XRK3F2_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 0.208694
GCLC glutamate-cysteine ligase, catalytic subunit 0.158307
B2M beta-2-microglobulin 0.137306
TPT1 tumor protein, translationally-controlled 1 0.110553
RNF213 ring finger protein 213 0.10506
FTL ferritin, light polypeptide 0.102958
MACC1 metastasis associated in colon cancer 1 0.099116
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0948311
LMO7 LIM domain 7 0.0932259
EXT1 exostosin glycosyltransferase 1 0.0920144
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0893182
AREG amphiregulin 0.0822917
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0784203
PERP PERP, TP53 apoptosis effector 0.0748937
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0748626
LOC102724023 ES1 protein homolog, mitochondrial 0.0728229
TMC5 transmembrane channel-like 5 0.0700476
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0699528
VCL vinculin 0.0635486
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0622799
PKM pyruvate kinase, muscle 0.0617689
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0611293
LPP LIM domain containing preferred translocation partner in lipoma 0.0602973
N4BP2L2 NEDD4 binding protein 2-like 2 0.0600389
MYO1E myosin IE 0.0542306
AKAP13 A kinase (PRKA) anchor protein 13 0.0532568
EIF1 eukaryotic translation initiation factor 1 0.053145
ETV6 ets variant 6 0.0530431
FNIP2 folliculin interacting protein 2 0.0514502
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0506745
HLA-B major histocompatibility complex, class I, B 0.0499869
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.049925
SMAD3 SMAD family member 3 0.048192
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0477614
ACTG1 actin gamma 1 0.0476518
LURAP1L leucine rich adaptor protein 1-like 0.0472116
RND3 Rho family GTPase 3 0.0464695
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0452234
RPL19 ribosomal protein L19 0.0444513
KYNU kynureninase 0.0441123
CATSPERB catsper channel auxiliary subunit beta 0.0438233
SLC38A2 solute carrier family 38, member 2 0.0433089
EPSTI1 epithelial stromal interaction 1 (breast) 0.0425463
TSC22D1 TSC22 domain family, member 1 0.0417345
RPL35A ribosomal protein L35a 0.0413829
TXNRD1 thioredoxin reductase 1 0.0409627
ZNF292 zinc finger protein 292 0.0409002
SERINC5 serine incorporator 5 0.0403539
FNIP1 folliculin interacting protein 1 0.039557
TJP1 tight junction protein 1 0.0394265
MUC13 mucin 13, cell surface associated 0.0388156
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0386395
TRIM2 tripartite motif containing 2 0.0381001
DST dystonin 0.0380323
DUSP16 dual specificity phosphatase 16 0.0377164
SYT1 synaptotagmin I 0.0367759
KLF5 Kruppel-like factor 5 (intestinal) 0.0362724
STS steroid sulfatase (microsomal), isozyme S 0.0359035
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0356586
MUC20 mucin 20, cell surface associated 0.0355924
HLA-A major histocompatibility complex, class I, A 0.0349258
RPLP0 ribosomal protein, large, P0 0.0346397
MX2 MX dynamin-like GTPase 2 0.0344737
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0343226
SP100 SP100 nuclear antigen 0.0341908
PLSCR2 phospholipid scramblase 2 0.0341206
WWOX WW domain containing oxidoreductase 0.0340686
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0338722
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0329964
RPS6 ribosomal protein S6 0.0328644
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0316379
UBC ubiquitin C 0.0312048
RPS8 ribosomal protein S8 0.0311176
IFI6 interferon, alpha-inducible protein 6 0.030949
RBM47 RNA binding motif protein 47 0.0303536
TOX3 TOX high mobility group box family member 3 0.0301538
IFITM3 interferon induced transmembrane protein 3 0.0300343
EREG epiregulin 0.0299257
ZBTB20 zinc finger and BTB domain containing 20 0.0296354
EPS8 epidermal growth factor receptor pathway substrate 8 0.0291859
ANKRD12 ankyrin repeat domain 12 0.0289709
PHF3 PHD finger protein 3 0.028227
RPL11 ribosomal protein L11 0.0278378
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0269125
HKDC1 hexokinase domain containing 1 0.0268723
RPL9 ribosomal protein L9 0.0267631
MEIS2 Meis homeobox 2 0.0266712
AHI1 Abelson helper integration site 1 0.0266077
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0266029
SIK3 SIK family kinase 3 0.0263161
RACK1 receptor for activated C kinase 1 0.0262861
ALCAM activated leukocyte cell adhesion molecule 0.0259928
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0255648
CTSB cathepsin B 0.0253522
JAK1 Janus kinase 1 0.0252962
RPL23 ribosomal protein L23 0.0252604
MX1 MX dynamin-like GTPase 1 0.025235
PHACTR4 phosphatase and actin regulator 4 0.0249561
RPL28 ribosomal protein L28 0.0248165
MTUS1 microtubule associated tumor suppressor 1 0.0248068

decreased expression

Symbol Name Standardized Value
LYZ lysozyme -0.0675722
GMDS GDP-mannose 4,6-dehydratase -0.0642174
ITGA6 integrin, alpha 6 -0.0641065
