XRK3F2_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AGTPBP1 ATP/GTP binding protein 1 0.0920616
FTL ferritin, light polypeptide 0.0874328
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0672622
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0631293
KYNU kynureninase 0.0627215
COL8A1 collagen, type VIII, alpha 1 0.0618849
EIF1 eukaryotic translation initiation factor 1 0.0602647
MYOF myoferlin 0.0584612
PDLIM5 PDZ and LIM domain 5 0.0578633
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0569406
CD109 CD109 molecule 0.0527296
RPS6 ribosomal protein S6 0.0513197
TRIO trio Rho guanine nucleotide exchange factor 0.0500993
ZEB2 zinc finger E-box binding homeobox 2 0.049539
NTN4 netrin 4 0.0483703
SAMD4A sterile alpha motif domain containing 4A 0.0482265
MAP7 microtubule-associated protein 7 0.0473653
PCBP2 poly(rC) binding protein 2 0.0450086
RPL31 ribosomal protein L31 0.0428138
LGALS3 lectin, galactoside-binding, soluble, 3 0.0400652
VIM vimentin 0.0399212
ABLIM1 actin binding LIM protein 1 0.0397182
RPS23 ribosomal protein S23 0.0389857
XYLT1 xylosyltransferase I 0.0389744
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0382729
KIF16B kinesin family member 16B 0.0379857
NEK7 NIMA-related kinase 7 0.0377396
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0369035
FLRT2 fibronectin leucine rich transmembrane protein 2 0.035173
EEF2 eukaryotic translation elongation factor 2 0.0331773
SORBS2 sorbin and SH3 domain containing 2 0.0327052
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0325875
RPL9 ribosomal protein L9 0.0320444
MFSD12 major facilitator superfamily domain containing 12 0.0318386
NFX1 nuclear transcription factor, X-box binding 1 0.030878
FMNL2 formin-like 2 0.0304331
IGF1R insulin-like growth factor 1 receptor 0.0304279
RPL19 ribosomal protein L19 0.030184
OLFML2A olfactomedin-like 2A 0.029887
EXT1 exostosin glycosyltransferase 1 0.0297804
LDHA lactate dehydrogenase A 0.0292994
TXNRD1 thioredoxin reductase 1 0.0292651
PALLD palladin, cytoskeletal associated protein 0.0292374
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0289365
RPLP0 ribosomal protein, large, P0 0.0287642
RPS13 ribosomal protein S13 0.0287512
SPAG9 sperm associated antigen 9 0.0278677
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.026117
RPL37A ribosomal protein L37a 0.0260245
EZR ezrin 0.0258484
SQSTM1 sequestosome 1 0.0257598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0253835
RPL7 ribosomal protein L7 0.0250409
ESYT2 extended synaptotagmin-like protein 2 0.0244884
RPS8 ribosomal protein S8 0.0244382
LOC102724023 ES1 protein homolog, mitochondrial 0.0241152
RHOA ras homolog family member A 0.0240393
PTEN phosphatase and tensin homolog 0.0235848
RPS4X ribosomal protein S4, X-linked 0.0231813
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0231447
OXSR1 oxidative stress responsive 1 0.0229337
MYPN myopalladin 0.0229146
ATXN1 ataxin 1 0.0227232
FRY furry homolog (Drosophila) 0.0226981
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.021967
CREB5 cAMP responsive element binding protein 5 0.0218701
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0218377
ZFHX3 zinc finger homeobox 3 0.021715
TGFBI transforming growth factor, beta-induced, 68kDa 0.0214744
ANTXR1 anthrax toxin receptor 1 0.0211231
RPS29 ribosomal protein S29 0.0209731
RASAL2 RAS protein activator like 2 0.0209593
PKM pyruvate kinase, muscle 0.0209499
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.020791
FNIP1 folliculin interacting protein 1 0.0206535
MGST1 microsomal glutathione S-transferase 1 0.0204543
SMAD2 SMAD family member 2 0.0202705
RPS19 ribosomal protein S19 0.0202597
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0199881
CTIF CBP80/20-dependent translation initiation factor 0.0193227
AUTS2 autism susceptibility candidate 2 0.0185799
RPL5 ribosomal protein L5 0.0184522
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0182719
RPL4 ribosomal protein L4 0.0182108
RPL7A ribosomal protein L7a 0.0181411
DST dystonin 0.0179831
KLF3 Kruppel-like factor 3 (basic) 0.0178817
SRRM2 serine/arginine repetitive matrix 2 0.0175915
ULK1 unc-51 like autophagy activating kinase 1 0.0174676
RACK1 receptor for activated C kinase 1 0.0172566
CLIP1 CAP-GLY domain containing linker protein 1 0.0172263
RPL11 ribosomal protein L11 0.0170875
ARHGAP32 Rho GTPase activating protein 32 0.017051
RHOB ras homolog family member B 0.0170269
RAB7A RAB7A, member RAS oncogene family 0.0169394
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0168409
RPS5 ribosomal protein S5 0.016822
ASTN2 astrotactin 2 0.0165713
MT2A metallothionein 2A 0.0165399
PRR5L proline rich 5 like 0.0165212

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.215236
FN1 fibronectin 1 -0.213859
PDE4D phosphodiesterase 4D, cAMP-specific -0.2133
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.152704
