Yersinia infection Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a type three secretion system (T3SS) to express its pathogenicity. Through inactivation of small GTPases by YopT protease, YopE GTPase-activating protein, and YpkA/YopO sequestration of GDP-bound small GTPases, Yersinia prevents its uptake by phagocytic cells and disrupts the actin cytoskeleton. YopH phosphatase shuts down phagocytosis by dephosphorylating key host proteins as well as suppresses T cell activation. Yersinia induces macrophage pyroptosis via YopB/YopD activation of canonical and noncanonical inflammasomes and YopT/YopE-mediated activation of pyrin. These effects are counteracted by YopK and YopM. YopP/J is a member of an ubiquitin-like protein cysteine protease family and simultaneously targets signaling components of the MAPK and NF-kappaB signaling pathways following activation of Toll-like receptor4 to inhibit production of proinflammatory cytokines. (Kyoto Encyclopedia of Genes and Genomes, hsa05135)
External Link https://www.kegg.jp/entry/hsa05135
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Genes

138 proteins participating in the Yersinia infection pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARF6 ADP-ribosylation factor 6
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD4 CD4 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CD8B2 CD8b2 molecule
CDC42 cell division cycle 42
CHUK conserved helix-loop-helix ubiquitous kinase
CLSTN1 calsyntenin 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCL8 chemokine (C-X-C motif) ligand 8
DOCK1 dedicator of cytokinesis 1
ELMO1 engulfment and cell motility 1
ELMO2 engulfment and cell motility 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FYB1 FYN binding protein 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GSK3B glycogen synthase kinase 3 beta
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIMK1 LIM domain kinase 1
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MEFV Mediterranean fever
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NLRP3 NLR family, pyrin domain containing 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKN1 protein kinase N1
PKN2 protein kinase N2
PLCG1 phospholipase C, gamma 1
POTEF POTE ankyrin domain family, member F
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RHOG ras homolog family member G
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SKAP2 src kinase associated phosphoprotein 2
SPNS1 spinster homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa