ZFX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description zinc finger protein, X-linked|This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 7543)
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Genes

337 genes differentially expressed following the ZFX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ANGPTL5 angiopoietin-like 5 2.91446
HES4 hes family bHLH transcription factor 4 2.91446
STAB1 stabilin 1 2.91446
FNDC1 fibronectin type III domain containing 1 2.91446
HPCAL4 hippocalcin like 4 2.91446
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.91446
HKDC1 hexokinase domain containing 1 2.91446
CCR6 chemokine (C-C motif) receptor 6 2.91446
LMOD3 leiomodin 3 (fetal) 2.91446
AZIN2 antizyme inhibitor 2 2.91446
CD68 CD68 molecule 2.91446
PRSS22 protease, serine, 22 2.91446
CIB4 calcium and integrin binding family member 4 2.91446
MRC1 mannose receptor, C type 1 2.91446
SNTN sentan, cilia apical structure protein 2.91446
TAL2 T-cell acute lymphocytic leukemia 2 2.91446
MYO1A myosin IA 2.91446
GCM1 glial cells missing homolog 1 (Drosophila) 2.91446
ICAM2 intercellular adhesion molecule 2 2.91446
TG thyroglobulin 2.91446
ITGA8 integrin, alpha 8 2.91446
TEX29 testis expressed 29 2.91446
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.91446
LOC124904542 uncharacterized LOC124904542 2.91446
RPL3L ribosomal protein L3-like 2.86602
CLEC5A C-type lectin domain family 5, member A 2.86602
ELOA2 elongin A2 2.86602
DLX4 distal-less homeobox 4 2.86602
CCDC197 coiled-coil domain containing 197 2.86602
LGI1 leucine-rich, glioma inactivated 1 2.86602
WNT8B wingless-type MMTV integration site family, member 8B 2.86602
PCDH8 protocadherin 8 2.86602
PTGFR prostaglandin F receptor (FP) 2.86602
SPRR1B small proline-rich protein 1B 2.86602
KRT27 keratin 27, type I 2.86602
SH2D6 SH2 domain containing 6 2.86602
FFAR4 free fatty acid receptor 4 2.86602
SLC15A5 solute carrier family 15, member 5 2.86602
SIGLEC9 sialic acid binding Ig-like lectin 9 2.86602
MYOM3 myomesin 3 2.86602
CFAP107 cilia and flagella associated protein 107 2.86602
HCRTR2 hypocretin (orexin) receptor 2 2.86602
HBZ hemoglobin, zeta 2.86602
PEAK3 PEAK family member 3 2.86602
SLC51B solute carrier family 51, beta subunit 2.86602
NOTCH2NLB notch 2 N-terminal like B 2.86602
PRSS27 protease, serine 27 2.86602
SOST sclerostin 2.86602
SPDEF SAM pointed domain containing ETS transcription factor 2.86602
TMEM52B transmembrane protein 52B 2.86602
MNX1 motor neuron and pancreas homeobox 1 2.86602
NEUROD1 neuronal differentiation 1 2.86602
TDO2 tryptophan 2,3-dioxygenase 2.86602
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.86602
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.86602
KRT72 keratin 72, type II 2.86602
LHFPL7 LHFPL tetraspan subfamily member 7 2.86602
MYMK myomaker, myoblast fusion factor 2.86602
H4C15 H4 clustered histone 15 2.86602
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.86602
NMUR2 neuromedin U receptor 2 2.86602
CIMAP1B ciliary microtubule associated protein 1B 2.86602
EVPL envoplakin 2.86602
CCDC38 coiled-coil domain containing 38 2.86602
ADIPOQ adiponectin, C1Q and collagen domain containing 2.86602
PLN phospholamban 2.86602
GJD2 gap junction protein, delta 2, 36kDa 2.86602
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.86602
TLR1 toll-like receptor 1 2.86602
PNLIPRP1 pancreatic lipase-related protein 1 2.86602
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.86602
SLC22A25 solute carrier family 22, member 25 2.86602
C3ORF80 chromosome 3 open reading frame 80 2.86602
HAO2 hydroxyacid oxidase 2 (long chain) 2.86602
S100G S100 calcium binding protein G 2.86602
GATA4 GATA binding protein 4 2.86602
GATA2 GATA binding protein 2 2.86602
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.86602
DNAAF1 dynein, axonemal, assembly factor 1 2.86602
FIMP1 fertilization-influencing membrane protein 1 2.86602
PLCZ1 phospholipase C, zeta 1 2.86602
TMPRSS6 transmembrane protease, serine 6 2.86602
HTRA4 HtrA serine peptidase 4 2.86602
ASB4 ankyrin repeat and SOCS box containing 4 2.86602
MIOX myo-inositol oxygenase 2.86602
