Zeta DNA polymerase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. (Gene Ontology, GO_0016035)
External Link http://amigo.geneontology.org/amigo/term/GO:0016035
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355 proteins co-occuring with the Zeta DNA polymerase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 3.691
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 3.281
REV1 REV1, polymerase (DNA directed) 3.256
POLH polymerase (DNA directed), eta 2.739
POLM polymerase (DNA directed), mu 2.711
POLL polymerase (DNA directed), lambda 2.67
POLD2 polymerase (DNA directed), delta 2, accessory subunit 2.598
RAD18 RAD18 E3 ubiquitin protein ligase 2.562
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.354
PCNA proliferating cell nuclear antigen 2.304
PRIMPOL primase and polymerase (DNA-directed) 2.276
ERCC1 excision repair cross-complementation group 1 2.23
FANCD2 Fanconi anemia, complementation group D2 2.099
EME1 essential meiotic structure-specific endonuclease 1 2.038
MUS81 MUS81 structure-specific endonuclease subunit 2.019
FANCI Fanconi anemia, complementation group I 1.994
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 1.985
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.975
SLX4 SLX4 structure-specific endonuclease subunit 1.971
FANCM Fanconi anemia, complementation group M 1.962
UNG uracil-DNA glycosylase 1.956
RAD52 RAD52 homolog (S. cerevisiae) 1.952
XPA xeroderma pigmentosum, complementation group A 1.948
FANCE Fanconi anemia, complementation group E 1.908
DCLRE1A DNA cross-link repair 1A 1.902
RAD51 RAD51 recombinase 1.895
FANCL Fanconi anemia, complementation group L 1.892
FAAP24 FA core complex associated protein 24 1.877
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 1.868
FAAP100 FA core complex associated protein 100 1.859
SHLD2 shieldin complex subunit 2 1.857
UBE2N ubiquitin-conjugating enzyme E2N 1.85
BRCA1 breast cancer 1, early onset 1.837
TENT4A terminal nucleotidyltransferase 4A 1.815
EXO1 exonuclease 1 1.813
FANCC Fanconi anemia, complementation group C 1.798
FANCF Fanconi anemia, complementation group F 1.777
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.758
TP53BP1 tumor protein p53 binding protein 1 1.752
FANCG Fanconi anemia, complementation group G 1.752
FANCA Fanconi anemia, complementation group A 1.75
BRCA2 breast cancer 2, early onset 1.746
RAD51C RAD51 paralog C 1.715
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.69
XPC xeroderma pigmentosum, complementation group C 1.68
FANCB Fanconi anemia, complementation group B 1.672
SHLD1 shieldin complex subunit 1 1.659
RBBP8 retinoblastoma binding protein 8 1.657
CHEK2 checkpoint kinase 2 1.653
FAN1 FANCD2/FANCI-associated nuclease 1 1.65
PALB2 partner and localizer of BRCA2 1.648
RAD50 RAD50 homolog (S. cerevisiae) 1.629
ERCC2 excision repair cross-complementation group 2 1.624
NTHL1 nth endonuclease III-like 1 (E. coli) 1.616
POLK polymerase (DNA directed) kappa 1.611
NEIL1 nei endonuclease VIII-like 1 (E. coli) 1.594
HUS1 HUS1 checkpoint homolog (S. pombe) 1.587
FAAP20 FA core complex associated protein 20 1.586
WDR48 WD repeat domain 48 1.571
ATM ATM serine/threonine kinase 1.562
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 1.543
CHEK1 checkpoint kinase 1 1.54
RAD23B RAD23 homolog B (S. cerevisiae) 1.536
TRIP13 thyroid hormone receptor interactor 13 1.525
HELQ helicase, POLQ-like 1.521
FEN1 flap structure-specific endonuclease 1 1.509
RAD17 RAD17 homolog (S. pombe) 1.509
POLR1B polymerase (RNA) I polypeptide B, 128kDa 1.504
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.502
MSH3 mutS homolog 3 1.485
DNA2 DNA replication helicase/nuclease 2 1.485
MSH2 mutS homolog 2 1.484
TP53 tumor protein p53 1.473
USP1 ubiquitin specific peptidase 1 1.47
RTEL1 regulator of telomere elongation helicase 1 1.466
UBE2T ubiquitin-conjugating enzyme E2T 1.462
ERCC6 excision repair cross-complementation group 6 1.455
PIF1 PIF1 5'-to-3' DNA helicase 1.446
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1.438
POLI polymerase (DNA directed) iota 1.434
RAD9A RAD9 homolog A (S. pombe) 1.424
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.419
CENPX centromere protein X 1.41
OGG1 8-oxoguanine DNA glycosylase 1.391
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 1.39
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.39
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 1.382
PARP1 poly (ADP-ribose) polymerase 1 1.382
SPRTN SprT-like N-terminal domain 1.373
RFWD3 ring finger and WD repeat domain 3 1.372
DBF4 DBF4 zinc finger 1.367
HLTF helicase-like transcription factor 1.361
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.36
ERCC4 excision repair cross-complementation group 4 1.359
ERCC3 excision repair cross-complementation group 3 1.356
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.356
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.347
MSH6 mutS homolog 6 1.346
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1.345
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.339
STN1 STN1 subunit of CST complex 1.321
AHDC1 AT hook, DNA binding motif, containing 1 1.319
WRN Werner syndrome, RecQ helicase-like 1.304
RECQL RecQ helicase-like 1.301
POLE polymerase (DNA directed), epsilon, catalytic subunit 1.298
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 1.285
RAD51B RAD51 paralog B 1.275
H2AX H2A.X variant histone 1.267
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.26
SCAI suppressor of cancer cell invasion 1.251
RAD51D RAD51 paralog D 1.238
AICDA activation-induced cytidine deaminase 1.232
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.228
FOXN2 forkhead box N2 1.221
ATRIP ATR interacting protein 1.22
ZRANB3 zinc finger, RAN-binding domain containing 3 1.207
NEXMIF neurite extension and migration factor 1.204
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 1.202
RAD54B RAD54 homolog B (S. cerevisiae) 1.19
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 1.189
CENPS-CORT CENPS-CORT readthrough 1.181
DCLRE1B DNA cross-link repair 1B 1.178
ATAD5 ATPase family, AAA domain containing 5 1.178
NEIL2 nei endonuclease VIII-like 2 (E. coli) 1.174
HSF2BP heat shock transcription factor 2 binding protein 1.169
CHAMP1 chromosome alignment maintaining phosphoprotein 1 1.166
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.157
CDC45 cell division cycle 45 1.152
PRPF19 pre-mRNA processing factor 19 1.15
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.146
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 1.144
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.133
RMI1 RecQ mediated genome instability 1 1.129
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 1.127
CLSPN claspin 1.125
MPG N-methylpurine-DNA glycosylase 1.125
EXOG endo/exonuclease (5'-3'), endonuclease G-like 1.122
MLH1 mutL homolog 1 1.121
POLN polymerase (DNA directed) nu 1.118
MUTYH mutY homolog 1.111
RMI2 RecQ mediated genome instability 2 1.108
DDB2 damage-specific DNA binding protein 2, 48kDa 1.095
MGMT O-6-methylguanine-DNA methyltransferase 1.093
RECQL4 RecQ protein-like 4 1.074
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 1.073
ANKRD17 ankyrin repeat domain 17 1.068
APOBEC3A_B APOBEC3A and APOBEC3B deletion hybrid 1.068
PRMT5 protein arginine methyltransferase 5 1.06
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 1.051
PRAF2 PRA1 domain family, member 2 1.049
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.049
PARP4 poly (ADP-ribose) polymerase family, member 4 1.047
H2AZ2 H2A.Z variant histone 2 1.04
TDP1 tyrosyl-DNA phosphodiesterase 1 1.034
HMGB4 high mobility group box 4 1.03
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 1.028
PIPOX pipecolic acid oxidase 1.026
PARP3 poly (ADP-ribose) polymerase family, member 3 1.025
TTK TTK protein kinase 1.024
XAB2 XPA binding protein 2 1.013
GEN1 GEN1 Holliday junction 5' flap endonuclease 1.001
UBE2A ubiquitin-conjugating enzyme E2A 1.0
TOP1 topoisomerase (DNA) I 0.995
MBD4 methyl-CpG binding domain protein 4 0.994
CCNJ cyclin J 0.988
ZNF654 zinc finger protein 654 0.981
BIVM-ERCC5 BIVM-ERCC5 readthrough 0.976
TWNK twinkle mtDNA helicase 0.976
HOXC4 homeobox C4 0.974
TOPBP1 topoisomerase (DNA) II binding protein 1 0.971
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.968
PNKP polynucleotide kinase 3'-phosphatase 0.964
APLF aprataxin and PNKP like factor 0.964
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.962
CDC7 cell division cycle 7 0.961
