| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | XRK3F2 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the XRK3F2_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0977427 |
| PDE10A | phosphodiesterase 10A | 0.0844557 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0722564 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0674266 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0660476 |
| DENND5B | DENN/MADD domain containing 5B | 0.0637951 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0566819 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0532788 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0531049 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0522977 |
| BMP5 | bone morphogenetic protein 5 | 0.050914 |
| AEBP2 | AE binding protein 2 | 0.0495313 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0472118 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0452108 |
| WWOX | WW domain containing oxidoreductase | 0.0443563 |
| RNF213 | ring finger protein 213 | 0.043995 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0421646 |
| HLA-B | major histocompatibility complex, class I, B | 0.0418877 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.040056 |
| TXNRD1 | thioredoxin reductase 1 | 0.0397891 |
| NCOA7 | nuclear receptor coactivator 7 | 0.03967 |
| RPS8 | ribosomal protein S8 | 0.0384095 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0383956 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0381172 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0370404 |
| RPL37 | ribosomal protein L37 | 0.0355756 |
| RPS3 | ribosomal protein S3 | 0.0352437 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0343284 |
| RPL37A | ribosomal protein L37a | 0.0342902 |
| SQSTM1 | sequestosome 1 | 0.0332759 |
| GOLGB1 | golgin B1 | 0.0330291 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.032153 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0305203 |
| VIM | vimentin | 0.0305108 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0301843 |
| MACROD2 | MACRO domain containing 2 | 0.0298369 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0295843 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0292641 |
| ADAR | adenosine deaminase, RNA-specific | 0.0285485 |
| MED13L | mediator complex subunit 13-like | 0.0284684 |
| PHF3 | PHD finger protein 3 | 0.027621 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.027484 |
| BPTF | bromodomain PHD finger transcription factor | 0.0273221 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0269183 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.026511 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.025806 |
| AHNAK | AHNAK nucleoprotein | 0.0257917 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0255628 |
| RPL31 | ribosomal protein L31 | 0.0255087 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0254517 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0252738 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0251907 |
| RPL35A | ribosomal protein L35a | 0.0250148 |
| GNAS | GNAS complex locus | 0.0248329 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0247719 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0244473 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0241078 |
| ATF6 | activating transcription factor 6 | 0.0238798 |
| ATXN1 | ataxin 1 | 0.0238634 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0237956 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0237905 |
| SSH2 | slingshot protein phosphatase 2 | 0.0237828 |
| CANX | calnexin | 0.0235992 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0235798 |
| RPS12 | ribosomal protein S12 | 0.023506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.023405 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0233837 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0232558 |
| EXOC4 | exocyst complex component 4 | 0.0229792 |
| B2M | beta-2-microglobulin | 0.0228352 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0226483 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0226318 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0223505 |
| FTL | ferritin, light polypeptide | 0.0223041 |
| MRTFA | myocardin related transcription factor A | 0.021716 |
| CUX1 | cut-like homeobox 1 | 0.0216075 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0215762 |
| DSPP | dentin sialophosphoprotein | 0.0214149 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0211466 |
| ENO1 | enolase 1, (alpha) | 0.0211235 |
| SMYD3 | SET and MYND domain containing 3 | 0.0207684 |
| AGBL4 | ATP/GTP binding protein-like 4 | 0.0207573 |
| SUMF1 | sulfatase modifying factor 1 | 0.0204233 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0203679 |
| RPL11 | ribosomal protein L11 | 0.0203016 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0202386 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0201195 |
| STX8 | syntaxin 8 | 0.0198592 |
| EXOC6B | exocyst complex component 6B | 0.0197685 |
| DST | dystonin | 0.0197128 |
| TRIM37 | tripartite motif containing 37 | 0.0195802 |
| ETV6 | ets variant 6 | 0.0194891 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0194889 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0188495 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0187542 |
| MAP7 | microtubule-associated protein 7 | 0.0186056 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0183048 |
| FOXP1 | forkhead box P1 | 0.0182774 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0181529 |
| CEP112 | centrosomal protein 112kDa | 0.0181288 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.379598 |
| EGR1 | early growth response 1 | -0.106786 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0823247 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0779599 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0739316 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0729493 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.070814 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0678862 |
| MCL1 | myeloid cell leukemia 1 | -0.0597615 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0579399 |
| POTEF | POTE ankyrin domain family, member F | -0.0549033 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0545296 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0543912 |
| RTN4 | reticulon 4 | -0.0539053 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0527301 |
| ACTN1 | actinin, alpha 1 | -0.0522952 |
| NABP1 | nucleic acid binding protein 1 | -0.0512381 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0499657 |
| STC1 | stanniocalcin 1 | -0.0488829 |
| TMSB10 | thymosin beta 10 | -0.0487305 |
| TPM3 | tropomyosin 3 | -0.0481882 |
| CDK17 | cyclin-dependent kinase 17 | -0.0470885 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0465805 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0460458 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0448137 |
| RBM25 | RNA binding motif protein 25 | -0.0439835 |
| FMNL2 | formin-like 2 | -0.0436878 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0425695 |
| HMGA2 | high mobility group AT-hook 2 | -0.0418521 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0411328 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0396484 |
| PFN1 | profilin 1 | -0.039493 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0372656 |
| RRM2 | ribonucleotide reductase M2 | -0.036104 |
| CCNL1 | cyclin L1 | -0.0359212 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0358096 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0352193 |
| GPHN | gephyrin | -0.0350243 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0349331 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0347991 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0338384 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0332483 |
| CDCP1 | CUB domain containing protein 1 | -0.0330826 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0328941 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0328224 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0327858 |
| YBX3 | Y box binding protein 3 | -0.0320946 |
| YBX1 | Y box binding protein 1 | -0.0318716 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0315109 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0313397 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0311304 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0310993 |
| ATP13A3 | ATPase type 13A3 | -0.0309696 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0306992 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.030506 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0304318 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0302943 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0301759 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0295076 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0294638 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0290248 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0288826 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0276597 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0269802 |
| MT2A | metallothionein 2A | -0.0267732 |
| SNX9 | sorting nexin 9 | -0.0261787 |
| SRPK1 | SRSF protein kinase 1 | -0.0261587 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0260415 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.025994 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.025831 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0256807 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0255977 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0255717 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0254252 |
| NUP58 | nucleoporin 58 | -0.0252446 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0252284 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0251305 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0248139 |
| SBF2 | SET binding factor 2 | -0.0247672 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0246395 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0245559 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0244986 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.024246 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0240736 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.024066 |
| PHIP | pleckstrin homology domain interacting protein | -0.0239525 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0239433 |
| NOP58 | NOP58 ribonucleoprotein | -0.0238094 |
| TPI1 | triosephosphate isomerase 1 | -0.0236313 |
| PNN | pinin, desmosome associated protein | -0.0233831 |
| GOLGA4 | golgin A4 | -0.0232578 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.023208 |
| RASA2 | RAS p21 protein activator 2 | -0.022868 |
| ANO6 | anoctamin 6 | -0.0228323 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.022604 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0225677 |
| COG5 | component of oligomeric golgi complex 5 | -0.0224204 |
| TPM2 | tropomyosin 2 (beta) | -0.0223848 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0222663 |
| ANXA5 | annexin A5 | -0.0221509 |
