XRK3F2_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0876371
WARS1 tryptophanyl-tRNA synthetase 1 0.0874825
MT2A metallothionein 2A 0.0862456
TMSB10 thymosin beta 10 0.0687431
RPL35A ribosomal protein L35a 0.0671018
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.051918
VIM vimentin 0.0438879
RPL23 ribosomal protein L23 0.0433092
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0385399
EIF1 eukaryotic translation initiation factor 1 0.0379307
HLA-B major histocompatibility complex, class I, B 0.0343477
RPS4X ribosomal protein S4, X-linked 0.0342913
RSAD2 radical S-adenosyl methionine domain containing 2 0.033783
KLF6 Kruppel-like factor 6 0.0335697
RPL31 ribosomal protein L31 0.0329917
MT1X metallothionein 1X 0.0324198
IFITM1 interferon induced transmembrane protein 1 0.0318978
TPT1 tumor protein, translationally-controlled 1 0.0295723
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0288298
IFIH1 interferon induced with helicase C domain 1 0.0286352
SLC38A2 solute carrier family 38, member 2 0.0286133
EPHA4 EPH receptor A4 0.0276606
SQSTM1 sequestosome 1 0.027424
RPS8 ribosomal protein S8 0.0269139
RPL36 ribosomal protein L36 0.0254281
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0230534
ACTG1 actin gamma 1 0.0229582
RACK1 receptor for activated C kinase 1 0.0227622
TOP1 topoisomerase (DNA) I 0.0225864
FTL ferritin, light polypeptide 0.0224078
SOD2 superoxide dismutase 2, mitochondrial 0.022328
CFB complement factor B 0.0222988
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0222707
ISG15 ISG15 ubiquitin-like modifier 0.0221644
MB21D2 Mab-21 domain containing 2 0.0221599
RPL32 ribosomal protein L32 0.0216488
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0214407
ARF1 ADP-ribosylation factor 1 0.0213503
IARS1 isoleucyl-tRNA synthetase 1 0.0209949
RPS27A ribosomal protein S27a 0.0202266
NAP1L1 nucleosome assembly protein 1-like 1 0.0201634
RPL12 ribosomal protein L12 0.0196465
RPS24 ribosomal protein S24 0.0194263
RPS29 ribosomal protein S29 0.0192631
RPS20 ribosomal protein S20 0.0192409
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0191049
RGS4 regulator of G-protein signaling 4 0.0188297
COL5A2 collagen, type V, alpha 2 0.0179853
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0172763
CAVIN1 caveolae associated protein 1 0.0172713
IRF1 interferon regulatory factor 1 0.0172615
RPS5 ribosomal protein S5 0.0172129
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0170647
USP9X ubiquitin specific peptidase 9, X-linked 0.0168601
RPN1 ribophorin I 0.016471
RPL4 ribosomal protein L4 0.0163353
CALU calumenin 0.0160873
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0156751
PLSCR1 phospholipid scramblase 1 0.0156111
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0153653
RPLP1 ribosomal protein, large, P1 0.0151617
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0150143
GARS1 glycyl-tRNA synthetase 1 0.0149629
HLA-C major histocompatibility complex, class I, C 0.0145673
NPR2 natriuretic peptide receptor 2 0.0145502
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0145124
MT1E metallothionein 1E 0.0144463
CCL5 chemokine (C-C motif) ligand 5 0.0143273
BBS9 Bardet-Biedl syndrome 9 0.0142506
RPS13 ribosomal protein S13 0.0142358
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.014153
RPLP0 ribosomal protein, large, P0 0.0140926
RPL9 ribosomal protein L9 0.0139966
TJP1 tight junction protein 1 0.0139857
BZW1 basic leucine zipper and W2 domains 1 0.0139373
ZNFX1 zinc finger, NFX1-type containing 1 0.0138007
KLF10 Kruppel-like factor 10 0.0137136
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0136704
AHI1 Abelson helper integration site 1 0.0136113
RPS21 ribosomal protein S21 0.0135542
UBAP2L ubiquitin associated protein 2-like 0.0133984
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0132639
SOX12 SRY (sex determining region Y)-box 12 0.0132005
JMJD1C jumonji domain containing 1C 0.0131184
RAB1A RAB1A, member RAS oncogene family 0.0129739
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.0127853
RPL19 ribosomal protein L19 0.0127559
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0127398
RPS23 ribosomal protein S23 0.0127299
CUL1 cullin 1 0.0126783
WTAP Wilms tumor 1 associated protein 0.0126486
RUNX1 runt-related transcription factor 1 0.0125561
SGMS2 sphingomyelin synthase 2 0.0125093
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0124223
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0123228
CCAR1 cell division cycle and apoptosis regulator 1 0.012305
LDHA lactate dehydrogenase A 0.012206
B2M beta-2-microglobulin 0.0122008
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0121323
ANKRD50 ankyrin repeat domain 50 0.0120584

decreased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 -0.183731
POTEF POTE ankyrin domain family, member F -0.161933
PTMA prothymosin, alpha -0.158575
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.13707
