAB crystallin, alpha B
CS citrate synthase
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DIABLO diablo, IAP-binding mitochondrial protein
DTX3 deltex 3, E3 ubiquitin ligase
DYNLL2 dynein, light chain, LC8-type 2
DZIP3 DAZ interacting zinc finger protein 3
E2F1 E2F transcription factor 1
EIF4B eukaryotic translation initiation factor 4B
ELAVL1 ELAV like RNA binding protein 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
EXTL3 exostosin-like glycosyltransferase 3
FADD Fas (TNFRSF6)-associated via death domain
FAIM Fas apoptotic inhibitory molecule
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FBXO45 F-box protein 45
GIGYF2 GRB10 interacting GYF protein 2
GSK3B glycogen synthase kinase 3 beta
GSPT1 G1 to S phase transition 1
GTSE1 G-2 and S-phase expressed 1
HAX1 HCLS1 associated protein X-1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSPA4 heat shock 70kDa protein 4
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRF3 interferon regulatory factor 3
ITCH itchy E3 ubiquitin protein ligase
IVNS1ABP influenza virus NS1A binding protein
KCTD6 potassium channel tetramerization domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIAA0930 KIAA0930
LATS1 large tumor suppressor kinase 1
MAGED1 melanoma antigen family D1
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPHOSPH9 M-phase phosphoprotein 9
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO6 myosin VI
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NET1 neuroepithelial cell transforming 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH1 notch 1
NT5DC2 5'-nucleotidase domain containing 2
NUDCD2 NudC domain containing 2
NUP153 nucleoporin 153kDa
OSBPL10 oxysterol binding protein-like 10
OSBPL9 oxysterol binding protein-like 9
OTUD1 OTU deubiquitinase 1
PEG10 paternally expressed 10
PFAS phosphoribosylformylglycinamidine synthase
PGAM5 phosphoglycerate mutase family member 5
PKN2 protein kinase N2
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PTEN phosphatase and tensin homolog
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD50 RAD50 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RIPK4 receptor-interacting serine-threonine kinase 4
RLIM ring finger protein, LIM domain interacting
RPS27A ribosomal protein S27a
SCARA3 scavenger receptor class A, member 3
SEC23IP SEC23 interacting protein
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEPT4 septin 4
SERTAD1 SERTA domain containing 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIVA1 SIVA1, apoptosis-inducing factor
SMAD7 SMAD family member 7
SPRYD3 SPRY domain containing 3
SSB Sjogren syndrome antigen B (autoantigen La)
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STRADB STE20-related kinase adaptor beta
STRAP serine/threonine kinase receptor associated protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBK1 TANK-binding kinase 1
TCAF1 TRPM8 channel-associated factor 1
TCEAL1 transcription elongation factor A (SII)-like 1
TCEAL2 transcription elongation factor A (SII)-like 2
TCEAL4 transcription elongation factor A (SII)-like 4
TCF25 transcription factor 25 (basic helix-loop-helix)
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TOLLIP toll interacting protein
TOM1L1 target of myb1 (chicken)-like 1
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM32 tripartite motif containing 32
TRIM8 tripartite motif containing 8
TRIP12 thyroid hormone receptor interactor 12
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USO1 USO1 vesicle transport factor
USP11 ubiquitin specific peptidase 11
USP19 ubiquitin specific peptidase 19
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDYHV1 WDYHV motif containing 1
WRNIP1 Werner helicase interacting protein 1
XAF1 XIAP associated factor 1
ZNF24 zinc finger protein 24