XRK3F2_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

118 genes differentially expressed following the XRK3F2_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.250837
PDE4D phosphodiesterase 4D, cAMP-specific 0.215209
EFNA5 ephrin-A5 0.146143
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.129971
GPC6 glypican 6 0.11928
DST dystonin 0.117431
FMN1 formin 1 0.102367
RORA RAR-related orphan receptor A 0.101129
PDE10A phosphodiesterase 10A 0.0960162
PCBP3 poly(rC) binding protein 3 0.0944934
CUX1 cut-like homeobox 1 0.0897896
PTPRM protein tyrosine phosphatase, receptor type, M 0.0821269
STC1 stanniocalcin 1 0.0759934
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0730898
EGFR epidermal growth factor receptor 0.0696548
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0689436
MYO1E myosin IE 0.0612266
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0603735
PCBP2 poly(rC) binding protein 2 0.0601077
SLTM SAFB-like, transcription modulator 0.0588105
PSD3 pleckstrin and Sec7 domain containing 3 0.0563507
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0543304
NDRG1 N-myc downstream regulated 1 0.0474591
NHSL1 NHS-like 1 0.045789
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0456757
PARD3 par-3 family cell polarity regulator 0.0440289
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0423113
ERRFI1 ERBB receptor feedback inhibitor 1 0.0399565
EPS8 epidermal growth factor receptor pathway substrate 8 0.0383906
FNDC3B fibronectin type III domain containing 3B 0.0366212
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0363921
CDH13 cadherin 13 0.0356689
NKD1 naked cuticle homolog 1 (Drosophila) 0.0326379
RPLP2 ribosomal protein, large, P2 0.0325953
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0311773
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0294475
ATXN1 ataxin 1 0.0283649
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0220103
VMP1 vacuole membrane protein 1 0.0220025
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.021561
CANX calnexin 0.017987
ANKRD11 ankyrin repeat domain 11 0.0156161
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0125879
MT2A metallothionein 2A 0.0122153
SMYD3 SET and MYND domain containing 3 0.0116382
VIM vimentin 0.0106919
BPTF bromodomain PHD finger transcription factor 0.00931537
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00801546
SND1 staphylococcal nuclease and tudor domain containing 1 0.00759634
VCL vinculin 0.00678177
ENO1 enolase 1, (alpha) 0.00542628
EGR1 early growth response 1 0.00486323
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00368619
TBC1D22A TBC1 domain family, member 22A 0.00353514
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.00140843

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.167788
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14601
TMSB10 thymosin beta 10 -0.113161
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.111205
TXNIP thioredoxin interacting protein -0.104274
LMO7 LIM domain 7 -0.10288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.102557
RPL35A ribosomal protein L35a -0.10013
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0952989
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.089702
B2M beta-2-microglobulin -0.082417
ACTG1 actin gamma 1 -0.0809355
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0805993
CALD1 caldesmon 1 -0.071734
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0709367
TRIO trio Rho guanine nucleotide exchange factor -0.0708434
AKAP13 A kinase (PRKA) anchor protein 13 -0.0706556
MACF1 microtubule-actin crosslinking factor 1 -0.0688401
RNF145 ring finger protein 145 -0.0666986
HMGA2 high mobility group AT-hook 2 -0.0661073
FLNB filamin B, beta -0.0628493
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0622992
PGK1 phosphoglycerate kinase 1 -0.0597748
EXT1 exostosin glycosyltransferase 1 -0.0585692
PTK2 protein tyrosine kinase 2 -0.0582024
AOPEP aminopeptidase O (putative) -0.0561319
PRRC2C proline-rich coiled-coil 2C -0.054845
PTMA prothymosin, alpha -0.05368
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0530947
NCOA2 nuclear receptor coactivator 2 -0.0502472
RBM25 RNA binding motif protein 25 -0.0494441
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0492734
SETD5 SET domain containing 5 -0.0482213
UBC ubiquitin C -0.0479182
RNF213 ring finger protein 213 -0.0461964
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0447662
RPL26 ribosomal protein L26 -0.0424863
GOLGA4 golgin A4 -0.0356474
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0353597
HLA-B major histocompatibility complex, class I, B -0.0347526
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0328024
NAP1L1 nucleosome assembly protein 1-like 1 -0.0313187
CCNI cyclin I -0.0311437
NAV2 neuron navigator 2 -0.0308896
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0305561
SEC31A SEC31 homolog A (S. cerevisiae) -0.0304944
ZBTB20 zinc finger and BTB domain containing 20 -0.0279393
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0266937
PKM pyruvate kinase, muscle -0.0252067
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245486
CD44 CD44 molecule (Indian blood group) -0.0237001
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0234729
MAML2 mastermind-like 2 (Drosophila) -0.0214289
FNDC3A fibronectin type III domain containing 3A -0.0194635
PRKCA protein kinase C, alpha -0.0176705
ASPH aspartate beta-hydroxylase -0.0146381
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0114496
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.00997802
SPAG9 sperm associated antigen 9 -0.00809582
CSNK1A1 casein kinase 1, alpha 1 -0.00501136
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00438134
RAD51B RAD51 paralog B -0.00437138
AKAP12 A kinase (PRKA) anchor protein 12 -0.00298834