YWHAQ Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta|This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10971)
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Genes

330 genes differentially expressed following the YWHAQ gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TPBGL trophoblast glycoprotein-like 3.1702
FOXA1 forkhead box A1 3.1702
PKP1 plakophilin 1 3.1702
SOX18 SRY (sex determining region Y)-box 18 3.1702
TCHH trichohyalin 3.1702
SKOR2 SKI family transcriptional corepressor 2 3.1702
PAX2 paired box 2 3.1702
SIGLEC9 sialic acid binding Ig-like lectin 9 3.1702
OLFM4 olfactomedin 4 3.1702
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.1702
CD160 CD160 molecule 3.1702
MAGEA8 melanoma antigen family A8 3.1702
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.1702
CD93 CD93 molecule 3.1702
ASB15 ankyrin repeat and SOCS box containing 15 3.1702
ZNF503 zinc finger protein 503 3.1702
COLEC10 collectin sub-family member 10 (C-type lectin) 3.1702
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.1702
LIPH lipase, member H 3.1702
HPCAL4 hippocalcin like 4 3.1702
IL22RA1 interleukin 22 receptor, alpha 1 3.1702
PLIN1 perilipin 1 3.1702
NEU4 sialidase 4 3.1702
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.1702
THEMIS thymocyte selection associated 3.1702
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.1702
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.1702
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.1702
TDO2 tryptophan 2,3-dioxygenase 3.1702
EPHB3 EPH receptor B3 3.1702
CCDC87 coiled-coil domain containing 87 3.1702
IL23R interleukin 23 receptor 3.1702
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.1702
INTS9 integrator complex subunit 9 3.1702
PRSS41 protease, serine, 41 3.1702
PRDM13 PR domain containing 13 3.1702
GPR26 G protein-coupled receptor 26 3.1702
POSTN periostin, osteoblast specific factor 3.1702
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.1702
ARRDC5 arrestin domain containing 5 3.1702
CLEC5A C-type lectin domain family 5, member A 3.1702
LONRF2 LON peptidase N-terminal domain and ring finger 2 3.1702
LRRC63 leucine rich repeat containing 63 3.1702
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 3.1702
TAS2R13 taste receptor, type 2, member 13 3.1702
OR5A2 olfactory receptor, family 5, subfamily A, member 2 3.1702
HABP2 hyaluronan binding protein 2 3.1702
CATSPERT catsper channel auxiliary subunit tau 3.1702
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.1702
RAX2 retina and anterior neural fold homeobox 2 3.1702
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 3.1702
HTRA4 HtrA serine peptidase 4 3.1702
ELOVL3 ELOVL fatty acid elongase 3 3.1702
STX1B syntaxin 1B 3.1702
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.1702
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.1702
ASB4 ankyrin repeat and SOCS box containing 4 3.1702
RAB6D RAB6D, member RAS oncogene family 3.1702
CCN6 cellular communication network factor 6 3.1702
PLPP4 phospholipid phosphatase 4 3.1702
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.1702
CIMIP4 ciliary microtubule inner protein 4 3.1702
C17ORF113 chromosome 17 open reading frame 113 3.1702
MINDY4B MINDY family member 4B 3.1702
ARMH2 armadillo like helical domain containing 2 3.1702
CCDC197 coiled-coil domain containing 197 3.1702
GARIN6 golgi associated RAB2 interactor family member 6 3.1702
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.1702
SOFU1 sperm-oocyte fusion factor 1 3.1702
RDH8 retinol dehydrogenase 8 (all-trans) 3.1702
GPR37L1 G protein-coupled receptor 37 like 1 3.1702
C1ORF162 chromosome 1 open reading frame 162 3.1702
CXCL16 chemokine (C-X-C motif) ligand 16 3.1702
TMCO2 transmembrane and coiled-coil domains 2 3.1702
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.1702
LGALS7B lectin, galactoside-binding, soluble, 7B 3.1702
FAM170A family with sequence similarity 170, member A 3.1702
RLBP1 retinaldehyde binding protein 1 3.1702
TBX20 T-box 20 3.1702
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.1702
