|PhosphoSitePlus Substrates of Kinases
|sterile alpha motif and leucine zipper containing kinase AZK|This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 51776)
|Downloads & Tools
3 substrates of the kinase ZAK from the curated PhosphoSitePlus Substrates of Kinases dataset.