XRK3F2_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description XRK3F2 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the XRK3F2_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.183105
MT2A metallothionein 2A 0.136608
FTL ferritin, light polypeptide 0.113219
HLA-B major histocompatibility complex, class I, B 0.108448
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.106287
EIF1 eukaryotic translation initiation factor 1 0.0898405
LDHA lactate dehydrogenase A 0.085893
HDAC9 histone deacetylase 9 0.0731717
RPS6 ribosomal protein S6 0.0705761
BICC1 BicC family RNA binding protein 1 0.068361
EEF2 eukaryotic translation elongation factor 2 0.0645356
HLA-A major histocompatibility complex, class I, A 0.0615617
B2M beta-2-microglobulin 0.0608448
KYNU kynureninase 0.0606741
RPS23 ribosomal protein S23 0.0592797
SQSTM1 sequestosome 1 0.0583912
RPS8 ribosomal protein S8 0.0573522
SOD2 superoxide dismutase 2, mitochondrial 0.0550871
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.053981
RPS13 ribosomal protein S13 0.0538517
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.04562
FBXO32 F-box protein 32 0.0440831
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0433301
SLC38A2 solute carrier family 38, member 2 0.0433074
RPL19 ribosomal protein L19 0.0427324
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0414399
RPL9 ribosomal protein L9 0.0414055
RND3 Rho family GTPase 3 0.0413966
RPL31 ribosomal protein L31 0.0409543
RPL37A ribosomal protein L37a 0.0404782
ENO1 enolase 1, (alpha) 0.0403041
IFITM3 interferon induced transmembrane protein 3 0.0394891
RPL11 ribosomal protein L11 0.0367576
RPS10 ribosomal protein S10 0.0359163
RPL5 ribosomal protein L5 0.0354169
RPL7A ribosomal protein L7a 0.0352485
GDF15 growth differentiation factor 15 0.0350987
PGK1 phosphoglycerate kinase 1 0.0334705
ACTG1 actin gamma 1 0.033232
RPLP2 ribosomal protein, large, P2 0.0318244
KLHL24 kelch-like family member 24 0.0318209
ENO2 enolase 2 (gamma, neuronal) 0.0312523
HLA-E major histocompatibility complex, class I, E 0.0308556
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0306749
RPS29 ribosomal protein S29 0.0302729
TPT1 tumor protein, translationally-controlled 1 0.0301832
RPL37 ribosomal protein L37 0.0300801
LOC102724023 ES1 protein homolog, mitochondrial 0.029884
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.029773
CTSB cathepsin B 0.0296893
RPL23 ribosomal protein L23 0.029498
PTPRK protein tyrosine phosphatase, receptor type, K 0.0293946
RPS25 ribosomal protein S25 0.0292371
RPL7 ribosomal protein L7 0.0289118
NAP1L1 nucleosome assembly protein 1-like 1 0.028353
NDRG1 N-myc downstream regulated 1 0.028207
RPS19 ribosomal protein S19 0.0281111
RPLP0 ribosomal protein, large, P0 0.0275739
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0275332
IER3 immediate early response 3 0.0275021
ADM adrenomedullin 0.0272723
RPS3 ribosomal protein S3 0.0264436
OSBPL8 oxysterol binding protein-like 8 0.0263393
RPL35A ribosomal protein L35a 0.0261626
BTG1 B-cell translocation gene 1, anti-proliferative 0.0261178
RACK1 receptor for activated C kinase 1 0.0256885
SVIL supervillin 0.0254986
ISG15 ISG15 ubiquitin-like modifier 0.0253176
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0246156
RNF213 ring finger protein 213 0.0245916
PHF3 PHD finger protein 3 0.0243824
CD44 CD44 molecule (Indian blood group) 0.0243665
RPS20 ribosomal protein S20 0.0233817
PKM pyruvate kinase, muscle 0.0230566
FOXP1 forkhead box P1 0.0229479
EEF1G eukaryotic translation elongation factor 1 gamma 0.0228419
ZBTB38 zinc finger and BTB domain containing 38 0.0222961
SP100 SP100 nuclear antigen 0.0222518
RPS16 ribosomal protein S16 0.0222117
FBXL7 F-box and leucine-rich repeat protein 7 0.0222039
RPL36A ribosomal protein L36a 0.0221257
RPS12 ribosomal protein S12 0.0220624
RPL13A ribosomal protein L13a 0.0218023
RPL28 ribosomal protein L28 0.021704
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0216187
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0214796
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0214572
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0214109
RPS14 ribosomal protein S14 0.0212354
RPL10A ribosomal protein L10a 0.0211116
TMSB10 thymosin beta 10 0.0210659
RPL36 ribosomal protein L36 0.0209978
RPS27A ribosomal protein S27a 0.0209114
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.020859
DSTN destrin (actin depolymerizing factor) 0.0206287
PHIP pleckstrin homology domain interacting protein 0.0203904
RPL8 ribosomal protein L8 0.0203543
ANKRD12 ankyrin repeat domain 12 0.0202871
MT1X metallothionein 1X 0.0202523
RPL32 ribosomal protein L32 0.0201694

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.146227
FRMD4A FERM domain containing 4A -0.138731
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0840182