PDC phosducin 3.1702
TLR6 toll-like receptor 6 3.1702
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.1702
CLEC6A C-type lectin domain family 6, member A 3.1702
CSAG2 CSAG family, member 2 3.1702
TUBA4B tubulin, alpha 4b 3.1702
LRRC72 leucine rich repeat containing 72 3.1702
IL1RN interleukin 1 receptor antagonist 3.1702
CELA2A chymotrypsin-like elastase family, member 2A 3.1702
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.1702
CCR8 chemokine (C-C motif) receptor 8 3.1702
NPFF neuropeptide FF-amide peptide precursor 3.1702
TAS2R3 taste receptor, type 2, member 3 3.1702
CD3G CD3g molecule, gamma (CD3-TCR complex) 3.1702
AGXT2 alanine--glyoxylate aminotransferase 2 3.1702
ERICH6 glutamate-rich 6 3.1702
MRLN myoregulin 3.1702
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.1702
NPIPB15 nuclear pore complex interacting protein family, member B15 3.1702
LRRC32 leucine rich repeat containing 32 3.1702
KRT14 keratin 14, type I 3.1702
IGLL1 immunoglobulin lambda-like polypeptide 1 3.1702
SLC38A3 solute carrier family 38, member 3 3.1702
RAB27B RAB27B, member RAS oncogene family 3.1702
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.1702
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.1702
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.1702
TBC1D28 TBC1 domain family, member 28 3.1702
EPX eosinophil peroxidase 3.1702
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.1702
ADGRF4 adhesion G protein-coupled receptor F4 3.1702
CLUL1 clusterin-like 1 (retinal) 3.1702
CLDN34 claudin 34 3.1702
EFCAB3 EF-hand calcium binding domain 3 3.1702
IL18 interleukin 18 3.1702
THBD thrombomodulin 3.1702
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.1702
SST somatostatin 3.1702
POU2AF1 POU class 2 associating factor 1 3.1702
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.1702
ZC3H12D zinc finger CCCH-type containing 12D 3.1702
TMEM207 transmembrane protein 207 3.1702
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.1702
WFDC8 WAP four-disulfide core domain 8 3.1702
CLEC9A C-type lectin domain family 9, member A 3.1702
OR1M1 olfactory receptor, family 1, subfamily M, member 1 3.1702
CDHR5 cadherin-related family member 5 3.1702
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.1702
MAT2A methionine adenosyltransferase II, alpha 3.1702
AQP7 aquaporin 7 3.1702
THTPA thiamine triphosphatase 3.1702
FITM1 fat storage-inducing transmembrane protein 1 3.1702
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.1702
PITX1 paired-like homeodomain 1 3.1702
LHB luteinizing hormone beta polypeptide 3.1702
GOLGA8R golgin A8 family, member R 3.1702
SPNS3 spinster homolog 3 (Drosophila) 3.1702
SLC36A3 solute carrier family 36, member 3 3.1702
TAS2R46 taste receptor, type 2, member 46 3.1702
CFB complement factor B 3.1702
ACSM2B acyl-CoA synthetase medium-chain family member 2B 3.1702
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 3.1702
CRTAM cytotoxic and regulatory T cell molecule 3.1702
STOML3 stomatin (EPB72)-like 3 3.1702
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.1702
GOLGA8M golgin A8 family, member M 3.1702
BTG4 B-cell translocation gene 4 3.1702
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.1702
GSTA2 glutathione S-transferase alpha 2 3.1702
PLA2G2C phospholipase A2, group IIC 3.1702
TSPAN19 tetraspanin 19 3.1702
SNTN sentan, cilia apical structure protein 3.1702
ESPNL espin-like 3.1702
OR2H2 olfactory receptor, family 2, subfamily H, member 2 3.1702
ADAM12 ADAM metallopeptidase domain 12 3.1702
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.1702
DIDO1 death inducer-obliterator 1 3.13844
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 3.1073
PTPN11 protein tyrosine phosphatase, non-receptor type 11 3.10647
STRBP spermatid perinuclear RNA binding protein 2.9675
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 2.91304
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 2.85806
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.81312
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 2.77945
