XPA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description xeroderma pigmentosum, complementation group A|This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7507)
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Genes

314 genes differentially expressed following the XPA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR75 G protein-coupled receptor 75 3.30082
HES7 hes family bHLH transcription factor 7 3.30082
HORMAD1 HORMA domain containing 1 3.30082
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 3.30082
LMO1 LIM domain only 1 (rhombotin 1) 3.30082
PAX6 paired box 6 3.30082
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.30082
ANKRD34A ankyrin repeat domain 34A 3.30082
ADAMTSL5 ADAMTS-like 5 3.30082
PCDH8 protocadherin 8 3.30082
SLC35G5 solute carrier family 35, member G5 3.30082
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.30082
GLUD2 glutamate dehydrogenase 2 3.30082
AGTR1 angiotensin II receptor, type 1 3.30082
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.30082
ASB15 ankyrin repeat and SOCS box containing 15 3.30082
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.30082
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.30082
SACK1C scaffolding CK1 anchoring protein C 3.30082
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.30082
SLC46A3 solute carrier family 46, member 3 3.30082
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.30082
TDRD9 tudor domain containing 9 3.30082
TNS4 tensin 4 3.30082
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.30082
TENM2 teneurin transmembrane protein 2 3.30082
BTBD16 BTB (POZ) domain containing 16 3.30082
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.30082
MEIG1 meiosis/spermiogenesis associated 1 3.30082
FXYD2 FXYD domain containing ion transport regulator 2 3.30082
CD22 CD22 molecule 3.30082
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.30082
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.30082
VCX variable charge, X-linked 3.30082
CLEC14A C-type lectin domain family 14, member A 3.30082
MRC1 mannose receptor, C type 1 3.30082
UBA7 ubiquitin-like modifier activating enzyme 7 3.30082
OC90 otoconin 90 3.30082
COPZ2 coatomer protein complex, subunit zeta 2 3.30082
RIMBP3C RIMS binding protein 3C 3.30082
S100A3 S100 calcium binding protein A3 3.30082
NPIPA3 nuclear pore complex interacting protein family, member A3 3.30082
TAS2R10 taste receptor, type 2, member 10 3.30082
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 3.30082
LGALS2 lectin, galactoside-binding, soluble, 2 3.30082
IL32 interleukin 32 3.30082
LOC124901872 uncharacterized LOC124901872 3.30082
PTH1R parathyroid hormone 1 receptor 3.30082
ZNF726 zinc finger protein 726 3.30082
VGLL2 vestigial-like family member 2 3.30082
ACER1 alkaline ceramidase 1 3.30082
SPATA31C2 SPATA31 subfamily C, member 2 3.30082
FMO2 flavin containing monooxygenase 2 (non-functional) 3.30082
PDC phosducin 3.30082
TMPRSS7 transmembrane protease, serine 7 3.30082
PAPOLB poly(A) polymerase beta (testis specific) 3.30082
GIPC3 GIPC PDZ domain containing family, member 3 3.30082
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.30082
CCN3 cellular communication network factor 3 3.30082
LOC124900192 uncharacterized LOC124900192 3.30082
NOTCH2NLB notch 2 N-terminal like B 3.30082
SPAAR small regulatory polypeptide of amino acid response 3.30082
SMIM35 small integral membrane protein 35 3.30082
POU2AF2 POU class 2 homeobox associating factor 2 3.30082
CBY2 chibby family member 2 3.30082
TMEM273 transmembrane protein 273 3.30082
RTL5 retrotransposon Gag like 5 3.30082
FAM237B family with sequence similarity 237 member B 3.30082
C4ORF50 chromosome 4 open reading frame 50 3.30082
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.30082
C3ORF80 chromosome 3 open reading frame 80 3.30082
PRB2 proline-rich protein BstNI subfamily 2 3.30082
LIPC lipase, hepatic 3.30082
