ZAP70 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description zeta-chain (TCR) associated protein kinase 70kDa|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7535)
External Link http://www.ncbi.nlm.nih.gov/gene/7535
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Genes

11 substrates of the kinase ZAP70 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
DBNL drebrin-like
DUSP3 dual specificity phosphatase 3
GAB2 GRB2-associated binding protein 2
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
SH2B3 SH2B adaptor protein 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
THEMIS thymocyte selection associated
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa