| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. (Chemical Entities of Biological Interest Ontology, CHEBI_10093) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/8969 |
| Similar Terms | |
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198 proteins with high or low expression in Yohimbine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGA | fibrinogen alpha chain | 3.6 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 2.16 |
| PIP | prolactin-induced protein | 2.01 |
| FGB | fibrinogen beta chain | 1.53 |
| FN1 | fibronectin 1 | 1.52 |
| ANKRD12 | ankyrin repeat domain 12 | 1.37 |
| TEN1 | TEN1 CST complex subunit | 1.22 |
| FAT4 | FAT atypical cadherin 4 | 1.01 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.97 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.96 |
| MIER2 | mesoderm induction early response 1, family member 2 | 0.6 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.58 |
| ENKD1 | enkurin domain containing 1 | 0.52 |
| FBXO41 | F-box protein 41 | 0.51 |
| RNF4 | ring finger protein 4 | 0.47 |
| ZNF302 | zinc finger protein 302 | 0.47 |
| PTMA | prothymosin, alpha | 0.45 |
| CCDC91 | coiled-coil domain containing 91 | 0.44 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.44 |
| TPM2 | tropomyosin 2 (beta) | 0.44 |
| EVL | Enah/Vasp-like | 0.4 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.39 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.38 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.38 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.38 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.38 |
| LMO4 | LIM domain only 4 | 0.35 |
| VGF | VGF nerve growth factor inducible | 0.34 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.33 |
| YAP1 | Yes-associated protein 1 | 0.32 |
| SYAP1 | synapse associated protein 1 | 0.32 |
| CCDC170 | coiled-coil domain containing 170 | 0.32 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.32 |
| PMF1 | polyamine-modulated factor 1 | 0.32 |
| CDCA4 | cell division cycle associated 4 | 0.31 |
| GTSF1 | gametocyte specific factor 1 | 0.31 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.3 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.3 |
| CYBRD1 | cytochrome b reductase 1 | 0.3 |
| ZNF175 | zinc finger protein 175 | 0.3 |
| MIIP | migration and invasion inhibitory protein | 0.3 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.3 |
| ZXDB | zinc finger, X-linked, duplicated B | 0.29 |
| TEPSIN | TEPSIN adaptor related protein complex 4 accessory protein | 0.29 |
| UBAP1 | ubiquitin associated protein 1 | 0.29 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.28 |
| PRR3 | proline rich 3 | 0.28 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.28 |
| PYGM | phosphorylase, glycogen, muscle | 0.28 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.27 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | 0.27 |
| STX16 | syntaxin 16 | 0.27 |
| CCDC73 | coiled-coil domain containing 73 | 0.27 |
| PTMS | parathymosin | 0.27 |
| TMC4 | transmembrane channel-like 4 | 0.26 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.26 |
| TNNC2 | troponin C type 2 (fast) | 0.26 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.26 |
| PER2 | period circadian clock 2 | 0.26 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.25 |
| LAMA3 | laminin, alpha 3 | 0.25 |
| HAL | histidine ammonia-lyase | 0.25 |
| ZNF14 | zinc finger protein 14 | 0.25 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | 0.25 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.24 |
| FAM221A | family with sequence similarity 221, member A | 0.24 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.24 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.24 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.24 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.24 |
| CCDC9B | coiled-coil domain containing 9B | 0.23 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.23 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.23 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.23 |
| MIF4GD | MIF4G domain containing | 0.23 |
| CCDC85B | coiled-coil domain containing 85B | 0.23 |
| IER2 | immediate early response 2 | 0.23 |
| FDX1 | ferredoxin 1 | 0.23 |
| FADS3 | fatty acid desaturase 3 | 0.23 |
| RBM20 | RNA binding motif protein 20 | 0.23 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.22 |
| CARD8 | caspase recruitment domain family, member 8 | 0.22 |
| BSDC1 | BSD domain containing 1 | 0.22 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.22 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 0.22 |
| ZNF692 | zinc finger protein 692 | 0.22 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.22 |
| TP73 | tumor protein p73 | 0.22 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | 0.22 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.22 |
| KRT222 | keratin 222, type II | 0.22 |
| TROAP | trophinin associated protein | 0.22 |
| EPN3 | epsin 3 | 0.21 |
| CLDND1 | claudin domain containing 1 | 0.21 |
| GGACT | gamma-glutamylamine cyclotransferase | 0.21 |
| CXORF56 | chromosome X open reading frame 56 | 0.21 |
