YY1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description YY1 transcription factor|YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7528)
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Genes

351 genes differentially expressed following the YY1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.78275
DEFB105A defensin, beta 105A 3.78275
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.78275
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.78275
PGA5 pepsinogen 5, group I (pepsinogen A) 3.78275
SAA4 serum amyloid A4, constitutive 3.78275
UTS2 urotensin 2 3.78275
PGLYRP2 peptidoglycan recognition protein 2 3.78275
TRPC5OS TRPC5 opposite strand 3.78275
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.78275
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.78275
MUC22 mucin 22 3.78275
HBZ hemoglobin, zeta 3.78275
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.78275
TSPO2 translocator protein 2 3.78275
CD68 CD68 molecule 3.78275
LOC102724877 uncharacterized LOC102724877 3.78275
ERAP2 endoplasmic reticulum aminopeptidase 2 3.78275
BTBD16 BTB (POZ) domain containing 16 3.78275
TAS2R43 taste receptor, type 2, member 43 3.78275
ANGPTL3 angiopoietin-like 3 3.78275
IL37 interleukin 37 3.78275
CNTN6 contactin 6 3.78275
PCDHGC3 protocadherin gamma subfamily C, 3 3.78275
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.78275
ZNF648 zinc finger protein 648 3.78275
LPA lipoprotein, Lp(a) 3.78275
NLRP4 NLR family, pyrin domain containing 4 3.78275
MROH2A maestro heat-like repeat family member 2A 3.78275
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.78275
LRRC72 leucine rich repeat containing 72 3.78275
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.78275
ABRA actin binding Rho activating protein 3.78275
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.78275
BARX2 BARX homeobox 2 3.78275
TMEM217 transmembrane protein 217 3.78275
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.78275
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.78275
ZNF503 zinc finger protein 503 3.78275
SCRT1 scratch family zinc finger 1 3.78275
NKAPL NFKB activating protein-like 3.78275
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.78275
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.78275
ESM1 endothelial cell-specific molecule 1 3.78275
COL20A1 collagen, type XX, alpha 1 3.78275
HLX H2.0-like homeobox 3.78275
TPBGL trophoblast glycoprotein-like 3.78275
SLC22A10 solute carrier family 22, member 10 3.78275
CLDN9 claudin 9 3.78275
CPNE6 copine VI (neuronal) 3.78275
PVRIG poliovirus receptor related immunoglobulin domain containing 3.78275
DMBX1 diencephalon/mesencephalon homeobox 1 3.78275
GDF10 growth differentiation factor 10 3.78275
HES5 hes family bHLH transcription factor 5 3.78275
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.78275
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.78275
NRROS negative regulator of reactive oxygen species 3.78275
SBSN suprabasin 3.78275
GPR21 G protein-coupled receptor 21 3.78275
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.78275
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.78275
OLIG3 oligodendrocyte transcription factor 3 3.78275
WT1 Wilms tumor 1 3.78275
S100G S100 calcium binding protein G 3.78275
EXOC3L4 exocyst complex component 3-like 4 3.78275
TCF23 transcription factor 23 3.78275
TM4SF20 transmembrane 4 L six family member 20 3.78275
SPDYC speedy/RINGO cell cycle regulator family member C 3.78275
SSTR1 somatostatin receptor 1 3.78275
IL12RB1 interleukin 12 receptor, beta 1 3.78275
ST18 suppression of tumorigenicity 18, zinc finger 3.78275
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.78275
KLK3 kallikrein-related peptidase 3 3.78275
KLK5 kallikrein-related peptidase 5 3.78275
DHH desert hedgehog 3.78275
MUC13 mucin 13, cell surface associated 3.78275
PNLIPRP3 pancreatic lipase-related protein 3 3.78275
CRHR1 corticotropin releasing hormone receptor 1 3.78275
C22ORF42 chromosome 22 open reading frame 42 3.78275
C11ORF16 chromosome 11 open reading frame 16 3.78275
WFDC9 WAP four-disulfide core domain 9 3.78275
WFDC5 WAP four-disulfide core domain 5 3.78275
KLF2 Kruppel-like factor 2 3.78275
CTAGE9 CTAGE family, member 9 3.78275
AQP8 aquaporin 8 3.78275
RESP18 regulated endocrine-specific protein 18 3.78275
MUC7 mucin 7, secreted 3.78275
