ZIC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Zic family member 1|This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7545)
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Genes

293 genes differentially expressed following the ZIC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.13596
GPR52 G protein-coupled receptor 52 3.13596
ZFYVE9 zinc finger, FYVE domain containing 9 3.13596
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.13596
IGFL3 IGF-like family member 3 3.13596
ENTHD1 ENTH domain containing 1 3.13596
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.13596
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.13596
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.13596
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 3.13596
FAM167A family with sequence similarity 167, member A 3.13596
PARP3 poly (ADP-ribose) polymerase family, member 3 3.13596
KLF17 Kruppel-like factor 17 3.13596
FPR2 formyl peptide receptor 2 3.13596
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.13596
GPR75 G protein-coupled receptor 75 3.13596
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.13596
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.13596
SOX1 SRY (sex determining region Y)-box 1 3.13596
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.13596
MUC6 mucin 6, oligomeric mucus/gel-forming 3.13596
PDIA2 protein disulfide isomerase family A, member 2 3.13596
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.13596
CA1 carbonic anhydrase I 3.13596
RFPL2 ret finger protein-like 2 3.13596
ADAMTSL5 ADAMTS-like 5 3.13596
TDRD6 tudor domain containing 6 3.13596
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.13596
RGPD3 RANBP2-like and GRIP domain containing 3 3.13596
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.13596
GNRHR gonadotropin-releasing hormone receptor 3.13596
HCRTR2 hypocretin (orexin) receptor 2 3.13596
MFAP5 microfibrillar associated protein 5 3.13596
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.13596
TM4SF1 transmembrane 4 L six family member 1 3.13596
PEAR1 platelet endothelial aggregation receptor 1 3.13596
CLEC19A C-type lectin domain family 19, member A 3.13596
ADTRP androgen-dependent TFPI-regulating protein 3.13596
GJA10 gap junction protein, alpha 10, 62kDa 3.13596
PAX8 paired box 8 3.13596
PAX3 paired box 3 3.13596
XCL1 chemokine (C motif) ligand 1 3.13596
OXT oxytocin/neurophysin I prepropeptide 3.13596
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.13596
SPADH spermadhesin family member 3.13596
HAO2 hydroxyacid oxidase 2 (long chain) 3.13596
OTOF otoferlin 3.13596
ROPN1B rhophilin associated tail protein 1B 3.13596
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.13596
KRT81 keratin 81, type II 3.13596
PDC phosducin 3.13596
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.13596
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.13596
RAB6D RAB6D, member RAS oncogene family 3.13596
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.13596
CFAP97D1 CFAP97 domain containing 1 3.13596
PRR20G proline rich 20G 3.13596
DAAM2-AS1 DAAM2 antisense RNA 1 3.13596
CIMAP1B ciliary microtubule associated protein 1B 3.13596
CTXND1 cortexin domain containing 1 3.13596
MAJIN membrane anchored junction protein 3.13596
CFAP107 cilia and flagella associated protein 107 3.13596
CFAP206 cilia and flagella associated protein 206 3.13596
DEFB131B defensin beta 131B 3.13596
ADRB3 adrenoceptor beta 3 3.13596
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.13596
SPATA25 spermatogenesis associated 25 3.13596
TFEC transcription factor EC 3.13596
NHLRC4 NHL repeat containing 4 3.13596
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.13596
MAG myelin associated glycoprotein 3.13596
TUBA3D tubulin, alpha 3d 3.13596
PCDHB11 protocadherin beta 11 3.13596
ARL5C ADP-ribosylation factor-like 5C 3.13596
SLC35D3 solute carrier family 35, member D3 3.13596
PGC progastricsin (pepsinogen C) 3.13596
MIP major intrinsic protein of lens fiber 3.13596
C1QL2 complement component 1, q subcomponent-like 2 3.13596
CFC1 cripto, FRL-1, cryptic family 1 3.13596
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.13596
GATA6 GATA binding protein 6 3.13596
LRRN4CL LRRN4 C-terminal like 3.13596
ACE2 angiotensin I converting enzyme 2 3.13596
SAMD10 sterile alpha motif domain containing 10 3.13596
RGS21 regulator of G-protein signaling 21 3.13596
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.13596
ATP13A5 ATPase type 13A5 3.13596
CFP complement factor properdin 3.13596
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 3.13596
SERINC4 serine incorporator 4 3.13596
MEFV Mediterranean fever 3.13596
MAB21L3 mab-21-like 3 (C. elegans) 3.13596
CCDC27 coiled-coil domain containing 27 3.13596
