XRK3F2_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.178492
PABPC1 poly(A) binding protein, cytoplasmic 1 0.125904
ALCAM activated leukocyte cell adhesion molecule 0.119311
LIMCH1 LIM and calponin homology domains 1 0.104826
SAMD4A sterile alpha motif domain containing 4A 0.0914496
LPP LIM domain containing preferred translocation partner in lipoma 0.0881877
TRIO trio Rho guanine nucleotide exchange factor 0.0829513
SQSTM1 sequestosome 1 0.0797619
NDRG1 N-myc downstream regulated 1 0.0788392
FBXO32 F-box protein 32 0.0787719
NAV2 neuron navigator 2 0.0748374
SOX4 SRY (sex determining region Y)-box 4 0.0746179
FTL ferritin, light polypeptide 0.0742043
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0691507
EXT1 exostosin glycosyltransferase 1 0.068964
SAMD12 sterile alpha motif domain containing 12 0.0653313
LDHA lactate dehydrogenase A 0.0650343
RUNX1 runt-related transcription factor 1 0.0631117
ZBTB20 zinc finger and BTB domain containing 20 0.0620695
FHIT fragile histidine triad 0.0617477
UBC ubiquitin C 0.0610536
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0568235
IFI27 interferon, alpha-inducible protein 27 0.0567161
RAD51B RAD51 paralog B 0.0545029
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0539925
MYOF myoferlin 0.0525623
EFNA5 ephrin-A5 0.0520555
APLP2 amyloid beta (A4) precursor-like protein 2 0.0515746
RNF213 ring finger protein 213 0.0503227
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0501731
MGST1 microsomal glutathione S-transferase 1 0.0499891
TXNIP thioredoxin interacting protein 0.0493857
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0486928
DSPP dentin sialophosphoprotein 0.0471904
MACC1 metastasis associated in colon cancer 1 0.0471497
STEAP4 STEAP family member 4 0.0455043
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0453804
RPLP0 ribosomal protein, large, P0 0.045374
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0450174
FN1 fibronectin 1 0.0443548
KRT7 keratin 7, type II 0.0425847
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0425386
ARHGAP20 Rho GTPase activating protein 20 0.0425183
MYO6 myosin VI 0.0423275
KLHL24 kelch-like family member 24 0.0421018
RPL19 ribosomal protein L19 0.0420716
PCBP2 poly(rC) binding protein 2 0.0418839
LOC102724023 ES1 protein homolog, mitochondrial 0.0417385
ARRDC3 arrestin domain containing 3 0.0415373
RHOBTB3 Rho-related BTB domain containing 3 0.0398524
ATXN1 ataxin 1 0.0396014
CD47 CD47 molecule 0.0388884
TBC1D5 TBC1 domain family, member 5 0.0384815
RPS23 ribosomal protein S23 0.0384558
PGBD5 piggyBac transposable element derived 5 0.0383204
IFITM3 interferon induced transmembrane protein 3 0.038198
RPL32 ribosomal protein L32 0.0381376
ENO1 enolase 1, (alpha) 0.0368789
FER fer (fps/fes related) tyrosine kinase 0.0365871
PLSCR1 phospholipid scramblase 1 0.0365549
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.036553
RPL9 ribosomal protein L9 0.0359802
EIF1 eukaryotic translation initiation factor 1 0.0357543
RPL7 ribosomal protein L7 0.035744
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0350729
AKAP9 A kinase (PRKA) anchor protein 9 0.0350436
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0350328
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0347592
PATJ PATJ crumbs cell polarity complex component 0.0347431
IFITM1 interferon induced transmembrane protein 1 0.0345008
NEBL nebulette 0.033912
SMYD3 SET and MYND domain containing 3 0.0333246
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0329965
ERBIN erbb2 interacting protein 0.0326467
EXOC4 exocyst complex component 4 0.0321581
RPS13 ribosomal protein S13 0.0317193
PHF3 PHD finger protein 3 0.0314766
ZSWIM6 zinc finger, SWIM-type containing 6 0.0314125
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0313462
PDLIM5 PDZ and LIM domain 5 0.0312544
CCSER1 coiled-coil serine-rich protein 1 0.0309353
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0308384
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0307939
FOXP1 forkhead box P1 0.0305552
ZNF148 zinc finger protein 148 0.0303973
PRELID2 PRELI domain containing 2 0.0303791
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0303359
ETV6 ets variant 6 0.0302453
ARHGAP42 Rho GTPase activating protein 42 0.0296521
ANKRD28 ankyrin repeat domain 28 0.0293927
ARB2A ARB2 cotranscriptional regulator A 0.0291371
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0291191
TXNRD1 thioredoxin reductase 1 0.0287601
TTC3 tetratricopeptide repeat domain 3 0.0286398
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0285187
BPTF bromodomain PHD finger transcription factor 0.0285028
EEF2 eukaryotic translation elongation factor 2 0.0282874
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0281985
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0280825
SVIL supervillin 0.028071

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.230311
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.133001
ASPH aspartate beta-hydroxylase -0.0919255
