XRK3F2_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.173629
LMO7 LIM domain 7 0.146011
PTPRK protein tyrosine phosphatase, receptor type, K 0.120692
FGFR2 fibroblast growth factor receptor 2 0.116639
TMC5 transmembrane channel-like 5 0.10656
RNF213 ring finger protein 213 0.0964434
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0918133
B2M beta-2-microglobulin 0.0899562
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0867839
LPP LIM domain containing preferred translocation partner in lipoma 0.0828835
MYOF myoferlin 0.0799494
EZR ezrin 0.0798734
RUNX1 runt-related transcription factor 1 0.0751183
EIF1 eukaryotic translation initiation factor 1 0.0701079
CDK6 cyclin-dependent kinase 6 0.0685128
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0654915
CD2AP CD2-associated protein 0.0612719
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0609528
FNDC3B fibronectin type III domain containing 3B 0.0596787
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0572767
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0569422
AHR aryl hydrocarbon receptor 0.0555094
MBNL2 muscleblind-like splicing regulator 2 0.055336
MACC1 metastasis associated in colon cancer 1 0.0548217
ZBTB20 zinc finger and BTB domain containing 20 0.0521472
SLC38A2 solute carrier family 38, member 2 0.051186
HLA-E major histocompatibility complex, class I, E 0.0490016
BCAS3 breast carcinoma amplified sequence 3 0.0457038
DSPP dentin sialophosphoprotein 0.0455403
MTUS1 microtubule associated tumor suppressor 1 0.0454338
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0444625
LOC102724023 ES1 protein homolog, mitochondrial 0.0444292
PLSCR1 phospholipid scramblase 1 0.044369
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0441206
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0423364
HDAC9 histone deacetylase 9 0.041438
SP100 SP100 nuclear antigen 0.0413073
RBM47 RNA binding motif protein 47 0.0412602
TPT1 tumor protein, translationally-controlled 1 0.0407014
FOXP1 forkhead box P1 0.0399538
SH3RF1 SH3 domain containing ring finger 1 0.0397612
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.039579
KLHL24 kelch-like family member 24 0.038198
MGAM2 maltase-glucoamylase 2 (putative) 0.0374925
AKAP13 A kinase (PRKA) anchor protein 13 0.0371161
TXNRD1 thioredoxin reductase 1 0.0367781
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0357882
GDA guanine deaminase 0.0356931
EXOC4 exocyst complex component 4 0.0354014
NUPR1 nuclear protein, transcriptional regulator, 1 0.0350344
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.034092
DST dystonin 0.0340679
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0335688
IFI6 interferon, alpha-inducible protein 6 0.0335424
ARHGAP32 Rho GTPase activating protein 32 0.0332556
CADPS2 Ca++-dependent secretion activator 2 0.0326759
CLDN4 claudin 4 0.032584
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.031686
XAF1 XIAP associated factor 1 0.0316488
ATXN1 ataxin 1 0.0314114
UBE2H ubiquitin-conjugating enzyme E2H 0.0312892
IL1RAP interleukin 1 receptor accessory protein 0.0308714
KLF6 Kruppel-like factor 6 0.0306399
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0304483
FTL ferritin, light polypeptide 0.030014
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0298534
IFI27 interferon, alpha-inducible protein 27 0.0297921
TJP1 tight junction protein 1 0.0291976
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0289813
XRN1 5'-3' exoribonuclease 1 0.0288722
ADGRF1 adhesion G protein-coupled receptor F1 0.0278148
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0274685
CLMN calmin (calponin-like, transmembrane) 0.0273484
NCEH1 neutral cholesterol ester hydrolase 1 0.0268641
STK24 serine/threonine kinase 24 0.0267841
PRKN parkin RBR E3 ubiquitin protein ligase 0.0264065
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0264038
PATJ PATJ crumbs cell polarity complex component 0.0261154
FAM135A family with sequence similarity 135, member A 0.0259132
AOPEP aminopeptidase O (putative) 0.0257909
MX2 MX dynamin-like GTPase 2 0.025453
ETV6 ets variant 6 0.025374
BPTF bromodomain PHD finger transcription factor 0.0250941
TXNIP thioredoxin interacting protein 0.024872
SQSTM1 sequestosome 1 0.024795
ITGB8 integrin, beta 8 0.0247893
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0245425
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0245398
JAK1 Janus kinase 1 0.024472
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.02425
SHROOM3 shroom family member 3 0.0239499
EPS8 epidermal growth factor receptor pathway substrate 8 0.0239418
SAMD9 sterile alpha motif domain containing 9 0.0236026
RIGI RNA sensor RIG-I 0.0234965
IFITM1 interferon induced transmembrane protein 1 0.0234291
MACROD2 MACRO domain containing 2 0.0225002
