XRK3F2_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SQSTM1 sequestosome 1 0.137364
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.124395
CSTB cystatin B (stefin B) 0.0983656
RHOBTB3 Rho-related BTB domain containing 3 0.0906657
HDAC9 histone deacetylase 9 0.082852
MT2A metallothionein 2A 0.0827298
VIM vimentin 0.0826026
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0767809
B2M beta-2-microglobulin 0.0709311
RND3 Rho family GTPase 3 0.0675866
CTSB cathepsin B 0.0603936
CCND1 cyclin D1 0.0585755
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0574741
EIF1 eukaryotic translation initiation factor 1 0.0538208
ZBTB20 zinc finger and BTB domain containing 20 0.0479118
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0477764
HLA-B major histocompatibility complex, class I, B 0.0467611
CD44 CD44 molecule (Indian blood group) 0.0451122
FNIP1 folliculin interacting protein 1 0.0432217
FBXL7 F-box and leucine-rich repeat protein 7 0.0429417
NAV2 neuron navigator 2 0.0425134
ANTXR1 anthrax toxin receptor 1 0.0417808
FBN1 fibrillin 1 0.0414144
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0411334
RSAD2 radical S-adenosyl methionine domain containing 2 0.0404333
PBX3 pre-B-cell leukemia homeobox 3 0.040385
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.039096
JMJD1C jumonji domain containing 1C 0.0390893
NPC1 Niemann-Pick disease, type C1 0.0376896
TPT1 tumor protein, translationally-controlled 1 0.0375637
FTL ferritin, light polypeptide 0.0374169
LMO7 LIM domain 7 0.0361553
UBC ubiquitin C 0.0361131
AUTS2 autism susceptibility candidate 2 0.0359896
SP100 SP100 nuclear antigen 0.0352391
AHNAK2 AHNAK nucleoprotein 2 0.0342657
SLC39A11 solute carrier family 39, member 11 0.0341933
FNDC3B fibronectin type III domain containing 3B 0.0341887
KLHL24 kelch-like family member 24 0.0340593
NAP1L1 nucleosome assembly protein 1-like 1 0.0340167
RNF213 ring finger protein 213 0.0338395
PODXL podocalyxin-like 0.0326217
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.032603
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.032172
OPTN optineurin 0.0321543
SFTPA2 surfactant protein A2 0.031223
IGFBP7 insulin-like growth factor binding protein 7 0.0308802
DOCK5 dedicator of cytokinesis 5 0.0307993
HLA-E major histocompatibility complex, class I, E 0.0305731
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0302722
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0301724
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0289943
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0287665
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0286455
WDFY1 WD repeat and FYVE domain containing 1 0.0285814
IFITM1 interferon induced transmembrane protein 1 0.028231
FMNL2 formin-like 2 0.0273589
HLA-A major histocompatibility complex, class I, A 0.0267113
FBXL2 F-box and leucine-rich repeat protein 2 0.0264217
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0263213
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0260156
RPS8 ribosomal protein S8 0.0257319
ANKRD12 ankyrin repeat domain 12 0.0253842
OGA O-GlcNAcase 0.0248943
TIMP2 TIMP metallopeptidase inhibitor 2 0.0248711
RPL37A ribosomal protein L37a 0.0246818
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0245073
FOXP1 forkhead box P1 0.0244429
RABGAP1L RAB GTPase activating protein 1-like 0.0241849
RPS13 ribosomal protein S13 0.0241398
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0238406
EEF2 eukaryotic translation elongation factor 2 0.0236976
PGRMC2 progesterone receptor membrane component 2 0.0236927
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0236114
MYO9A myosin IXA 0.0234538
RAB7A RAB7A, member RAS oncogene family 0.0234211
IFITM3 interferon induced transmembrane protein 3 0.0233537
GOLGA4 golgin A4 0.0229073
TTC3 tetratricopeptide repeat domain 3 0.0226438
RPS3 ribosomal protein S3 0.0224151
MMP12 matrix metallopeptidase 12 0.0224094
AKAP9 A kinase (PRKA) anchor protein 9 0.0223036
RPL31 ribosomal protein L31 0.0222741
IFI16 interferon, gamma-inducible protein 16 0.0221127
MYOF myoferlin 0.0219594
NT5C2 5'-nucleotidase, cytosolic II 0.0216929
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0215916
FNIP2 folliculin interacting protein 2 0.0215078
RPS6 ribosomal protein S6 0.021439
OSBPL8 oxysterol binding protein-like 8 0.0213983
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0212755
BPTF bromodomain PHD finger transcription factor 0.0212666
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021129
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0210629
TXNIP thioredoxin interacting protein 0.02087
RPS12 ribosomal protein S12 0.0208091
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0206741
SORBS2 sorbin and SH3 domain containing 2 0.0205288
ACTG1 actin gamma 1 0.0202106
DOCK9 dedicator of cytokinesis 9 0.0201794

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.328825
