XRK3F2_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.198101
FTL ferritin, light polypeptide 0.0975715
VIM vimentin 0.0746432
B2M beta-2-microglobulin 0.0702232
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0666498
KYNU kynureninase 0.0605511
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0581046
SQSTM1 sequestosome 1 0.0580103
MT2A metallothionein 2A 0.0570474
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0512215
IFI6 interferon, alpha-inducible protein 6 0.0505881
RPL31 ribosomal protein L31 0.0502827
PARP14 poly (ADP-ribose) polymerase family, member 14 0.046237
IFI44L interferon-induced protein 44-like 0.0461263
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0456562
TRIO trio Rho guanine nucleotide exchange factor 0.0450644
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0445865
RPS8 ribosomal protein S8 0.0441368
RPS6 ribosomal protein S6 0.0437116
SOD2 superoxide dismutase 2, mitochondrial 0.0432212
RPS29 ribosomal protein S29 0.0426814
RPLP1 ribosomal protein, large, P1 0.0421708
RPL35A ribosomal protein L35a 0.0417915
RPLP0 ribosomal protein, large, P0 0.0407108
LDHA lactate dehydrogenase A 0.0405551
RPS19 ribosomal protein S19 0.0403307
RNF213 ring finger protein 213 0.0401937
NTN4 netrin 4 0.0393916
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0391853
NAP1L1 nucleosome assembly protein 1-like 1 0.0363211
RPL11 ribosomal protein L11 0.0361808
RPS13 ribosomal protein S13 0.0361158
PKM pyruvate kinase, muscle 0.036009
RPL37A ribosomal protein L37a 0.035627
HLA-B major histocompatibility complex, class I, B 0.0343427
RPL36 ribosomal protein L36 0.0330715
SP100 SP100 nuclear antigen 0.0318882
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0314373
MX2 MX dynamin-like GTPase 2 0.031224
RPL19 ribosomal protein L19 0.0309665
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0307915
RPS12 ribosomal protein S12 0.0305872
LOC102724023 ES1 protein homolog, mitochondrial 0.0305047
FNDC3B fibronectin type III domain containing 3B 0.0305022
C15ORF48 chromosome 15 open reading frame 48 0.0303294
RPL37 ribosomal protein L37 0.0302875
RPL28 ribosomal protein L28 0.0301666
LRMDA leucine rich melanocyte differentiation associated 0.0300371
IFITM3 interferon induced transmembrane protein 3 0.0295396
EIF1 eukaryotic translation initiation factor 1 0.0293662
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.029256
RPS23 ribosomal protein S23 0.0292022
RPS25 ribosomal protein S25 0.0291271
ENO1 enolase 1, (alpha) 0.0287346
RPL23 ribosomal protein L23 0.0286018
FBXO32 F-box protein 32 0.0284824
RPLP2 ribosomal protein, large, P2 0.0278689
PCBP2 poly(rC) binding protein 2 0.0276667
PLIN2 perilipin 2 0.0271145
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0265744
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263418
RPL32 ribosomal protein L32 0.0261081
RPS17 ribosomal protein S17 0.0258955
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0257869
RPS27 ribosomal protein S27 0.0251698
ISG15 ISG15 ubiquitin-like modifier 0.0250648
IFI27 interferon, alpha-inducible protein 27 0.0248976
RPL9 ribosomal protein L9 0.0248078
SLC38A2 solute carrier family 38, member 2 0.0247756
RPS3 ribosomal protein S3 0.0241168
RAD51B RAD51 paralog B 0.0240874
RPS11 ribosomal protein S11 0.0240336
HLA-A major histocompatibility complex, class I, A 0.023911
CA12 carbonic anhydrase XII 0.0239055
KSR1 kinase suppressor of ras 1 0.0237169
IFITM1 interferon induced transmembrane protein 1 0.0236705
RPL5 ribosomal protein L5 0.0236601
RACK1 receptor for activated C kinase 1 0.0234733
TPST1 tyrosylprotein sulfotransferase 1 0.0233628
INTS6 integrator complex subunit 6 0.0232734
WWOX WW domain containing oxidoreductase 0.0230819
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0229663
RPL12 ribosomal protein L12 0.0228371
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.022715
SAMD9L sterile alpha motif domain containing 9-like 0.0226656
EXT1 exostosin glycosyltransferase 1 0.0225464
FOXP1 forkhead box P1 0.0223063
RPS16 ribosomal protein S16 0.0223003
MX1 MX dynamin-like GTPase 1 0.0220074
STK38L serine/threonine kinase 38 like 0.0217451
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0216141
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0215814
HLA-E major histocompatibility complex, class I, E 0.0213937
RPS21 ribosomal protein S21 0.0213912
RPL7 ribosomal protein L7 0.0213456
UBC ubiquitin C 0.021336
HEG1 heart development protein with EGF-like domains 1 0.0213083
SAMD9 sterile alpha motif domain containing 9 0.021306
SFTPA2 surfactant protein A2 0.0207264
RPL15 ribosomal protein L15 0.0207214

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.143024
CXCL8 chemokine (C-X-C motif) ligand 8 -0.13844
NAMPT nicotinamide phosphoribosyltransferase -0.133087
PDE4D phosphodiesterase 4D, cAMP-specific -0.127786
HMGA2 high mobility group AT-hook 2 -0.120137
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.107081