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.956
ERCC5 excision repair cross-complementation group 5 0.955
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.938
SPO11 SPO11 meiotic protein covalently bound to DSB 0.934
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.932
SMC5 structural maintenance of chromosomes 5 0.927
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 0.919
SLF2 SMC5-SMC6 complex localization factor 2 0.917
ZFR zinc finger RNA binding protein 0.911
CUL4B cullin 4B 0.902
POLGARF POLG alternative reading frame 0.9
DDB1 damage-specific DNA binding protein 1, 127kDa 0.897
TRAIP TRAF interacting protein 0.893
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.893
RFC2 replication factor C (activator 1) 2, 40kDa 0.883
PDIK1L PDLIM1 interacting kinase 1 like 0.882
HMGN5 high mobility group nucleosome binding domain 5 0.882
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.881
CRB2 crumbs family member 2 0.878
TOP2A topoisomerase (DNA) II alpha 170kDa 0.873
LIG4 ligase IV, DNA, ATP-dependent 0.872
GYG2 glycogenin 2 0.871
ZMIZ1 zinc finger, MIZ-type containing 1 0.867
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 0.867
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.866
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.865
FAM114A2 family with sequence similarity 114, member A2 0.864
PEBP4 phosphatidylethanolamine-binding protein 4 0.86
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.854
SUGCT succinyl-CoA:glutarate-CoA transferase 0.847
NUGGC nuclear GTPase, germinal center associated 0.845
CDC6 cell division cycle 6 0.845
MDC1 mediator of DNA-damage checkpoint 1 0.844
RAD51AP1 RAD51 associated protein 1 0.836
NHEJ1 nonhomologous end-joining factor 1 0.834
EME2 essential meiotic structure-specific endonuclease subunit 2 0.832
RNF113A ring finger protein 113A 0.816
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.815
PIAS1 protein inhibitor of activated STAT, 1 0.81
CDK3 cyclin-dependent kinase 3 0.805
HORMAD1 HORMA domain containing 1 0.803
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 0.803
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.801
UBE2I ubiquitin-conjugating enzyme E2I 0.801
USP44 ubiquitin specific peptidase 44 0.799
UIMC1 ubiquitin interaction motif containing 1 0.794
TTC23 tetratricopeptide repeat domain 23 0.787
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.785
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.782
CPA4 carboxypeptidase A4 0.775
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.772
PARP2 poly (ADP-ribose) polymerase 2 0.769
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.766
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.764
PPP1R3F protein phosphatase 1, regulatory subunit 3F 0.763
MEMO1 mediator of cell motility 1 0.761
GCNA germ cell nuclear acidic peptidase 0.76
CNOT4 CCR4-NOT transcription complex, subunit 4 0.749
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.748
TDP2 tyrosyl-DNA phosphodiesterase 2 0.747
ZNF124 zinc finger protein 124 0.747
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.745
RNF213 ring finger protein 213 0.744
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.743
RRM1 ribonucleotide reductase M1 0.741
SMC6 structural maintenance of chromosomes 6 0.739
MRE11 MRE11 homolog, double strand break repair nuclease 0.737
CUL4A cullin 4A 0.731
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.73
TOP3A topoisomerase (DNA) III alpha 0.727
SIM2 single-minded family bHLH transcription factor 2 0.723
WWOX WW domain containing oxidoreductase 0.72
UBE2B ubiquitin-conjugating enzyme E2B 0.715
CNTN6 contactin 6 0.714
WRNIP1 Werner helicase interacting protein 1 0.708
SOX4 SRY (sex determining region Y)-box 4 0.704
ZNF281 zinc finger protein 281 0.701
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.698
DNAH8 dynein, axonemal, heavy chain 8 0.697
CDC27 cell division cycle 27 0.697
REC114 REC114 meiotic recombination protein 0.696
BARD1 BRCA1 associated RING domain 1 0.696
UVSSA UV-stimulated scaffold protein A 0.692
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.691
MCM9 minichromosome maintenance complex component 9 0.682
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.68