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.165609
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.153154
COL5A1 collagen, type V, alpha 1 -0.133239
MAP1B microtubule-associated protein 1B -0.122687
TMSB10 thymosin beta 10 -0.11909
AKAP12 A kinase (PRKA) anchor protein 12 -0.113775
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110019
CDH13 cadherin 13 -0.100389
COL8A1 collagen, type VIII, alpha 1 -0.0930416
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.085278
LOX lysyl oxidase -0.0779929
PLAT plasminogen activator, tissue -0.0758894
DLG1 discs, large homolog 1 (Drosophila) -0.0755372
NAV1 neuron navigator 1 -0.0699568
ABI3BP ABI family, member 3 (NESH) binding protein -0.066237
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0549197
TAGLN2 transgelin 2 -0.0519835
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.05176
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.04932
EGFR epidermal growth factor receptor -0.0489358
FLT1 fms-related tyrosine kinase 1 -0.0470297
ASPH aspartate beta-hydroxylase -0.0456883
POTEF POTE ankyrin domain family, member F -0.0450589
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0432479
THBS2 thrombospondin 2 -0.0407849
EFNA5 ephrin-A5 -0.0396263
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0396006
FN1 fibronectin 1 -0.0390663
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0388169
PFN1 profilin 1 -0.03849
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0380283
S100A10 S100 calcium binding protein A10 -0.0378544
PDE4D phosphodiesterase 4D, cAMP-specific -0.0378513
MACF1 microtubule-actin crosslinking factor 1 -0.0376177
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0374745
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0369604
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0366641
CALR calreticulin -0.0363315
LMNA lamin A/C -0.0353959
HSPB1 heat shock 27kDa protein 1 -0.0353338
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0332101
FRMD4A FERM domain containing 4A -0.0329586
RRBP1 ribosome binding protein 1 -0.0308168
LRRC17 leucine rich repeat containing 17 -0.0305143
GARS1 glycyl-tRNA synthetase 1 -0.029676
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0295274
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0292599
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290615
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288498
TPM3 tropomyosin 3 -0.027729
IL7R interleukin 7 receptor -0.027501
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0264289
OASL 2'-5'-oligoadenylate synthetase-like -0.0258522
SAMD9 sterile alpha motif domain containing 9 -0.0257879
PRSS23 protease, serine, 23 -0.0245869
WARS1 tryptophanyl-tRNA synthetase 1 -0.0240228
VEGFA vascular endothelial growth factor A -0.0233249
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0226183
TENT5A terminal nucleotidyltransferase 5A -0.0223525
ANXA1 annexin A1 -0.0223453
SH3KBP1 SH3-domain kinase binding protein 1 -0.0222005
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0215651
C12ORF75 chromosome 12 open reading frame 75 -0.0211368
SP3 Sp3 transcription factor -0.0211027
FNDC3A fibronectin type III domain containing 3A -0.0210482
SLC38A1 solute carrier family 38, member 1 -0.0210132
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -0.0207871
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0206914
EXT1 exostosin glycosyltransferase 1 -0.020689
RAI14 retinoic acid induced 14 -0.0204853
BHLHE40 basic helix-loop-helix family, member e40 -0.0204268
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0203941
CKAP4 cytoskeleton-associated protein 4 -0.0203911
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0202735
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0197502
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0195286
FSTL1 follistatin-like 1 -0.0194706
PDIA6 protein disulfide isomerase family A, member 6 -0.0194563
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0194146
ACTN4 actinin, alpha 4 -0.0192043
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0190655
MAP4 microtubule-associated protein 4 -0.018925
MSN moesin -0.0187986
JAZF1 JAZF zinc finger 1 -0.017897
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0178792
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0178568
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0178422
NCOR2 nuclear receptor corepressor 2 -0.0177894
ADAM9 ADAM metallopeptidase domain 9 -0.0175814
ELL2 elongation factor, RNA polymerase II, 2 -0.0171901
CDK6 cyclin-dependent kinase 6 -0.0171448
SYTL3 synaptotagmin-like 3 -0.0171265
COL3A1 collagen, type III, alpha 1 -0.0168117
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0167248
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0166828
FOSL1 FOS-like antigen 1 -0.0164836
CARS1 cysteinyl-tRNA synthetase 1 -0.0164772
SON SON DNA binding protein -0.0161522
CEP170 centrosomal protein 170kDa -0.0160914