ZAP70 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description zeta-chain (TCR) associated protein kinase 70kDa|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7535)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_ZAP70
Similar Terms
Downloads & Tools

Genes

27 co-expressed genes for ZAP70 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
CD247 CD247 molecule
CD7 CD7 molecule
CD96 CD96 molecule
CTSW cathepsin W
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMM granzyme M (lymphocyte met-ase 1)
IL18RAP interleukin 18 receptor accessory protein
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MATK megakaryocyte-associated tyrosine kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NKG7 natural killer cell granule protein 7
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PRKCH protein kinase C, eta
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RORA RAR-related orphan receptor A
SH2D1A SH2 domain containing 1A
SUN2 Sad1 and UNC84 domain containing 2
TRD T cell receptor delta locus
TXK TXK tyrosine kinase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa