Zafirlukast Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A carbamate ester that has formula C31H33N3O6S. (Chemical Entities of Biological Interest Ontology, CHEBI_10100)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5717
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Genes

200 proteins with high or low expression in Zafirlukast relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 2.68
ZSCAN32 zinc finger and SCAN domain containing 32 1.82
PGK2 phosphoglycerate kinase 2 1.81
KLHL23 kelch-like family member 23 1.71
MT1X metallothionein 1X 1.56
VAV1 vav 1 guanine nucleotide exchange factor 1.38
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1.24
FAT4 FAT atypical cadherin 4 1.09
DSCAM Down syndrome cell adhesion molecule 0.99
ABHD4 abhydrolase domain containing 4 0.96
MDM1 Mdm1 nuclear protein homolog (mouse) 0.86
BSN bassoon presynaptic cytomatrix protein 0.84
SULF2 sulfatase 2 0.74
RPL35 ribosomal protein L35 0.72
ZFP62 ZFP62 zinc finger protein 0.69
H1-2 H1.2 linker histone, cluster member 0.68
RPL24 ribosomal protein L24 0.68
ERCC8 excision repair cross-complementation group 8 0.68
HIST2H2BC histone cluster 2, H2bc (pseudogene) 0.68
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.67
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.64
SP100 SP100 nuclear antigen 0.63
RPLP1 ribosomal protein, large, P1 0.63
RPS27A ribosomal protein S27a 0.61
RPL10 ribosomal protein L10 0.6
KMT2B lysine (K)-specific methyltransferase 2B 0.6
POLQ polymerase (DNA directed), theta 0.6
RPL37 ribosomal protein L37 0.58
FBXO44 F-box protein 44 0.57
PRR3 proline rich 3 0.56
RPL23 ribosomal protein L23 0.56
ENO1 enolase 1, (alpha) 0.56
RPS14 ribosomal protein S14 0.55
MANF mesencephalic astrocyte-derived neurotrophic factor 0.55
RPL15 ribosomal protein L15 0.54
RMI2 RecQ mediated genome instability 2 0.54
NIN ninein (GSK3B interacting protein) 0.54
FGF2 fibroblast growth factor 2 (basic) 0.52
CCDC158 coiled-coil domain containing 158 0.51
NEB nebulin 0.51
CFAP58 cilia and flagella associated protein 58 0.5
OSBPL1A oxysterol binding protein-like 1A 0.5
TTLL4 tubulin tyrosine ligase-like family member 4 0.5
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.49
GPR161 G protein-coupled receptor 161 0.49
ATP5PF ATP synthase peripheral stalk subunit F6 0.47
RPS6 ribosomal protein S6 0.47
PUM1 pumilio RNA-binding family member 1 0.47
SLC43A3 solute carrier family 43, member 3 0.46
PEX7 peroxisomal biogenesis factor 7 0.46
ANGPTL4 angiopoietin-like 4 0.46
INPP5K inositol polyphosphate-5-phosphatase K 0.45
TACSTD2 tumor-associated calcium signal transducer 2 0.45
TUBB1 tubulin, beta 1 class VI 0.44
MFSD6 major facilitator superfamily domain containing 6 0.43
NAP1L1 nucleosome assembly protein 1-like 1 0.43
MAGEA2 melanoma antigen family A2 0.42
RPS25 ribosomal protein S25 0.42
RPL28 ribosomal protein L28 0.42
ERCC1 excision repair cross-complementation group 1 0.42
RPL13A ribosomal protein L13a 0.42
H1-3 H1.3 linker histone, cluster member 0.42
ADIRF adipogenesis regulatory factor 0.41
VAMP4 vesicle-associated membrane protein 4 0.41
RPL23A ribosomal protein L23a 0.41
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.41
RPL7A ribosomal protein L7a 0.41
SERF2 small EDRK-rich factor 2 0.41
EIF5A2 eukaryotic translation initiation factor 5A2 0.4
JPT1 Jupiter microtubule associated homolog 1 0.4
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.4
MRPL12 mitochondrial ribosomal protein L12 0.4
EEF2 eukaryotic translation elongation factor 2 0.4
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.4
TPM4 tropomyosin 4 0.4
CES2 carboxylesterase 2 0.39
C2ORF72 chromosome 2 open reading frame 72 0.39
RNF2 ring finger protein 2 0.39
ANXA1 annexin A1 0.39
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.39
SASH1 SAM and SH3 domain containing 1 0.39
NUCLEOLIN nucleolin multifunctional protein 0.39
HSPE1 heat shock 10kDa protein 1 0.38
NFYA nuclear transcription factor Y, alpha 0.37
PPA1 pyrophosphatase (inorganic) 1 0.37
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.37
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.37
C11ORF49 chromosome 11 open reading frame 49 0.37
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.36
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 0.36
SCLT1 sodium channel and clathrin linker 1 0.36
H3C1 H3 clustered histone 1 0.35
MGST1 microsomal glutathione S-transferase 1 0.35
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.34
H1-5 H1.5 linker histone, cluster member 0.34
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 0.34
COTL1 coactosin-like F-actin binding protein 1 0.34
MIEF1 mitochondrial elongation factor 1 0.34
PTPRB protein tyrosine phosphatase, receptor type, B 0.34
OASL 2'-5'-oligoadenylate synthetase-like 0.34

