YWHAE Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon|This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 7531)
External Link http://www.ncbi.nlm.nih.gov/gene/7531
Similar Terms
Downloads & Tools

Genes

211 interacting proteins for hub protein YWHAE from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM22 ADAM metallopeptidase domain 22
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADRM1 adhesion regulating molecule 1
AGXT alanine-glyoxylate aminotransferase
AKAP13 A kinase (PRKA) anchor protein 13
ALDOA aldolase A, fructose-bisphosphate
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN1 ataxin 1
BAD BCL2-associated agonist of cell death
BCR breakpoint cluster region
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF84 chromosome 11 open reading frame 84
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC37 cell division cycle 37
CDK11B cyclin-dependent kinase 11B
CDK14 cyclin-dependent kinase 14
CDK16 cyclin-dependent kinase 16
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP95 centrosomal protein 95kDa
CFAP43 cilia and flagella associated protein 43
CGNL1 cingulin-like 1
CHAF1A chromatin assembly factor 1, subunit A (p150)
CLNS1A chloride channel, nucleotide-sensitive, 1A
COPRS coordinator of PRMT5, differentiation stimulator
COX2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DISC1 disrupted in schizophrenia 1
DLG4 discs, large homolog 4 (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
EMD emerin
ENKD1 enkurin domain containing 1
FAM13B family with sequence similarity 13, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GPI glucose-6-phosphate isomerase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAP2 GRB2-related adaptor protein 2
GRB10 growth factor receptor-bound protein 10
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDAC9 histone deacetylase 9
HDLBP high density lipoprotein binding protein
HDX highly divergent homeobox
HIST2H4B histone cluster 2, H4b
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HNF1A HNF1 homeobox A
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGF1R insulin-like growth factor 1 receptor
ILF2 interleukin enhancer binding factor 2
ING1 inhibitor of growth family, member 1
IPO8 importin 8
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK9 potassium channel, two pore domain subfamily K, member 9
KIAA0232 KIAA0232
KIF1C kinesin family member 1C
KIF23 kinesin family member 23
KLC1 kinesin light chain 1
KPNB1 karyopherin (importin) beta 1
KRT18 keratin 18, type I
KSR1 kinase suppressor of ras 1
LDHB lactate dehydrogenase B
LRMP lymphoid-restricted membrane protein
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MDM4 MDM4, p53 regulator
MSL2 male-specific lethal 2 homolog (Drosophila)
MST1R macrophage stimulating 1 receptor
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NCOR2 nuclear receptor corepressor 2
NDEL1 nudE neurodevelopment protein 1-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUAK1 NUAK family, SNF1-like kinase, 1
PAPOLA poly(A) polymerase alpha
PARD6G par-6 family cell polarity regulator gamma
PCBP1 poly(rC) binding protein 1
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PKM pyruvate kinase, muscle
PNLIP pancreatic lipase
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCG protein kinase C, gamma
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
QPCTL glutaminyl-peptide cyclotransferase-like
RACGAP1 Rac GTPase activating protein 1
RAD52 RAD52 homolog (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1GAP2 RAP1 GTPase activating protein 2
RASAL3 RAS protein activator like 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM10 RNA binding motif protein 10
RBMXL1 RNA binding motif protein, X-linked-like 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS3 regulator of G-protein signaling 3
RICTOR RPTOR independent companion of MTOR, complex 2
RIN1 Ras and Rab interactor 1
RIPK3 receptor-interacting serine-threonine kinase 3
RPGR retinitis pigmentosa GTPase regulator
RPL4 ribosomal protein L4
RPL6 ribosomal protein L6
RPLP0 ribosomal protein, large, P0
RPS3 ribosomal protein S3
RPS8 ribosomal protein S8
RUVBL2 RuvB-like AAA ATPase 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SH3BP4 SH3-domain binding protein 4
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORBS2 sorbin and SH3 domain containing 2
SPIN1 spindlin 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SSFA2 sperm specific antigen 2
STOML2 stomatin (EPB72)-like 2
SYN2 synapsin II
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAZ tafazzin
TBC1D3 TBC1 domain family, member 3
TBC1D3F TBC1 domain family, member 3F
TBK1 TANK-binding kinase 1
TBP TATA box binding protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB1 transforming growth factor, beta 1
TKT transketolase
TLK1 tousled-like kinase 1
TMPO thymopoietin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUBA3E tubulin, alpha 3e
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
ULK2 unc-51 like autophagy activating kinase 2
USP43 ubiquitin specific peptidase 43
VIM vimentin
WNK1 WNK lysine deficient protein kinase 1
WWTR1 WW domain containing transcription regulator 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF839 zinc finger protein 839