XRK3F2_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.24708
NLGN1 neuroligin 1 0.210116
AREG amphiregulin 0.133504
TMSB10 thymosin beta 10 0.11323
VIM vimentin 0.111457
PDE4D phosphodiesterase 4D, cAMP-specific 0.0866674
CNRIP1 cannabinoid receptor interacting protein 1 0.0773469
TENM3 teneurin transmembrane protein 3 0.0757103
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.065674
SLC38A2 solute carrier family 38, member 2 0.0637506
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0631238
EIF1 eukaryotic translation initiation factor 1 0.0566686
ZBTB20 zinc finger and BTB domain containing 20 0.049263
FTL ferritin, light polypeptide 0.0457531
HSPB1 heat shock 27kDa protein 1 0.0431087
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0414625
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0397367
CELF2 CUGBP, Elav-like family member 2 0.0396208
HDAC9 histone deacetylase 9 0.0393206
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.036736
MED13L mediator complex subunit 13-like 0.0350308
RPL31 ribosomal protein L31 0.0335646
NRXN3 neurexin 3 0.0323975
RPS23 ribosomal protein S23 0.0317861
EPHA5 EPH receptor A5 0.0315677
DPYD dihydropyrimidine dehydrogenase 0.0310272
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0303398
CLPTM1L CLPTM1-like 0.0301189
PCDH7 protocadherin 7 0.0301178
LPP LIM domain containing preferred translocation partner in lipoma 0.0297519
EXOC6B exocyst complex component 6B 0.0288965
ANKRD12 ankyrin repeat domain 12 0.028008
RIMS2 regulating synaptic membrane exocytosis 2 0.0277812
PCDH9 protocadherin 9 0.0277641
MPG N-methylpurine-DNA glycosylase 0.0267368
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.026706
MGAT4C MGAT4 family, member C 0.0257696
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0256403
RPS19 ribosomal protein S19 0.025529
RPL19 ribosomal protein L19 0.025488
CDK6 cyclin-dependent kinase 6 0.0247746
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0247267
RPL36 ribosomal protein L36 0.0243221
PRR16 proline rich 16 0.024311
NFIB nuclear factor I/B 0.0242907
RPS13 ribosomal protein S13 0.024181
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.024033
AHR aryl hydrocarbon receptor 0.0239409
EPHA6 EPH receptor A6 0.0239099
JMJD1C jumonji domain containing 1C 0.023634
CPOX coproporphyrinogen oxidase 0.0234793
RPS29 ribosomal protein S29 0.022261
PCBP2 poly(rC) binding protein 2 0.0219245
CCSER1 coiled-coil serine-rich protein 1 0.0216627
BCAS3 breast carcinoma amplified sequence 3 0.0216183
WWOX WW domain containing oxidoreductase 0.0216152
ATP11A ATPase, class VI, type 11A 0.0212933
NABP1 nucleic acid binding protein 1 0.0211735
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0211486
NEBL nebulette 0.0209519
TMCC1 transmembrane and coiled-coil domain family 1 0.0207812
PDGFC platelet derived growth factor C 0.0205529
NEGR1 neuronal growth regulator 1 0.0204987
USP9X ubiquitin specific peptidase 9, X-linked 0.0204606
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.020356
RPL7 ribosomal protein L7 0.0201119
EDN1 endothelin 1 0.0200471
GJA1 gap junction protein, alpha 1, 43kDa 0.0194171
CARD16 caspase recruitment domain family, member 16 0.0191054
RPL9 ribosomal protein L9 0.0189713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0184225
NCOA1 nuclear receptor coactivator 1 0.0182429
MAML3 mastermind-like 3 (Drosophila) 0.018182
EXOC4 exocyst complex component 4 0.0176386
HMGA2 high mobility group AT-hook 2 0.01717
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0171456
RNF213 ring finger protein 213 0.0171027
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0168337
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0166095
LOC102724023 ES1 protein homolog, mitochondrial 0.0164656
ZSWIM6 zinc finger, SWIM-type containing 6 0.0164013
CEP112 centrosomal protein 112kDa 0.0160545
DNAH14 dynein, axonemal, heavy chain 14 0.0158073
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0157499
PRDX1 peroxiredoxin 1 0.0157403
DLC1 DLC1 Rho GTPase activating protein 0.015669
RPL28 ribosomal protein L28 0.0155516
RPL32 ribosomal protein L32 0.0154254
CCND1 cyclin D1 0.0154096
RPS10 ribosomal protein S10 0.0153079
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0152565
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.015104
NFE2L2 nuclear factor, erythroid 2-like 2 0.0149678
RCC1 regulator of chromosome condensation 1 0.0145607
NEK7 NIMA-related kinase 7 0.0144753
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0144589
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0143949
ARB2A ARB2 cotranscriptional regulator A 0.014327
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0141973
RAD51B RAD51 paralog B 0.0141568

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.118055
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0955677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0881153
