YWHAE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon|This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 7531)
Similar Terms
Downloads & Tools

Genes

328 genes differentially expressed following the YWHAE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM153A family with sequence similarity 153, member A 3.79824
PDYN prodynorphin 3.79824
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.79824
GPR151 G protein-coupled receptor 151 3.79824
RSPO1 R-spondin 1 3.79824
GYPE glycophorin E (MNS blood group) 3.79824
ADAD2 adenosine deaminase domain containing 2 3.79824
MYOM3 myomesin 3 3.79824
GIMAP2 GTPase, IMAP family member 2 3.79824
OTUD6A OTU deubiquitinase 6A 3.79824
RAX retina and anterior neural fold homeobox 3.79824
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.79824
TBX21 T-box 21 3.79824
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.79824
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.79824
CCDC116 coiled-coil domain containing 116 3.79824
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.79824
MYBPHL myosin binding protein H-like 3.79824
OR5B12 olfactory receptor, family 5, subfamily B, member 12 3.79824
PI16 peptidase inhibitor 16 3.79824
ANKRD22 ankyrin repeat domain 22 3.79824
POSTN periostin, osteoblast specific factor 3.79824
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.79824
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.79824
SPACA5 sperm acrosome associated 5 3.79824
FAM181B family with sequence similarity 181, member B 3.79824
NMUR1 neuromedin U receptor 1 3.79824
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.79824
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 3.79824
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.79824
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 3.79824
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 3.79824
CD34 CD34 molecule 3.79824
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.79824
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.79824
TNS4 tensin 4 3.79824
OCM2 oncomodulin 2 3.79824
CD68 CD68 molecule 3.79824
TCP11 t-complex 11, testis-specific 3.79824
TRPC5OS TRPC5 opposite strand 3.79824
PRDM13 PR domain containing 13 3.79824
PRDM12 PR domain containing 12 3.79824
BMP3 bone morphogenetic protein 3 3.79824
BMP5 bone morphogenetic protein 5 3.79824
PITX3 paired-like homeodomain 3 3.79824
LOC122394732 uncharacterized LOC122394732 3.79824
OTOS otospiralin 3.79824
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.79824
GPX5 glutathione peroxidase 5 3.79824
STMN4 stathmin-like 4 3.79824
PDC phosducin 3.79824
TRIM31 tripartite motif containing 31 3.79824
ACSL5 acyl-CoA synthetase long-chain family member 5 3.79824
IMPG1 interphotoreceptor matrix proteoglycan 1 3.79824
PRDM7 PR domain containing 7 3.79824
PTH1R parathyroid hormone 1 receptor 3.79824
GIPC3 GIPC PDZ domain containing family, member 3 3.79824
SPMAP1 sperm microtubule associated protein 1 3.79824
ZC3H11C zinc finger CCCH-type containing 11C 3.79824
NOTCH2NLB notch 2 N-terminal like B 3.79824
RHEX regulator of hemoglobinization and erythroid cell expansion 3.79824
SERTM2 serine rich and transmembrane domain containing 2 3.79824
STPG3 sperm-tail PG-rich repeat containing 3 3.79824
H2BC3 H2B clustered histone 3 3.79824
DEPP1 DEPP autophagy regulator 1 3.79824
SELE selectin E 3.79824
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.79824
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.79824
GDF9 growth differentiation factor 9 3.79824
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.79824
DAO D-amino-acid oxidase 3.79824
LOC122455340 uncharacterized LOC122455340 3.79824
CFAP99 cilia and flagella associated protein 99 3.79824
ARL5C ADP-ribosylation factor-like 5C 3.79824
PTPRH protein tyrosine phosphatase, receptor type, H 3.79824
PRB4 proline-rich protein BstNI subfamily 4 3.79824
CDX1 caudal type homeobox 1 3.79824
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.79824
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.79824
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.79824
GPR85 G protein-coupled receptor 85 3.79824
