ZW10 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description zw10 kinetochore protein|This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 9183)
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Genes

355 genes differentially expressed following the ZW10 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLF hepatic leukemia factor 3.23988
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.23988
GLUD2 glutamate dehydrogenase 2 3.23988
PDYN prodynorphin 3.23988
FOXA1 forkhead box A1 3.23988
HES3 hes family bHLH transcription factor 3 3.23988
UNC13C unc-13 homolog C (C. elegans) 3.23988
PCDHGB3 protocadherin gamma subfamily B, 3 3.23988
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.23988
PDE7B phosphodiesterase 7B 3.23988
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.23988
MGAM2 maltase-glucoamylase 2 (putative) 3.23988
MUC1 mucin 1, cell surface associated 3.23988
HCRTR1 hypocretin (orexin) receptor 1 3.23988
UPK3A uroplakin 3A 3.23988
ARID3C AT rich interactive domain 3C (BRIGHT-like) 3.23988
WDR87 WD repeat domain 87 3.23988
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.23988
ADGRE3 adhesion G protein-coupled receptor E3 3.23988
IGFL2 IGF-like family member 2 3.23988
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.23988
PLIN1 perilipin 1 3.23988
SLC16A11 solute carrier family 16, member 11 3.23988
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.23988
OLIG3 oligodendrocyte transcription factor 3 3.23988
OLIG2 oligodendrocyte lineage transcription factor 2 3.23988
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 3.23988
TRIM42 tripartite motif containing 42 3.23988
NEUROG2 neurogenin 2 3.23988
MMP21 matrix metallopeptidase 21 3.23988
CAPS calcyphosine 3.23988
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.23988
KRTAP5-5 keratin associated protein 5-5 3.23988
CLCF1 cardiotrophin-like cytokine factor 1 3.23988
FGF4 fibroblast growth factor 4 3.23988
FGF6 fibroblast growth factor 6 3.23988
BTBD19 BTB (POZ) domain containing 19 3.23988
SMIM5 small integral membrane protein 5 3.23988
SHISA7 shisa family member 7 3.23988
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.23988
GDNF glial cell derived neurotrophic factor 3.23988
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.23988
ALPK2 alpha-kinase 2 3.23988
FBLN7 fibulin 7 3.23988
UNC45B unc-45 homolog B (C. elegans) 3.23988
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.23988
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.23988
GADL1 glutamate decarboxylase-like 1 3.23988
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 3.23988
USP50 ubiquitin specific peptidase 50 3.23988
NRGN neurogranin (protein kinase C substrate, RC3) 3.23988
TMPRSS11F transmembrane protease, serine 11F 3.23988
CIMIP3 ciliary microtubule inner protein 3 3.23988
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.23988
FIMP1 fertilization-influencing membrane protein 1 3.23988
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.23988
BDKRB2 bradykinin receptor B2 3.23988
TMEM265 transmembrane protein 265 3.23988
DOK7 docking protein 7 3.23988
IMPG2 interphotoreceptor matrix proteoglycan 2 3.23988
GATA3 GATA binding protein 3 3.23988
GATA2 GATA binding protein 2 3.23988
GATA4 GATA binding protein 4 3.23988
AANAT aralkylamine N-acetyltransferase 3.23988
LTB4R2 leukotriene B4 receptor 2 3.23988
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.23988
PNMA8C PNMA family member 8C 3.23988
SMIM43 small integral membrane protein 43 3.23988
TEX13D TEX13 family member D 3.23988
CFAP157 cilia and flagella associated protein 157 3.23988
DYNLT4 dynein light chain Tctex-type 4 3.23988
PLAAT2 phospholipase A and acyltransferase 2 3.23988
NSG2 neuronal vesicle trafficking associated 2 3.23988
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.23988
ANGPTL8 angiopoietin like 8 3.23988
GOLGA6L7 golgin A6 family like 7 3.23988
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.23988
MFRP membrane frizzled-related protein 3.23988
FAM131C family with sequence similarity 131, member C 3.23988
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.23988
ITK IL2-inducible T-cell kinase 3.23988
VIT vitrin 3.23988
OASL 2'-5'-oligoadenylate synthetase-like 3.23988
HHEX hematopoietically expressed homeobox 3.23988
