| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | XRK3F2 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the XRK3F2_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.247224 |
| IGF2 | insulin-like growth factor 2 | 0.230705 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.225485 |
| ITGAV | integrin, alpha V | 0.154388 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.133167 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.103468 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0987359 |
| ENAH | enabled homolog (Drosophila) | 0.0982828 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0979309 |
| VCL | vinculin | 0.0921882 |
| APOB | apolipoprotein B | 0.0871442 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0866572 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0719607 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.069475 |
| FOXP1 | forkhead box P1 | 0.0645619 |
| CLEC16A | C-type lectin domain family 16, member A | 0.0619014 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0618936 |
| TNS3 | tensin 3 | 0.0607425 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0601705 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0528812 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0497667 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0491458 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0491228 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.048363 |
| MSI2 | musashi RNA-binding protein 2 | 0.0482937 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0467036 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0464302 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0463047 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.045958 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0445459 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0441758 |
| CTSB | cathepsin B | 0.043851 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0438095 |
| SKIL | SKI-like proto-oncogene | 0.0426423 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0422711 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.04189 |
| SMAD3 | SMAD family member 3 | 0.0417958 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0417132 |
| RNF213 | ring finger protein 213 | 0.0412263 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0411726 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0410644 |
| DSPP | dentin sialophosphoprotein | 0.0396799 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0382627 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0379743 |
| KYNU | kynureninase | 0.0378888 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0372851 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0360089 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0356556 |
| TXNRD1 | thioredoxin reductase 1 | 0.035155 |
| MRTFA | myocardin related transcription factor A | 0.0343186 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0340644 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0340561 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0337937 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0337116 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.033457 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0331918 |
| ZNF644 | zinc finger protein 644 | 0.032903 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0326086 |
| PALLD | palladin, cytoskeletal associated protein | 0.0324161 |
| DST | dystonin | 0.0323774 |
| ALPK2 | alpha-kinase 2 | 0.0321009 |
| ATXN1 | ataxin 1 | 0.0318215 |
| PTCHD4 | patched domain containing 4 | 0.0315764 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0315303 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0314244 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0313351 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0305544 |
| GLIS3 | GLIS family zinc finger 3 | 0.030083 |
| MYO1E | myosin IE | 0.0298077 |
| FAM107B | family with sequence similarity 107, member B | 0.0296738 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0296026 |
| PRKCA | protein kinase C, alpha | 0.0295301 |
| HNMT | histamine N-methyltransferase | 0.0290926 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0290265 |
| KLF6 | Kruppel-like factor 6 | 0.0288374 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0288302 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0288172 |
| CADM1 | cell adhesion molecule 1 | 0.028805 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0286884 |
| FILIP1L | filamin A interacting protein 1-like | 0.0285442 |
| RPLP0 | ribosomal protein, large, P0 | 0.028527 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0284831 |
| JMJD1C | jumonji domain containing 1C | 0.02834 |
| EXOC6B | exocyst complex component 6B | 0.0281736 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.0279584 |
| TPM1 | tropomyosin 1 (alpha) | 0.0278056 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0275076 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0273581 |
| SIK3 | SIK family kinase 3 | 0.0273304 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0271798 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0271754 |
| AHR | aryl hydrocarbon receptor | 0.0269092 |
| TCIM | transcriptional and immune response regulator | 0.0266291 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0264517 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0261095 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0259431 |
| FHIT | fragile histidine triad | 0.0259039 |
| SKI | SKI proto-oncogene | 0.025816 |
| RSU1 | Ras suppressor protein 1 | 0.0256757 |
| CLIC4 | chloride intracellular channel 4 | 0.0255675 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.137565 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.115641 |
| MT2A | metallothionein 2A | -0.110256 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.100089 |
| EHBP1 | EH domain binding protein 1 | -0.0950964 |
| APOA2 | apolipoprotein A-II | -0.0938376 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0929914 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0891432 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0835875 |
| TMSB10 | thymosin beta 10 | -0.0827076 |
| ASPH | aspartate beta-hydroxylase | -0.0693914 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0604667 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0574513 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0574243 |
| A2M | alpha-2-macroglobulin | -0.0532923 |
| TRIM26 | tripartite motif containing 26 | -0.0531988 |
| GPC3 | glypican 3 | -0.053106 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.050691 |
| FRMD5 | FERM domain containing 5 | -0.0503273 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.049026 |
| LYZ | lysozyme | -0.0480289 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0474067 |
| HMGA1 | high mobility group AT-hook 1 | -0.0461332 |
| ATP10A | ATPase, class V, type 10A | -0.0423318 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0417621 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0405386 |
| NHSL1 | NHS-like 1 | -0.0396203 |
| TF | transferrin | -0.0378254 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0376218 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0372719 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0369517 |
| FMNL2 | formin-like 2 | -0.0366828 |
| PTMA | prothymosin, alpha | -0.0364358 |
| APOA1 | apolipoprotein A-I | -0.0362662 |
| NDRG1 | N-myc downstream regulated 1 | -0.0359206 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0353545 |
| AHSG | alpha-2-HS-glycoprotein | -0.0353348 |
| KIAA1217 | KIAA1217 | -0.0333379 |
| NPR2 | natriuretic peptide receptor 2 | -0.0332089 |
| ITGA1 | integrin, alpha 1 | -0.0327927 |
| FN1 | fibronectin 1 | -0.0315756 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0312474 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0307019 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.03017 |
| RRBP1 | ribosome binding protein 1 | -0.0301416 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0299821 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0299301 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0297997 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0294817 |
| HMGA2 | high mobility group AT-hook 2 | -0.029393 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0293086 |
| CPE | carboxypeptidase E | -0.0291323 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0287877 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0286787 |
| CALR | calreticulin | -0.0280947 |
| NPAS2 | neuronal PAS domain protein 2 | -0.028063 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0280517 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0275807 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.027353 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0269691 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0269257 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.025865 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0258416 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0252575 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0252223 |
| VEGFA | vascular endothelial growth factor A | -0.0251249 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0246539 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0243759 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0241738 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0241509 |
| H1-0 | H1.0 linker histone | -0.023701 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0228659 |
| FABP1 | fatty acid binding protein 1, liver | -0.0226356 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0222254 |
| CST3 | cystatin C | -0.022215 |
| DOK6 | docking protein 6 | -0.022195 |
| APOE | apolipoprotein E | -0.021966 |
| TPM4 | tropomyosin 4 | -0.0218763 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0217644 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0214835 |
| CP | ceruloplasmin (ferroxidase) | -0.0211881 |
| RPS19 | ribosomal protein S19 | -0.0211123 |
| S100A9 | S100 calcium binding protein A9 | -0.0210344 |
| RPS24 | ribosomal protein S24 | -0.0209525 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0209216 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0207281 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0206969 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0202022 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0197011 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0196508 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0194905 |
| TMEM123 | transmembrane protein 123 | -0.0193446 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0193094 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0192777 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.019224 |
| OSMR | oncostatin M receptor | -0.0190988 |
| PEG10 | paternally expressed 10 | -0.0182964 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0182953 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0181286 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0178685 |