TATDN1 TatD DNase domain containing 1 0.68
PDPK1 3-phosphoinositide dependent protein kinase 1 0.68
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.677
APTX aprataxin 0.672
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) 0.668
ZNF618 zinc finger protein 618 0.664
TRIM65 tripartite motif containing 65 0.661
TMC6 transmembrane channel-like 6 0.658
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.657
FSBP fibrinogen silencer binding protein 0.656
TDG thymine-DNA glycosylase 0.655
ANKLE1 ankyrin repeat and LEM domain containing 1 0.653
SPTA1 spectrin, alpha, erythrocytic 1 0.649
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.648
PLK1 polo-like kinase 1 0.648
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.647
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.646
H2BC21 H2B clustered histone 21 0.646
FBH1 F-box DNA helicase 1 0.643
CDC20 cell division cycle 20 0.641
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.641
HOXA11 homeobox A11 0.64
PAXX PAXX non-homologous end joining factor 0.629
KLK11 kallikrein-related peptidase 11 0.628
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.628
TP73 tumor protein p73 0.626
GTF2I general transcription factor IIi 0.625
CLSTN1 calsyntenin 1 0.619
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.619
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 0.618
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 0.618
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.615
DDIT3 DNA-damage-inducible transcript 3 0.613
SETDB1 SET domain, bifurcated 1 0.612
ZNF121 zinc finger protein 121 0.611
SIRT1 sirtuin 1 0.61
CDA cytidine deaminase 0.61
MSH4 mutS homolog 4 0.603
SUMO4 small ubiquitin-like modifier 4 0.599
EGFR epidermal growth factor receptor 0.595
TMEM14A transmembrane protein 14A 0.595
HOXA9 homeobox A9 0.594
CDK4 cyclin-dependent kinase 4 0.593
BCL2 B-cell CLL/lymphoma 2 0.593
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.589
RNASEH1 ribonuclease H1 0.582
MINK1 misshapen-like kinase 1 0.58
BCL2L1 BCL2-like 1 0.58
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.576
SLCO2A1 solute carrier organic anion transporter family, member 2A1 0.576
DNTT DNA nucleotidylexotransferase 0.57
FOXO1 forkhead box O1 0.57
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.568
SAMD7 sterile alpha motif domain containing 7 0.567
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 0.564
SRSF1 serine/arginine-rich splicing factor 1 0.563
E2F1 E2F transcription factor 1 0.562
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.561
EIF5A2 eukaryotic translation initiation factor 5A2 0.557
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.555
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.552
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 0.552
TRIM8 tripartite motif containing 8 0.552
RPA4 replication protein A4, 30kDa 0.549
H4C7 H4 clustered histone 7 0.549
RBMY1D RNA binding motif protein, Y-linked, family 1, member D 0.546
FHIT fragile histidine triad 0.545
WEE1 WEE1 G2 checkpoint kinase 0.544
GAGE1 G antigen 1 0.544
CGAS cyclic GMP-AMP synthase 0.54
RAD54L RAD54-like (S. cerevisiae) 0.539
CCND1 cyclin D1 0.532
BIN2 bridging integrator 2 0.532
H4C15 H4 clustered histone 15 0.531
UFD1 ubiquitin recognition factor in ER associated degradation 1 0.531
TTLL9 tubulin tyrosine ligase-like family member 9 0.53
BMP7 bone morphogenetic protein 7 0.529
CD274 CD274 molecule 0.528
ALG11 ALG11, alpha-1,2-mannosyltransferase 0.528
POLRMT polymerase (RNA) mitochondrial (DNA directed) 0.528
PTEN phosphatase and tensin homolog 0.525
KMT5A lysine methyltransferase 5A 0.523
POTEF POTE ankyrin domain family, member F 0.523
MGME1 mitochondrial genome maintenance exonuclease 1 0.521
RNF130 ring finger protein 130 0.521
GINS3 GINS complex subunit 3 (Psf3 homolog) 0.52
H1-0 H1.0 linker histone 0.516
YPEL3 yippee-like 3 (Drosophila) 0.513
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0.511
HDGF hepatoma-derived growth factor 0.508
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.507
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.503
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.503
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.5