ZAP70 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description zeta-chain (TCR) associated protein kinase 70kDa|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7535)
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100 substrates of the kinase ZAP70 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
PDS5B PDS5 cohesin associated factor B 99.93
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 99.91
PDCD5 programmed cell death 5 99.74
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.69
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.69
PM20D2 peptidase M20 domain containing 2 99.54
SH3BP2 SH3-domain binding protein 2 99.47
THEMIS2 thymocyte selection associated family member 2 99.45
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.43
ARHGAP35 Rho GTPase activating protein 35 99.26
PLD1 phospholipase D1, phosphatidylcholine-specific 99.25
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 99.17
IRS4 insulin receptor substrate 4 99.155
SH2D1B SH2 domain containing 1B 99.15
BYSL bystin-like 99.13
IL7R interleukin 7 receptor 99.13
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.04
CENPF centromere protein F, 350/400kDa 98.99
ZSCAN25 zinc finger and SCAN domain containing 25 98.93
DLG3 discs, large homolog 3 (Drosophila) 98.825
BLNK B-cell linker 98.8
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 98.71
TNRC6B trinucleotide repeat containing 6B 98.67
DPF2 D4, zinc and double PHD fingers family 2 98.58
DGKK diacylglycerol kinase, kappa 98.47
PDZK1IP1 PDZK1 interacting protein 1 98.4
FOXM1 forkhead box M1 98.38
MLEC malectin 98.34
LAX1 lymphocyte transmembrane adaptor 1 98.32
SF3A3 splicing factor 3a, subunit 3, 60kDa 98.21
ARHGAP30 Rho GTPase activating protein 30 98.14
HEMGN hemogen 98.1
MAT2A methionine adenosyltransferase II, alpha 98.05
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 98.01
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 97.97
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 97.96
CDK5RAP2 CDK5 regulatory subunit associated protein 2 97.94
MCC mutated in colorectal cancers 97.81
FGD5 FYVE, RhoGEF and PH domain containing 5 97.79
F5 coagulation factor V (proaccelerin, labile factor) 97.77
RNF2 ring finger protein 2 97.74
C9ORF78 chromosome 9 open reading frame 78 97.7
MARVELD3 MARVEL domain containing 3 97.68
PARD6B par-6 family cell polarity regulator beta 97.66
ARHGAP5 Rho GTPase activating protein 5 97.64
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 97.61
SH2D3C SH2 domain containing 3C 97.55
WBP2 WW domain binding protein 2 97.54
CEP43 centrosomal protein 43 97.53
CD82 CD82 molecule 97.46
MAP3K3 mitogen-activated protein kinase kinase kinase 3 97.42
CKAP4 cytoskeleton-associated protein 4 97.31
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 97.27
PRRC2B proline-rich coiled-coil 2B 97.26
GAB3 GRB2-associated binding protein 3 97.24
HCFC2 host cell factor C2 97.24
CASQ2 calsequestrin 2 (cardiac muscle) 97.05
DDIAS DNA damage-induced apoptosis suppressor 97.04
EPB41L5 erythrocyte membrane protein band 4.1 like 5 96.93
RABL6 RAB, member RAS oncogene family-like 6 96.91
PELP1 proline, glutamate and leucine rich protein 1 96.91
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 96.89
SFSWAP splicing factor, suppressor of white-apricot family 96.87
ZNF598 zinc finger protein 598 96.81
IL1R1 interleukin 1 receptor, type I 96.74
MEF2A myocyte enhancer factor 2A 96.7
TIGIT T cell immunoreceptor with Ig and ITIM domains 96.65
ZNF639 zinc finger protein 639 96.63
TRAF3IP2 TRAF3 interacting protein 2 96.54
CEP68 centrosomal protein 68kDa 96.5
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 96.5
GPATCH11 G patch domain containing 11 96.45
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 96.26
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 96.23
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 96.19
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 96.17
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 96.1
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 95.93
SIPA1L1 signal-induced proliferation-associated 1 like 1 95.89
SRL sarcalumenin 95.69
NIBAN2 niban apoptosis regulator 2 95.67
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 95.64
TRPV2 transient receptor potential cation channel, subfamily V, member 2 95.62
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 95.56
PLPPR4 phospholipid phosphatase related 4 95.47
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 95.43
DOK4 docking protein 4 95.34
KAT2A K(lysine) acetyltransferase 2A 95.27
DOK2 docking protein 2, 56kDa 95.25
HBS1L HBS1-like translational GTPase 95.12
BAG4 BCL2-associated athanogene 4 95.01
STRIP1 striatin interacting protein 1 94.94
ALOX5 arachidonate 5-lipoxygenase 94.88
PTPN7 protein tyrosine phosphatase, non-receptor type 7 94.83
SON SON DNA binding protein 94.8
KCTD12 potassium channel tetramerization domain containing 12 94.59
RPS14 ribosomal protein S14 94.49
KAT2B K(lysine) acetyltransferase 2B 94.48
MFAP1 microfibrillar-associated protein 1 94.41
CD93 CD93 molecule 94.405