OOSP1 oocyte secreted protein 1, pseudogene 3.79824
PTH parathyroid hormone 3.79824
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 3.79824
CCR4 chemokine (C-C motif) receptor 4 3.79824
TCF23 transcription factor 23 3.79824
NPFF neuropeptide FF-amide peptide precursor 3.79824
LECT2 leukocyte cell-derived chemotaxin 2 3.79824
SLAMF1 signaling lymphocytic activation molecule family member 1 3.79824
ERAS ES cell expressed Ras 3.79824
C5AR2 complement component 5a receptor 2 3.79824
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.79824
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.79824
ZNF132 zinc finger protein 132 3.79824
NXNL1 nucleoredoxin-like 1 3.79824
CST7 cystatin F (leukocystatin) 3.79824
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.79824
TPSB2 tryptase beta 2 (gene/pseudogene) 3.79824
TRADD TNFRSF1A-associated via death domain 3.79824
LRRC46 leucine rich repeat containing 46 3.79824
FNDC1 fibronectin type III domain containing 1 3.79824
GAL3ST2 galactose-3-O-sulfotransferase 2 3.79824
ZXDA zinc finger, X-linked, duplicated A 3.79824
ALOX15B arachidonate 15-lipoxygenase, type B 3.79824
OR4D10 olfactory receptor, family 4, subfamily D, member 10 3.79824
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.79824
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.79824
HOXD3 homeobox D3 3.79824
PHOSPHO1 phosphatase, orphan 1 3.79824
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.79824
PKDREJ polycystin (PKD) family receptor for egg jelly 3.79824
CBX8 chromobox homolog 8 3.79824
IBSP integrin-binding sialoprotein 3.79824
MOG myelin oligodendrocyte glycoprotein 3.79824
KLHDC1 kelch domain containing 1 3.79824
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.79824
HPGDS hematopoietic prostaglandin D synthase 3.79824
EOMES eomesodermin 3.79824
CCDC178 coiled-coil domain containing 178 3.79824
FOXS1 forkhead box S1 3.79824
PRH2 proline-rich protein HaeIII subfamily 2 3.79824
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.79824
AMN amnion associated transmembrane protein 3.79824
IL36R interleukin 36 receptor 3.79824
SMR3B submaxillary gland androgen regulated protein 3B 3.79824
COX7B2 cytochrome c oxidase subunit VIIb2 3.79824
CHI3L2 chitinase 3-like 2 3.79824
KLK14 kallikrein-related peptidase 14 3.79824
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.79824
ITGA11 integrin, alpha 11 3.79824
RBM28 RNA binding motif protein 28 3.79824
CFI complement factor I 3.79824
GPBAR1 G protein-coupled bile acid receptor 1 3.79824
LAMP3 lysosomal-associated membrane protein 3 3.79824
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 3.79824
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.79824
IFITM10 interferon induced transmembrane protein 10 3.79824
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.79824
ARGFX arginine-fifty homeobox 3.79824
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.79824
TAS2R42 taste receptor, type 2, member 42 3.79824
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.79824
HEPACAM hepatic and glial cell adhesion molecule 3.79824
TMPRSS13 transmembrane protease, serine 13 3.79824
TGM7 transglutaminase 7 3.79824
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.79824
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.79824
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.79824
BANF2 barrier to autointegration factor 2 3.79824
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.79824
PLGLB2 plasminogen-like B2 3.79824
BOD1L2 biorientation of chromosomes in cell division 1-like 2 3.79824
IL33 interleukin 33 3.79824
PXT1 peroxisomal, testis specific 1 3.79824
NBPF10 neuroblastoma breakpoint family, member 10 3.76878
AQP4 aquaporin 4 3.48844
LAMA4 laminin, alpha 4 3.38468
SPACA9 sperm acrosome associated 9 3.19397
CEP126 centrosomal protein 126kDa 3.18584
CENPV centromere protein V 2.99123
NHSL2 NHS-like 2 2.93169
NGEF neuronal guanine nucleotide exchange factor 2.92728
KIF19 kinesin family member 19 2.92728
SPON2 spondin 2, extracellular matrix protein 2.92728
CDKL5 cyclin-dependent kinase-like 5 2.80951
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.68742