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.78275
ZAR1 zygote arrest 1 3.78275
H2BK1 H2B.K variant histone 1 3.78275
ZNF593OS ZNF593 opposite strand 3.78275
CFAP107 cilia and flagella associated protein 107 3.78275
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.78275
GOLGA6L22 golgin A6 family-like 22 3.78275
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.78275
IDI2 isopentenyl-diphosphate delta isomerase 2 3.78275
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.78275
LYZ lysozyme 3.78275
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.78275
GSTA2 glutathione S-transferase alpha 2 3.78275
TPPP3 tubulin polymerization-promoting protein family member 3 3.78275
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.78275
IL9R interleukin 9 receptor 3.78275
LRTM2 leucine-rich repeats and transmembrane domains 2 3.78275
CCDC166 coiled-coil domain containing 166 3.78275
SPATA25 spermatogenesis associated 25 3.78275
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.78275
ADRB3 adrenoceptor beta 3 3.78275
PRSS55 protease, serine, 55 3.78275
DMTN dematin actin binding protein 3.78275
TRIM29 tripartite motif containing 29 3.78275
RGR retinal G protein coupled receptor 3.78275
ERP27 endoplasmic reticulum protein 27 3.78275
TTR transthyretin 3.78275
CHRM1 cholinergic receptor, muscarinic 1 3.78275
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.78275
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.78275
GCM2 glial cells missing homolog 2 (Drosophila) 3.78275
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.78275
SMYD1 SET and MYND domain containing 1 3.78275
STMN4 stathmin-like 4 3.78275
RD3 retinal degeneration 3 3.78275
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.78275
LRRC43 leucine rich repeat containing 43 3.78275
C20ORF202 chromosome 20 open reading frame 202 3.78275
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.78275
HP haptoglobin 3.78275
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.78275
APLNR apelin receptor 3.78275
HRH4 histamine receptor H4 3.73871
PCDHGB2 protocadherin gamma subfamily B, 2 3.73871
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.73871
FANCE Fanconi anemia, complementation group E 3.6701
CD7 CD7 molecule 3.62016
MT2A metallothionein 2A 3.30169
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 3.27375
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 3.16651
SPAG7 sperm associated antigen 7 3.10635
GLI4 GLI family zinc finger 4 3.10131
APC2 adenomatosis polyposis coli 2 2.99117
ZNF414 zinc finger protein 414 2.97254
ISCA2 iron-sulfur cluster assembly 2 2.9639
ZNF84 zinc finger protein 84 2.92882
LINGO3 leucine rich repeat and Ig domain containing 3 2.90554
C4ORF50 chromosome 4 open reading frame 50 2.88081
TSC1 tuberous sclerosis 1 2.80101
IRX3 iroquois homeobox 3 2.77931
NCAM2 neural cell adhesion molecule 2 2.7754
PRKCE protein kinase C, epsilon 2.72827
PCDHGA12 protocadherin gamma subfamily A, 12 2.69841
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.69841
PYDC1 PYD (pyrin domain) containing 1 2.62372
TMEM106B transmembrane protein 106B 2.58362
CFAP210 cilia and flagella associated protein 210 2.55708
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.54464
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.54464
TMEM234 transmembrane protein 234 2.53666
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.4523
RBM18 RNA binding motif protein 18 2.4523
SNCAIP synuclein, alpha interacting protein 2.44971
CLTB clathrin, light chain B 2.42182
MAP7D2 MAP7 domain containing 2 2.4146
NCAPD3 non-SMC condensin II complex, subunit D3 2.3547
SPMIP9 sperm microtubule inner protein 9 2.33795
FPR1 formyl peptide receptor 1 2.33795
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.33795
LHX4 LIM homeobox 4 2.3186
H2AC8 H2A clustered histone 8 2.3186
ADAM29 ADAM metallopeptidase domain 29 2.24444
GATA4 GATA binding protein 4 2.24444
GOLM1 golgi membrane protein 1 2.24358
AKAP7 A kinase (PRKA) anchor protein 7 2.23321
FMNL3 formin-like 3 2.20996
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 2.20996
PAQR6 progestin and adipoQ receptor family member VI 2.20797
C22ORF15 chromosome 22 open reading frame 15 2.20797
LRRC26 leucine rich repeat containing 26 2.20797
LUZP1 leucine zipper protein 1 2.19044
NOD1 nucleotide-binding oligomerization domain containing 1 2.18233
