XRK3F2_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.171546
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.116889
CXCL8 chemokine (C-X-C motif) ligand 8 0.113803
ZBTB20 zinc finger and BTB domain containing 20 0.0821621
NAV2 neuron navigator 2 0.0726097
VIM vimentin 0.0681232
EIF1 eukaryotic translation initiation factor 1 0.0589165
B2M beta-2-microglobulin 0.0583212
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0532769
HLA-B major histocompatibility complex, class I, B 0.0529339
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0520229
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.050672
SQSTM1 sequestosome 1 0.0504722
SP100 SP100 nuclear antigen 0.0500041
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0498822
SOD2 superoxide dismutase 2, mitochondrial 0.0495156
RPS8 ribosomal protein S8 0.0486844
ACTG1 actin gamma 1 0.0456496
IFI6 interferon, alpha-inducible protein 6 0.0445401
RIGI RNA sensor RIG-I 0.0431613
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0413049
FTL ferritin, light polypeptide 0.0388161
LPP LIM domain containing preferred translocation partner in lipoma 0.0376075
PLSCR1 phospholipid scramblase 1 0.0351628
RSAD2 radical S-adenosyl methionine domain containing 2 0.0333385
RND3 Rho family GTPase 3 0.0332929
TPT1 tumor protein, translationally-controlled 1 0.0331034
RPL35A ribosomal protein L35a 0.0321604
RPL11 ribosomal protein L11 0.0320299
FBXL7 F-box and leucine-rich repeat protein 7 0.0297464
EEF2 eukaryotic translation elongation factor 2 0.0294968
RPS6 ribosomal protein S6 0.0292545
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0288919
UBC ubiquitin C 0.0285946
HLA-E major histocompatibility complex, class I, E 0.0279397
TM4SF1 transmembrane 4 L six family member 1 0.0274614
HDAC9 histone deacetylase 9 0.0271294
TGFBI transforming growth factor, beta-induced, 68kDa 0.0269741
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0267183
FNIP1 folliculin interacting protein 1 0.0264274
RPS3 ribosomal protein S3 0.0262389
RPLP0 ribosomal protein, large, P0 0.0261743
MX2 MX dynamin-like GTPase 2 0.0259689
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.025423
RPL37A ribosomal protein L37a 0.0251453
FNDC3B fibronectin type III domain containing 3B 0.0244696
ISG15 ISG15 ubiquitin-like modifier 0.02441
IL6 interleukin 6 0.0243881
RPS20 ribosomal protein S20 0.0242681
RPL30 ribosomal protein L30 0.0242357
BACE2 beta-site APP-cleaving enzyme 2 0.0241126
MT1X metallothionein 1X 0.0238819
SAMD9 sterile alpha motif domain containing 9 0.0236032
RPS12 ribosomal protein S12 0.0234348
HLA-A major histocompatibility complex, class I, A 0.0234203
ALCAM activated leukocyte cell adhesion molecule 0.023205
RPL7 ribosomal protein L7 0.0230331
IFITM3 interferon induced transmembrane protein 3 0.0222147
RPS13 ribosomal protein S13 0.0220213
FMNL2 formin-like 2 0.021971
RPL31 ribosomal protein L31 0.0214431
RACK1 receptor for activated C kinase 1 0.0213327
CCND1 cyclin D1 0.0213177
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0211082
RPL28 ribosomal protein L28 0.0208313
ZFPM2 zinc finger protein, FOG family member 2 0.0205588
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019854
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0196264
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0191122
GOLGB1 golgin B1 0.0188312
CD44 CD44 molecule (Indian blood group) 0.0187507
TTC28 tetratricopeptide repeat domain 28 0.0184949
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0183937
PITPNB phosphatidylinositol transfer protein, beta 0.018321
FBXO32 F-box protein 32 0.0182638
SLC38A2 solute carrier family 38, member 2 0.0181946
AHNAK AHNAK nucleoprotein 0.018053
ZBTB38 zinc finger and BTB domain containing 38 0.0175694
PTPRK protein tyrosine phosphatase, receptor type, K 0.0175626
PTK2 protein tyrosine kinase 2 0.0174749
IFI44L interferon-induced protein 44-like 0.0174206
BBS9 Bardet-Biedl syndrome 9 0.017404
SVIL supervillin 0.0173088
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0172938
RPL7A ribosomal protein L7a 0.017135
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0171133
RPL9 ribosomal protein L9 0.0170974
RPS16 ribosomal protein S16 0.0169726
IGFBP7 insulin-like growth factor binding protein 7 0.0168437
RPS25 ribosomal protein S25 0.0168398
ZNFX1 zinc finger, NFX1-type containing 1 0.0168232
PDLIM5 PDZ and LIM domain 5 0.0166979
IFIH1 interferon induced with helicase C domain 1 0.0166295
TUBB tubulin, beta class I 0.0164356
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0162217
CTSB cathepsin B 0.0161472
CDK14 cyclin-dependent kinase 14 0.0160867
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0160422
RPS5 ribosomal protein S5 0.0158052
RPL13A ribosomal protein L13a 0.0156979

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.473977
FN1 fibronectin 1 -0.230296
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183809
