ZNF274 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description zinc finger protein 274|This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10782)
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Genes

342 genes differentially expressed following the ZNF274 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDILT protein disulfide isomerase-like, testis expressed 3.18775
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.18775
PGAM4 phosphoglycerate mutase family member 4 3.18775
PCDHB1 protocadherin beta 1 3.18775
MILR1 mast cell immunoglobulin-like receptor 1 3.18775
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.18775
TBX15 T-box 15 3.18775
MYBPC3 myosin binding protein C, cardiac 3.18775
SLC25A41 solute carrier family 25, member 41 3.18775
SKOR1 SKI family transcriptional corepressor 1 3.18775
TKTL1 transketolase-like 1 3.18775
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.18775
IL22RA1 interleukin 22 receptor, alpha 1 3.18775
BTN1A1 butyrophilin, subfamily 1, member A1 3.18775
HNF4A hepatocyte nuclear factor 4, alpha 3.18775
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.18775
FER1L6 fer-1-like family member 6 3.18775
CFHR3 complement factor H-related 3 3.18775
TMPRSS11A transmembrane protease, serine 11A 3.18775
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.18775
CD6 CD6 molecule 3.18775
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.18775
ZNF492 zinc finger protein 492 3.18775
COLEC10 collectin sub-family member 10 (C-type lectin) 3.18775
CSTL1 cystatin-like 1 3.18775
PAX2 paired box 2 3.18775
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 3.18775
CRYGC crystallin, gamma C 3.18775
TAS2R13 taste receptor, type 2, member 13 3.18775
PRDM13 PR domain containing 13 3.18775
TMC3 transmembrane channel-like 3 3.18775
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.18775
EPHB3 EPH receptor B3 3.18775
ARSH arylsulfatase family, member H 3.18775
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.18775
GPR78 G protein-coupled receptor 78 3.18775
NPIPA3 nuclear pore complex interacting protein family, member A3 3.18775
BTC betacellulin 3.18775
GLRA3 glycine receptor, alpha 3 3.18775
C6ORF58 chromosome 6 open reading frame 58 3.18775
SIGLEC9 sialic acid binding Ig-like lectin 9 3.18775
MFAP5 microfibrillar associated protein 5 3.18775
NUGGC nuclear GTPase, germinal center associated 3.18775
CA6 carbonic anhydrase VI 3.18775
REN renin 3.18775
GCKR glucokinase (hexokinase 4) regulator 3.18775
SFTPB surfactant protein B 3.18775
GUCY2F guanylate cyclase 2F, retinal 3.18775
PCDH8 protocadherin 8 3.18775
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.18775
FAM3D family with sequence similarity 3, member D 3.18775
SPMAP1 sperm microtubule associated protein 1 3.18775
CLDN16 claudin 16 3.18775
ALX4 ALX homeobox 4 3.18775
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.18775
PAPOLB poly(A) polymerase beta (testis specific) 3.18775
TMEM196 transmembrane protein 196 3.18775
DOK7 docking protein 7 3.18775
DOK2 docking protein 2, 56kDa 3.18775
MYL10 myosin, light chain 10, regulatory 3.18775
SPATA2L spermatogenesis associated 2-like 3.18775
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.18775
YPEL4 yippee-like 4 (Drosophila) 3.18775
GBP6 guanylate binding protein family, member 6 3.18775
MT3 metallothionein 3 3.18775
OR1R1 olfactory receptor family 1 subfamily R member 1 3.18775
H2BK1 H2B.K variant histone 1 3.18775
GREP1 glycine rich extracellular protein 1 3.18775
SPEM2 SPEM family member 2 3.18775
CBLIF cobalamin binding intrinsic factor 3.18775
CCN5 cellular communication network factor 5 3.18775
LORICRIN loricrin cornified envelope precursor protein 3.18775
PLAAT4 phospholipase A and acyltransferase 4 3.18775
NECTIN4 nectin cell adhesion molecule 4 3.18775
CAVIN2 caveolae associated protein 2 3.18775
OR8G5 olfactory receptor, family 8, subfamily G, member 5 3.18775
REP15 RAB15 effector protein 3.18775
COL6A6 collagen, type VI, alpha 6 3.18775
GOLGA6L4 golgin A6 family-like 4 3.18775
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.18775
MAL mal, T-cell differentiation protein 3.18775