STC1 stanniocalcin 1 -0.0992999
GOLGA4 golgin A4 -0.0947058
EFNA5 ephrin-A5 -0.0912634
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0903938
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0894283
FN1 fibronectin 1 -0.0870984
USP34 ubiquitin specific peptidase 34 -0.0840487
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0803465
SDK1 sidekick cell adhesion molecule 1 -0.0794726
IGFBP3 insulin-like growth factor binding protein 3 -0.0766934
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0737808
RBM39 RNA binding motif protein 39 -0.07107
KDM2A lysine (K)-specific demethylase 2A -0.0690141
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0681671
AKAP13 A kinase (PRKA) anchor protein 13 -0.0670348
GRB10 growth factor receptor-bound protein 10 -0.0668888
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0667408
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0666382
AKAP12 A kinase (PRKA) anchor protein 12 -0.0660469
LOX lysyl oxidase -0.0655482
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.065396
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.065159
RAB1A RAB1A, member RAS oncogene family -0.0641322
MSRB3 methionine sulfoxide reductase B3 -0.059145
SEC31A SEC31 homolog A (S. cerevisiae) -0.0587085
MTSS1 metastasis suppressor 1 -0.0586426
ANTXR2 anthrax toxin receptor 2 -0.0536587
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0509257
TFPI2 tissue factor pathway inhibitor 2 -0.0500254
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0496054
FBXL13 F-box and leucine-rich repeat protein 13 -0.0471599
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0467617
COPA coatomer protein complex, subunit alpha -0.0451189
NRP1 neuropilin 1 -0.0450593
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0449094
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.044825
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0435141
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0432999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0424984
ELL2 elongation factor, RNA polymerase II, 2 -0.0423213
PSD3 pleckstrin and Sec7 domain containing 3 -0.0422815
CD44 CD44 molecule (Indian blood group) -0.0415385
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0414659
CALU calumenin -0.0408897
DOCK5 dedicator of cytokinesis 5 -0.0407052
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0403193
SRP54 signal recognition particle 54kDa -0.040311
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0398128
ARHGAP5 Rho GTPase activating protein 5 -0.0397303
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0389186
LMAN1 lectin, mannose-binding, 1 -0.0381824
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0379406
MON2 MON2 homolog (S. cerevisiae) -0.0378818
HDLBP high density lipoprotein binding protein -0.0378114
FAM13A family with sequence similarity 13, member A -0.0376133
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0375731
OSMR oncostatin M receptor -0.037373
RAP1B RAP1B, member of RAS oncogene family -0.0368035
KMT2C lysine (K)-specific methyltransferase 2C -0.0367683
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0364283
SETD5 SET domain containing 5 -0.0359789
JMJD1C jumonji domain containing 1C -0.0358151
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0358078
COG5 component of oligomeric golgi complex 5 -0.0357102
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0354272
TTC3 tetratricopeptide repeat domain 3 -0.0346745
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0345243
ARF4 ADP-ribosylation factor 4 -0.0341913
MACF1 microtubule-actin crosslinking factor 1 -0.0341421
DNER delta/notch-like EGF repeat containing -0.0337943
SEC23A Sec23 homolog A (S. cerevisiae) -0.0331548
HM13 histocompatibility (minor) 13 -0.0329806
NRG1 neuregulin 1 -0.0326751
NPAS2 neuronal PAS domain protein 2 -0.0326175
SPAG9 sperm associated antigen 9 -0.0326057
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0325448
ESYT2 extended synaptotagmin-like protein 2 -0.0325292
BLZF1 basic leucine zipper nuclear factor 1 -0.0324953
ZFC3H1 zinc finger, C3H1-type containing -0.0322407
BIRC6 baculoviral IAP repeat containing 6 -0.0321762
FAM107B family with sequence similarity 107, member B -0.032155
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0315355
SEC24A SEC24 family member A -0.0315088
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0314277
DLG1 discs, large homolog 1 (Drosophila) -0.0313252
ZFAND3 zinc finger, AN1-type domain 3 -0.0312529
JARID2 jumonji, AT rich interactive domain 2 -0.0311684
NAV3 neuron navigator 3 -0.0311304
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0311057
OXSR1 oxidative stress responsive 1 -0.0310001
SEC24D SEC24 family member D -0.030813
PYGL phosphorylase, glycogen, liver -0.0307933
KMT2E lysine (K)-specific methyltransferase 2E -0.0307147
TAS2R14 taste receptor, type 2, member 14 -0.0306908