ITK IL2-inducible T-cell kinase 2.86602
HTD2 hydroxyacyl-thioester dehydratase type 2 2.86602
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.86602
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.86602
ALOX15 arachidonate 15-lipoxygenase 2.86602
IGFL2 IGF-like family member 2 2.86602
GNLY granulysin 2.86602
CELF6 CUGBP, Elav-like family member 6 2.86602
SPINK4 serine peptidase inhibitor, Kazal type 4 2.86602
PRICKLE4 prickle homolog 4 (Drosophila) 2.86602
CABP4 calcium binding protein 4 2.86602
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.86602
FGF21 fibroblast growth factor 21 2.86602
LAPTM5 lysosomal protein transmembrane 5 2.86602
NALF1 NALCN channel auxiliary factor 1 2.86602
IZUMO4 IZUMO family member 4 2.86602
RLBP1 retinaldehyde binding protein 1 2.86602
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.86602
TAS2R5 taste receptor, type 2, member 5 2.86602
FABP9 fatty acid binding protein 9, testis 2.86602
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.86602
SRL sarcalumenin 2.86602
BNIP5 BCL2 interacting protein 5 2.86602
FGA fibrinogen alpha chain 2.86602
CLRN2 clarin 2 2.86602
C11ORF91 chromosome 11 open reading frame 91 2.86602
ADGRA1 adhesion G protein-coupled receptor A1 2.86602
TNR tenascin R 2.86602
AMIGO1 adhesion molecule with Ig-like domain 1 2.86602
C18ORF63 chromosome 18 open reading frame 63 2.86602
MR1 major histocompatibility complex, class I-related 2.86602
IL17REL interleukin 17 receptor E-like 2.86602
ZNF366 zinc finger protein 366 2.86602
PSKH2 protein serine kinase H2 2.86602
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.86602
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.86602
EOMES eomesodermin 2.86602
ZMYND10 zinc finger, MYND-type containing 10 2.86602
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.86602
DRC7 dynein regulatory complex subunit 7 2.86602
HSPA1L heat shock 70kDa protein 1-like 2.86602
LGALS12 lectin, galactoside-binding, soluble, 12 2.86602
GSC2 goosecoid homeobox 2 2.86602
NT5DC4 5'-nucleotidase domain containing 4 2.86602
KLK2 kallikrein-related peptidase 2 2.86602
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.86602
DSC1 desmocollin 1 2.86602
HK3 hexokinase 3 (white cell) 2.86602
MUC17 mucin 17, cell surface associated 2.86602
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.86602
TRIM55 tripartite motif containing 55 2.86602
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.86602
MAMLD1 mastermind-like domain containing 1 2.86602
CLEC4D C-type lectin domain family 4, member D 2.86602
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.86602
ERICH6B glutamate-rich 6B 2.86602
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.86602
SCML4 sex comb on midleg-like 4 (Drosophila) 2.86602
CSF1R colony stimulating factor 1 receptor 2.86602
BTG4 B-cell translocation gene 4 2.86602
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.86602
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.86602
MT1M metallothionein 1M 2.86602
CHRM4 cholinergic receptor, muscarinic 4 2.86602
ANGPTL6 angiopoietin-like 6 2.86602
CD80 CD80 molecule 2.86602
PATE2 prostate and testis expressed 2 2.86602
SSX1 synovial sarcoma, X breakpoint 1 2.86602
NLRP14 NLR family, pyrin domain containing 14 2.86602
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.86602
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.86602
CFB complement factor B 2.86602
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.86602
SYTL4 synaptotagmin-like 4 2.86602
PADI1 peptidyl arginine deiminase, type I 2.86602
EPO erythropoietin 2.86602
SP100 SP100 nuclear antigen 2.86602
GOLGA8R golgin A8 family, member R 2.86602
TBC1D28 TBC1 domain family, member 28 2.86602
ANKRD33 ankyrin repeat domain 33 2.86602
CARD6 caspase recruitment domain family, member 6 2.86602
LPO lactoperoxidase 2.86602
IL10RA interleukin 10 receptor, alpha 2.86602
NUTM2D NUT family member 2D 2.86602
ZNF648 zinc finger protein 648 2.86602
RTEL1 regulator of telomere elongation helicase 1 2.84646
ARHGAP10 Rho GTPase activating protein 10 2.83661
BTLA B and T lymphocyte associated 2.79088
TMEM213 transmembrane protein 213 2.79088
