XPC Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description xeroderma pigmentosum, complementation group C|This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7508)
External Link http://www.ncbi.nlm.nih.gov/gene/7508
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161 interacting proteins for XPC from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADGRV1 adhesion G protein-coupled receptor V1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
APC adenomatous polyposis coli
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AXIN1 axin 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BANF1 barrier to autointegration factor 1
BBS9 Bardet-Biedl syndrome 9
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CCDC77 coiled-coil domain containing 77
CCNH cyclin H
CCNT1 cyclin T1
CDC14A cell division cycle 14A
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK17 cyclin-dependent kinase 17
CELF1 CUGBP, Elav-like family member 1
CELF2 CUGBP, Elav-like family member 2
CETN2 centrin, EF-hand protein, 2
CETN3 centrin, EF-hand protein, 3
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHRAC1 chromatin accessibility complex 1
CLASP2 cytoplasmic linker associated protein 2
CROCC ciliary rootlet coiled-coil, rootletin
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DIAPH3 diaphanous-related formin 3
DYNLL2 dynein, light chain, LC8-type 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELAVL1 ELAV like RNA binding protein 1
ENKD1 enkurin domain containing 1
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERI2 ERI1 exoribonuclease family member 2
FAM110B family with sequence similarity 110, member B
FAM64A family with sequence similarity 64, member A
FLII flightless I homolog (Drosophila)
FRG1 FSHD region gene 1
FYTTD1 forty-two-three domain containing 1
GIPC1 GIPC PDZ domain containing family, member 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GSK3B glycogen synthase kinase 3 beta
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
H2AFX H2A histone family, member X
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HLTF helicase-like transcription factor
HMGB1 high mobility group box 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPB1 heat shock 27kDa protein 1
IQCB1 IQ motif containing B1
IQGAP3 IQ motif containing GTPase activating protein 3
KLHL40 kelch-like family member 40
LAGE3 L antigen family, member 3
LARS leucyl-tRNA synthetase
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP2 microtubule-associated protein 2
MATR3 matrin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NARF nuclear prelamin A recognition factor
NOL8 nucleolar protein 8
OGG1 8-oxoguanine DNA glycosylase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OTUD4 OTU deubiquitinase 4
PAPD7 PAP associated domain containing 7
PCM1 pericentriolar material 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNA proliferating cell nuclear antigen
PDCD7 programmed cell death 7
PHF5A PHD finger protein 5A
PLEC plectin
POC5 POC5 centriolar protein
POU5F1 POU class 5 homeobox 1
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRPF3 pre-mRNA processing factor 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTBP1 polypyrimidine tract binding protein 1
PTBP2 polypyrimidine tract binding protein 2
PTBP3 polypyrimidine tract binding protein 3
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RALY RALY heterogeneous nuclear ribonucleoprotein
RB1CC1 RB1-inducible coiled-coil 1
RBM14 RNA binding motif protein 14
RBM4 RNA binding motif protein 4
RBMS1 RNA binding motif, single stranded interacting protein 1
RNF111 ring finger protein 111
RNPC3 RNA-binding region (RNP1, RRM) containing 3
RPA1 replication protein A1, 70kDa
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae)
SACK1D scaffolding CK1 anchoring protein D
SACK1H scaffolding CK1 anchoring protein H
SACS sacsin molecular chaperone
SCN3A sodium channel, voltage gated, type III alpha subunit
SETX senataxin
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SMAD1 SMAD family member 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12)
SRRM1 serine/arginine repetitive matrix 1
STIP1 stress-induced phosphoprotein 1
SUGP2 SURP and G patch domain containing 2
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARDBP TAR DNA binding protein
TCF20 transcription factor 20 (AR1)
TDG thymine-DNA glycosylase
TEX15 testis expressed 15
TMEM33 transmembrane protein 33
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TRIM21 tripartite motif containing 21
TRIM33 tripartite motif containing 33
UBC ubiquitin C
UBE4B ubiquitination factor E4B
UNC45A unc-45 homolog A (C. elegans)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP11 ubiquitin specific peptidase 11
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WRAP53 WD repeat containing, antisense to TP53
XIRP1 xin actin binding repeat containing 1
XPA xeroderma pigmentosum, complementation group A
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZCCHC6 zinc finger, CCHC domain containing 6
ZMAT5 zinc finger, matrin-type 5
ZNF512B zinc finger protein 512B