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 2.76034
POLI polymerase (DNA directed) iota 2.6913
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 2.65961
EBNA1BP2 EBNA1 binding protein 2 2.65961
C3ORF18 chromosome 3 open reading frame 18 2.65487
RANBP1 RAN binding protein 1 2.6187
TSHR thyroid stimulating hormone receptor 2.5491
TXN thioredoxin 2.53407
SCAI suppressor of cancer cell invasion 2.51913
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.47257
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.47257
ARID5A AT rich interactive domain 5A (MRF1-like) 2.43449
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.4037
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.40335
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 2.39246
RPL28 ribosomal protein L28 2.36719
NOTCH2NLA notch 2 N-terminal like A 2.36599
RPL13 ribosomal protein L13 2.354
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough 2.34652
ZNF621 zinc finger protein 621 2.32732
NFE2L2 nuclear factor, erythroid 2-like 2 2.32732
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.29603
TTC31 tetratricopeptide repeat domain 31 2.28746
AOPEP aminopeptidase O (putative) 2.28603
TFAM transcription factor A, mitochondrial 2.27911
RPL37A ribosomal protein L37a 2.27411
PRR12 proline rich 12 2.26751
WDR1 WD repeat domain 1 2.26164
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.26164
GCSH glycine cleavage system protein H (aminomethyl carrier) 2.22978
H2AX H2A.X variant histone 2.2292
GPR39 G protein-coupled receptor 39 2.22056
RRP1B ribosomal RNA processing 1B 2.20823
OXCT1 3-oxoacid CoA transferase 1 2.20822
LYPLAL1 lysophospholipase-like 1 2.20087
CNTN5 contactin 5 2.17628
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.17628
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.17628
NGFR nerve growth factor receptor 2.17628
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.17628
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.17628
DMRT1 doublesex and mab-3 related transcription factor 1 2.17628
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.17628
EMP2 epithelial membrane protein 2 2.17222
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.1679
FGF13 fibroblast growth factor 13 2.1679
ZNF189 zinc finger protein 189 2.1679
RNF38 ring finger protein 38 2.1639
ICE1 interactor of little elongation complex ELL subunit 1 2.15988
ARHGAP24 Rho GTPase activating protein 24 2.14211
AP4M1 adaptor-related protein complex 4, mu 1 subunit 2.13549
LAG3 lymphocyte-activation gene 3 2.1283
PRRT4 proline-rich transmembrane protein 4 2.10541
DRC4 dynein regulatory complex subunit 4 2.10311
FUBP3 far upstream element (FUSE) binding protein 3 2.10307
LRRN3 leucine rich repeat neuronal 3 2.0966
KRT10 keratin 10, type I 2.09403
NBAS neuroblastoma amplified sequence 2.06328
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.0586
TPI1 triosephosphate isomerase 1 2.05699
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.05699
ATCAY ataxia, cerebellar, Cayman type 2.03901
RBM4B RNA binding motif protein 4B 2.03518
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 2.0293
CLTCL1 clathrin, heavy chain-like 1 2.02815

decreased expression

Symbol Name Standardized Value
IGFL3 IGF-like family member 3 -3.1702
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.1702
LPO lactoperoxidase -3.1702
TNMD tenomodulin -3.1702
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -3.1702
CD86 CD86 molecule -3.1702
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.1702
FGF16 fibroblast growth factor 16 -3.1702
FOXD1 forkhead box D1 -3.1702
CD19 CD19 molecule -3.1702
ZNF132 zinc finger protein 132 -3.1702
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -3.1702
MEIG1 meiosis/spermiogenesis associated 1 -3.1702
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -3.1702
TDRD6 tudor domain containing 6 -3.1702
GJA4 gap junction protein, alpha 4, 37kDa -3.1702
MEP1B meprin A, beta -3.1702
BMP1 bone morphogenetic protein 1 -3.1702
TMC2 transmembrane channel-like 2 -3.1702