DST dystonin -0.1276
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.116283
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110692
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.109738
PSD3 pleckstrin and Sec7 domain containing 3 -0.0995607
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0948497
FMNL2 formin-like 2 -0.0897916
MACF1 microtubule-actin crosslinking factor 1 -0.0808827
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0807753
PRELID2 PRELI domain containing 2 -0.0773814
DOCK11 dedicator of cytokinesis 11 -0.0756352
RPS2 ribosomal protein S2 -0.0755946
TRIO trio Rho guanine nucleotide exchange factor -0.0748678
KMT2E lysine (K)-specific methyltransferase 2E -0.0724692
CADM2 cell adhesion molecule 2 -0.0714298
CENPF centromere protein F, 350/400kDa -0.0707934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0697692
KTN1 kinectin 1 (kinesin receptor) -0.0674385
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0667838
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0654279
CD44 CD44 molecule (Indian blood group) -0.0641998
USP34 ubiquitin specific peptidase 34 -0.0637811
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0631597
CANX calnexin -0.0610191
CFAP299 cilia and flagella associated protein 299 -0.0601663
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.059744
ARHGAP5 Rho GTPase activating protein 5 -0.0596335
EGR1 early growth response 1 -0.0588768
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0577913
LOXL2 lysyl oxidase-like 2 -0.0577569
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0577512
TPM3 tropomyosin 3 -0.057579
PDE10A phosphodiesterase 10A -0.0554633
MKI67 marker of proliferation Ki-67 -0.0549445
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.053965
CAPRIN2 caprin family member 2 -0.0539544
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0533425
XPO1 exportin 1 -0.0525029
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.052136
SDK1 sidekick cell adhesion molecule 1 -0.0521099
MYOF myoferlin -0.0506517
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0505808
WWTR1 WW domain containing transcription regulator 1 -0.0501221
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.049362
APP amyloid beta (A4) precursor protein -0.0483862
RAI1 retinoic acid induced 1 -0.0481007
CLIP2 CAP-GLY domain containing linker protein 2 -0.0471394
TXNIP thioredoxin interacting protein -0.0455506
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0455388
FNIP1 folliculin interacting protein 1 -0.0455308
EFNA5 ephrin-A5 -0.0454346
KDM4C lysine (K)-specific demethylase 4C -0.0453554
DLG1 discs, large homolog 1 (Drosophila) -0.0451304
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0441931
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0441401
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0439278
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0438316
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0438214
BCAR3 breast cancer anti-estrogen resistance 3 -0.0436223
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0433996
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0427847
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0425269
MYH9 myosin, heavy chain 9, non-muscle -0.0424529
KDM2A lysine (K)-specific demethylase 2A -0.0424235
VMP1 vacuole membrane protein 1 -0.0420161
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0418686
TGM2 transglutaminase 2 -0.041834
TMSB4X thymosin beta 4, X-linked -0.0411031
CDK6 cyclin-dependent kinase 6 -0.041097
FLNB filamin B, beta -0.0409291
ENO1 enolase 1, (alpha) -0.0408232
MCL1 myeloid cell leukemia 1 -0.040485
FAF1 Fas (TNFRSF6) associated factor 1 -0.0400139
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0399506
SET SET nuclear proto-oncogene -0.0398937
PIAS2 protein inhibitor of activated STAT, 2 -0.0394964
YEATS2 YEATS domain containing 2 -0.0391022
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0390719
SMYD3 SET and MYND domain containing 3 -0.0390652
NHSL1 NHS-like 1 -0.0390426
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0390299
TM4SF1 transmembrane 4 L six family member 1 -0.0388229
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0370206
RCOR1 REST corepressor 1 -0.0369716
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0369504
ZMYND8 zinc finger, MYND-type containing 8 -0.036655
GCLM glutamate-cysteine ligase, modifier subunit -0.0366527
GSK3B glycogen synthase kinase 3 beta -0.0365342
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0365227
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0365204
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.03617
YBX1 Y box binding protein 1 -0.0360952
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0360937
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0358049
NPAS2 neuronal PAS domain protein 2 -0.0357936
MYO10 myosin X -0.0356331