Zileuton_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Zileuton perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Zileuton_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.219573
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.153756
AKAP12 A kinase (PRKA) anchor protein 12 0.144046
TRIO trio Rho guanine nucleotide exchange factor 0.0960201
DLG1 discs, large homolog 1 (Drosophila) 0.0934434
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.082508
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0746601
FNDC3B fibronectin type III domain containing 3B 0.0643527
COL8A1 collagen, type VIII, alpha 1 0.0584444
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0544142
MYOF myoferlin 0.0521937
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0521116
PLAT plasminogen activator, tissue 0.0505916
DST dystonin 0.0493924
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0444588
C1D C1D nuclear receptor corepressor 0.0444371
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423708
SLC39A11 solute carrier family 39, member 11 0.0402434
PRELID2 PRELI domain containing 2 0.0389528
FLNB filamin B, beta 0.0383364
ELL2 elongation factor, RNA polymerase II, 2 0.0379869
POTEF POTE ankyrin domain family, member F 0.0371014
HDAC9 histone deacetylase 9 0.0361138
ZFP36L1 ZFP36 ring finger protein-like 1 0.0355964
FNIP1 folliculin interacting protein 1 0.034724
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0332703
CD109 CD109 molecule 0.0328672
NAV1 neuron navigator 1 0.031859
ANKIB1 ankyrin repeat and IBR domain containing 1 0.030285
L1CAM L1 cell adhesion molecule 0.0291127
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.028874
ESYT2 extended synaptotagmin-like protein 2 0.0287674
SLC22A23 solute carrier family 22, member 23 0.0275291
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0270468
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026884
BHLHE40 basic helix-loop-helix family, member e40 0.0258594
YEATS2 YEATS domain containing 2 0.0258433
ANO6 anoctamin 6 0.0257492
ZNF292 zinc finger protein 292 0.0257455
MSN moesin 0.0255397
SBF2 SET binding factor 2 0.0254173
RUNX1 runt-related transcription factor 1 0.0246452
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0243062
UBA6 ubiquitin-like modifier activating enzyme 6 0.0242545
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0241474
FAM219A family with sequence similarity 219, member A 0.0236563
ANKRD36 ankyrin repeat domain 36 0.023395
COL5A1 collagen, type V, alpha 1 0.0232046
MMP12 matrix metallopeptidase 12 0.0228195
SEPTIN9 septin 9 0.0225935
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.02252
SP3 Sp3 transcription factor 0.0224422
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.022364
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0220543
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0216852
VEGFA vascular endothelial growth factor A 0.0216848
NFE2L1 nuclear factor, erythroid 2-like 1 0.0212501
NAV2 neuron navigator 2 0.0212139
TAPBP TAP binding protein (tapasin) 0.0212107
EGFR epidermal growth factor receptor 0.0211893
RNF144A ring finger protein 144A 0.0211073
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0210532
ADAM9 ADAM metallopeptidase domain 9 0.0207707
ARRDC3 arrestin domain containing 3 0.0207341
MYADM myeloid-associated differentiation marker 0.0205501
DCLK2 doublecortin-like kinase 2 0.0204675
ABI3BP ABI family, member 3 (NESH) binding protein 0.020268
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0202016
ZMIZ1 zinc finger, MIZ-type containing 1 0.0198038
NCOR2 nuclear receptor corepressor 2 0.0196509
PBX3 pre-B-cell leukemia homeobox 3 0.0195107
SYTL3 synaptotagmin-like 3 0.0193461
CYLD cylindromatosis (turban tumor syndrome) 0.0191017
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0189329
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0188706
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0185264
PFKP phosphofructokinase, platelet 0.0178392
MACF1 microtubule-actin crosslinking factor 1 0.0174814
BACE2 beta-site APP-cleaving enzyme 2 0.0174632
MBNL2 muscleblind-like splicing regulator 2 0.0166413
SDK1 sidekick cell adhesion molecule 1 0.0166351
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0166324
NOTCH2 notch 2 0.0166297
FOSL1 FOS-like antigen 1 0.016591
SETD5 SET domain containing 5 0.016533
ARL15 ADP-ribosylation factor-like 15 0.0163234
AUTS2 autism susceptibility candidate 2 0.0161893
STEAP3 STEAP family member 3, metalloreductase 0.0161414
EGLN1 egl-9 family hypoxia-inducible factor 1 0.016088
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0158389
TPM3 tropomyosin 3 0.0157923
WDFY2 WD repeat and FYVE domain containing 2 0.0156285
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0155616
MYH9 myosin, heavy chain 9, non-muscle 0.0154539
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0153751