SCGB1D2 secretoglobin, family 1D, member 2 3.13596
ALOXE3 arachidonate lipoxygenase 3 3.13596
TIPE2 TNF alpha induced protein 8 like 2 3.13596
VNN2 vanin 2 3.13596
DQX1 DEAQ box RNA-dependent ATPase 1 3.13596
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.13596
TBPL2 TATA box binding protein like 2 3.13596
SLC25A52 solute carrier family 25, member 52 3.13596
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.13596
KRTAP5-11 keratin associated protein 5-11 3.13596
ERICH4 glutamate-rich 4 3.13596
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.13596
CST1 cystatin SN 3.13596
EPGN epithelial mitogen 3.13596
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.13596
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.13596
CNR2 cannabinoid receptor 2 (macrophage) 3.13596
C10ORF105 chromosome 10 open reading frame 105 3.13596
TEX29 testis expressed 29 3.13596
MB myoglobin 3.13596
GOLGA8K golgin A8 family, member K 3.13596
GOLGA8R golgin A8 family, member R 3.13596
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.13596
EFCC1 EF-hand and coiled-coil domain containing 1 3.13596
SLC38A3 solute carrier family 38, member 3 3.13596
OCM oncomodulin 3.13596
BSPH1 binder of sperm protein homolog 1 3.13596
GLRB glycine receptor, beta 3.13596
ANKRD53 ankyrin repeat domain 53 3.13596
TPPP2 tubulin polymerization-promoting protein family member 2 3.13596
NPPA natriuretic peptide A 3.13596
PDCD1LG2 programmed cell death 1 ligand 2 3.13596
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.13596
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.13596
ZMYND12 zinc finger, MYND-type containing 12 3.13596
TCF21 transcription factor 21 3.13596
TPRX1 tetra-peptide repeat homeobox 1 3.13596
ARGFX arginine-fifty homeobox 3.13596
SOST sclerostin 3.13596
R3HDML R3H domain containing-like 3.13596
ANGPTL3 angiopoietin-like 3 3.13596
TCF3 transcription factor 3 3.13596
IRX4 iroquois homeobox 4 3.13596
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.13596
ANXA1 annexin A1 3.13596
IL37 interleukin 37 3.13596
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.13596
GCSAML germinal center-associated, signaling and motility-like 3.13596
CGA glycoprotein hormones, alpha polypeptide 3.13596
WFDC10A WAP four-disulfide core domain 10A 3.13596
NLRP6 NLR family, pyrin domain containing 6 3.13596
DIO1 deiodinase, iodothyronine, type I 3.13596
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.13596
PRSS54 protease, serine, 54 3.13596
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.13596
ETV2 ets variant 2 3.13596
KIF4B kinesin family member 4B 3.13596
MAEL maelstrom spermatogenic transposon silencer 3.13596
GYS2 glycogen synthase 2 (liver) 3.13596
MAGEA9B melanoma antigen family A9B 3.13596
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.13596
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.13596
UPK1A uroplakin 1A 3.00676
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2.78707
METTL26 methyltransferase like 26 2.73655
RPLP1 ribosomal protein, large, P1 2.71021
FRY furry homolog (Drosophila) 2.64369
TPRN taperin 2.59103
NEFM neurofilament, medium polypeptide 2.58775
TSLIG3B tRNA splicing ligase complex subunit 3B 2.55119
HEATR6 HEAT repeat containing 6 2.52471
ZNF671 zinc finger protein 671 2.51288
NT5DC2 5'-nucleotidase domain containing 2 2.48172
CNR1 cannabinoid receptor 1 (brain) 2.47631
FYB2 FYN binding protein 2 2.47631
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.47631
COMMD8 COMM domain containing 8 2.41961
MAP7D3 MAP7 domain containing 3 2.41844
ART1 ADP-ribosyltransferase 1 2.38622
LARS1 leucyl-tRNA synthetase 1 2.37127
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.36403
HIST1H2BF histone cluster 1, H2bf 2.34802
LOC124902436 talanin 2.34802
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.34002
PHF14 PHD finger protein 14 2.31994
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 2.31229
RIMKLB ribosomal modification protein rimK-like family member B 2.24533
SHROOM4 shroom family member 4 2.24397
DENR density-regulated protein 2.24397
MIEF1 mitochondrial elongation factor 1 2.24256
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.2156
LOC124906010 uncharacterized LOC124906010 2.2156
RELL1 RELT-like 1 2.1128
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 2.09583
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C 2.08196
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.07125
DEUP1 deuterosome assembly protein 1 2.07125
SESN2 sestrin 2 2.06509
TECPR1 tectonin beta-propeller repeat containing 1 2.04054
HDAC8 histone deacetylase 8 2.01474
RBM15B RNA binding motif protein 15B 2.00384
PISD phosphatidylserine decarboxylase 2.00065

decreased expression

Symbol Name Standardized Value