TRIM37 tripartite motif containing 37 2.6695
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.66324
INO80D INO80 complex subunit D 2.6619
ACOT7 acyl-CoA thioesterase 7 2.6196
ZNF14 zinc finger protein 14 2.61476
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 2.5507
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.53561
UBQLN4 ubiquilin 4 2.53561
TMEM204 transmembrane protein 204 2.53561
LURAP1L leucine rich adaptor protein 1-like 2.53561
RIMKLB ribosomal modification protein rimK-like family member B 2.45597
MISP3 MISP family member 3 2.43164
PGLYRP1 peptidoglycan recognition protein 1 2.43118
RAD51B RAD51 paralog B 2.36561
CTBP1 C-terminal binding protein 1 2.34878
SLC25A43 solute carrier family 25, member 43 2.33464
SRSF12 serine/arginine-rich splicing factor 12 2.32068
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.31803
ESD esterase D 2.31452
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.30469
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.30313
FEM1C fem-1 homolog c (C. elegans) 2.30313
DPH6 diphthamine biosynthesis 6 2.29808
RPUSD1 RNA pseudouridylate synthase domain containing 1 2.29608
FGD3 FYVE, RhoGEF and PH domain containing 3 2.29175
RPL32 ribosomal protein L32 2.28229
TMEM161A transmembrane protein 161A 2.27021
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 2.25328
HMGXB4 HMG box domain containing 4 2.18142
FYCO1 FYVE and coiled-coil domain containing 1 2.17972
ZSCAN31 zinc finger and SCAN domain containing 31 2.16432
CXORF38 chromosome X open reading frame 38 2.16432
GPHRB golgi pH regulator B 2.16432
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.1521
KCTD6 potassium channel tetramerization domain containing 6 2.14734
ZFHX3 zinc finger homeobox 3 2.12104
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.12104
MAML1 mastermind-like 1 (Drosophila) 2.12104
RUSC2 RUN and SH3 domain containing 2 2.12104
MIB2 mindbomb E3 ubiquitin protein ligase 2 2.11494
SAYSD1 SAYSVFN motif domain containing 1 2.10387
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.10384
HMGXB3 HMG box domain containing 3 2.0952
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.0813
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.06007
APOM apolipoprotein M 2.05171
TTBK2 tau tubulin kinase 2 2.04339
PCDHGA10 protocadherin gamma subfamily A, 10 2.03011
EPAS1 endothelial PAS domain protein 1 2.02802
ANGPTL4 angiopoietin-like 4 2.02802
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 2.02574
SIRT2 sirtuin 2 2.0185
BZW2 basic leucine zipper and W2 domains 2 2.00887

decreased expression

Symbol Name Standardized Value
TRIM38 tripartite motif containing 38 -3.79824
ITPKB inositol-trisphosphate 3-kinase B -3.79824
EGFL6 EGF-like-domain, multiple 6 -3.79824
NT5E 5'-nucleotidase, ecto (CD73) -3.79824
OXCT2 3-oxoacid CoA transferase 2 -3.79824
FYB2 FYN binding protein 2 -3.79824
DSCAML1 Down syndrome cell adhesion molecule like 1 -3.79824
C2 complement component 2 -3.79824
METRN meteorin, glial cell differentiation regulator -3.79824
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -3.79824
IGFLR1 IGF-like family receptor 1 -3.77335
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -3.44765
TMEM144 transmembrane protein 144 -3.40293
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -3.38468
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.38468
PNPLA1 patatin-like phospholipase domain containing 1 -3.38468
ZBTB42 zinc finger and BTB domain containing 42 -3.38468
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -3.38468
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -3.38468
CARD6 caspase recruitment domain family, member 6 -3.38468
FGF18 fibroblast growth factor 18 -3.38468
PCDHB12 protocadherin beta 12 -3.38468
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -3.38468
CD226 CD226 molecule -3.38468
PRB3 proline-rich protein BstNI subfamily 3 -3.38468
FAM9B family with sequence similarity 9, member B -3.38468
TAFA3 TAFA chemokine like family member 3 -3.38468
CCN3 cellular communication network factor 3 -3.38468
PDCD1LG2 programmed cell death 1 ligand 2 -3.38468
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.38468