TRIM60 tripartite motif containing 60 3.18775
IRF8 interferon regulatory factor 8 3.18775
TUBA3E tubulin, alpha 3e 3.18775
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.18775
PTPRC protein tyrosine phosphatase, receptor type, C 3.18775
SLFN14 schlafen family member 14 3.18775
ZIC4 Zic family member 4 3.18775
GZMM granzyme M (lymphocyte met-ase 1) 3.18775
SLC45A2 solute carrier family 45, member 2 3.18775
F5 coagulation factor V (proaccelerin, labile factor) 3.18775
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.18775
IL7R interleukin 7 receptor 3.18775
PLB1 phospholipase B1 3.18775
S100B S100 calcium binding protein B 3.18775
S100G S100 calcium binding protein G 3.18775
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.18775
INSRR insulin receptor-related receptor 3.18775
FAM186A family with sequence similarity 186, member A 3.18775
PRR18 proline rich 18 3.18775
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.18775
TBC1D10C TBC1 domain family, member 10C 3.18775
RAB40A RAB40A, member RAS oncogene family 3.18775
BRDT bromodomain, testis-specific 3.18775
KLF2 Kruppel-like factor 2 3.18775
GAB3 GRB2-associated binding protein 3 3.18775
ISL1 ISL LIM homeobox 1 3.18775
FNDC8 fibronectin type III domain containing 8 3.18775
TEKT2 tektin 2 (testicular) 3.18775
CHI3L2 chitinase 3-like 2 3.18775
PCDHGB1 protocadherin gamma subfamily B, 1 3.18775
CD177 CD177 molecule 3.18775
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.18775
FZD1 frizzled class receptor 1 3.18775
WDFY4 WDFY family member 4 3.18775
LRRK2 leucine-rich repeat kinase 2 3.18775
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.18775
FAM135B family with sequence similarity 135, member B 3.18775
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.18775
CERKL ceramide kinase-like 3.18775
C17ORF99 chromosome 17 open reading frame 99 3.18775
JSRP1 junctional sarcoplasmic reticulum protein 1 3.18775
WFDC6 WAP four-disulfide core domain 6 3.18775
GOLGA6C golgin A6 family, member C 3.18775
KLHL41 kelch-like family member 41 3.18775
AKNAD1 AKNA domain containing 1 3.18775
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.18775
TRIM55 tripartite motif containing 55 3.18775
DUOX2 dual oxidase 2 3.18775
GLOD5 glyoxalase domain containing 5 3.18775
BAHCC1 BAH domain and coiled-coil containing 1 3.18775
CPSF4L cleavage and polyadenylation specific factor 4-like 3.18775
CXCR2 chemokine (C-X-C motif) receptor 2 3.18775
CRHR1 corticotropin releasing hormone receptor 1 3.18775
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.18775
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.18775
MUC13 mucin 13, cell surface associated 3.18775
SAMD7 sterile alpha motif domain containing 7 3.18775
OR11G2 olfactory receptor, family 11, subfamily G, member 2 3.18775
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.18775
ARHGAP40 Rho GTPase activating protein 40 3.18775
ASCL3 achaete-scute family bHLH transcription factor 3 3.18775
LOXL4 lysyl oxidase-like 4 3.18775
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.18775
IRX5 iroquois homeobox 5 3.18775
CNR2 cannabinoid receptor 2 (macrophage) 3.18775
ANKRD30A ankyrin repeat domain 30A 3.18775
CXORF58 chromosome X open reading frame 58 3.18775
ANKRD30B ankyrin repeat domain 30B 3.18775
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.18775
SFTA2 surfactant associated 2 3.18775
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.18775
LRRC24 leucine rich repeat containing 24 3.18775
UPK1B uroplakin 1B 3.18775
R3HDML R3H domain containing-like 3.18775
CFP complement factor properdin 3.18775
ZNF396 zinc finger protein 396 3.18775
IGIP IgA-inducing protein 3.18775
LAMP3 lysosomal-associated membrane protein 3 3.18775
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.18775
SYNGR4 synaptogyrin 4 3.18775
BRI3 brain protein I3 3.18775
OTOP2 otopetrin 2 3.18775
TMEM31 transmembrane protein 31 3.18775
IL10RA interleukin 10 receptor, alpha 3.18775
SLC38A8 solute carrier family 38, member 8 3.18775
RGS8 regulator of G-protein signaling 8 3.18775
DEFB135 defensin, beta 135 3.18775
MMEL1 membrane metallo-endopeptidase-like 1 3.18775
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.18775