| BAIAP2 | BAI1-associated protein 2 | 0.21 |
| ALPK3 | alpha-kinase 3 | 0.21 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | -1.31 |
| CDC26 | cell division cycle 26 | -0.76 |
| MCM9 | minichromosome maintenance complex component 9 | -0.67 |
| DAP | death-associated protein | -0.65 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | -0.6 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.53 |
| SYNPO | synaptopodin | -0.52 |
| EMP3 | epithelial membrane protein 3 | -0.51 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.51 |
| MED29 | mediator complex subunit 29 | -0.51 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.51 |
| CALD1 | caldesmon 1 | -0.5 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.47 |
| IL10RB | interleukin 10 receptor, beta | -0.46 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.45 |
| TPPP | tubulin polymerization promoting protein | -0.45 |
| UST | uronyl-2-sulfotransferase | -0.41 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.39 |
| PHETA1 | PH domain containing endocytic trafficking adaptor 1 | -0.37 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.37 |
| PLEC | plectin | -0.36 |
| DTNA | dystrobrevin, alpha | -0.36 |
| MYO18B | myosin XVIIIB | -0.36 |
| ZNF532 | zinc finger protein 532 | -0.35 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | -0.35 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.35 |
| RGN | regucalcin | -0.34 |
| CCNI | cyclin I | -0.34 |
| H3C1 | H3 clustered histone 1 | -0.34 |
| ZNF729 | zinc finger protein 729 | -0.33 |
| CHPF2 | chondroitin polymerizing factor 2 | -0.33 |
| DST | dystonin | -0.33 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.32 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.32 |
| TMEM106C | transmembrane protein 106C | -0.32 |
| SUSD1 | sushi domain containing 1 | -0.31 |
| WDR90 | WD repeat domain 90 | -0.31 |
| MT-CO2 | cytochrome c oxidase subunit II | -0.31 |
| POM121C | POM121 transmembrane nucleoporin C | -0.31 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.31 |
| LIPH | lipase, member H | -0.3 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.3 |
| CLDN3 | claudin 3 | -0.3 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.28 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.28 |
| ZBTB6 | zinc finger and BTB domain containing 6 | -0.28 |
| BMERB1 | bMERB domain containing 1 | -0.28 |
| YAF2 | YY1 associated factor 2 | -0.28 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | -0.28 |
| ZNF226 | zinc finger protein 226 | -0.28 |
| TMEM222 | transmembrane protein 222 | -0.28 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.27 |
| ADSS1 | adenylosuccinate synthase 1 | -0.27 |
| GLRX | glutaredoxin (thioltransferase) | -0.27 |
| NCOA4 | nuclear receptor coactivator 4 | -0.27 |
| RNF26 | ring finger protein 26 | -0.27 |
| NRP1 | neuropilin 1 | -0.26 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | -0.26 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | -0.26 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.26 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.26 |
| TANK | TRAF family member-associated NFKB activator | -0.26 |
| ERG28 | ergosterol biosynthesis 28 homolog | -0.26 |
| ITM2B | integral membrane protein 2B | -0.26 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.25 |
| AOC1 | amine oxidase, copper containing 1 | -0.24 |
| SLC25A38 | solute carrier family 25, member 38 | -0.24 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.24 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.24 |
| NRBF2 | nuclear receptor binding factor 2 | -0.24 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.24 |
| TAZ | tafazzin | -0.24 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.24 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.24 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | -0.24 |
| XIRP1 | xin actin binding repeat containing 1 | -0.24 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.24 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.23 |
| VGLL4 | vestigial-like family member 4 | -0.23 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.23 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.23 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.23 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.23 |
| FAM120C | family with sequence similarity 120C | -0.23 |
| SPATA20 | spermatogenesis associated 20 | -0.23 |
| SLC41A3 | solute carrier family 41, member 3 | -0.22 |
| ATP9A | ATPase, class II, type 9A | -0.22 |
| FKBPL | FK506 binding protein like | -0.22 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.22 |
| SYTL2 | synaptotagmin-like 2 | -0.22 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.22 |
| CERS4 | ceramide synthase 4 | -0.22 |
| STK36 | serine/threonine kinase 36 | -0.22 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.22 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.22 |
| ERLIN2 | ER lipid raft associated 2 | -0.22 |
| ATXN1 | ataxin 1 | -0.22 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.22 |
| NBR1 | neighbor of BRCA1 gene 1 | -0.22 |