RAET1G retinoic acid early transcript 1G 3.23988
USH1G Usher syndrome 1G (autosomal recessive) 3.23988
NRN1 neuritin 1 3.23988
WEE2 WEE1 homolog 2 (S. pombe) 3.23988
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.23988
IL31RA interleukin 31 receptor A 3.23988
CALCA calcitonin-related polypeptide alpha 3.23988
ULBP2 UL16 binding protein 2 3.23988
SAMD11 sterile alpha motif domain containing 11 3.23988
IL1RN interleukin 1 receptor antagonist 3.23988
PTH parathyroid hormone 3.23988
CDKN2A cyclin-dependent kinase inhibitor 2A 3.23988
NPFF neuropeptide FF-amide peptide precursor 3.23988
PRRT4 proline-rich transmembrane protein 4 3.23988
MIP major intrinsic protein of lens fiber 3.23988
PGC progastricsin (pepsinogen C) 3.23988
IL6 interleukin 6 3.23988
MSX1 msh homeobox 1 3.23988
GPR75 G protein-coupled receptor 75 3.23988
MFSD6L major facilitator superfamily domain containing 6-like 3.23988
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.23988
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.23988
GOLGA6C golgin A6 family, member C 3.23988
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.23988
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.23988
CLEC4D C-type lectin domain family 4, member D 3.23988
MAMLD1 mastermind-like domain containing 1 3.23988
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 3.23988
CRHR1 corticotropin releasing hormone receptor 1 3.23988
IL11 interleukin 11 3.23988
C20ORF144 chromosome 20 open reading frame 144 3.23988
RESP18 regulated endocrine-specific protein 18 3.23988
C11ORF96 chromosome 11 open reading frame 96 3.23988
BAIAP3 BAI1-associated protein 3 3.23988
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.23988
PCDHGB4 protocadherin gamma subfamily B, 4 3.23988
EBF4 early B-cell factor 4 3.23988
TSNAXIP1 translin-associated factor X interacting protein 1 3.23988
SOWAHA sosondowah ankyrin repeat domain family member A 3.23988
CNTF ciliary neurotrophic factor 3.23988
RAD21L1 RAD21-like 1 (S. pombe) 3.23988
DYDC1 DPY30 domain containing 1 3.23988
LCT lactase 3.23988
ZBP1 Z-DNA binding protein 1 3.23988
SPATA9 spermatogenesis associated 9 3.23988
CTXN2 cortexin 2 3.23988
ADAP1 ArfGAP with dual PH domains 1 3.23988
ABLIM3 actin binding LIM protein family, member 3 3.23988
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.23988
LAMB3 laminin, beta 3 3.23988
FAM151A family with sequence similarity 151, member A 3.23988
CXORF58 chromosome X open reading frame 58 3.23988
EOMES eomesodermin 3.23988
LRRC24 leucine rich repeat containing 24 3.23988
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 3.23988
SIDT1 SID1 transmembrane family, member 1 3.23988
CFB complement factor B 3.23988
CLEC1A C-type lectin domain family 1, member A 3.23988
CYTH4 cytohesin 4 3.23988
SPEF1 sperm flagellar 1 3.23988
COL9A2 collagen, type IX, alpha 2 3.23988
TUBA4B tubulin, alpha 4b 3.23988
DMRT1 doublesex and mab-3 related transcription factor 1 3.23988
NT5C1B 5'-nucleotidase, cytosolic IB 3.23988
ART1 ADP-ribosyltransferase 1 3.23988
CA5A carbonic anhydrase VA, mitochondrial 3.23988
OR4D1 olfactory receptor, family 4, subfamily D, member 1 3.23988
BCL2L15 BCL2-like 15 3.23988
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.23988
QRFP pyroglutamylated RFamide peptide 3.23988
CRTAM cytotoxic and regulatory T cell molecule 3.23988
THEM5 thioesterase superfamily member 5 3.23988
SP100 SP100 nuclear antigen 3.23988
PLA2G2C phospholipase A2, group IIC 3.23988
MMP10 matrix metallopeptidase 10 3.23988
AMER2 APC membrane recruitment protein 2 3.23988
POTEE POTE ankyrin domain family, member E 3.23988
CLCA4 chloride channel accessory 4 3.23988
PGM5 phosphoglucomutase 5 3.23988
TTC36 tetratricopeptide repeat domain 36 3.23988
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.23988
BCAS1 breast carcinoma amplified sequence 1 3.23988
ALLC allantoicase 3.23988
TSKS testis-specific serine kinase substrate 3.23988
MMP12 matrix metallopeptidase 12 3.23988
FAM25G family with sequence similarity 25, member G 3.23988
KIF4B kinesin family member 4B 3.23988
CDCP2 CUB domain containing protein 2 3.23988
CDC14C cell division cycle 14C 3.23988
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 3.23988
LPO lactoperoxidase 3.23988
POTEF POTE ankyrin domain family, member F 3.23988
