XRK3F2_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.222109
PM20D1 peptidase M20 domain containing 1 0.190534
VIM vimentin 0.159195
FTL ferritin, light polypeptide 0.148148
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.122278
NTN4 netrin 4 0.099828
EIF1 eukaryotic translation initiation factor 1 0.083272
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0713295
KYNU kynureninase 0.070096
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0647224
MYOF myoferlin 0.0642122
TXNRD1 thioredoxin reductase 1 0.063819
KIAA0319 KIAA0319 0.0624476
PDE4D phosphodiesterase 4D, cAMP-specific 0.0590044
SVIL supervillin 0.0584276
ZFHX3 zinc finger homeobox 3 0.0444014
FGB fibrinogen beta chain 0.0407436
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0399988
SQSTM1 sequestosome 1 0.0383193
RPS8 ribosomal protein S8 0.038154
LDHA lactate dehydrogenase A 0.0380393
RNF213 ring finger protein 213 0.0363229
ZBTB20 zinc finger and BTB domain containing 20 0.0358167
FGG fibrinogen gamma chain 0.0337541
IGF1R insulin-like growth factor 1 receptor 0.0332855
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0326807
RPLP0 ribosomal protein, large, P0 0.0325965
RPL31 ribosomal protein L31 0.032595
HLA-B major histocompatibility complex, class I, B 0.032498
HDAC9 histone deacetylase 9 0.0318651
WWOX WW domain containing oxidoreductase 0.031391
HLA-A major histocompatibility complex, class I, A 0.0311078
TPT1 tumor protein, translationally-controlled 1 0.0299272
PARD3B par-3 family cell polarity regulator beta 0.0289909
EXOC6B exocyst complex component 6B 0.0286792
FHIT fragile histidine triad 0.0284948
FGA fibrinogen alpha chain 0.0281938
RPL35A ribosomal protein L35a 0.027418
NNMT nicotinamide N-methyltransferase 0.0272646
HLA-E major histocompatibility complex, class I, E 0.0270295
LOC102724023 ES1 protein homolog, mitochondrial 0.0264762
ACTG1 actin gamma 1 0.0262946
AHNAK AHNAK nucleoprotein 0.0257052
BCAS3 breast carcinoma amplified sequence 3 0.0252765
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0249329
RPS13 ribosomal protein S13 0.0245436
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0243385
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0240236
B2M beta-2-microglobulin 0.0238158
SMOC1 SPARC related modular calcium binding 1 0.0237378
KTN1 kinectin 1 (kinesin receptor) 0.0236618
RPL19 ribosomal protein L19 0.0233545
FBXL20 F-box and leucine-rich repeat protein 20 0.023085
RPLP1 ribosomal protein, large, P1 0.0227687
CUX1 cut-like homeobox 1 0.0223803
RPL11 ribosomal protein L11 0.0218441
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0217241
TNS3 tensin 3 0.0216876
RPL37A ribosomal protein L37a 0.0214842
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0214265
HMOX1 heme oxygenase 1 0.0213353
RPS25 ribosomal protein S25 0.0208201
RPS27 ribosomal protein S27 0.0206239
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0198735
BBS9 Bardet-Biedl syndrome 9 0.0195827
EPHA5 EPH receptor A5 0.019566
DENND5B DENN/MADD domain containing 5B 0.0195032
KLHL24 kelch-like family member 24 0.0192438
NEGR1 neuronal growth regulator 1 0.0190341
RPS27A ribosomal protein S27a 0.0188384
RPS29 ribosomal protein S29 0.0186305
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0185773
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0184434
PRKN parkin RBR E3 ubiquitin protein ligase 0.0183922
PDE10A phosphodiesterase 10A 0.0181897
SPIDR scaffolding protein involved in DNA repair 0.018112
BASP1 brain abundant, membrane attached signal protein 1 0.0179391
TNRC6B trinucleotide repeat containing 6B 0.0177513
RHOB ras homolog family member B 0.0173234
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0172569
RPL30 ribosomal protein L30 0.0170581
HSPB1 heat shock 27kDa protein 1 0.0170109
LGALS12 lectin, galactoside-binding, soluble, 12 0.0169793
FNDC3B fibronectin type III domain containing 3B 0.0169711
PATJ PATJ crumbs cell polarity complex component 0.0168731
RPS20 ribosomal protein S20 0.0168355
WIPF1 WAS/WASL interacting protein family, member 1 0.0168253
RPS16 ribosomal protein S16 0.0167355
UBC ubiquitin C 0.0164704
TPM4 tropomyosin 4 0.0164553
TGFBI transforming growth factor, beta-induced, 68kDa 0.0163349
FOXN3 forkhead box N3 0.0162795
AHR aryl hydrocarbon receptor 0.0160755
NFE2L2 nuclear factor, erythroid 2-like 2 0.0159258
DNAH5 dynein, axonemal, heavy chain 5 0.0156682
RPS17 ribosomal protein S17 0.0155374
RPL28 ribosomal protein L28 0.0154674
METAP2 methionyl aminopeptidase 2 0.0154618
UBB ubiquitin B 0.0154218
KIAA1217 KIAA1217 0.0154084

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.173494
DOCK4 dedicator of cytokinesis 4 -0.137474
MT2A metallothionein 2A -0.13711
GRAMD1B GRAM domain containing 1B -0.136192
THSD4 thrombospondin, type I, domain containing 4 -0.116303
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.114786
ZFAND3 zinc finger, AN1-type domain 3 -0.0849357
TFPI2 tissue factor pathway inhibitor 2 -0.0839616
TM4SF1 transmembrane 4 L six family member 1 -0.0837049
FMNL2 formin-like 2 -0.0780137
MCL1 myeloid cell leukemia 1 -0.0769002
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0697695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.068828
FAM107B family with sequence similarity 107, member B -0.0621152
WDR43 WD repeat domain 43 -0.0589983
RBM39 RNA binding motif protein 39 -0.0570703
NAV3 neuron navigator 3 -0.0568892
ANKRD11 ankyrin repeat domain 11 -0.0568075
FLNB filamin B, beta -0.0567246
SAMD4A sterile alpha motif domain containing 4A -0.0555802
MACF1 microtubule-actin crosslinking factor 1 -0.0552983
TPM3 tropomyosin 3 -0.0536546
STC1 stanniocalcin 1 -0.0536279
PTK2 protein tyrosine kinase 2 -0.0525196
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0522238
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0517725
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.051589
NRG1 neuregulin 1 -0.0515297
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0515272
AKAP12 A kinase (PRKA) anchor protein 12 -0.0504934
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0486598
APP amyloid beta (A4) precursor protein -0.0478647
ELL2 elongation factor, RNA polymerase II, 2 -0.0473435
RBM25 RNA binding motif protein 25 -0.0472838
PARD3 par-3 family cell polarity regulator -0.0462135
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0458445
NHSL1 NHS-like 1 -0.0456082
ACTN1 actinin, alpha 1 -0.045598
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0455269
NOP58 NOP58 ribonucleoprotein -0.0445429
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0441253
POTEF POTE ankyrin domain family, member F -0.0441239
USP3 ubiquitin specific peptidase 3 -0.0434867
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0426291
MAML3 mastermind-like 3 (Drosophila) -0.0425386
COPA coatomer protein complex, subunit alpha -0.041885
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0416623
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0412429
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0411396
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0405802
DOCK5 dedicator of cytokinesis 5 -0.0399523
EGR1 early growth response 1 -0.0398561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0396293
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0388986
ASPH aspartate beta-hydroxylase -0.0383375
ZEB1 zinc finger E-box binding homeobox 1 -0.0380217
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0375984
DENND4A DENN/MADD domain containing 4A -0.0374324
PUM2 pumilio RNA-binding family member 2 -0.0371047
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0367934
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0366553
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0362314
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0361195
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0359232
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0351113
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0347007
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0345431
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0337023
TOP1 topoisomerase (DNA) I -0.0336651
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0330087
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0329639
SLC38A1 solute carrier family 38, member 1 -0.0323526
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0323284
ARHGAP26 Rho GTPase activating protein 26 -0.0322183
CCNL1 cyclin L1 -0.0319613
ZNF207 zinc finger protein 207 -0.0318983
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0315181
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0312845
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0309893
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0308056
CYRIB CYFIP related Rac1 interactor B -0.0306114
RNF145 ring finger protein 145 -0.0303908
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0301123
RTN4 reticulon 4 -0.0300798
RICTOR RPTOR independent companion of MTOR, complex 2 -0.029994
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0297063
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0294499
PDLIM5 PDZ and LIM domain 5 -0.0294103
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0289105
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0283714
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0283068
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.028104
TFG TRK-fused gene -0.0278938
BIRC6 baculoviral IAP repeat containing 6 -0.0278893
ECT2 epithelial cell transforming 2 -0.0277888
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0277491
KIF5B kinesin family member 5B -0.0274732
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0273948
YBX1 Y box binding protein 1 -0.0273365
BMP6 bone morphogenetic protein 6 -0.0272356