IKZF1 IKAROS family zinc finger 1 (Ikaros) -3.1702
ETV2 ets variant 2 -3.1702
EMCN endomucin -3.1702
HIGD1C HIG1 hypoxia inducible domain family, member 1C -3.1702
OLAH oleoyl-ACP hydrolase -3.1702
ITGA11 integrin, alpha 11 -3.1702
TTC16 tetratricopeptide repeat domain 16 -3.1702
MISP3 MISP family member 3 -3.1702
GOLGA6L7 golgin A6 family like 7 -3.1702
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -3.1702
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.1702
ANKRD55 ankyrin repeat domain 55 -3.1702
FAM163B family with sequence similarity 163, member B -3.1702
AQP4 aquaporin 4 -3.1702
GLIPR1L2 GLI pathogenesis-related 1 like 2 -3.1702
MEIOSIN meiosis initiator -3.1702
S100G S100 calcium binding protein G -3.1702
VAV1 vav 1 guanine nucleotide exchange factor -3.1702
GPR150 G protein-coupled receptor 150 -3.1702
H3-7 H3.7 histone (putative) -3.1702
OR56A4 olfactory receptor, family 56, subfamily A, member 4 -3.1702
ZNF365 zinc finger protein 365 -3.1702
BRICD5 BRICHOS domain containing 5 -3.1702
SYCE3 synaptonemal complex central element protein 3 -3.06912
TK1 thymidine kinase 1, soluble -2.88595
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.84389
RAB33A RAB33A, member RAS oncogene family -2.83614
ZRANB3 zinc finger, RAN-binding domain containing 3 -2.83363
ZNF692 zinc finger protein 692 -2.81839
ARHGAP8 Rho GTPase activating protein 8 -2.76825
CFAP96 cilia and flagella associated protein 96 -2.7651
ULK1 unc-51 like autophagy activating kinase 1 -2.74266
IL6ST-DT IL6ST divergent transcript -2.72045
RREB1 ras responsive element binding protein 1 -2.69619
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -2.69619
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.68295
ARL9 ADP-ribosylation factor-like 9 -2.57555
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.53611
CSNK1D casein kinase 1, delta -2.50618
SDHAF2 succinate dehydrogenase complex assembly factor 2 -2.50473
ACTA1 actin, alpha 1, skeletal muscle -2.46184
MYO7A myosin VIIA -2.46184
CYB5D2 cytochrome b5 domain containing 2 -2.46184
ZNF691 zinc finger protein 691 -2.45359
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -2.43895
FAM111A family with sequence similarity 111, member A -2.43629
USP6 ubiquitin specific peptidase 6 -2.42056
PIR pirin (iron-binding nuclear protein) -2.36527
ZBTB39 zinc finger and BTB domain containing 39 -2.32365
CCNE1 cyclin E1 -2.31476
C11ORF98 chromosome 11 open reading frame 98 -2.29446
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.28603
EXOSC4 exosome component 4 -2.27772
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -2.2575
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.25203
GSKIP GSK3B interacting protein -2.25203
KEL Kell blood group, metallo-endopeptidase -2.23997
DDB2 damage-specific DNA binding protein 2, 48kDa -2.23429
LYG2 lysozyme G-like 2 -2.23429
ZNF90 zinc finger protein 90 -2.23429
PHLDA1 pleckstrin homology-like domain, family A, member 1 -2.23369
COX20 COX20 cytochrome c oxidase assembly factor -2.22662
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.21051
C11ORF58 chromosome 11 open reading frame 58 -2.20158
MFSD2B major facilitator superfamily domain containing 2B -2.17628
ZNF121 zinc finger protein 121 -2.16773
DNAAF8 dynein axonemal assembly factor 8 -2.1603
RNASE4 ribonuclease, RNase A family, 4 -2.1603
COL9A1 collagen, type IX, alpha 1 -2.14239
RBFA ribosome binding factor A (putative) -2.14239
DRP2 dystrophin related protein 2 -2.12738
ZNF227 zinc finger protein 227 -2.10311
MYB v-myb avian myeloblastosis viral oncogene homolog -2.10304
BORCS7 BLOC-1 related complex subunit 7 -2.0966
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.06825
ITGA7 integrin, alpha 7 -2.06825
YAP1 Yes-associated protein 1 -2.06328
FAM20C family with sequence similarity 20, member C -2.06328
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.05699
NKAIN2 Na+/K+ transporting ATPase interacting 2 -2.04471
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 -2.03954
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.0293