EFHB EF-hand domain family, member B 3.30082
PVRIG poliovirus receptor related immunoglobulin domain containing 3.30082
CPED1 cadherin-like and PC-esterase domain containing 1 3.30082
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.30082
PRB1 proline-rich protein BstNI subfamily 1 3.30082
FER1L6 fer-1-like family member 6 3.30082
FAM178B family with sequence similarity 178, member B 3.30082
NPNT nephronectin 3.30082
SCRT2 scratch family zinc finger 2 3.30082
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.30082
TAS1R1 taste receptor, type 1, member 1 3.30082
TMEM179 transmembrane protein 179 3.30082
GJD2 gap junction protein, delta 2, 36kDa 3.30082
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.30082
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.30082
TLR4 toll-like receptor 4 3.30082
NHLRC4 NHL repeat containing 4 3.30082
TACSTD2 tumor-associated calcium signal transducer 2 3.30082
GJA4 gap junction protein, alpha 4, 37kDa 3.30082
TMEM132E transmembrane protein 132E 3.30082
NUPR1 nuclear protein, transcriptional regulator, 1 3.30082
TEKT2 tektin 2 (testicular) 3.30082
PCDH12 protocadherin 12 3.30082
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.30082
FBXO40 F-box protein 40 3.30082
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 3.30082
UTS2R urotensin 2 receptor 3.30082
CTXN2 cortexin 2 3.30082
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.30082
SPINK9 serine peptidase inhibitor, Kazal type 9 3.30082
TDRD10 tudor domain containing 10 3.30082
ARHGAP20 Rho GTPase activating protein 20 3.30082
CNTF ciliary neurotrophic factor 3.30082
CT55 cancer/testis antigen 55 3.30082
CTAGE15 CTAGE family, member 15 3.30082
RAD51AP2 RAD51 associated protein 2 3.30082
CLRN1 clarin 1 3.30082
CYSLTR1 cysteinyl leukotriene receptor 1 3.30082
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.30082
ITGB7 integrin, beta 7 3.30082
LSMEM1 leucine-rich single-pass membrane protein 1 3.30082
PLD6 phospholipase D family, member 6 3.30082
ADAP1 ArfGAP with dual PH domains 1 3.30082
GPR146 G protein-coupled receptor 146 3.30082
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.30082
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.30082
CLEC18B C-type lectin domain family 18, member B 3.30082
TRIML1 tripartite motif family-like 1 3.30082
GOLGA8R golgin A8 family, member R 3.30082
CFH complement factor H 3.30082
GFY golgi-associated, olfactory signaling regulator 3.30082
EFCC1 EF-hand and coiled-coil domain containing 1 3.30082
LRRC25 leucine rich repeat containing 25 3.30082
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.30082
DLX2 distal-less homeobox 2 3.30082
IP6K3 inositol hexakisphosphate kinase 3 3.30082
PGR progesterone receptor 3.30082
IDI2 isopentenyl-diphosphate delta isomerase 2 3.30082
PLCD4 phospholipase C, delta 4 3.30082
SH2D1B SH2 domain containing 1B 3.30082
PFN4 profilin family, member 4 3.30082
ITGA8 integrin, alpha 8 3.30082
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 3.30082
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.30082
CD177 CD177 molecule 3.30082
NUTM2A NUT family member 2A 3.30082
AMER2 APC membrane recruitment protein 2 3.30082
DAND5 DAN domain family member 5, BMP antagonist 3.30082
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.30082
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.30082
CHRM4 cholinergic receptor, muscarinic 4 3.30082
TGM7 transglutaminase 7 3.30082
BPIFC BPI fold containing family C 3.30082
TRAF3IP3 TRAF3 interacting protein 3 3.30082
APOL1 apolipoprotein L, 1 3.30082
CHAD chondroadherin 3.30082
CGA glycoprotein hormones, alpha polypeptide 3.30082
LIMS3 LIM and senescent cell antigen-like domains 3 3.30082
ADRA1B adrenoceptor alpha 1B 3.30082
POTEJ POTE ankyrin domain family, member J 3.30082
PF4V1 platelet factor 4 variant 1 3.30082
KIF4B kinesin family member 4B 3.30082
HGFAC HGF activator 3.30082