COL6A3 collagen, type VI, alpha 3 -0.165391
TIMP3 TIMP metallopeptidase inhibitor 3 -0.125737
COL1A1 collagen, type I, alpha 1 -0.107941
NDRG1 N-myc downstream regulated 1 -0.0987149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0933176
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.081569
ASPH aspartate beta-hydroxylase -0.0731987
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0611198
COL5A1 collagen, type V, alpha 1 -0.0583864
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0479509
PDE10A phosphodiesterase 10A -0.047016
COL1A2 collagen, type I, alpha 2 -0.0465091
CDH13 cadherin 13 -0.0460263
VEGFA vascular endothelial growth factor A -0.044724
EGR1 early growth response 1 -0.0435202
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0434843
LOX lysyl oxidase -0.0418076
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0395927
CALR calreticulin -0.0364273
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0354721
GARS1 glycyl-tRNA synthetase 1 -0.034961
ELL2 elongation factor, RNA polymerase II, 2 -0.0338132
ATP13A3 ATPase type 13A3 -0.033456
GLIS3 GLIS family zinc finger 3 -0.0331593
CADM1 cell adhesion molecule 1 -0.0316743
CANX calnexin -0.0314305
F3 coagulation factor III (thromboplastin, tissue factor) -0.0307493
MAP1B microtubule-associated protein 1B -0.0303104
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0302642
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0273764
LMAN1 lectin, mannose-binding, 1 -0.0268197
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0267971
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0266591
ECE1 endothelin converting enzyme 1 -0.0265099
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255731
PDE4D phosphodiesterase 4D, cAMP-specific -0.0253944
PSD3 pleckstrin and Sec7 domain containing 3 -0.0251168
LOXL2 lysyl oxidase-like 2 -0.0250043
CALU calumenin -0.0245948
PRELID2 PRELI domain containing 2 -0.0240964
FBXL13 F-box and leucine-rich repeat protein 13 -0.0239685
BBX bobby sox homolog (Drosophila) -0.0239583
HYOU1 hypoxia up-regulated 1 -0.0237528
COL6A1 collagen, type VI, alpha 1 -0.0236379
DLG1 discs, large homolog 1 (Drosophila) -0.0229167
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225058
ZNF292 zinc finger protein 292 -0.0214272
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0212477
MAP4 microtubule-associated protein 4 -0.0212291
HILPDA hypoxia inducible lipid droplet-associated -0.0211118
PDIA6 protein disulfide isomerase family A, member 6 -0.0210586
RRBP1 ribosome binding protein 1 -0.0208674
COL7A1 collagen, type VII, alpha 1 -0.0207722
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0205024
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0204824
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0203946
YBX1 Y box binding protein 1 -0.0200944
TENT5A terminal nucleotidyltransferase 5A -0.0195346
TRIO trio Rho guanine nucleotide exchange factor -0.0193592
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0193037
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0192698
PDIA3 protein disulfide isomerase family A, member 3 -0.019096
DPYD dihydropyrimidine dehydrogenase -0.0190473
RUNX1 runt-related transcription factor 1 -0.0189731
COL6A2 collagen, type VI, alpha 2 -0.0188631
FRMD4A FERM domain containing 4A -0.0187221
HDLBP high density lipoprotein binding protein -0.0185855
TFG TRK-fused gene -0.018554
SMYD3 SET and MYND domain containing 3 -0.0183483
CALD1 caldesmon 1 -0.0181132
EGFR epidermal growth factor receptor -0.017963
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0178769
TENM3 teneurin transmembrane protein 3 -0.0176485
NBAS neuroblastoma amplified sequence -0.0176023
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0175103
OXR1 oxidation resistance 1 -0.017419
BNC2 basonuclin 2 -0.0171931
GOLGA4 golgin A4 -0.0170803
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0168718
CABIN1 calcineurin binding protein 1 -0.0165926
TMEM165 transmembrane protein 165 -0.0164997
IARS1 isoleucyl-tRNA synthetase 1 -0.0164738
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.016392
LTBP1 latent transforming growth factor beta binding protein 1 -0.0163873
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0162903
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0160795
TSC22D2 TSC22 domain family, member 2 -0.0160638
PTPRF protein tyrosine phosphatase, receptor type, F -0.016027
ARHGAP35 Rho GTPase activating protein 35 -0.0158677
ARHGAP29 Rho GTPase activating protein 29 -0.015752
ABI3BP ABI family, member 3 (NESH) binding protein -0.0157499
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.015737
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0155584
TPM4 tropomyosin 4 -0.0154344
SETD5 SET domain containing 5 -0.0153721
USP3 ubiquitin specific peptidase 3 -0.0153665
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0152936