NPSR1 neuropeptide S receptor 1 -0.0578646
ARHGAP26 Rho GTPase activating protein 26 -0.046385
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0371958
NDRG1 N-myc downstream regulated 1 -0.0370945
SSH2 slingshot protein phosphatase 2 -0.0366455
PRKCA protein kinase C, alpha -0.0354819
MAML2 mastermind-like 2 (Drosophila) -0.0335453
C6ORF132 chromosome 6 open reading frame 132 -0.0327666
H1-0 H1.0 linker histone -0.0323524
ZMYND8 zinc finger, MYND-type containing 8 -0.0319888
MACF1 microtubule-actin crosslinking factor 1 -0.0295869
TNS4 tensin 4 -0.0269174
TRERF1 transcriptional regulating factor 1 -0.0242692
ASPH aspartate beta-hydroxylase -0.0238566
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0235814
TM4SF19 transmembrane 4 L six family member 19 -0.0215435
SORBS1 sorbin and SH3 domain containing 1 -0.0202498
SPATA13 spermatogenesis associated 13 -0.0196676
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0193235
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0190495
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.018437
TPM3 tropomyosin 3 -0.0178903
SDC4 syndecan 4 -0.0171426
NECTIN2 nectin cell adhesion molecule 2 -0.0170739
S100A6 S100 calcium binding protein A6 -0.0169698
PDE4D phosphodiesterase 4D, cAMP-specific -0.0167894
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0165068
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0164005
PTMA prothymosin, alpha -0.0162761
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0162265
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0159853
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0158983
TNIK TRAF2 and NCK interacting kinase -0.0158818
LEMD1 LEM domain containing 1 -0.0157753
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0156614
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0155523
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0154206
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0154193
LAMA4 laminin, alpha 4 -0.0152494
IGFBP3 insulin-like growth factor binding protein 3 -0.0151396
ETNK1 ethanolamine kinase 1 -0.015126
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.01511
METTL15 methyltransferase like 15 -0.0150298
PTEN phosphatase and tensin homolog -0.0148394
SREBF2 sterol regulatory element binding transcription factor 2 -0.0146864
PSD3 pleckstrin and Sec7 domain containing 3 -0.0146593
TSHZ2 teashirt zinc finger homeobox 2 -0.014259
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0140212
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0140145
CEMIP cell migration inducing protein, hyaluronan binding -0.0139477
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0138683
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0137512
ESYT2 extended synaptotagmin-like protein 2 -0.0137284
BCLAF1 BCL2-associated transcription factor 1 -0.0132762
FOXB1 forkhead box B1 -0.0132732
RAB6A RAB6A, member RAS oncogene family -0.0132359
STYXL2 serine/threonine/tyrosine interacting like 2 -0.0130947
FERMT1 fermitin family member 1 -0.0129353
SH3PXD2A SH3 and PX domains 2A -0.0128342
SCARB1 scavenger receptor class B, member 1 -0.0127111
DNM2 dynamin 2 -0.0127057
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0125988
ACBD3 acyl-CoA binding domain containing 3 -0.012552
SDCBP2 syndecan binding protein (syntenin) 2 -0.0124035
LRRC8A leucine rich repeat containing 8 family, member A -0.0123946
ATAD2 ATPase family, AAA domain containing 2 -0.0123452
ATP11A ATPase, class VI, type 11A -0.0122947
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0122054
CDK6 cyclin-dependent kinase 6 -0.0121534
EPN2 epsin 2 -0.0121045
FOSL1 FOS-like antigen 1 -0.0120957
CCDC146 coiled-coil domain containing 146 -0.0119296
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0119096
MKI67 marker of proliferation Ki-67 -0.0117983
TJP2 tight junction protein 2 -0.0117227
RCOR1 REST corepressor 1 -0.0116917
VASP vasodilator-stimulated phosphoprotein -0.0116788
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0116486
AKAP12 A kinase (PRKA) anchor protein 12 -0.0116432
NPAS2 neuronal PAS domain protein 2 -0.0114529
RBM25 RNA binding motif protein 25 -0.011436
TPM4 tropomyosin 4 -0.0114208
ITGB4 integrin, beta 4 -0.0114072
TMPRSS4 transmembrane protease, serine 4 -0.011402
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0113908
ABHD17C abhydrolase domain containing 17C -0.0113655
VEGFA vascular endothelial growth factor A -0.0112364
CALU calumenin -0.0112291
NCOR2 nuclear receptor corepressor 2 -0.0112088
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0111738
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0110701
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0110586
AHNAK AHNAK nucleoprotein -0.0109831
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0109746
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0109096
DENND1A DENN/MADD domain containing 1A -0.010885
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0107681