ADAM21 ADAM metallopeptidase domain 21 3.30082
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.30082
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 3.30082
GP1BA glycoprotein Ib (platelet), alpha polypeptide 3.30082
PLA2G4E phospholipase A2, group IVE 3.30082
MYT1L myelin transcription factor 1-like 3.16552
GGACT gamma-glutamylamine cyclotransferase 3.16552
NOD2 nucleotide-binding oligomerization domain containing 2 3.13069
TRMT6 tRNA methyltransferase 6 3.01933
DDHD1 DDHD domain containing 1 2.97492
RGS6 regulator of G-protein signaling 6 2.86671
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 2.82138
KAZN kazrin, periplakin interacting protein 2.78445
NYX nyctalopin 2.74965
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.70388
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.68557
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 2.6838
NELFA negative elongation factor complex member A 2.61568
ZNF200 zinc finger protein 200 2.5986
CYB5R2 cytochrome b5 reductase 2 2.53431
SOBP sine oculis binding protein homolog (Drosophila) 2.47605
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.4468
TAPT1 transmembrane anterior posterior transformation 1 2.43296
SETBP1 SET binding protein 1 2.41961
GORAB golgin, RAB6-interacting 2.38834
KIF21B kinesin family member 21B 2.35885
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 2.32594
WDR89 WD repeat domain 89 2.32141
AAGAB alpha- and gamma-adaptin binding protein 2.31519
LHX6 LIM homeobox 6 2.31519
APLN apelin 2.31519
HMX2 H6 family homeobox 2 2.31519
WNK1 WNK lysine deficient protein kinase 1 2.29219
ARHGAP9 Rho GTPase activating protein 9 2.28046
TMEM184B transmembrane protein 184B 2.19863
IFFO2 intermediate filament family orphan 2 2.18283
ARHGAP29 Rho GTPase activating protein 29 2.169
ZFTA zinc finger translocation associated 2.15957
PLAC8L1 PLAC8-like 1 2.15664
NOL8 nucleolar protein 8 2.14569
NTNG1 netrin G1 2.11565
CDC25A cell division cycle 25A 2.10338
DHDH dihydrodiol dehydrogenase (dimeric) 2.10014
S1PR5 sphingosine-1-phosphate receptor 5 2.10014
CRYBG3 beta-gamma crystallin domain containing 3 2.08853
CDK12 cyclin-dependent kinase 12 2.08498
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2.06672
NEURL1 neuralized E3 ubiquitin protein ligase 1 2.06158
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.04608
SP140L SP140 nuclear body protein-like 2.04318
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.03059
GEMIN7 gem (nuclear organelle) associated protein 7 2.02936
DUSP19 dual specificity phosphatase 19 2.02589

decreased expression

Symbol Name Standardized Value
BHLHE40 basic helix-loop-helix family, member e40 -3.30082
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.30082
AMDHD1 amidohydrolase domain containing 1 -3.30082
DAZAP2 DAZ associated protein 2 -3.30082
FGF18 fibroblast growth factor 18 -3.30082
RNF222 ring finger protein 222 -3.30082
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -3.30082
AGBL4 ATP/GTP binding protein-like 4 -3.30082
CATSPERD catsper channel auxiliary subunit delta -3.30082
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -3.30082
TBX22 T-box 22 -3.30082
DNAH1 dynein, axonemal, heavy chain 1 -3.30082
SUCO SUN domain containing ossification factor -3.30082
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -3.30082
ARSA arylsulfatase A -3.30082
FAM216B family with sequence similarity 216, member B -3.30082
ACOT12 acyl-CoA thioesterase 12 -3.30082
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -3.30082
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -3.30082
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.30082
ZBTB42 zinc finger and BTB domain containing 42 -3.30082
IQCC IQ motif containing C -3.30082
ZFP69 ZFP69 zinc finger protein -3.30082
HSPB2 heat shock 27kDa protein 2 -3.30082
ALAS2 5'-aminolevulinate synthase 2 -3.30082
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -3.30082