NTN4 netrin 4 0.0223687
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0223291
TRAM1 translocation associated membrane protein 1 0.0223257
SERINC5 serine incorporator 5 0.0220745

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.182165
GMDS GDP-mannose 4,6-dehydratase -0.124149
TMSB10 thymosin beta 10 -0.119846
PTMA prothymosin, alpha -0.118334
POTEF POTE ankyrin domain family, member F -0.111382
CEMIP cell migration inducing protein, hyaluronan binding -0.079
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0668655
S100A10 S100 calcium binding protein A10 -0.0652379
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0617746
S100A6 S100 calcium binding protein A6 -0.0611853
ITGA6 integrin, alpha 6 -0.06015
P4HB prolyl 4-hydroxylase, beta polypeptide -0.058855
TNIK TRAF2 and NCK interacting kinase -0.0552848
VEGFA vascular endothelial growth factor A -0.0500172
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0481678
ANO1 anoctamin 1, calcium activated chloride channel -0.0472882
HMGA1 high mobility group AT-hook 1 -0.0471341
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0441763
ASPH aspartate beta-hydroxylase -0.0422271
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.042096
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0418771
FLNB filamin B, beta -0.0417808
KRT7 keratin 7, type II -0.0383486
ANLN anillin, actin binding protein -0.0354503
AREG amphiregulin -0.0354405
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0344185
PFN1 profilin 1 -0.0338748
ANXA2 annexin A2 -0.0328757
RPL35A ribosomal protein L35a -0.0326986
DLC1 DLC1 Rho GTPase activating protein -0.031643
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0312417
EHBP1 EH domain binding protein 1 -0.0311658
LYZ lysozyme -0.0310395
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.030899
TPM4 tropomyosin 4 -0.0303358
ENO1 enolase 1, (alpha) -0.0300933
HMGB1 high mobility group box 1 -0.0297766
TFF2 trefoil factor 2 -0.0294707
KLHL29 kelch-like family member 29 -0.0292276
PDIA6 protein disulfide isomerase family A, member 6 -0.0290205
CLDN7 claudin 7 -0.0289131
ANKRD11 ankyrin repeat domain 11 -0.0288047
EGR1 early growth response 1 -0.028759
S100A9 S100 calcium binding protein A9 -0.028661
SETD5 SET domain containing 5 -0.0283198
GARS1 glycyl-tRNA synthetase 1 -0.0282326
NDRG1 N-myc downstream regulated 1 -0.0281088
RCOR1 REST corepressor 1 -0.0277691
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0274385
WDR45B WD repeat domain 45B -0.0270947
RPL23 ribosomal protein L23 -0.0270889
AUTS2 autism susceptibility candidate 2 -0.0264266
WWC1 WW and C2 domain containing 1 -0.0262285
BCL2L1 BCL2-like 1 -0.0262084
ACACA acetyl-CoA carboxylase alpha -0.0259538
ACTN4 actinin, alpha 4 -0.0258976
DEK DEK proto-oncogene -0.0256938
SULF2 sulfatase 2 -0.0255369
S100A11 S100 calcium binding protein A11 -0.0254876
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0254332
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0254101
KRT8 keratin 8, type II -0.0249104
KLK10 kallikrein-related peptidase 10 -0.0247508
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0245544
PLEC plectin -0.0243913
GRB10 growth factor receptor-bound protein 10 -0.0243389
GNAS GNAS complex locus -0.0243234
RBM25 RNA binding motif protein 25 -0.0242621
WSB1 WD repeat and SOCS box containing 1 -0.0236062
MAML2 mastermind-like 2 (Drosophila) -0.0234184
RPLP1 ribosomal protein, large, P1 -0.0233528
C6ORF132 chromosome 6 open reading frame 132 -0.0232166
VMP1 vacuole membrane protein 1 -0.0231357
KRT18 keratin 18, type I -0.0230948
TNS4 tensin 4 -0.0230044
RPS17 ribosomal protein S17 -0.0228617
FOSL1 FOS-like antigen 1 -0.0228306
SCFD1 sec1 family domain containing 1 -0.0223834
TPM3 tropomyosin 3 -0.0223763
FDPS farnesyl diphosphate synthase -0.0222209
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0221627
MORF4L2 mortality factor 4 like 2 -0.0221344
RRM2 ribonucleotide reductase M2 -0.0221188
NCOR1 nuclear receptor corepressor 1 -0.0217958
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0217441
ITGB4 integrin, beta 4 -0.0217428
TFRC transferrin receptor -0.0217058
IARS1 isoleucyl-tRNA synthetase 1 -0.0216991
ONECUT3 one cut homeobox 3 -0.0215421
PRKCA protein kinase C, alpha -0.0213397
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0212823
DUSP6 dual specificity phosphatase 6 -0.0210234
CD9 CD9 molecule -0.0209736
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0204013
INTS6 integrator complex subunit 6 -0.0203329
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0201564
SHB Src homology 2 domain containing adaptor protein B -0.020083
TFF1 trefoil factor 1 -0.0200278
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0199576
PRRC2C proline-rich coiled-coil 2C -0.0198249