low expression

Symbol Name Standardized Value
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.73
ECM1 extracellular matrix protein 1 -1.32
SBSN suprabasin -1.21
FUNDC1 FUN14 domain containing 1 -0.82
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -0.82
PIP prolactin-induced protein -0.78
ERICH5 glutamate-rich 5 -0.7
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.64
PLAUR plasminogen activator, urokinase receptor -0.63
BBS4 Bardet-Biedl syndrome 4 -0.59
MNT MAX network transcriptional repressor -0.57
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.56
FAN1 FANCD2/FANCI-associated nuclease 1 -0.56
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -0.51
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -0.51
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.5
LGALSL lectin, galactoside-binding-like -0.48
LMBR1 limb development membrane protein 1 -0.47
CCAR2 cell cycle and apoptosis regulator 2 -0.47
TMEM64 transmembrane protein 64 -0.47
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.46
MYO18B myosin XVIIIB -0.46
FAM102B family with sequence similarity 102, member B -0.45
CLASP2 cytoplasmic linker associated protein 2 -0.45
BTBD3 BTB (POZ) domain containing 3 -0.45
TMEM192 transmembrane protein 192 -0.44
HSPA8 heat shock 70kDa protein 8 -0.44
TMEM97 transmembrane protein 97 -0.44
ARSK arylsulfatase family, member K -0.43
CLIC3 chloride intracellular channel 3 -0.43
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -0.43
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -0.43
PABPN1 poly(A) binding protein, nuclear 1 -0.42
RITA1 RBPJ interacting and tubulin associated 1 -0.41
JAG1 jagged 1 -0.41
HYKK hydroxylysine kinase -0.41
EMP3 epithelial membrane protein 3 -0.41
TRAPPC6A trafficking protein particle complex 6A -0.4
CLTCL1 clathrin, heavy chain-like 1 -0.4
ZNF250 zinc finger protein 250 -0.4
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -0.39
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.39
CST6 cystatin E/M -0.39
COL7A1 collagen, type VII, alpha 1 -0.38
KCTD17 potassium channel tetramerization domain containing 17 -0.38
OTC ornithine carbamoyltransferase -0.38
PLAAT3 phospholipase A and acyltransferase 3 -0.37
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.37
TTC30B tetratricopeptide repeat domain 30B -0.37
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -0.37
DXO decapping exoribonuclease -0.37
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.37
CCDC66 coiled-coil domain containing 66 -0.36
ZNF35 zinc finger protein 35 -0.36
LRP10 low density lipoprotein receptor-related protein 10 -0.35
SGMS2 sphingomyelin synthase 2 -0.34
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.34
CDK8 cyclin-dependent kinase 8 -0.34
DERPC DERPC proline and glycine rich nuclear protein -0.34
PCNX1 pecanex 1 -0.34
CNTNAP1 contactin associated protein 1 -0.34
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.33
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.33
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.33
ABHD17C abhydrolase domain containing 17C -0.33
SLC38A1 solute carrier family 38, member 1 -0.33
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.33
KCTD6 potassium channel tetramerization domain containing 6 -0.32
MYBPC1 myosin binding protein C, slow type -0.32
PIWIL2 piwi-like RNA-mediated gene silencing 2 -0.32
ULBP1 UL16 binding protein 1 -0.31
ZNF57 zinc finger protein 57 -0.31
SLC12A8 solute carrier family 12, member 8 -0.31
CYTH1 cytohesin 1 -0.31
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -0.31
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.3
SP140 SP140 nuclear body protein -0.3
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -0.3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -0.3
OSGIN1 oxidative stress induced growth inhibitor 1 -0.3
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.3
DUOX1 dual oxidase 1 -0.3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.3
TMEM120B transmembrane protein 120B -0.3
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -0.3
ZBTB44 zinc finger and BTB domain containing 44 -0.29
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.29
ZNF580 zinc finger protein 580 -0.29
FXR1 fragile X mental retardation, autosomal homolog 1 -0.29
TMEM184A transmembrane protein 184A -0.28
BMPR1B bone morphogenetic protein receptor, type IB -0.28
SSH2 slingshot protein phosphatase 2 -0.28
ZNF616 zinc finger protein 616 -0.28
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -0.28
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.28
C2CD4C C2 calcium-dependent domain containing 4C -0.28
IMMT inner membrane protein, mitochondrial -0.28
SERINC3 serine incorporator 3 -0.28
POF1B premature ovarian failure, 1B -0.28
TENT4A terminal nucleotidyltransferase 4A -0.28