THUMPD1 THUMP domain containing 1 2.18233
EPS15 epidermal growth factor receptor pathway substrate 15 2.16877
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.16877
NEU3 sialidase 3 (membrane sialidase) 2.16877
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.16555
ASMT acetylserotonin O-methyltransferase 2.16496
GARNL3 GTPase activating Rap/RanGAP domain-like 3 2.15021
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.14837
SNTG1 syntrophin, gamma 1 2.14804
RNF114 ring finger protein 114 2.12885
COX20 COX20 cytochrome c oxidase assembly factor 2.12885
MAP1B microtubule-associated protein 1B 2.12843
MPND MPN domain containing 2.09517
DPY30 dpy-30 homolog (C. elegans) 2.07938
ACSS3 acyl-CoA synthetase short-chain family member 3 2.07938
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.07563
GAK cyclin G associated kinase 2.06866
COMMD3 COMM domain containing 3 2.06833
ZNF816 zinc finger protein 816 2.06833
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) 2.0674
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.06218
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.05407
ZNF740 zinc finger protein 740 2.05227
GALR1 galanin receptor 1 2.05141
HHIP hedgehog interacting protein 2.04863
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.04759
CXCL12 chemokine (C-X-C motif) ligand 12 2.04452
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.04175
TNRC18 trinucleotide repeat containing 18 2.04175
ZNF264 zinc finger protein 264 2.04108
SYVN1 synovial apoptosis inhibitor 1, synoviolin 2.03833
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.03597
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.02632
ACOXL acyl-CoA oxidase-like 2.02001
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.01138
VMA12 vacuolar ATPase assembly factor VMA12 2.01078
ZBTB11 zinc finger and BTB domain containing 11 2.01078
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.01078
TMEM245 transmembrane protein 245 2.01078
ATRNL1 attractin-like 1 2.01078
ANO8 anoctamin 8 2.01078
AFTPH aftiphilin 2.01078

decreased expression

Symbol Name Standardized Value
RDH16 retinol dehydrogenase 16 (all-trans) -3.78275
SCGB3A1 secretoglobin, family 3A, member 1 -3.78275
SLC46A2 solute carrier family 46, member 2 -3.78275
SMIM22 small integral membrane protein 22 -3.78275
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -3.78275
CHADL chondroadherin-like -3.78275
PLVAP plasmalemma vesicle associated protein -3.78275
KLHL6 kelch-like family member 6 -3.78275
S100A14 S100 calcium binding protein A14 -3.78275
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -3.78275
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -3.78275
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -3.78275
IRX4 iroquois homeobox 4 -3.78275
NRGN neurogranin (protein kinase C substrate, RC3) -3.78275
ICAM2 intercellular adhesion molecule 2 -3.78275
CAMK1G calcium/calmodulin-dependent protein kinase IG -3.78275
KCNIP3 Kv channel interacting protein 3, calsenilin -3.78275
CDCP2 CUB domain containing protein 2 -3.78275
ADAD2 adenosine deaminase domain containing 2 -3.78275
GPR26 G protein-coupled receptor 26 -3.78275
HRG histidine-rich glycoprotein -3.78275
PTPRH protein tyrosine phosphatase, receptor type, H -3.78275
PDE1B phosphodiesterase 1B, calmodulin-dependent -3.78275
PRDM7 PR domain containing 7 -3.78275
LY6G6D lymphocyte antigen 6 complex, locus G6D -3.78275
CFAP206 cilia and flagella associated protein 206 -3.78275
GOLGA6L7 golgin A6 family like 7 -3.78275
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.78275
GBX2 gastrulation brain homeobox 2 -3.78275
ZC3H11C zinc finger CCCH-type containing 11C -3.78275
SYT5 synaptotagmin V -3.78275
GPR35 G protein-coupled receptor 35 -3.78275
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -3.78275
RTL5 retrotransposon Gag like 5 -3.78275
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -3.78275
STX11 syntaxin 11 -3.78275
DRD3 dopamine receptor D3 -3.78275
SCN4B sodium channel, voltage gated, type IV beta subunit -3.78275
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -3.78275
CXCL13 chemokine (C-X-C motif) ligand 13 -3.78275
TEX29 testis expressed 29 -3.78275
BAG1 BCL2-associated athanogene -3.40444
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -3.3391
VPS35L VPS35 endosomal protein sorting factor like -3.29101
RPL30 ribosomal protein L30 -3.23951