PDE10A phosphodiesterase 10A -0.0666582
IGFBP3 insulin-like growth factor binding protein 3 -0.0609108
VCL vinculin -0.0555341
COL6A3 collagen, type VI, alpha 3 -0.0548201
GLIS3 GLIS family zinc finger 3 -0.0525615
AKAP12 A kinase (PRKA) anchor protein 12 -0.0525478
CADM1 cell adhesion molecule 1 -0.051423
ELL2 elongation factor, RNA polymerase II, 2 -0.0472869
TENT5A terminal nucleotidyltransferase 5A -0.0464915
EGR1 early growth response 1 -0.0443259
SFRP1 secreted frizzled-related protein 1 -0.0411512
EXT1 exostosin glycosyltransferase 1 -0.0400435
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0390184
MYH9 myosin, heavy chain 9, non-muscle -0.0362261
NAV1 neuron navigator 1 -0.0349103
COL1A1 collagen, type I, alpha 1 -0.0338843
COL1A2 collagen, type I, alpha 2 -0.0332647
RTN4 reticulon 4 -0.0309291
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0307479
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0303546
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0292307
ZMYND8 zinc finger, MYND-type containing 8 -0.0282715
SMAD3 SMAD family member 3 -0.0277172
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0273259
MSN moesin -0.0267474
LOX lysyl oxidase -0.0262346
ATP13A3 ATPase type 13A3 -0.0261105
TRIO trio Rho guanine nucleotide exchange factor -0.0254943
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0248763
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0244556
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.02268
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0223166
RRBP1 ribosome binding protein 1 -0.0218349
NRN1 neuritin 1 -0.021138
TENM2 teneurin transmembrane protein 2 -0.0209659
DLG1 discs, large homolog 1 (Drosophila) -0.0208953
TNNC1 troponin C type 1 (slow) -0.0207167
FLNB filamin B, beta -0.0202365
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0200793
MAP1B microtubule-associated protein 1B -0.0198558
ASPH aspartate beta-hydroxylase -0.0198324
CENPF centromere protein F, 350/400kDa -0.0196715
MKI67 marker of proliferation Ki-67 -0.0195232
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0192432
SBF2 SET binding factor 2 -0.0191654
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0190256
CLMP CXADR-like membrane protein -0.01891
THBS2 thrombospondin 2 -0.0187152
MAP4 microtubule-associated protein 4 -0.0185224
PHF21A PHD finger protein 21A -0.01844
COL5A1 collagen, type V, alpha 1 -0.0181676
ZFAND3 zinc finger, AN1-type domain 3 -0.0180038
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0177062
BRWD3 bromodomain and WD repeat domain containing 3 -0.0172871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.017258
STAU1 staufen double-stranded RNA binding protein 1 -0.0171461
JUN jun proto-oncogene -0.0170159
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0169132
EHBP1 EH domain binding protein 1 -0.0168929
KDM2A lysine (K)-specific demethylase 2A -0.0168377
PPARD peroxisome proliferator-activated receptor delta -0.0163776
CLIC4 chloride intracellular channel 4 -0.016232
COL8A1 collagen, type VIII, alpha 1 -0.0159245
DENND5A DENN/MADD domain containing 5A -0.0157773
PSD3 pleckstrin and Sec7 domain containing 3 -0.0157544
ICAM1 intercellular adhesion molecule 1 -0.0157369
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0154804
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0152222
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.015202
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0150604
SAMD3 sterile alpha motif domain containing 3 -0.0150126
CREB5 cAMP responsive element binding protein 5 -0.0148142
ACTN1 actinin, alpha 1 -0.0146363
KIRREL3 kin of IRRE like 3 (Drosophila) -0.014538
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0145189
NPEPPS aminopeptidase puromycin sensitive -0.0143794
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0143446
TOP2A topoisomerase (DNA) II alpha 170kDa -0.014325
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0143193
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0141783
ABTB3 ankyrin repeat and BTB domain containing 3 -0.014153
TNIP1 TNFAIP3 interacting protein 1 -0.0141131
PTMA prothymosin, alpha -0.0139602
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0138261
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.013629
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0136035
CHD1 chromodomain helicase DNA binding protein 1 -0.0135413
STK17A serine/threonine kinase 17a -0.0134325
PRKN parkin RBR E3 ubiquitin protein ligase -0.0133821
CRY1 cryptochrome circadian clock 1 -0.0133634
THBS1 thrombospondin 1 -0.0133545
NF1 neurofibromin 1 -0.0132183
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.013121
BNC2 basonuclin 2 -0.0129214
KLHL4 kelch-like family member 4 -0.0128787
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.012807
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0126911