Y-27632-832 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the Y-27632-832 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AHI1 Abelson helper integration site 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATG12 autophagy related 12
BTBD7 BTB (POZ) domain containing 7
C10ORF95 chromosome 10 open reading frame 95
C9ORF9 chromosome 9 open reading frame 9
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACYBP calcyclin binding protein
CD8A CD8a molecule
CDC25C cell division cycle 25C
CLCN2 chloride channel, voltage-sensitive 2
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CRELD1 cysteine-rich with EGF-like domains 1
CUL7 cullin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHODH dihydroorotate dehydrogenase (quinone)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EXPH5 exophilin 5
FAM134B family with sequence similarity 134, member B
FBXO9 F-box protein 9
FLJ42627 uncharacterized LOC645644
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
GRM4 glutamate receptor, metabotropic 4
GRM8 glutamate receptor, metabotropic 8
GSTM1 glutathione S-transferase mu 1
GTDC1 glycosyltransferase-like domain containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IPO8 importin 8
IPO9 importin 9
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIAA0894 KIAA0894 protein
KLF9 Kruppel-like factor 9
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC647070 uncharacterized LOC647070
LTC4S leukotriene C4 synthase
MCM3AP minichromosome maintenance complex component 3 associated protein
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MLX MLX, MAX dimerization protein
MOCS1 molybdenum cofactor synthesis 1
MZT2B mitotic spindle organizing protein 2B
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKX3-2 NK3 homeobox 2
NPHP4 nephronophthisis 4
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PDAP1 PDGFA associated protein 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLH polymerase (DNA directed), eta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPT2 palmitoyl-protein thioesterase 2
RAG2 recombination activating gene 2
RAPSN receptor-associated protein of the synapse
RFTN1 raftlin, lipid raft linker 1
RGS14 regulator of G-protein signaling 14
RIMS2 regulating synaptic membrane exocytosis 2
RIOK3 RIO kinase 3
RNF24 ring finger protein 24
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAPCD1 suppressor APC domain containing 1
SATB2 SATB homeobox 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SGSM3 small G protein signaling modulator 3
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC38A7 solute carrier family 38, member 7
SMC1A structural maintenance of chromosomes 1A
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRSF11 serine/arginine-rich splicing factor 11
SULF1 sulfatase 1
TACC1 transforming, acidic coiled-coil containing protein 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX261 testis expressed 261
TMEM212 transmembrane protein 212
TMPRSS4 transmembrane protease, serine 4
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TPMT thiopurine S-methyltransferase
UBQLN4 ubiquilin 4
USP34 ubiquitin specific peptidase 34
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPR1 vasoactive intestinal peptide receptor 1
WAS Wiskott-Aldrich syndrome
ZNF248 zinc finger protein 248
ZNF287 zinc finger protein 287
ZNF37BP zinc finger protein 37B, pseudogene

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARF5 ADP-ribosylation factor 5
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BIK BCL2-interacting killer (apoptosis-inducing)
C16ORF59 chromosome 16 open reading frame 59
C19ORF24 chromosome 19 open reading frame 24
C22ORF29 chromosome 22 open reading frame 29
C2ORF49 chromosome 2 open reading frame 49
C5ORF28 chromosome 5 open reading frame 28
CARD8 caspase recruitment domain family, member 8
CDC37L1 cell division cycle 37-like 1
CENPJ centromere protein J
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLSPN claspin
CRABP1 cellular retinoic acid binding protein 1
CTAGE9 CTAGE family, member 9
CXORF56 chromosome X open reading frame 56
CYB5R1 cytochrome b5 reductase 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EMD emerin
ETAA1 Ewing tumor-associated antigen 1
EXOC5 exocyst complex component 5
FCHSD2 FCH and double SH3 domains 2
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FKBP2 FK506 binding protein 2, 13kDa
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FRS2 fibroblast growth factor receptor substrate 2
GATA6 GATA binding protein 6
GCHFR GTP cyclohydrolase I feedback regulator
HOXC10 homeobox C10
ICK intestinal cell (MAK-like) kinase
IGFBP6 insulin-like growth factor binding protein 6
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIF3A kinesin family member 3A
KRT15 keratin 15, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPD3 LY6/PLAUR domain containing 3
MANSC1 MANSC domain containing 1
MEX3C mex-3 RNA binding family member C
MICB MHC class I polypeptide-related sequence B
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTSS1L metastasis suppressor 1-like
MYO1F myosin IF
NAP1L2 nucleosome assembly protein 1-like 2
NDFIP1 Nedd4 family interacting protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L3 nuclear factor, erythroid 2-like 3
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NUBPL nucleotide binding protein-like
PCNXL4 pecanex-like 4 (Drosophila)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLIN3 perilipin 3
PPCS phosphopantothenoylcysteine synthetase
QARS glutaminyl-tRNA synthetase
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF2 ring finger protein 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A40 solute carrier family 25, member 40
SMAD5 SMAD family member 5
SOAT1 sterol O-acyltransferase 1
SSFA2 sperm specific antigen 2
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STARD5 StAR-related lipid transfer (START) domain containing 5
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYNJ2BP synaptojanin 2 binding protein
TAGLN transgelin
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMCO3 transmembrane and coiled-coil domains 3
TMEM104 transmembrane protein 104
TMEM109 transmembrane protein 109
TMEM115 transmembrane protein 115
TMEM254 transmembrane protein 254
TUBA3C tubulin, alpha 3c
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
USP6NL USP6 N-terminal like
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
YIPF3 Yip1 domain family, member 3
ZBTB39 zinc finger and BTB domain containing 39
ZMAT5 zinc finger, matrin-type 5
ZNF250 zinc finger protein 250
ZNF532 zinc finger protein 532
ZNF813 zinc finger protein 813