ADAM21 ADAM metallopeptidase domain 21 3.18775
PPP1R3C protein phosphatase 1, regulatory subunit 3C 3.18775
LYPD5 LY6/PLAUR domain containing 5 3.18775
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.18775
PCDH19 protocadherin 19 3.06081
NOTCH4 notch 4 3.06081
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.06081
TFEB transcription factor EB 3.06081
MATN3 matrilin 3 3.03349
ARL4A ADP-ribosylation factor-like 4A 2.96582
PROSER3 proline and serine rich 3 2.83462
ATAD3A ATPase family, AAA domain containing 3A 2.77357
PABIR3 PABIR family member 3 2.67138
ANXA4 annexin A4 2.58772
C11ORF42 chromosome 11 open reading frame 42 2.57571
ARC activity-regulated cytoskeleton-associated protein 2.53407
NES nestin 2.53407
OSBPL11 oxysterol binding protein-like 11 2.5101
ALMS1 Alstrom syndrome protein 1 2.50108
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.50108
SMIM15 small integral membrane protein 15 2.49964
SRSF4 serine/arginine-rich splicing factor 4 2.49836
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.45271
TRIM28 tripartite motif containing 28 2.44303
TMEM91 transmembrane protein 91 2.42554
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 2.42554
METTL9 methyltransferase like 9 2.39725
MTMR3 myotubularin related protein 3 2.39175
H4C6 H4 clustered histone 6 2.38861
CUTA cutA divalent cation tolerance homolog (E. coli) 2.36759
TUBD1 tubulin, delta 1 2.36004
RBM12 RNA binding motif protein 12 2.35701
CHMP7 charged multivesicular body protein 7 2.34422
CCT8 chaperonin containing TCP1, subunit 8 (theta) 2.34258
UBR1 ubiquitin protein ligase E3 component n-recognin 1 2.33985
KPTN kaptin (actin binding protein) 2.33845
SARNP SAP domain containing ribonucleoprotein 2.31293
MMP19 matrix metallopeptidase 19 2.2865
NLRP2 NLR family, pyrin domain containing 2 2.24899
PHTF2 putative homeodomain transcription factor 2 2.24801
GPATCH8 G patch domain containing 8 2.22956
ZNF18 zinc finger protein 18 2.22052
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.21753
ZSWIM8 zinc finger, SWIM-type containing 8 2.19888
NUP210 nucleoporin 210kDa 2.19736
LAMA1 laminin, alpha 1 2.14898
RRAGA Ras-related GTP binding A 2.14887
SNTG2 syntrophin, gamma 2 2.1395
TMED4 transmembrane emp24 protein transport domain containing 4 2.11686
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.11649
CNOT9 CCR4-NOT transcription complex subunit 9 2.11323
MRPL28 mitochondrial ribosomal protein L28 2.09935
GPSM3 G-protein signaling modulator 3 2.09827
THAP12 THAP domain containing 12 2.08223
FAIM Fas apoptotic inhibitory molecule 2.0812
DMXL1 Dmx-like 1 2.07417
FAM161B family with sequence similarity 161, member B 2.07417
RBP2 retinol binding protein 2, cellular 2.07417
WDR87 WD repeat domain 87 2.07417
GFI1B growth factor independent 1B transcription repressor 2.07417
LMNTD2 lamin tail domain containing 2 2.07417
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.06376
C15ORF61 chromosome 15 open reading frame 61 2.0614
MOAP1 modulator of apoptosis 1 2.04542
LAYN layilin 2.04542
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.04542
ZNF585A zinc finger protein 585A 2.0259
RPGR retinitis pigmentosa GTPase regulator 2.01263
DEXI Dexi homolog (mouse) 2.00341

decreased expression

Symbol Name Standardized Value
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -3.18775
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -3.18775
LYNX1 Ly6/neurotoxin 1 -3.18775
GOLGA6L7 golgin A6 family like 7 -3.18775
KRTAP5-11 keratin associated protein 5-11 -3.18775
CD70 CD70 molecule -3.18775
COPZ2 coatomer protein complex, subunit zeta 2 -3.18775
CLIC2 chloride intracellular channel 2 -3.18775
TENT5C terminal nucleotidyltransferase 5C -3.18775
BTNL9 butyrophilin-like 9 -3.18775
HES3 hes family bHLH transcription factor 3 -3.18775
TRIM73 tripartite motif containing 73 -3.18775
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -3.18775
RLN1 relaxin 1 -3.18775
RAD17 RAD17 homolog (S. pombe) -3.18775
TWIST1 twist family bHLH transcription factor 1 -3.18775
ACADL acyl-CoA dehydrogenase, long chain -3.18775
RDH16 retinol dehydrogenase 16 (all-trans) -3.18775