CELA2B chymotrypsin-like elastase family, member 2B 3.23988
RIOK3 RIO kinase 3 3.19568
HBEGF heparin-binding EGF-like growth factor 3.10291
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 3.10291
IFI16 interferon, gamma-inducible protein 16 3.10291
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 3.10291
CARD14 caspase recruitment domain family, member 14 3.10291
ARRDC2 arrestin domain containing 2 3.0815
C9ORF78 chromosome 9 open reading frame 78 3.05272
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.97992
RUMY4 RUMY family member 4 2.94777
YBX2 Y box binding protein 2 2.91189
TRABD2A TraB domain containing 2A 2.88938
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.85601
GNL1 guanine nucleotide binding protein-like 1 2.76881
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.70736
IQANK1 IQ motif and ankyrin repeat containing 1 2.70562
SMN2 survival of motor neuron 2, centromeric 2.68567
SURF6 surfeit 6 2.65946
MRPL1 mitochondrial ribosomal protein L1 2.63904
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.62964
EMD emerin 2.62479
COL2A1 collagen, type II, alpha 1 2.51526
WDR55 WD repeat domain 55 2.50488
MYEF2 myelin expression factor 2 2.49306
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.4788
ZNF678 zinc finger protein 678 2.45216
NATD1 N-acetyltransferase domain containing 1 2.43788
GSDMA gasdermin A 2.42078
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.42078
SLC15A5 solute carrier family 15, member 5 2.41202
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.40772
BBS12 Bardet-Biedl syndrome 12 2.40053
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.39879
SORBS3 sorbin and SH3 domain containing 3 2.38345
VIL1 villin 1 2.32664
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.31197
PRDM14 PR domain containing 14 2.29123
GANAB glucosidase, alpha; neutral AB 2.28547
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.28184
CCNA1 cyclin A1 2.28184
INO80B INO80 complex subunit B 2.26371
FGD3 FYVE, RhoGEF and PH domain containing 3 2.26371
YAF2 YY1 associated factor 2 2.26371
CD151 CD151 molecule (Raph blood group) 2.25889
CCAR2 cell cycle and apoptosis regulator 2 2.21147
LRRC4B leucine rich repeat containing 4B 2.20385
GINM1 glycoprotein integral membrane 1 2.18445
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.16276
ATOSB atos homolog B 2.16247
LIPA lipase A, lysosomal acid, cholesterol esterase 2.16247
KIF1C kinesin family member 1C 2.15406
FRMD3 FERM domain containing 3 2.15406
GDAP1 ganglioside induced differentiation associated protein 1 2.13941
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.11665
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.11525
NME5 NME/NM23 family member 5 2.11525
PLD6 phospholipase D family, member 6 2.11525
NPB neuropeptide B 2.11525
GGACT gamma-glutamylamine cyclotransferase 2.11525
ACSL6 acyl-CoA synthetase long-chain family member 6 2.11525
ZNF572 zinc finger protein 572 2.11525
AQP3 aquaporin 3 (Gill blood group) 2.11525
MTFR2 mitochondrial fission regulator 2 2.11113
SEC11A SEC11 homolog A (S. cerevisiae) 2.09184
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.08081
SLC30A5 solute carrier family 30 (zinc transporter), member 5 2.06881
ABHD17C abhydrolase domain containing 17C 2.06837
NUP155 nucleoporin 155kDa 2.06837
PAK5 p21 (RAC1) activated kinase 5 2.05968
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 2.05968
MRPS34 mitochondrial ribosomal protein S34 2.05968
ZNF280B zinc finger protein 280B 2.05862
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.05836
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.03813
SMG8 SMG8 nonsense mediated mRNA decay factor 2.00988
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.00825

decreased expression

Symbol Name Standardized Value
EMCN endomucin -3.23988
ETNPPL ethanolamine-phosphate phospho-lyase -3.23988
ADORA1 adenosine A1 receptor -3.23988
ZNF582 zinc finger protein 582 -3.23988
AKAP14 A kinase (PRKA) anchor protein 14 -3.23988
ECE2 endothelin converting enzyme 2 -3.23988
IFIH1 interferon induced with helicase C domain 1 -3.23988
LMO2 LIM domain only 2 (rhombotin-like 1) -3.23988
NFAM1 NFAT activating protein with ITAM motif 1 -3.23988
ANKRD37 ankyrin repeat domain 37 -3.23988
NUTM2A NUT family member 2A -3.23988
POU3F4 POU class 3 homeobox 4 -3.23988
S100A1 S100 calcium binding protein A1 -3.23988
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.23988
CHD5 chromodomain helicase DNA binding protein 5 -3.23988
PPP1R3D protein phosphatase 1, regulatory subunit 3D -3.23988
GID8 GID complex subunit 8 -3.23988
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -3.23988
TEX101 testis expressed 101 -3.23988
ARMC12 armadillo repeat containing 12 -3.23988
GRID1 glutamate receptor, ionotropic, delta 1 -3.23988
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.23988
C9ORF43 chromosome 9 open reading frame 43 -3.23988
ETV3L ets variant 3-like -3.23988
SP110 SP110 nuclear body protein -3.23988
PNLIPRP1 pancreatic lipase-related protein 1 -3.23988
GOLGA8H golgin A8 family, member H -3.23988
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -3.23988
SYT15B synaptotagmin 15B -3.23988
MPPED1 metallophosphoesterase domain containing 1 -3.23988
SLC46A2 solute carrier family 46, member 2 -3.23988
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.23988
RAD9B RAD9 homolog B (S. pombe) -3.23988
IDO2 indoleamine 2,3-dioxygenase 2 -3.23988
FBXO48 F-box protein 48 -3.23988
LRRC43 leucine rich repeat containing 43 -3.23988
SNAI1 snail family zinc finger 1 -3.10291
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.91781
MAT2A methionine adenosyltransferase II, alpha -2.9064
VLDLR very low density lipoprotein receptor -2.88295
MRPS18C mitochondrial ribosomal protein S18C -2.86845
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.84914
TRIP12 thyroid hormone receptor interactor 12 -2.74224
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -2.73686
PCNX4 pecanex 4 -2.72356
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.64305
MYOM1 myomesin 1 -2.59512
RAB9B RAB9B, member RAS oncogene family -2.51706
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.51706
HLA-DRA major histocompatibility complex, class II, DR alpha -2.51706
EMC10 ER membrane protein complex subunit 10 -2.51085
NCKAP5L NCK-associated protein 5-like -2.49722
FMO5 flavin containing monooxygenase 5 -2.49417
MYH11 myosin, heavy chain 11, smooth muscle -2.49417
KLK8 kallikrein-related peptidase 8 -2.49417
PKP3 plakophilin 3 -2.49417
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.46211
ZNF763 zinc finger protein 763 -2.45645
CRCP CGRP receptor component -2.45217
GLI2 GLI family zinc finger 2 -2.3945
LRATD1 LRAT domain containing 1 -2.3753
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.35399
PLPP1 phospholipid phosphatase 1 -2.29635
WDR20 WD repeat domain 20 -2.29123
U2AF2 U2 small nuclear RNA auxiliary factor 2 -2.28361
HK2 hexokinase 2 -2.28102
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.26888
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.26606
COPB1 coatomer protein complex, subunit beta 1 -2.2514
ZNF212 zinc finger protein 212 -2.23917
PAXBP1 PAX3 and PAX7 binding protein 1 -2.23406
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.23222
TLK2 tousled-like kinase 2 -2.23222
F2R coagulation factor II (thrombin) receptor -2.21416
PAH phenylalanine hydroxylase -2.19843
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.19416
CNR1 cannabinoid receptor 1 (brain) -2.19136
LMNB2 lamin B2 -2.19136
RPH3A rabphilin 3A -2.19136
STX19 syntaxin 19 -2.19136
H3C7 H3 clustered histone 7 -2.19013
FBN2 fibrillin 2 -2.16276
H4C6 H4 clustered histone 6 -2.16276
KMT5A lysine methyltransferase 5A -2.16276
EIF5 eukaryotic translation initiation factor 5 -2.16276
GRAMD2A GRAM domain containing 2A -2.16276
CNGA4 cyclic nucleotide gated channel alpha 4 -2.16276
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.16276
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.16247
POT1 protection of telomeres 1 -2.15706
ATL3 atlastin GTPase 3 -2.12458
FASTKD1 FAST kinase domains 1 -2.12183
ANO8 anoctamin 8 -2.11242
RPUSD3 RNA pseudouridylate synthase domain containing 3 -2.06975
CCDC71 coiled-coil domain containing 71 -2.06837
CHD8 chromodomain helicase DNA binding protein 8 -2.05805
MTREX Mtr4 exosome RNA helicase -2.0495
DYNLT5 dynein light chain Tctex-type family member 5 -2.04797
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.0452
ZMYM5 zinc finger, MYM-type 5 -2.02724
LARP4 La ribonucleoprotein domain family, member 4 -2.01491
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.01251