| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | Yes-associated protein 1|This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] (NCBI Entrez Gene Database, 10413) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/YAP1_UP |
| Similar Terms | |
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90 genes differentially expressed following the YAP1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 |
| C8ORF48 | chromosome 8 open reading frame 48 |
| C8ORF58 | chromosome 8 open reading frame 58 |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV |
| CCDC8 | coiled-coil domain containing 8 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| CDK14 | cyclin-dependent kinase 14 |
| CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) |
| CXORF56 | chromosome X open reading frame 56 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa |
| DLX5 | distal-less homeobox 5 |
| DRAM2 | DNA-damage regulated autophagy modulator 2 |
| FAF2 | Fas associated factor family member 2 |
| FAM167A | family with sequence similarity 167, member A |
| FAM35A | family with sequence similarity 35, member A |
| FAM45A | family with sequence similarity 45, member A |
| FLOT1 | flotillin 1 |
| GLTSCR1 | glioma tumor suppressor candidate region gene 1 |
| GTPBP3 | GTP binding protein 3 (mitochondrial) |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 |
| KIAA1033 | KIAA1033 |
| LLGL1 | lethal giant larvae homolog 1 (Drosophila) |
| MAML2 | mastermind-like 2 (Drosophila) |
| MOCS2 | molybdenum cofactor synthesis 2 |
| MSN | moesin |
| MYLK | myosin light chain kinase |
| NMRK1 | nicotinamide riboside kinase 1 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma |
| PTPMT1 | protein tyrosine phosphatase, mitochondrial 1 |
| RAB40C | RAB40C, member RAS oncogene family |
| RFTN1 | raftlin, lipid raft linker 1 |
| RGCC | regulator of cell cycle |
| RHOQ | ras homolog family member Q |
| RPN2 | ribophorin II |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| SHISA4 | shisa family member 4 |
| SIAE | sialic acid acetylesterase |
| SNAP23 | synaptosomal-associated protein, 23kDa |
| SNX7 | sorting nexin 7 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
| ZNHIT6 | zinc finger, HIT-type containing 6 |
| Symbol | Name |
|---|---|
| ACOX2 | acyl-CoA oxidase 2, branched chain |
| APOBEC2 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 |
| C6ORF58 | chromosome 6 open reading frame 58 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit |
| CCDC87 | coiled-coil domain containing 87 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 |
| DOCK11 | dedicator of cytokinesis 11 |
| FAM122C | family with sequence similarity 122C |
| FICD | FIC domain containing |
| GOLGA2P5 | golgin A2 pseudogene 5 |
| GPR50 | G protein-coupled receptor 50 |
| GUCY2C | guanylate cyclase 2C |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 |
| IL4R | interleukin 4 receptor |
| IQCF1 | IQ motif containing F1 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) |
| KATNB1 | katanin p80 (WD repeat containing) subunit B 1 |
| LCA5L | Leber congenital amaurosis 5-like |
| LIMD1 | LIM domains containing 1 |
| LOC284023 | uncharacterized LOC284023 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 |
| MYLIP | myosin regulatory light chain interacting protein |
| MYO1B | myosin IB |
| ORC2 | origin recognition complex, subunit 2 |
| PDIK1L | PDLIM1 interacting kinase 1 like |
| PIGO | phosphatidylinositol glycan anchor biosynthesis, class O |
| PRCC | papillary renal cell carcinoma (translocation-associated) |
| RFX1 | regulatory factor X, 1 (influences HLA class II expression) |
| RHBDL1 | rhomboid, veinlet-like 1 (Drosophila) |
| SLC17A7 | solute carrier family 17 (vesicular glutamate transporter), member 7 |
| SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 5 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 |
| TAS2R7 | taste receptor, type 2, member 7 |
| TEX101 | testis expressed 101 |
| THNSL1 | threonine synthase-like 1 (S. cerevisiae) |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TSPY26P | testis specific protein, Y-linked 26, pseudogene |
| UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 |
| VSNL1 | visinin-like 1 |
| WBSCR16 | Williams-Beuren syndrome chromosome region 16 |
| WSCD2 | WSC domain containing 2 |
| ZBTB39 | zinc finger and BTB domain containing 39 |
| ZNF645 | zinc finger protein 645 |