C2CD2L C2CD2-like 2.79088
ZNF816 zinc finger protein 816 2.7342
TMEM216 transmembrane protein 216 2.7342
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.7342
MFN2 mitofusin 2 2.65241
BBX bobby sox homolog (Drosophila) 2.63914
ZNF555 zinc finger protein 555 2.60317
ELOVL1 ELOVL fatty acid elongase 1 2.57918
PXK PX domain containing serine/threonine kinase 2.57197
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.56433
GET1 guided entry of tail-anchored proteins factor 1 2.5626
KIF26A kinesin family member 26A 2.5626
DMRT1 doublesex and mab-3 related transcription factor 1 2.53704
ZMYND12 zinc finger, MYND-type containing 12 2.53704
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.53704
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.53447
KCTD16 potassium channel tetramerization domain containing 16 2.48898
TWIST1 twist family bHLH transcription factor 1 2.46947
ALLC allantoicase 2.46947
USP48 ubiquitin specific peptidase 48 2.46842
ADGRL3 adhesion G protein-coupled receptor L3 2.45934
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.44532
LPAR1 lysophosphatidic acid receptor 1 2.42146
TNS2 tensin 2 2.4155
CST6 cystatin E/M 2.4155
FBXL18 F-box and leucine-rich repeat protein 18 2.41061
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.38582
KLK6 kallikrein-related peptidase 6 2.3793
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2.32519
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.32328
TM9SF1 transmembrane 9 superfamily member 1 2.30774
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2.29834
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 2.28594
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.25387
TBC1D12 TBC1 domain family, member 12 2.25115
SMIM20 small integral membrane protein 20 2.22414
MORC4 MORC family CW-type zinc finger 4 2.22406
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.21969
FRMD4A FERM domain containing 4A 2.19133
TMEM200B transmembrane protein 200B 2.18645
IRAK1 interleukin-1 receptor-associated kinase 1 2.17277
MTMR1 myotubularin related protein 1 2.16741
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 2.16649
SDE2 SDE2 telomere maintenance homolog (S. pombe) 2.15401
LRRC47 leucine rich repeat containing 47 2.14568
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.13066
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.12357
MINDY3 MINDY lysine 48 deubiquitinase 3 2.10434
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.09227
SCAMP2 secretory carrier membrane protein 2 2.08841
HDX highly divergent homeobox 2.08205
TXNDC16 thioredoxin domain containing 16 2.08187
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.07771
SYNM synemin, intermediate filament protein 2.05777
IL1RAP interleukin 1 receptor accessory protein 2.03767
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.03224
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 2.00686
TTF1 transcription termination factor, RNA polymerase I 2.00378
FASTKD1 FAST kinase domains 1 2.0023
INSIG2 insulin induced gene 2 2.0023

decreased expression

Symbol Name Standardized Value
PILRA paired immunoglobin-like type 2 receptor alpha -2.91446
IFI16 interferon, gamma-inducible protein 16 -2.91446
PCGF5 polycomb group ring finger 5 -2.86602
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.86602
ZNF792 zinc finger protein 792 -2.86602
PLK5 polo-like kinase 5 -2.86602
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.86602
CHSY3 chondroitin sulfate synthase 3 -2.86602
UNC13D unc-13 homolog D (C. elegans) -2.86602
C13ORF42 chromosome 13 open reading frame 42 -2.86602
RNF212 ring finger protein 212 -2.86602
TMC8 transmembrane channel-like 8 -2.86602
UCK2 uridine-cytidine kinase 2 -2.86602
SLIT1 slit homolog 1 (Drosophila) -2.86602
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.86602
ZCCHC24 zinc finger, CCHC domain containing 24 -2.86602
PMVK phosphomevalonate kinase -2.84586
SPNS2 spinster homolog 2 (Drosophila) -2.7342
CLNK cytokine-dependent hematopoietic cell linker -2.7342
IRX4 iroquois homeobox 4 -2.7342
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.7342
