YK-4-279 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/44632017
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Genes

198 proteins with high or low expression in YK-4-279 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
FN1 fibronectin 1 1.95
TNXB tenascin XB 1.8
CEP290 centrosomal protein 290kDa 1.65
SMTN smoothelin 1.44
CDT1 chromatin licensing and DNA replication factor 1 1.44
KIF20A kinesin family member 20A 1.39
COL14A1 collagen, type XIV, alpha 1 1.33
HBA1 hemoglobin, alpha 1 1.31
IGFBP6 insulin-like growth factor binding protein 6 1.21
F5 coagulation factor V (proaccelerin, labile factor) 1.2
ATF3 activating transcription factor 3 1.18
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.15
RNASE4 ribonuclease, RNase A family, 4 1.11
GTSE1 G-2 and S-phase expressed 1 1.11
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.1
TP53 tumor protein p53 1.1
FTH1 ferritin, heavy polypeptide 1 1.06
CST3 cystatin C 1.03
C1QTNF3 C1q and tumor necrosis factor related protein 3 1.02
PRX periaxin 0.98
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.98
UBE2S ubiquitin-conjugating enzyme E2S 0.97
PRDM10 PR domain containing 10 0.96
TIMP2 TIMP metallopeptidase inhibitor 2 0.96
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.9
PRELID3B PRELI domain containing 3B 0.89
PEX13 peroxisomal biogenesis factor 13 0.88
CDCA8 cell division cycle associated 8 0.88
CST6 cystatin E/M 0.87
INCENP inner centromere protein antigens 135/155kDa 0.87
VTN vitronectin 0.86
SNX19 sorting nexin 19 0.86
CCN2 cellular communication network factor 2 0.86
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.85
PUS3 pseudouridylate synthase 3 0.83
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.83
TROAP trophinin associated protein 0.83
ITM2B integral membrane protein 2B 0.82
TPCN1 two pore segment channel 1 0.82
BIRC5 baculoviral IAP repeat containing 5 0.81
ZC3H6 zinc finger CCCH-type containing 6 0.81
WNT10B wingless-type MMTV integration site family, member 10B 0.81
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.8
TIMP3 TIMP metallopeptidase inhibitor 3 0.8
F2 coagulation factor II (thrombin) 0.8
SERINC1 serine incorporator 1 0.79
KIF23 kinesin family member 23 0.78
SGO2 shugoshin 2 0.78
C9ORF40 chromosome 9 open reading frame 40 0.77
MNX1 motor neuron and pancreas homeobox 1 0.76
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.76
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.76
STK17B serine/threonine kinase 17b 0.76
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.76
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 0.75
RBAK RB-associated KRAB zinc finger 0.74
OTC ornithine carbamoyltransferase 0.74
FKBP2 FK506 binding protein 2, 13kDa 0.73
KIFC1 kinesin family member C1 0.73
APOE apolipoprotein E 0.72
CLU clusterin 0.72
KIF2C kinesin family member 2C 0.71
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 0.71
BAG3 BCL2-associated athanogene 3 0.71
MED18 mediator complex subunit 18 0.69
AURKA aurora kinase A 0.69
PRC1 protein regulator of cytokinesis 1 0.69
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.69
ZNF777 zinc finger protein 777 0.68
CDCA2 cell division cycle associated 2 0.67
BABAM2 BRISC and BRCA1 A complex member 2 0.67
KIAA1586 KIAA1586 0.67
MORF4L2 mortality factor 4 like 2 0.66
CPN1 carboxypeptidase N, polypeptide 1 0.66
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.66
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 0.65
CPA4 carboxypeptidase A4 0.65
YAF2 YY1 associated factor 2 0.65
SPOP speckle-type POZ protein 0.64
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.64
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.63
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.63
NDFIP2 Nedd4 family interacting protein 2 0.62
SHCBP1 SHC SH2-domain binding protein 1 0.62
NPEPL1 aminopeptidase-like 1 0.62
FTL ferritin, light polypeptide 0.62
RACGAP1 Rac GTPase activating protein 1 0.61
H1-0 H1.0 linker histone 0.61
ARHGAP23 Rho GTPase activating protein 23 0.61
CCAR2 cell cycle and apoptosis regulator 2 0.6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.6
ARMC5 armadillo repeat containing 5 0.6
DSTN destrin (actin depolymerizing factor) 0.6
KLHL21 kelch-like family member 21 0.6
UQCRB ubiquinol-cytochrome c reductase binding protein 0.6
ZNF749 zinc finger protein 749 0.6
PLEK pleckstrin 0.6
FSTL1 follistatin-like 1 0.59

