YAP1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description Yes-associated protein 1|This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] (NCBI Entrez Gene Database, 10413)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/YAP1_UP
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Genes

90 genes differentially expressed following the YAP1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
C8ORF48 chromosome 8 open reading frame 48
C8ORF58 chromosome 8 open reading frame 58
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC8 coiled-coil domain containing 8
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK14 cyclin-dependent kinase 14
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CXORF56 chromosome X open reading frame 56
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DLX5 distal-less homeobox 5
DRAM2 DNA-damage regulated autophagy modulator 2
FAF2 Fas associated factor family member 2
FAM167A family with sequence similarity 167, member A
FAM35A family with sequence similarity 35, member A
FAM45A family with sequence similarity 45, member A
FLOT1 flotillin 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GTPBP3 GTP binding protein 3 (mitochondrial)
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA1033 KIAA1033
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MOCS2 molybdenum cofactor synthesis 2
MSN moesin
MYLK myosin light chain kinase
NMRK1 nicotinamide riboside kinase 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
RAB40C RAB40C, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RPN2 ribophorin II
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHISA4 shisa family member 4
SIAE sialic acid acetylesterase
SNAP23 synaptosomal-associated protein, 23kDa
SNX7 sorting nexin 7
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNHIT6 zinc finger, HIT-type containing 6

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
C6ORF58 chromosome 6 open reading frame 58
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CCDC87 coiled-coil domain containing 87
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
DOCK11 dedicator of cytokinesis 11
FAM122C family with sequence similarity 122C
FICD FIC domain containing
GOLGA2P5 golgin A2 pseudogene 5
GPR50 G protein-coupled receptor 50
GUCY2C guanylate cyclase 2C
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IL4R interleukin 4 receptor
IQCF1 IQ motif containing F1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KATNB1 katanin p80 (WD repeat containing) subunit B 1
LCA5L Leber congenital amaurosis 5-like
LIMD1 LIM domains containing 1
LOC284023 uncharacterized LOC284023
LONRF2 LON peptidase N-terminal domain and ring finger 2
MYLIP myosin regulatory light chain interacting protein
MYO1B myosin IB
ORC2 origin recognition complex, subunit 2
PDIK1L PDLIM1 interacting kinase 1 like
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PRCC papillary renal cell carcinoma (translocation-associated)
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
TAS2R7 taste receptor, type 2, member 7
TEX101 testis expressed 101
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMP3 TIMP metallopeptidase inhibitor 3
TSPY26P testis specific protein, Y-linked 26, pseudogene
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
VSNL1 visinin-like 1
WBSCR16 Williams-Beuren syndrome chromosome region 16
WSCD2 WSC domain containing 2
ZBTB39 zinc finger and BTB domain containing 39
ZNF645 zinc finger protein 645