MTCL1 microtubule crosslinking factor 1 0.015191
TIMP2 TIMP metallopeptidase inhibitor 2 0.0151156
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.014995
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0149914
STK10 serine/threonine kinase 10 0.0149856

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.27346
TMSB10 thymosin beta 10 -0.242245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.216916
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18822
MT2A metallothionein 2A -0.121886
S100A10 S100 calcium binding protein A10 -0.114427
HLA-B major histocompatibility complex, class I, B -0.101816
PTMA prothymosin, alpha -0.0943686
S100A6 S100 calcium binding protein A6 -0.0813602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0787682
SQSTM1 sequestosome 1 -0.074744
LMNA lamin A/C -0.0707557
COL3A1 collagen, type III, alpha 1 -0.0694942
TPT1 tumor protein, translationally-controlled 1 -0.0603231
CAVIN1 caveolae associated protein 1 -0.0584356
B2M beta-2-microglobulin -0.0575756
CANX calnexin -0.0565858
CSTB cystatin B (stefin B) -0.0551329
TMSB4X thymosin beta 4, X-linked -0.053715
CCND1 cyclin D1 -0.0505041
NAP1L1 nucleosome assembly protein 1-like 1 -0.0488068
IFITM3 interferon induced transmembrane protein 3 -0.0486632
HLA-C major histocompatibility complex, class I, C -0.0485963
MEIS2 Meis homeobox 2 -0.0485505
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0463468
ACTG1 actin gamma 1 -0.0457634
THBS2 thrombospondin 2 -0.044944
ANXA2 annexin A2 -0.0448603
LOC112694756 uncharaterized LOC112694756 -0.0445584
AHNAK AHNAK nucleoprotein -0.0437107
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0420981
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0411917
COL1A2 collagen, type I, alpha 2 -0.0399984
RRBP1 ribosome binding protein 1 -0.0390053
EIF1 eukaryotic translation initiation factor 1 -0.038361
PRRC2C proline-rich coiled-coil 2C -0.0365908
RPS24 ribosomal protein S24 -0.0357473
RPL23 ribosomal protein L23 -0.0357146
HLA-E major histocompatibility complex, class I, E -0.0352319
RPL35A ribosomal protein L35a -0.035196
UBC ubiquitin C -0.0351497
FTL ferritin, light polypeptide -0.0350309
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0347052
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0335651
RPS6 ribosomal protein S6 -0.0332549
VDAC1 voltage-dependent anion channel 1 -0.031932
HDLBP high density lipoprotein binding protein -0.0317658
SP100 SP100 nuclear antigen -0.0316823
HSPB1 heat shock 27kDa protein 1 -0.0316397
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0314713
ARF1 ADP-ribosylation factor 1 -0.0308841
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0304785
TM4SF1 transmembrane 4 L six family member 1 -0.0299992
S100A4 S100 calcium binding protein A4 -0.0298492
MT1X metallothionein 1X -0.029703
RPL28 ribosomal protein L28 -0.02881
GNAS GNAS complex locus -0.0287775
RPLP2 ribosomal protein, large, P2 -0.0287335
RPS3 ribosomal protein S3 -0.0284722
TUBB4B tubulin, beta 4B class IVb -0.0281394
S100A11 S100 calcium binding protein A11 -0.0277436
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0276274
KPNB1 karyopherin (importin) beta 1 -0.02748
IFITM1 interferon induced transmembrane protein 1 -0.0273477
RPL12 ribosomal protein L12 -0.0272653
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0266928
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0264495
RPL19 ribosomal protein L19 -0.0263749
RHOBTB3 Rho-related BTB domain containing 3 -0.0261743
RPS8 ribosomal protein S8 -0.0260759
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0260685
RPS27A ribosomal protein S27a -0.0255012
H3-3B H3.3 histone B -0.0254679
TTC3 tetratricopeptide repeat domain 3 -0.0253446
SMC4 structural maintenance of chromosomes 4 -0.0252505
TPM4 tropomyosin 4 -0.025248
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0251751
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0251017
RPL34 ribosomal protein L34 -0.0248018
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0247829
FBXO11 F-box protein 11 -0.0245637
NPR2 natriuretic peptide receptor 2 -0.0243025
ZSWIM6 zinc finger, SWIM-type containing 6 -0.02424
RPL37A ribosomal protein L37a -0.0237966
VCL vinculin -0.0237671
RPL26 ribosomal protein L26 -0.0236927
RAB1A RAB1A, member RAS oncogene family -0.023678
MYL12B myosin, light chain 12B, regulatory -0.0236399
RAD21 RAD21 homolog (S. pombe) -0.0236055
RACK1 receptor for activated C kinase 1 -0.0234544
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0234076
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0233206
RPLP1 ribosomal protein, large, P1 -0.023061
RPS19 ribosomal protein S19 -0.0230347
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0229637
LOX lysyl oxidase -0.0228865
LGALS1 lectin, galactoside-binding, soluble, 1 -0.022675
CEP350 centrosomal protein 350kDa -0.0226012
GARS1 glycyl-tRNA synthetase 1 -0.0225872
RIGI RNA sensor RIG-I -0.0224089