GRB10 growth factor receptor-bound protein 10 -0.0614247
LAMC2 laminin, gamma 2 -0.056516
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0562752
TPT1 tumor protein, translationally-controlled 1 -0.0514998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0462455
TOP1 topoisomerase (DNA) I -0.04536
CCND1 cyclin D1 -0.0447257
TMSB10 thymosin beta 10 -0.0434597
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0425663
RPL34 ribosomal protein L34 -0.0411593
CAVIN1 caveolae associated protein 1 -0.0388237
TPM4 tropomyosin 4 -0.0386954
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0382997
ELL2 elongation factor, RNA polymerase II, 2 -0.0376753
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0373507
DUSP6 dual specificity phosphatase 6 -0.0370997
RCOR1 REST corepressor 1 -0.0368636
SH3KBP1 SH3-domain kinase binding protein 1 -0.0355226
RPLP1 ribosomal protein, large, P1 -0.0348963
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.034717
RAD21 RAD21 homolog (S. pombe) -0.0344326
PLEC plectin -0.0336315
BASP1 brain abundant, membrane attached signal protein 1 -0.0320933
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0315881
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0303488
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0298434
KDM3A lysine (K)-specific demethylase 3A -0.0295686
RPS24 ribosomal protein S24 -0.0282073
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0281999
SLMAP sarcolemma associated protein -0.0275167
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0272229
STRN3 striatin, calmodulin binding protein 3 -0.026748
CALR calreticulin -0.0266634
BLZF1 basic leucine zipper nuclear factor 1 -0.0266045
TMSB4X thymosin beta 4, X-linked -0.0265302
TM4SF1 transmembrane 4 L six family member 1 -0.0261678
SPAG9 sperm associated antigen 9 -0.0256777
RAB1A RAB1A, member RAS oncogene family -0.0256194
TSC22D2 TSC22 domain family, member 2 -0.0256178
MACF1 microtubule-actin crosslinking factor 1 -0.023964
STAU1 staufen double-stranded RNA binding protein 1 -0.0238987
KDM5B lysine (K)-specific demethylase 5B -0.0236341
CRABP2 cellular retinoic acid binding protein 2 -0.0233872
MARCHF6 membrane associated ring-CH-type finger 6 -0.0232309
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0225129
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0225113
OSBPL3 oxysterol binding protein-like 3 -0.022022
HMGA2 high mobility group AT-hook 2 -0.0220024
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0217408
ANXA2 annexin A2 -0.0216171
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0213393
ZFAND3 zinc finger, AN1-type domain 3 -0.0210333
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0208477
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0205292
KPNB1 karyopherin (importin) beta 1 -0.0204309
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0202656
FBXO11 F-box protein 11 -0.0200511
HMGB1 high mobility group box 1 -0.0200132
BZW1 basic leucine zipper and W2 domains 1 -0.0200114
HPCAL1 hippocalcin-like 1 -0.0199857
NDFIP1 Nedd4 family interacting protein 1 -0.0199744
FAM162A family with sequence similarity 162, member A -0.0199582
RRBP1 ribosome binding protein 1 -0.0198533
MCL1 myeloid cell leukemia 1 -0.019729
UBE2K ubiquitin-conjugating enzyme E2K -0.0196259
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0196037
RLF rearranged L-myc fusion -0.0195829
PTK2 protein tyrosine kinase 2 -0.0193935
KRT18 keratin 18, type I -0.0192682
TRA2A transformer 2 alpha homolog (Drosophila) -0.0192359
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0190255
USP3 ubiquitin specific peptidase 3 -0.0189618
MSI2 musashi RNA-binding protein 2 -0.0188203
SEC24D SEC24 family member D -0.0187542
HMGA1 high mobility group AT-hook 1 -0.0186453
FAM107B family with sequence similarity 107, member B -0.0185872
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0183474
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0183104
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0183075
G0S2 G0/G1 switch 2 -0.0182631
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0181389
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0180272
RASA2 RAS p21 protein activator 2 -0.0180009
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0179728
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0179412
HILPDA hypoxia inducible lipid droplet-associated -0.0179123
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0178009
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0176952
IER3 immediate early response 3 -0.0176418
STK17A serine/threonine kinase 17a -0.0174521
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0173252
S100A10 S100 calcium binding protein A10 -0.0172819
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.017256
MAP2K1 mitogen-activated protein kinase kinase 1 -0.017025
FOSL1 FOS-like antigen 1 -0.0168867
BTBD7 BTB (POZ) domain containing 7 -0.0168279
AKAP12 A kinase (PRKA) anchor protein 12 -0.0167918