low expression

Symbol Name Standardized Value
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -1.72
SENP1 SUMO1/sentrin specific peptidase 1 -1.67
LMTK2 lemur tyrosine kinase 2 -1.67
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -1.62
EXO1 exonuclease 1 -1.49
ERN1 endoplasmic reticulum to nucleus signaling 1 -1.45
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -1.41
EHBP1 EH domain binding protein 1 -1.39
TACC1 transforming, acidic coiled-coil containing protein 1 -1.37
FBXO5 F-box protein 5 -1.33
CEP78 centrosomal protein 78kDa -1.33
USP37 ubiquitin specific peptidase 37 -1.33
MCL1 myeloid cell leukemia 1 -1.33
EXD2 exonuclease 3'-5' domain containing 2 -1.3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -1.29
RHOBTB3 Rho-related BTB domain containing 3 -1.28
CIR1 corepressor interacting with RBPJ, 1 -1.28
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -1.28
PDCD11 programmed cell death 11 -1.25
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -1.25
BHLHA15 basic helix-loop-helix family, member a15 -1.22
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -1.2
ZNF22 zinc finger protein 22 -1.19
TMEM9B TMEM9 domain family, member B -1.19
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -1.18
CCDC137 coiled-coil domain containing 137 -1.17
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -1.17
RGPD5 RANBP2-like and GRIP domain containing 5 -1.17
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -1.17
HOXB7 homeobox B7 -1.16
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -1.11
SIMC1 SUMO-interacting motifs containing 1 -1.11
SDC1 syndecan 1 -1.1
BCAP29 B-cell receptor-associated protein 29 -1.1
RRM2 ribonucleotide reductase M2 -1.09
PPL periplakin -1.09
ZCCHC9 zinc finger, CCHC domain containing 9 -1.09
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) -1.09
LRP5 low density lipoprotein receptor-related protein 5 -1.08
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -1.07
ZC3H12C zinc finger CCCH-type containing 12C -1.07
PNPLA2 patatin-like phospholipase domain containing 2 -1.07
CCNA2 cyclin A2 -1.05
TRIM36 tripartite motif containing 36 -1.05
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -1.05
CRAMP1 cramped chromatin regulator homolog 1 -1.04
RTL8C retrotransposon Gag like 8C -1.03
PDLIM2 PDZ and LIM domain 2 (mystique) -1.02
SHKBP1 SH3KBP1 binding protein 1 -1.02
CDC25B cell division cycle 25B -1.01
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -1.01
TPM2 tropomyosin 2 (beta) -1.0
PIAS4 protein inhibitor of activated STAT, 4 -0.99
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.99
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -0.99
ZNF768 zinc finger protein 768 -0.99
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -0.98
SREBF1 sterol regulatory element binding transcription factor 1 -0.98
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -0.97
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -0.97
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -0.97
BMS1 BMS1 ribosome biogenesis factor -0.97
NIFK nucleolar protein interacting with the FHA domain of MKI67 -0.96
MADD MAP-kinase activating death domain -0.96
TENT2 terminal nucleotidyltransferase 2 -0.96
LPIN1 lipin 1 -0.96
PTK7 protein tyrosine kinase 7 (inactive) -0.96
NOL12 nucleolar protein 12 -0.96
WRB tryptophan rich basic protein -0.95
NAV3 neuron navigator 3 -0.95
SREBF2 sterol regulatory element binding transcription factor 2 -0.95
RBM28 RNA binding motif protein 28 -0.95
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.94
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -0.94
DIAPH3 diaphanous-related formin 3 -0.94
TBC1D22B TBC1 domain family, member 22B -0.94
EXTL2 exostosin-like glycosyltransferase 2 -0.94
SRFBP1 serum response factor binding protein 1 -0.93
PLXNA3 plexin A3 -0.93
R3HDM4 R3H domain containing 4 -0.93
ZFAND5 zinc finger, AN1-type domain 5 -0.92
ZNF770 zinc finger protein 770 -0.92
RGS12 regulator of G-protein signaling 12 -0.92
MANEA mannosidase, endo-alpha -0.92
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -0.91
H1-2 H1.2 linker histone, cluster member -0.91
ATAD2 ATPase family, AAA domain containing 2 -0.91
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.91
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.91
S100PBP S100P binding protein -0.9
CDC34 cell division cycle 34 -0.9
RRBP1 ribosome binding protein 1 -0.89
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.89
CNTNAP3 contactin associated protein-like 3 -0.88
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 -0.88
DOP1B DOP1 leucine zipper like protein B -0.88
ARL2BP ADP-ribosylation factor-like 2 binding protein -0.88
CHURC1 churchill domain containing 1 -0.88
EXPH5 exophilin 5 -0.88