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0724252
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0721028
ASPH aspartate beta-hydroxylase -0.0696407
PTMA prothymosin, alpha -0.0690193
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0661497
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0626349
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0607405
AKAP12 A kinase (PRKA) anchor protein 12 -0.0597082
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0562831
TMEM123 transmembrane protein 123 -0.0532165
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0531091
H1-0 H1.0 linker histone -0.0525327
ANXA1 annexin A1 -0.0490176
TUBA1B tubulin, alpha 1b -0.0488685
MKI67 marker of proliferation Ki-67 -0.0480514
CSNK1A1 casein kinase 1, alpha 1 -0.0472532
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.047041
CANX calnexin -0.046388
YBX1 Y box binding protein 1 -0.0454624
TPM3 tropomyosin 3 -0.0447043
TM4SF1 transmembrane 4 L six family member 1 -0.0446254
CENPF centromere protein F, 350/400kDa -0.0439703
HMGA1 high mobility group AT-hook 1 -0.0434943
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0429296
MYL12B myosin, light chain 12B, regulatory -0.0424006
ENO1 enolase 1, (alpha) -0.0423866
KIF5B kinesin family member 5B -0.041516
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0408411
EGR1 early growth response 1 -0.0406765
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0402252
CLDN1 claudin 1 -0.0382969
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.037962
BIRC3 baculoviral IAP repeat containing 3 -0.0374692
PDIA6 protein disulfide isomerase family A, member 6 -0.0371504
CLTC clathrin, heavy chain (Hc) -0.0366327
SMC4 structural maintenance of chromosomes 4 -0.0365357
MAP1B microtubule-associated protein 1B -0.0354987
HMGB1 high mobility group box 1 -0.0352369
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0349353
XPO1 exportin 1 -0.0349223
BIRC6 baculoviral IAP repeat containing 6 -0.0347194
RPS2 ribosomal protein S2 -0.0346024
TPM4 tropomyosin 4 -0.0341033
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0340686
TAS2R14 taste receptor, type 2, member 14 -0.0336151
EHBP1 EH domain binding protein 1 -0.0331985
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0329119
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0327288
AFF4 AF4/FMR2 family, member 4 -0.0312089
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0306042
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0302269
SPATS2 spermatogenesis associated, serine-rich 2 -0.0300427
ZNF804A zinc finger protein 804A -0.02994
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0299332
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0295997
SLC38A1 solute carrier family 38, member 1 -0.0293957
RAB7A RAB7A, member RAS oncogene family -0.0292307
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0290999
VDAC1 voltage-dependent anion channel 1 -0.0290828
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0288611
WDR45B WD repeat domain 45B -0.0284487
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0281525
USP34 ubiquitin specific peptidase 34 -0.0279975
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0279313
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0269698
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0268541
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.026459
KPNB1 karyopherin (importin) beta 1 -0.0263877
ACTG1 actin gamma 1 -0.0261853
TPX2 TPX2, microtubule-associated -0.0261818
RPS27A ribosomal protein S27a -0.0261083
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0258942
MACF1 microtubule-actin crosslinking factor 1 -0.0258214
RPLP1 ribosomal protein, large, P1 -0.0244078
MTAP methylthioadenosine phosphorylase -0.0240824
PFN1 profilin 1 -0.023949
IFIH1 interferon induced with helicase C domain 1 -0.0237095
NHSL1 NHS-like 1 -0.0236121
HDGF hepatoma-derived growth factor -0.0230575
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0230082
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0228924
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0228334
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0227013
RSL1D1 ribosomal L1 domain containing 1 -0.0226311
NAV3 neuron navigator 3 -0.0226132
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0225143
SRP72 signal recognition particle 72kDa -0.0224906
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0223307
RAI14 retinoic acid induced 14 -0.0219296
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0217914
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0217542
CSDE1 cold shock domain containing E1, RNA-binding -0.0216588
PA2G4 proliferation-associated 2G4, 38kDa -0.0216218
LOC112694756 uncharaterized LOC112694756 -0.021514
PRR11 proline rich 11 -0.0213533
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0213175
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0213009