VWA7 von Willebrand factor A domain containing 7 -3.38468
TREH trehalase (brush-border membrane glycoprotein) -3.38468
GRK7 G protein-coupled receptor kinase 7 -3.38468
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -3.38468
WFDC8 WAP four-disulfide core domain 8 -3.38468
KLF1 Kruppel-like factor 1 (erythroid) -3.38468
POU4F1 POU class 4 homeobox 1 -3.38468
C11ORF91 chromosome 11 open reading frame 91 -3.38468
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 -3.38468
CCL28 chemokine (C-C motif) ligand 28 -3.30834
FREM3 FRAS1 related extracellular matrix 3 -3.20616
GPAT3 glycerol-3-phosphate acyltransferase 3 -3.20616
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -3.01155
S1PR1 sphingosine-1-phosphate receptor 1 -2.99436
H2BC18 H2B clustered histone 18 -2.97296
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.95837
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.93169
AMMECR1L AMMECR1-like -2.90525
PLPPR1 phospholipid phosphatase related 1 -2.80738
NPY5R neuropeptide Y receptor Y5 -2.76289
APEH acylaminoacyl-peptide hydrolase -2.74999
LDHD lactate dehydrogenase D -2.67427
DRC8 dynein regulatory complex subunit 8 -2.60811
CHMP4A charged multivesicular body protein 4A -2.57105
BCL3 B-cell CLL/lymphoma 3 -2.46338
PTCH1 patched 1 -2.45597
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -2.45488
COL8A1 collagen, type VIII, alpha 1 -2.42253
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.40775
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.38242
MTARC1 mitochondrial amidoxime reducing component 1 -2.38242
DNAAF3 dynein, axonemal, assembly factor 3 -2.36561
ETF1 eukaryotic translation termination factor 1 -2.36561
STX10 syntaxin 10 -2.32033
MIER1 mesoderm induction early response 1, transcriptional regulator -2.31453
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -2.31003
CATSPERQ catsper channel auxiliary subunit theta -2.30313
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.29175
SOGA3 SOGA family member 3 -2.29175
IRF4 interferon regulatory factor 4 -2.29175
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.29175
JADE1 jade family PHD finger 1 -2.28723
TAS2R31 taste receptor, type 2, member 31 -2.28288
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -2.26721
ADNP activity-dependent neuroprotector homeobox -2.26721
RGMB repulsive guidance molecule family member b -2.24187
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -2.19524
EEF1AKMT2 EEF1A lysine methyltransferase 2 -2.16432
RSPRY1 ring finger and SPRY domain containing 1 -2.14202
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.13813
MTO1 mitochondrial tRNA translation optimization 1 -2.12753
ACACB acetyl-CoA carboxylase beta -2.1219
FBXL2 F-box and leucine-rich repeat protein 2 -2.12104
GBA1 glucosylceramidase beta 1 -2.12104
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.12104
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.11108
SH3KBP1 SH3-domain kinase binding protein 1 -2.11108
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.11108
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.11108
TST thiosulfate sulfurtransferase (rhodanese) -2.10387
PBDC1 polysaccharide biosynthesis domain containing 1 -2.10384
GIPR gastric inhibitory polypeptide receptor -2.10281
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.10281
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -2.102
SLC35F3 solute carrier family 35, member F3 -2.09988
SPEF2 sperm flagellar 2 -2.08034
MTPN myotrophin -2.07151
ZNF589 zinc finger protein 589 -2.06085
TLR2 toll-like receptor 2 -2.06007
CARD8 caspase recruitment domain family, member 8 -2.06007
OXTR oxytocin receptor -2.06007
NOS2 nitric oxide synthase 2, inducible -2.06007
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.06007
USP9X ubiquitin specific peptidase 9, X-linked -2.04339
MIMS1 mitochondrial inner membrane scaffold 1 -2.04107
NCEH1 neutral cholesterol ester hydrolase 1 -2.0342
LIME1 Lck interacting transmembrane adaptor 1 -2.0342
ZIK1 zinc finger protein interacting with K protein 1 -2.00802
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.00089