BEND5 BEN domain containing 5 -2.96341
SSUH2 ssu-2 homolog (C. elegans) -2.85002
SLITRK4 SLIT and NTRK-like family, member 4 -2.84382
PURA purine-rich element binding protein A -2.83165
CAPN6 calpain 6 -2.82796
HSPB8 heat shock 22kDa protein 8 -2.80111
LINC02798 long intergenic non-protein coding RNA 2798 -2.7754
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.7754
COL9A2 collagen, type IX, alpha 2 -2.7754
SPAG4 sperm associated antigen 4 -2.7754
SCAF1 SR-related CTD-associated factor 1 -2.67402
RASIP1 Ras interacting protein 1 -2.63283
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.62796
SYT17 synaptotagmin XVII -2.58334
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough -2.55886
TMCO6 transmembrane and coiled-coil domains 6 -2.55607
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.53176
ZNF23 zinc finger protein 23 -2.50556
ZSWIM5 zinc finger, SWIM-type containing 5 -2.50556
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.408
CTSD cathepsin D -2.39502
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.37167
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.36683
VIPR1 vasoactive intestinal peptide receptor 1 -2.35957
PEX11B peroxisomal biogenesis factor 11 beta -2.35182
OTULINL OTU deubiquitinase with linear linkage specificity like -2.35182
IGSF3 immunoglobulin superfamily, member 3 -2.35112
MAP2K1 mitogen-activated protein kinase kinase 1 -2.33864
ZNF92 zinc finger protein 92 -2.29222
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -2.28063
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.28063
TNN tenascin N -2.27065
CNKSR3 CNKSR family member 3 -2.26594
EPHB4 EPH receptor B4 -2.25721
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.24703
MAK male germ cell-associated kinase -2.23321
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.22378
HSBP1L1 heat shock factor binding protein 1-like 1 -2.22343
CHCT1 CHD1 helical C-terminal domain containing 1 -2.22324
GTSF1 gametocyte specific factor 1 -2.22324
PRDM1 PR domain containing 1, with ZNF domain -2.22324
SPMIP3 sperm microtubule inner protein 3 -2.20996
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -2.20996
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -2.20996
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.20996
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.20996
BEAN1 brain expressed, associated with NEDD4, 1 -2.20996
MEIOB meiosis specific with OB domains -2.20996
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.201
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.19261
ZNG1E Zn regulated GTPase metalloprotein activator 1E -2.19044
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.17728
SFRP2 secreted frizzled-related protein 2 -2.16877
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.16877
SCRN1 secernin 1 -2.16877
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.16639
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.16555
GDF5 growth differentiation factor 5 -2.16514
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.15817
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.13067
CHD6 chromodomain helicase DNA binding protein 6 -2.12928
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -2.12885
DUSP19 dual specificity phosphatase 19 -2.12885
STX1B syntaxin 1B -2.12843
MARK4 MAP/microtubule affinity-regulating kinase 4 -2.09889
XPC xeroderma pigmentosum, complementation group C -2.09115
RIC3 RIC3 acetylcholine receptor chaperone -2.08697
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.07938
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -2.06866
CIB1 calcium and integrin binding 1 (calmyrin) -2.06217
TRAPPC1 trafficking protein particle complex 1 -2.05141
SH3D19 SH3 domain containing 19 -2.03597
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.03597
ANKRD44 ankyrin repeat domain 44 -2.03597
FRMD4A FERM domain containing 4A -2.03597
SLC22A31 solute carrier family 22, member 31 -2.03597
SH3YL1 SH3 and SYLF domain containing 1 -2.02442
PTPRA protein tyrosine phosphatase, receptor type, A -2.01534
IL20RB interleukin 20 receptor beta -2.01534
MCOLN3 mucolipin 3 -2.01522
RMI2 RecQ mediated genome instability 2 -2.01485
LARP4B La ribonucleoprotein domain family, member 4B -2.01164
ZNF808 zinc finger protein 808 -2.01164
ZNF266 zinc finger protein 266 -2.01078
SEPTIN10 septin 10 -2.00924