XPC Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description xeroderma pigmentosum, complementation group C|This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7508)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_XPC
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Genes

62 co-expressed genes for XPC from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ARCN1 archain 1
ARF5 ADP-ribosylation factor 5
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
BLCAP bladder cancer associated protein
C21ORF33 chromosome 21 open reading frame 33
CANX calnexin
CAPZB capping protein (actin filament) muscle Z-line, beta
CLN3 ceroid-lipofuscinosis, neuronal 3
CNBP CCHC-type zinc finger, nucleic acid binding protein
COIL coilin
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
COX5A cytochrome c oxidase subunit Va
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
CUX1 cut-like homeobox 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DNPEP aspartyl aminopeptidase
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DRG1 developmentally regulated GTP binding protein 1
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
FAF2 Fas associated factor family member 2
GLG1 golgi glycoprotein 1
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HTATSF1 HIV-1 Tat specific factor 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IK IK cytokine, down-regulator of HLA II
ILVBL ilvB (bacterial acetolactate synthase)-like
METAP1 methionyl aminopeptidase 1
NUBP1 nucleotide binding protein 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PDAP1 PDGFA associated protein 1
PEX11B peroxisomal biogenesis factor 11 beta
POR P450 (cytochrome) oxidoreductase
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
RAB11A RAB11A, member RAS oncogene family
RAB1A RAB1A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD23B RAD23 homolog B (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SARS seryl-tRNA synthetase
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SNW1 SNW domain containing 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TOR1A torsin family 1, member A (torsin A)
TPR translocated promoter region, nuclear basket protein
TUG1 taurine up-regulated 1 (non-protein coding)
UBA1 ubiquitin-like modifier activating enzyme 1
UBE2A ubiquitin-conjugating enzyme E2A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
URI1 URI1, prefoldin-like chaperone
VGLL4 vestigial-like family member 4
WIPI2 WD repeat domain, phosphoinositide interacting 2
XPC xeroderma pigmentosum, complementation group C
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNHIT1 zinc finger, HIT-type containing 1
ZZZ3 zinc finger, ZZ-type containing 3