PSD3 pleckstrin and Sec7 domain containing 3 -0.132748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.129131
CDH13 cadherin 13 -0.123231
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.107152
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.100844
NRCAM neuronal cell adhesion molecule -0.0914271
MAML3 mastermind-like 3 (Drosophila) -0.089682
ASPH aspartate beta-hydroxylase -0.0840949
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0840858
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0807571
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0697337
PCBP3 poly(rC) binding protein 3 -0.0686346
STC1 stanniocalcin 1 -0.0671344
PTMA prothymosin, alpha -0.0667174
TFPI2 tissue factor pathway inhibitor 2 -0.0654592
IGFBP3 insulin-like growth factor binding protein 3 -0.0636127
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0627206
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0625052
NPAS2 neuronal PAS domain protein 2 -0.0620392
DOCK4 dedicator of cytokinesis 4 -0.0596075
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0583822
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0569832
NALF1 NALCN channel auxiliary factor 1 -0.0555742
CANX calnexin -0.0508503
NAMPT nicotinamide phosphoribosyltransferase -0.0505799
TMSB10 thymosin beta 10 -0.0502373
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0497411
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0483755
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0466389
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0464052
RTN1 reticulon 1 -0.0449491
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0438704
RGS2 regulator of G-protein signaling 2 -0.0426985
SRGN serglycin -0.0419904
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0415477
PTPRM protein tyrosine phosphatase, receptor type, M -0.0414628
GRAMD1B GRAM domain containing 1B -0.041053
MCL1 myeloid cell leukemia 1 -0.0404233
ELL2 elongation factor, RNA polymerase II, 2 -0.0389193
DOCK5 dedicator of cytokinesis 5 -0.0376783
BZW1 basic leucine zipper and W2 domains 1 -0.0357052
BMERB1 bMERB domain containing 1 -0.034773
FNDC3A fibronectin type III domain containing 3A -0.0347474
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0344804
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0338565
VCL vinculin -0.0330583
ESM1 endothelial cell-specific molecule 1 -0.0327676
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0326811
LAMB1 laminin, beta 1 -0.0322978
NCOA7 nuclear receptor coactivator 7 -0.0319633
INHBA inhibin, beta A -0.0312619
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0305814
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.030462
GLIS3 GLIS family zinc finger 3 -0.0302407
RIGI RNA sensor RIG-I -0.0289764
GNAS GNAS complex locus -0.0288494
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0284202
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0281385
RAB3B RAB3B, member RAS oncogene family -0.0276307
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.027316
TMX4 thioredoxin-related transmembrane protein 4 -0.0272127
PDIA4 protein disulfide isomerase family A, member 4 -0.0270594
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.026675
PDE10A phosphodiesterase 10A -0.0261482
PYGL phosphorylase, glycogen, liver -0.0261391
NCKAP5 NCK-associated protein 5 -0.0258731
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0255702
EPHA4 EPH receptor A4 -0.0250755
PTPRD protein tyrosine phosphatase, receptor type, D -0.0244634
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0244564
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0244273
THSD4 thrombospondin, type I, domain containing 4 -0.0243824
PRELID2 PRELI domain containing 2 -0.0243229
OASL 2'-5'-oligoadenylate synthetase-like -0.0243208
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0234856
SOX4 SRY (sex determining region Y)-box 4 -0.0234833
IFIH1 interferon induced with helicase C domain 1 -0.0231947
BCAS3 breast carcinoma amplified sequence 3 -0.0230241
TM4SF1 transmembrane 4 L six family member 1 -0.0229402
EGR1 early growth response 1 -0.0226454
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0226054
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225092
CCDC68 coiled-coil domain containing 68 -0.0224724
RRBP1 ribosome binding protein 1 -0.0224337
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0223899
NHSL1 NHS-like 1 -0.0222725
TMSB4X thymosin beta 4, X-linked -0.0222676
RPH3AL rabphilin 3A-like (without C2 domains) -0.0221899
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0220582
PDIA6 protein disulfide isomerase family A, member 6 -0.0218908
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0215079
KIAA0825 KIAA0825 -0.0211198
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0210103
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0209941
UNC5D unc-5 homolog D (C. elegans) -0.020972
PTGR1 prostaglandin reductase 1 -0.0209017