CA10 carbonic anhydrase X -3.13596
HYAL1 hyaluronoglucosaminidase 1 -3.13596
HCRTR1 hypocretin (orexin) receptor 1 -3.13596
ROM1 retinal outer segment membrane protein 1 -3.13596
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -3.13596
IL12A interleukin 12A -3.13596
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -3.13596
CIMAP2 ciliary microtubule associated protein 2 -3.13596
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -3.13596
NIM1K NIM1 serine/threonine protein kinase -3.13596
CASR calcium-sensing receptor -3.13596
DNAH6 dynein, axonemal, heavy chain 6 -3.13596
BAAT bile acid CoA:amino acid N-acyltransferase -3.13596
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -3.13596
HYKK hydroxylysine kinase -3.13596
IL18R1 interleukin 18 receptor 1 -3.13596
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -3.13596
LRG1 leucine-rich alpha-2-glycoprotein 1 -3.13596
PRSS21 protease, serine, 21 (testisin) -3.13596
TRIL TLR4 interactor with leucine-rich repeats -3.13596
ASCL2 achaete-scute family bHLH transcription factor 2 -3.13596
SIX1 SIX homeobox 1 -3.13596
LCT lactase -3.13596
C19ORF85 chromosome 19 open reading frame 85 -3.13596
LEKR1 leucine, glutamate and lysine rich 1 -3.13596
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.13596
ITGB7 integrin, beta 7 -3.13596
IL1A interleukin 1, alpha -3.13596
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.13596
CATIP ciliogenesis associated TTC17 interacting protein -3.13596
LMNTD1 lamin tail domain containing 1 -3.13596
ZNF546 zinc finger protein 546 -3.13596
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) -3.13596
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) -3.13596
CD53 CD53 molecule -3.13596
FIBIN fin bud initiation factor homolog (zebrafish) -3.13596
EMP1 epithelial membrane protein 1 -3.13596
RFLNB refilin B -2.84321
KCTD19 potassium channel tetramerization domain containing 19 -2.80611
HMX2 H6 family homeobox 2 -2.78707
RNF175 ring finger protein 175 -2.66021
ARMH4 armadillo like helical domain containing 4 -2.6331
SNX8 sorting nexin 8 -2.61319
SACK1G scaffolding CK1 anchoring protein G -2.57236
NAGK N-acetylglucosamine kinase -2.5292
MASP2 mannan-binding lectin serine peptidase 2 -2.5292
TINCR tissue differentiation-inducing non-protein coding RNA -2.5292
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.51053
LRRC56 leucine rich repeat containing 56 -2.51053
METTL25 methyltransferase like 25 -2.51053
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -2.5028
XPOT exportin, tRNA -2.46035
ZNF182 zinc finger protein 182 -2.44583
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.44583
ANO10 anoctamin 10 -2.44583
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -2.40713
NADSYN1 NAD synthetase 1 -2.38622
FGFRL1 fibroblast growth factor receptor-like 1 -2.37447
TBKBP1 TBK1 binding protein 1 -2.37447
URGCP upregulator of cell proliferation -2.25708
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.25708
TMEM82 transmembrane protein 82 -2.25708
RND3 Rho family GTPase 3 -2.25215
HSH2D hematopoietic SH2 domain containing -2.23978
CCDC183 coiled-coil domain containing 183 -2.23978
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 -2.23978
C1ORF53 chromosome 1 open reading frame 53 -2.23978
STX19 syntaxin 19 -2.23978
SMOC1 SPARC related modular calcium binding 1 -2.21962
CSNK1G2 casein kinase 1, gamma 2 -2.21172
KHDC1 KH homology domain containing 1 -2.20478
ANKRD28 ankyrin repeat domain 28 -2.16844
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.15264
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.14143
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.11961
RMI1 RecQ mediated genome instability 1 -2.11401
PCYOX1 prenylcysteine oxidase 1 -2.11401
MECR mitochondrial trans-2-enoyl-CoA reductase -2.11401
CCDC61 coiled-coil domain containing 61 -2.09583
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.09583
MCM3AP minichromosome maintenance complex component 3 associated protein -2.09006
SP3 Sp3 transcription factor -2.08714
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.08714
BTG3 BTG family, member 3 -2.08697
FOCAD focadhesin -2.07125
ZNF34 zinc finger protein 34 -2.07125
ZNF248 zinc finger protein 248 -2.06509
WRAP53 WD repeat containing, antisense to TP53 -2.06386
BICC1 BicC family RNA binding protein 1 -2.05364
UBTD1 ubiquitin domain containing 1 -2.05032
PIGS phosphatidylinositol glycan anchor biosynthesis, class S -2.04656
FBXL7 F-box and leucine-rich repeat protein 7 -2.02844
ZNF713 zinc finger protein 713 -2.02725
MYLK3 myosin light chain kinase 3 -2.01352
RBM7 RNA binding motif protein 7 -2.00844
RBL2 retinoblastoma-like 2 -2.00373
RBM28 RNA binding motif protein 28 -2.00305
RALYL RALY RNA binding protein-like -2.00065