CD160 CD160 molecule -2.7342
GRM6 glutamate receptor, metabotropic 6 -2.7342
KRTAP13-4 keratin associated protein 13-4 -2.7342
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.7342
UBE2U ubiquitin-conjugating enzyme E2U (putative) -2.7342
CFAP299 cilia and flagella associated protein 299 -2.7342
CFAP141 cilia and flagella associated protein 141 -2.7342
CBLIF cobalamin binding intrinsic factor -2.7342
CFAP65 cilia and flagella associated protein 65 -2.7342
CDKN2A cyclin-dependent kinase inhibitor 2A -2.7342
CD96 CD96 molecule -2.7342
IGFL3 IGF-like family member 3 -2.7342
CNTNAP4 contactin associated protein-like 4 -2.7342
NCF1 neutrophil cytosolic factor 1 -2.7342
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.7342
UPK1B uroplakin 1B -2.7342
SP140L SP140 nuclear body protein-like -2.7342
C10ORF105 chromosome 10 open reading frame 105 -2.7342
ZNF835 zinc finger protein 835 -2.7342
CD177 CD177 molecule -2.7342
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.7342
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.7342
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.7342
TBC1D26 TBC1 domain family, member 26 -2.7342
WFDC1 WAP four-disulfide core domain 1 -2.7342
TTC16 tetratricopeptide repeat domain 16 -2.7342
TMPRSS13 transmembrane protease, serine 13 -2.7342
LYPD5 LY6/PLAUR domain containing 5 -2.7342
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.7342
AKR1B15 aldo-keto reductase family 1, member B15 -2.7342
GLS glutaminase -2.69392
ZNF124 zinc finger protein 124 -2.68917
RNF222 ring finger protein 222 -2.68696
COL2A1 collagen, type II, alpha 1 -2.6834
GMIP GEM interacting protein -2.61732
RAD50 RAD50 homolog (S. cerevisiae) -2.61732
MITF microphthalmia-associated transcription factor -2.59603
PROX1 prospero homeobox 1 -2.57918
RIMKLA ribosomal modification protein rimK-like family member A -2.56888
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.46466
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.42392
DTWD1 DTW domain containing 1 -2.42146
FBLN2 fibulin 2 -2.36162
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.3469
KDM1A lysine (K)-specific demethylase 1A -2.32519
LRRC8E leucine rich repeat containing 8 family, member E -2.30774
PDZD2 PDZ domain containing 2 -2.27598
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.27024
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.25115
RAB2B RAB2B, member RAS oncogene family -2.25115
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -2.23847
TSC22D4 TSC22 domain family, member 4 -2.23032
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -2.2263
TM4SF18 transmembrane 4 L six family member 18 -2.2263
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.22036
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.21661
ROM1 retinal outer segment membrane protein 1 -2.18849
LRPPRC leucine-rich pentatricopeptide repeat containing -2.17678
ZNF865 zinc finger protein 865 -2.16468
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.15776
ITPRID2 ITPR interacting domain containing 2 -2.15776
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.14181
VDAC1 voltage-dependent anion channel 1 -2.13715
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.12835
RIPK4 receptor-interacting serine-threonine kinase 4 -2.12431
DYNLT5 dynein light chain Tctex-type family member 5 -2.12431
CD36 CD36 molecule (thrombospondin receptor) -2.12431
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 -2.12431
MSR1 macrophage scavenger receptor 1 -2.12431
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.12431
DAB2IP DAB2 interacting protein -2.11092
CMC4 C-x(9)-C motif containing 4 -2.10894
SYNPO2L synaptopodin 2-like -2.10383
HDAC10 histone deacetylase 10 -2.10383
TWF1 twinfilin actin binding protein 1 -2.10039
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.09361
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.09361
PEX5 peroxisomal biogenesis factor 5 -2.08881
SH2B2 SH2B adaptor protein 2 -2.08187
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.06917
ADA2 adenosine deaminase 2 -2.05133
TBC1D2B TBC1 domain family, member 2B -2.01898