GPRASP1 G protein-coupled receptor associated sorting protein 1 -3.18775
CREB5 cAMP responsive element binding protein 5 -3.18775
ADAMTSL4 ADAMTS-like 4 -3.18775
ETNPPL ethanolamine-phosphate phospho-lyase -3.18775
C17ORF107 chromosome 17 open reading frame 107 -3.18775
LBHD1 LBH domain containing 1 -3.18775
OPTC opticin -3.18775
ADAP2 ArfGAP with dual PH domains 2 -3.18775
INSYN2B inhibitory synaptic factor family member 2B -3.18775
ATP5MGL ATP synthase membrane subunit g like -3.18775
SIGLEC15 sialic acid binding Ig-like lectin 15 -3.18775
DAPL1 death associated protein-like 1 -3.18775
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.18775
GLRB glycine receptor, beta -3.18775
EHD2 EH-domain containing 2 -3.18775
TACSTD2 tumor-associated calcium signal transducer 2 -3.18775
CDHR2 cadherin-related family member 2 -3.18775
ZNF750 zinc finger protein 750 -3.18775
CD52 CD52 molecule -3.18775
SSC5D scavenger receptor cysteine rich family, 5 domains -3.18775
RAD9B RAD9 homolog B (S. pombe) -3.18775
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -3.18775
HYAL2 hyaluronoglucosaminidase 2 -3.18775
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -3.18775
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -3.15115
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.15115
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -3.07303
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.99955
SLC35E4 solute carrier family 35, member E4 -2.98431
FAM50B family with sequence similarity 50, member B -2.97237
ARHGAP27 Rho GTPase activating protein 27 -2.97036
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -2.89742
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.84238
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.83462
AFG1L AFG1 like ATPase -2.83462
FAM13A family with sequence similarity 13, member A -2.80555
ZNF181 zinc finger protein 181 -2.75085
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -2.66422
CA5B carbonic anhydrase VB, mitochondrial -2.61553
IQCC IQ motif containing C -2.58126
YBX3 Y box binding protein 3 -2.55668
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.52708
NTNG2 netrin G2 -2.52708
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.50108
ZNF714 zinc finger protein 714 -2.49964
EP300 E1A binding protein p300 -2.46456
CLIC1 chloride intracellular channel 1 -2.46055
ACP1 acid phosphatase 1, soluble -2.45271
RCE1 Ras converting CAAX endopeptidase 1 -2.44502
ARHGAP22 Rho GTPase activating protein 22 -2.44303
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.44016
EPB41 erythrocyte membrane protein band 4.1 -2.43646
DKC1 dyskeratosis congenita 1, dyskerin -2.39791
COX7B cytochrome c oxidase subunit VIIb -2.38109
CASD1 CAS1 domain containing 1 -2.35019
ZNF597 zinc finger protein 597 -2.339
KIDINS220 kinase D-interacting substrate, 220kDa -2.30317
MRPS30 mitochondrial ribosomal protein S30 -2.30091
FRMPD3 FERM and PDZ domain containing 3 -2.28661
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.28428
ETHE1 ethylmalonic encephalopathy 1 -2.2499
RHCE Rh blood group, CcEe antigens -2.2496
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.24162
JUN jun proto-oncogene -2.22383
FLRT2 fibronectin leucine rich transmembrane protein 2 -2.21279
E2F4 E2F transcription factor 4, p107/p130-binding -2.21048
ATG2A autophagy related 2A -2.20157
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.20157
GHRL ghrelin/obestatin prepropeptide -2.20157
FGF8 fibroblast growth factor 8 (androgen-induced) -2.20157
ZNF114 zinc finger protein 114 -2.19736
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -2.18227
ZNF267 zinc finger protein 267 -2.1395
EMC8 ER membrane protein complex subunit 8 -2.13918
E2F2 E2F transcription factor 2 -2.13154
STIL SCL/TAL1 interrupting locus -2.1313
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.12765
TMEM74B transmembrane protein 74B -2.12757
MYO9B myosin IXB -2.0891
TKFC triokinase/FMN cyclase -2.0485
IFT172 intraflagellar transport 172 -2.04072
ZNF709 zinc finger protein 709 -2.02844
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02279
ARLN allregulin -2.01393
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.00341