Xerostomia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Dryness of the mouth due to salivary gland dysfunction. (Human Phenotype Ontology, HP_0000217)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D014987
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Genes

113 genes/proteins associated with the disease Xerostomia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.40367
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.19081
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.17796
BDNF brain-derived neurotrophic factor 2.08116
FOS FBJ murine osteosarcoma viral oncogene homolog 2.06909
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.97464
CAT catalase 1.90242
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.84251
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.82359
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.80472
PRL prolactin 1.78625
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.74581
TNF tumor necrosis factor 1.73778
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.73089
NPY neuropeptide Y 1.60407
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.58936
IL6 interleukin 6 1.58724
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.57806
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.57522
ARC activity-regulated cytoskeleton-associated protein 1.55525
SOD1 superoxide dismutase 1, soluble 1.54937
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.53506
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.52313
VEGFA vascular endothelial growth factor A 1.52212
DRD2 dopamine receptor D2 1.52036
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.51657
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.49941
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.49122
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.47167
TAC1 tachykinin, precursor 1 1.45405
CREB1 cAMP responsive element binding protein 1 1.39422
EGR1 early growth response 1 1.39254
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.3903
POMC proopiomelanocortin 1.38835
OPRM1 opioid receptor, mu 1 1.38807
DRD1 dopamine receptor D1 1.38612
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.37789
NUPR1 nuclear protein, transcriptional regulator, 1 1.37676
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.36648
SREBF2 sterol regulatory element binding transcription factor 2 1.36047
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.35069
TAGLN transgelin 1.34811
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.34111
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.31208
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.31089
MAPK14 mitogen-activated protein kinase 14 1.30819
PENK proenkephalin 1.30758
IFNG interferon, gamma 1.30666
MAPK1 mitogen-activated protein kinase 1 1.30056
CDK5 cyclin-dependent kinase 5 1.29502
INHBE inhibin, beta E 1.28703
BCL2 B-cell CLL/lymphoma 2 1.28703
CRH corticotropin releasing hormone 1.28456
IL2 interleukin 2 1.28395
PDYN prodynorphin 1.27845
GSTP1 glutathione S-transferase pi 1 1.27286
BAX BCL2-associated X protein 1.267
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.26514
CNR1 cannabinoid receptor 1 (brain) 1.2596
C10ORF10 chromosome 10 open reading frame 10 1.25338
FNDC4 fibronectin type III domain containing 4 1.24687
TH tyrosine hydroxylase 1.23993
HRH1 histamine receptor H1 1.2393
GRIK2 glutamate receptor, ionotropic, kainate 2 1.23424
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.22727
MAPK8 mitogen-activated protein kinase 8 1.22371
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.21076
AVP arginine vasopressin 1.20848
EGR2 early growth response 2 1.20622
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.20394
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.20262
SYP synaptophysin 1.19966
COMT catechol-O-methyltransferase 1.19246
FAS Fas cell surface death receptor 1.18783
IL1A interleukin 1, alpha 1.18391
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.1786
IL1B interleukin 1, beta 1.17662
GFRA2 GDNF family receptor alpha 2 1.17366
MAP2 microtubule-associated protein 2 1.17134
JUN jun proto-oncogene 1.17067
CCND1 cyclin D1 1.16467
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.15967
OPRL1 opiate receptor-like 1 1.15967
GDNF glial cell derived neurotrophic factor 1.15391
MAPK3 mitogen-activated protein kinase 3 1.14919
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.11741
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.10493
TIMP2 TIMP metallopeptidase inhibitor 2 1.10424
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.09716
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.09436
NOS2 nitric oxide synthase 2, inducible 1.09226
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.08726
HOMER1 homer scaffolding protein 1 1.07553
GRIK5 glutamate receptor, ionotropic, kainate 5 1.07482
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.07482
ADORA1 adenosine A1 receptor 1.06917
INS insulin 1.06261
CES2 carboxylesterase 2 1.06044
NPTX2 neuronal pentraxin II 1.05721
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.04757
PRKCB protein kinase C, beta 1.04352
GSK3B glycogen synthase kinase 3 beta 1.04314
JUNB jun B proto-oncogene 1.04088
LEP leptin 1.03976
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.03641
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.03567
EGFR epidermal growth factor receptor 1.03084
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.02933
NPPA natriuretic peptide A 1.02634
GAL galanin/GMAP prepropeptide 1.0241
GH1 growth hormone 1 1.02336
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.02151
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.01174