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -3.30082
CNTFR ciliary neurotrophic factor receptor -3.30082
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.30082
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.30082
ADRA2A adrenoceptor alpha 2A -3.30082
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.30082
UPK1A uroplakin 1A -3.30082
CFAP206 cilia and flagella associated protein 206 -3.30082
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -3.30082
MUC6 mucin 6, oligomeric mucus/gel-forming -3.30082
ZAN zonadhesin (gene/pseudogene) -3.30082
PCDHGB7 protocadherin gamma subfamily B, 7 -3.30082
STYK1 serine/threonine/tyrosine kinase 1 -3.30082
CCDC92 coiled-coil domain containing 92 -3.30082
WFDC8 WAP four-disulfide core domain 8 -3.30082
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.30082
ZNF2 zinc finger protein 2 -3.21792
NPIPA5 nuclear pore complex interacting protein family, member A5 -3.03488
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -3.03309
ALOX5 arachidonate 5-lipoxygenase -3.03236
AKR1E2 aldo-keto reductase family 1, member E2 -2.93387
RND2 Rho family GTPase 2 -2.90862
CCDC66 coiled-coil domain containing 66 -2.90248
SOX4 SRY (sex determining region Y)-box 4 -2.82315
PARP1 poly (ADP-ribose) polymerase 1 -2.73581
RWDD3 RWD domain containing 3 -2.68557
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -2.67663
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.57743
NAP1L1 nucleosome assembly protein 1-like 1 -2.52725
SCN1B sodium channel, voltage gated, type I beta subunit -2.48254
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.43296
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.43296
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.43296
SLC49A3 solute carrier family 49 member 3 -2.43296
NPY neuropeptide Y -2.43296
NOSIP nitric oxide synthase interacting protein -2.42249
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -2.41961
ATRIP ATR interacting protein -2.41961
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.39815
METAP1 methionyl aminopeptidase 1 -2.39266
WDR54 WD repeat domain 54 -2.3694
GOLGA8A golgin A8 family, member A -2.36623
VIM vimentin -2.32413
CDH7 cadherin 7, type 2 -2.32141
EXOC6 exocyst complex component 6 -2.30543
ACSL1 acyl-CoA synthetase long-chain family member 1 -2.30543
CUL5 cullin 5 -2.29373
ARGLU1 arginine and glutamate rich 1 -2.29192
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.27385
JARID2 jumonji, AT rich interactive domain 2 -2.25636
SIRAL1 SIR2 antiphage like 1 -2.21481
FTSJ3 FtsJ homolog 3 (E. coli) -2.20956
LINGO3 leucine rich repeat and Ig domain containing 3 -2.20294
TAOK2 TAO kinase 2 -2.18283
ANTXR1 anthrax toxin receptor 1 -2.17709
PPARG peroxisome proliferator-activated receptor gamma -2.17257
SPATA12 spermatogenesis associated 12 -2.17257
ECI2 enoyl-CoA delta isomerase 2 -2.15664
ADGRG5 adhesion G protein-coupled receptor G5 -2.1553
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.15101
MYRFL myelin regulatory factor-like -2.14373
C20ORF203 chromosome 20 open reading frame 203 -2.10857
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -2.10014
AATF apoptosis antagonizing transcription factor -2.10014
CCDC81 coiled-coil domain containing 81 -2.10014
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.10014
PHF7 PHD finger protein 7 -2.05744
CPOX coproporphyrinogen oxidase -2.05744
ZFP64 ZFP64 zinc finger protein -2.05696
B3GAT2 beta-1,3-glucuronyltransferase 2 -2.04966
ANKRD17 ankyrin repeat domain 17 -2.04608
RAB28 RAB28, member RAS oncogene family -2.03793
TTF1 transcription termination factor, RNA polymerase I -2.02344
SUB1 SUB1 homolog (S. cerevisiae) -2.01497
TTLL11 tubulin tyrosine ligase-like family member 11 -2.01379
ENDOD1 endonuclease domain containing 1 -2.01379
ZNF723 zinc finger protein 723 -2.01379
TCF24 transcription factor 24 -2.0089
XG Xg blood group -2.0089